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1. 发明申请

US20070255327A1 Implantable Medical Device with Electromechanical Delay Measurement for Lead Position and Ventricular 有权
标题翻译：可植入医疗器械，用于引导位置和心室的机电延迟测量
公开(公告)号：US20070255327A1
公开(公告)日：2007-11-01
申请号：US11380350
申请日：2006-04-26
申请人： Yong Cho , Beth Geiman Ferri , Tommy Bennett
发明人： Yong Cho , Beth Geiman Ferri , Tommy Bennett
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N2001/083
摘要： The cardiac rhythm management system includes an implantable medical device (IMD) with leads carrying electrodes for sensing cardiac electrical activity, and a physiologic sensor for sensing cardiac mechanical activity. The IMD measures electromechanical delays between electrical activity sensed by the electrodes and mechanical activity sensed by the physiologic sensor. The measured electromechanical delays can be used to detect lead dislodgement and to assess dyssynchrony between two areas of the heart, such as the right ventricle and the left ventricle.
摘要翻译：心律管理系统包括具有承载用于感测心脏电活动的电极的引线的可植入医疗装置（IMD）和用于感测心脏机械活动的生理传感器。 IMD测量由电极感测的电活动和生理传感器感测到的机械活动之间的机电延迟。测量的机电延迟可用于检测引线移动并评估心脏两个区域之间的不同步，例如右心室和左心室。

2. 发明申请

US20070255112A1 VOLUME DEPLETION DETECTION 有权
标题翻译：体积检测
公开(公告)号：US20070255112A1
公开(公告)日：2007-11-01
申请号：US11380710
申请日：2006-04-28
申请人： Robert Taepke , Yong Cho , Joel Lauer , Tommy Bennett
发明人： Robert Taepke , Yong Cho , Joel Lauer , Tommy Bennett
IPC分类号： A61B5/00
CPC分类号： A61B5/0215 , A61M5/14276 , A61M2205/3523 , A61N1/36521 , A61N1/36564 , A61N1/37258 , G06F19/00
摘要： Detection of volume depletion, particularly after an incidence of volume overload is disclosed. Various methods, systems, and devices are disclosed that sense and analyze a physiological parameter related to a patient's fluid level in order to warn patients of potentially dangerous volume depletion conditions while minimizing false notifications.
摘要翻译：体积消耗的检测，特别是容量过载发生之后。公开了各种方法，系统和装置，其感测和分析与患者的液体水平相关的生理参数，以便在最小化假通知的同时警告患者潜在危险的体积消耗条件。

3. 发明申请

US20070179385A1 Method for continuous baroreflex sensitivity measurement 有权
标题翻译：连续压力反射灵敏度测量方法
公开(公告)号：US20070179385A1
公开(公告)日：2007-08-02
申请号：US11343635
申请日：2006-01-31
申请人： Yong Cho , Tommy Bennett
发明人： Yong Cho , Tommy Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0816 , A61B5/7285 , A61N1/3627 , A61N1/36521 , A61N1/368
摘要： A medical device and method for determining baroreflex sensitivity (BRS) based on one or more respiration cycles. The BRS determination may be performed continuously based on measurements of heart rate, blood pressure, and respiration cycles.
摘要翻译：一种用于根据一个或多个呼吸周期来确定压力反射灵敏度（BRS）的医疗装置和方法。可以基于心率，血压和呼吸周期的测量来连续进行BRS测定。

4. 发明申请

US20070156057A1 Method and system for interpreting hemodynamic data incorporating patient posture information 审中-公开
标题翻译：用于解释包含患者姿势信息的血液动力学数据的方法和系统
公开(公告)号：US20070156057A1
公开(公告)日：2007-07-05
申请号：US11323895
申请日：2005-12-30
申请人： Yong Cho , Yongduk Cho , Tommy Bennett
发明人： Yong Cho , Yongduk Cho , Tommy Bennett
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61N1/36535 , A61N1/36542
摘要： Systems and methods for improving hemodynamic data interpretation by accounting for the effects of patient posture is disclosed. In certain embodiments, a posture signal is acquired and used to categorize hemodynamic data according to posture to facilitate distinguishing posture-related changes in acquired hemodynamic data from those due to pathophysiologic changes. Posture information may be used to normalize data acquired in various postures to facilitate interpretation of such data. Baseline measurements of hemodynamic data acquired in various postures may also be used to subsequently detect changes in patient posture without the need for an implanted posture sensor.
摘要翻译：公开了通过考虑患者姿势的影响来改善血液动力学数据解释的系统和方法。在某些实施例中，获取姿势信号并用于根据姿势对血液动力学数据进行分类，以便于将所获得的血液动力学数据中的姿势相关变化与由于病理生理变化引起的姿势相关的变化区分开。姿势信息可以用于对在各种姿势中获取的数据进行归一化，以便于解释这些数据。在各种姿势中获取的血液动力学数据的基线测量也可用于随后检测患者姿势的变化，而不需要植入的姿势传感器。

5. 发明申请

US20070179383A1 Methods of identifying and/or assessing cardiac arrhythmias using an implantable medical device 有权
标题翻译：使用可植入医疗装置识别和/或评估心律失常的方法
公开(公告)号：US20070179383A1
公开(公告)日：2007-08-02
申请号：US11342397
申请日：2006-01-30
申请人： Yong Cho , Tommy Bennett , Barbro Kjellstrom , Susan Vadnais
发明人： Yong Cho , Tommy Bennett , Barbro Kjellstrom , Susan Vadnais
IPC分类号： A61B5/02
CPC分类号： A61N1/056 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/042 , A61B5/046 , A61N1/3622 , A61N1/3627 , A61N1/37 , A61N1/3925 , G06F19/00 , G06F19/3418
摘要： Apparatus using one or more modes of statistical analysis with one or more monitored parameters of a patient's heart to identify and/or assess arrhythmias. Through use of the one or more modes of statistical analysis, a medical professional can be aided during evaluation of patient data for diagnosis of the patient. At least one of the monitored parameters may include one or more values used representatively for storage intervals of a selected length. As such, for each storage interval, a value may be determined for the one monitored parameter occurring at an upper percentile and a lower percentile. In addition, a median value may be determined for the one monitored parameter for each storage interval. Over a plurality of the storage intervals, these determined values can be used in one or more modes of statistical analysis to better identify and assess the arrhythmias.
摘要翻译：一种使用一种或多种统计分析模式的患者心脏的一个或多个监测参数来识别和/或评估心律失常的装置。通过使用一种或多种统计分析模式，可以在评估用于患者诊断的患者数据时辅助医学专业人员。所监视的参数中的至少一个可以包括代表性地用于所选长度的存储间隔的一个或多个值。因此，对于每个存储间隔，可以针对在上百分位数和下百分位数处发生的一个监视参数来确定值。此外，可以针对每个存储间隔的一个被监视的参数确定中值。在多个存储间隔中，这些确定的值可以用于一种或多种统计分析模式，以更好地识别和评估心律失常。

6. 发明申请

US20070073171A1 Methods for detecting and monitoring sleep disordered breathing using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测和监测睡眠无序呼吸的方法
公开(公告)号：US20070073171A1
公开(公告)日：2007-03-29
申请号：US11237354
申请日：2005-09-28
申请人： Yong Cho , Tommy Bennett , Barbro Kjellstrom
发明人： Yong Cho , Tommy Bennett , Barbro Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/4818 , A61B5/7239
摘要： A method of identifying sleep disordered breathing (SDB) in a patient includes monitoring a hemodynamic pressure, deriving high, middle, and low values representative of the distribution of the hemodynamic pressure over a storage interval, measuring a ratio of a lower range to a full range of the hemodynamic pressure based on the derived high, middle, and low values, and using the ratio to determine whether the patient has experienced an SDB episode. Certain embodiments of the invention compare the ratio to a threshold value to identify the occurrence of an SDB episode, while other embodiments of the invention identify the occurrence of an SDB episode by monitoring for a simultaneous increase in both the ratio and the full range of the hemodynamic pressure. In certain other embodiments of the invention, activity level and/or duration criteria may be employed to confirm the occurrence of an SDB episode detected using the ratio.
摘要翻译：识别患者中睡眠呼吸障碍（SDB）的方法包括监测血液动力学压力，导出代表存储间隔内血流动力压力分布的高，中，低值，测量下限范围与满基于导出的高，中，低值的血流动力压力范围，并使用该比例来确定患者是否经历SDB发作。本发明的某些实施方案将比率与阈值进行比较以鉴定SDB发作的发生，而本发明的其它实施方案通过监测SDB发作的比例和全部范围的同时增加来识别SDB发作的发生血流动力学压力。在本发明的某些其他实施方案中，可以使用活动水平和/或持续时间标准来确认使用该比率检测到的SDB发作的发生。

7. 发明申请

US20060173248A1 Derivation of flow contour from pressure waveform 有权
标题翻译：从压力波形推导流量轮廓
公开(公告)号：US20060173248A1
公开(公告)日：2006-08-03
申请号：US11045574
申请日：2005-01-27
申请人： Mustafa Karamanoglu , Tommy Bennett
发明人： Mustafa Karamanoglu , Tommy Bennett
IPC分类号： A61B5/00
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/029 , A61B5/7239
摘要： The present invention provides a system and method for estimating a blood flow waveform contour from a pressure signal. An arterial or ventricular pressure signal is acquired from a pressure sensor. Landmark points are identified on the pressure waveform that correspond to features of a flow waveform. In one embodiment, the landmark pressure waveform points correspond to the onset of flow, the peak flow, and the end of the systolic ejection phase. The landmark pressure waveform points define a contour that approximates the flow contour. Beat-by-beat flow contour estimation can be performed to allow computation of flow-related hemodynamic parameters such as stroke volume or cardiac output for use in patient monitoring and/or therapy management.
摘要翻译：本发明提供一种用于从压力信号估计血流波形轮廓的系统和方法。从压力传感器获取动脉或心室压力信号。在与流量波形的特征对应的压力波形上标识地标点。在一个实施例中，标记压力波形点对应于流动的开始，峰值流动和收缩期喷射阶段的结束。界标压力波形点定义近似流轮廓的轮廓。可以进行逐搏流轮廓估计，以允许计算流动相关的血液动力学参数，例如用于患者监测和/或治疗管理的中风体积或心输出量。

8. 发明申请

US20060167360A1 System and method for detecting artifactual hemodynamic waveform data 有权
标题翻译：用于检测人为血液动力波形数据的系统和方法
公开(公告)号：US20060167360A1
公开(公告)日：2006-07-27
申请号：US11044618
申请日：2005-01-27
申请人： Tommy Bennett , Mark Choi , David Igel , Michael Hill , Teresa Whitman
发明人： Tommy Bennett , Mark Choi , David Igel , Michael Hill , Teresa Whitman
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108
摘要： A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
摘要翻译：用于心血管分析的系统和方法包括能够基于检测到的压力产生血流动力压力波形数据的可植入医疗装置。分析血流动力学波形数据以识别在血流动力学波形中表示的人为因素数据。

9. 发明申请

US20060167358A1 Method and apparatus for muscle function measurement 有权
标题翻译：肌肉功能测量的方法和装置
公开(公告)号：US20060167358A1
公开(公告)日：2006-07-27
申请号：US11043819
申请日：2005-01-26
申请人： Mustafa Karamanoglu , Vincent Splett , Tommy Bennett
发明人： Mustafa Karamanoglu , Vincent Splett , Tommy Bennett
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, {dot over (E)}/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from {dot over (E)}/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译：本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。瞬时刚度比（E / E（t））以1 /秒为单位，与强键形成速率有关，并受肌肉纤维的钙处理性能和细胞内钙浓度的影响。因此，从{dot over（E / E（t））得到的指数提供肌肉肌力状态的量度。

10. 发明申请

US20060094967A1 Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous system 有权
标题翻译：提供受试者自主神经系统调节的诊断指标和治疗的方法和装置
公开(公告)号：US20060094967A1
公开(公告)日：2006-05-04
申请号：US10977073
申请日：2004-10-29
申请人： Tommy Bennett , Edwin Duffin , Robert Taepke , Barbro Kjellstrom
发明人： Tommy Bennett , Edwin Duffin , Robert Taepke , Barbro Kjellstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/4035 , A61B5/7239 , A61N1/36535 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/3702
摘要： A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.
摘要翻译：提供了一种用于确定用于患者监测或治疗递送控制的自主神经系统（ANS）或交感神经系统（SNS）活动指数的系统和方法。 ANS或SNS指数被计算为与自主神经或交感神经紧张度变化密切相关的多个被监测的生理变量的函数。这些受ANS影响的变量来自选定的血流动力学和/或电信号，并且可以包括与以下任何相关的变量：压力上升的最大速率（dP / dt最大值），最大压力下降速率（dP / dt分钟），脉压（PP），预喷射时间间隔（PEI）和/或收缩时间间隔（STI），心率（HR），心率变异性（HRV），以及压力反射增益。可以使用ANS或SNS指数的变化来自动调整设备传递的治疗。

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