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1. 发明授权

US06809091B1 Substances capable of inducing apoptosis 失效
标题翻译：能诱导细胞凋亡的物质
公开(公告)号：US06809091B1
公开(公告)日：2004-10-26
申请号：US09582554
申请日：2000-06-28
申请人： Yoko Tatsumi , Hiroaki Sagawa , Hiromu Ohnogi , Eiji Kobayashi , Hua-Kang Wu , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Yoko Tatsumi , Hiroaki Sagawa , Hiromu Ohnogi , Eiji Kobayashi , Hua-Kang Wu , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31555
CPC分类号： A61K31/7004 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/11 , A61K31/122 , A61K31/198 , A61K31/351 , A61K31/357 , A61K31/52 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/711 , C07C323/22 , C07C323/60 , C07C2601/08 , C07D473/00 , A23V2250/60 , A23V2250/638 , A23V2250/626
摘要： A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compounds which contain uronic acid and/or uronic acid derivatives] to a heating treatment: (a) pentose; (b) pentose derivatives; (c) compounds containing pentose; (d) compounds containing pentose derivatives.
摘要翻译：一种制备具有细胞凋亡诱导能力的物质的方法，其特征在于包括使至少一种选自以下（a），（b），（c）和（d）的化合物（不包括糖醛酸和/ 或糖醛酸衍生物; （a）戊糖;（b）戊糖衍生物;（c）含有戊糖的化合物;（d）含有戊糖衍生物的化合物。

2. 发明授权

US06482806B1 Product of heat treatment of uronic acid, food, drink, or drug including the product 失效
标题翻译：糖醛酸，食品，饮料或药品的热处理产品，包括产品
公开(公告)号：US06482806B1
公开(公告)日：2002-11-19
申请号：US09125397
申请日：1998-08-18
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
IPC分类号： A61K31727
CPC分类号： C07H7/033 , A61K8/60 , A61Q11/00 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.
摘要翻译：通过加热选自以下（a），（b）和（c）中的至少一种物质获得的产物：（a）糖醛酸或糖醛酸衍生物;（b）含有糖醛酸或含有糖醛酸的糖类化合物的糖类化合物酸衍生物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质;以及含有上述热处理物的食品，饮料或药剂。

3. 发明申请

US20050202064A1 Product of heat treatment of uronic acid, food, drink or drug including the product 审中-公开
标题翻译：产品的糖醛酸，食品，饮料或药物包括产品的热处理
公开(公告)号：US20050202064A1
公开(公告)日：2005-09-15
申请号：US11114071
申请日：2005-04-26
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Suzu Deguchi , Katsushige Ikai , Hiromu Ohnogi , Motoko Ueda , Akihiro Kondo , Ikunoshin Kato
IPC分类号： A23L3/3562 , A61K8/60 , A61K31/19 , A61K31/70 , A61K31/7012 , A61K31/715 , A61K31/727 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/737 , A61K35/00 , A61K35/12 , A61K35/74 , A61K36/00 , A61L2/16 , A61P35/00 , A61Q11/00 , C07H7/033 , C08B37/00
CPC分类号： C07H7/033 , A61K8/60 , A61Q11/00 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.
摘要翻译：通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。（a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

4. 发明授权

US06177592B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06177592B1
公开(公告)日：2001-01-23
申请号：US09341768
申请日：1999-07-16
申请人： Nobuto Koyama , Tatsuji Enoki , Katsushige Ikai , Hua-Kang Wu , Hiromu Ohnogi , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Hiroaki Sagawa , Hideto Chono , Ikunoshin Kato
发明人： Nobuto Koyama , Tatsuji Enoki , Katsushige Ikai , Hua-Kang Wu , Hiromu Ohnogi , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Hiroaki Sagawa , Hideto Chono , Ikunoshin Kato
IPC分类号： C07C6106
CPC分类号： C07C323/59 , A23K20/105 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , C07C2601/08 , Y02A50/478 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/70 , A23V2250/204 , A23V2250/06 , A23V2250/21
摘要： A compound represented by the following formula [I] or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is ═O and Z is H while, in the case of a cyclopentane ring, X is ═O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.)
摘要翻译：由下式[I]表示的化合物或光学活性物质或其盐（在该式中，五元环中虚线所示的键表示所述五元环可以是具有双键的环戊烯环和所述键饱和的环戊烷环，在环戊烯环的情况下，X为OH，Y为= O且Z为H，而在环戊烷环的情况下，X为= O，Y是OH，Z是OH，R是从含SH的化合物除去SH基团后的残基。

5. 发明授权

US06548543B1 Remedies or preventives containing cyclopentenone compounds as the active ingredient 失效
标题翻译：含环戊烯酮化合物作为活性成分的补救措施或预防措施
公开(公告)号：US06548543B1
公开(公告)日：2003-04-15
申请号：US09763244
申请日：2001-02-20
申请人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31215
CPC分类号： A61K31/215 , A61K31/22 , C07C69/013 , C07C2601/10 , Y02A50/411
摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.
摘要翻译：需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

6. 发明授权

US06380262B1 5-membered ring compounds 失效
标题翻译： 5元环化合物
公开(公告)号：US06380262B1
公开(公告)日：2002-04-30
申请号：US09762265
申请日：2001-02-06
申请人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07K5/0215 , A61K38/00
摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.
摘要翻译：由通式（I）表示的5-元环化合物，其旋光异构体或其盐。这些化合物具有包括致癌作用的生理活性。在所述式中，五元环中虚线所示的键表示该5元环可以是具有双键或饱和环戊烷环的环戊烯环，当5元环为环戊烯环时 X为OR 1，Y为= O且Z为H，当为环戊烷环时，X为= O，Y为OR 2，Z为OR 3，（其中R1为R4或 - （CO）-R5; R2为 H，-R6或 - （CO）-R7; R3为H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同，各自表示脂族，芳族或脂族芳族基团，R 5，R 7和R 9可以各自为H），条件是排除R2 = R3 = H的情况）; W表示通过从含SH化合物中除去SH而得到的残基。

7. 发明授权

US6087401A Cyclopentenones, process for preparing the same, and the use thereof 失效
标题翻译：环戊烯酮，其制备方法及其用途
公开(公告)号：US6087401A
公开(公告)日：2000-07-11
申请号：US230868
申请日：1999-02-02
申请人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Katsushige Ikai , Ikunoshin Kato
发明人： Nobuto Koyama , Hiroaki Sagawa , Eiji Kobayashi , Tatsuji Enoki , Hua-Kang Wu , Eiji Nishiyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A61K8/35 , A61K8/60 , A61K31/12 , A61Q5/00 , A61Q11/00 , A61Q19/00 , C07C45/67 , C07C49/707 , C07H7/033
CPC分类号： C07H7/033 , A61K8/35 , A61K8/60 , A61Q17/005 , A61Q19/00 , A61Q11/00 , A61Q19/10 , A61Q5/00
摘要： There is disclosed a method of manufacturing 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [1] which is characterized in that at least one substance selected from the following (a), (b) and (c) is heated.(a): uronic acid or uronic acid derivative(s);(b): a saccharide compound which contains uronic acid and/or uronic acid derivative(s); and(c): a substance containing a saccharide compound which contains uronic acid and/or uronic acid derivative(s). ##STR1##
摘要翻译： PCT No.PCT / JP97 / 03052 Sec。 371日期1999年2月2日 102（e）1999年2月2日PCT 1997年9月1日PCT PCT。公开号WO98 / 13328 日期：1998年4月2日公开了由下式[1]表示的4,5-二羟基-2-环戊烯-1-酮的制造方法，其特征在于，选自下述（a），（b）和（c）被加热。（a）：糖醛酸或糖醛酸衍生物; （b）：含有糖醛酸和/或糖醛酸衍生物的糖类化合物; 和（c）：含有糖醛酸和/或糖醛酸衍生物的糖类化合物的物质。

8. 发明授权

US06284801B1 Antirheumatic agents 失效
标题翻译：抗风湿剂
公开(公告)号：US06284801B1
公开(公告)日：2001-09-04
申请号：US09380239
申请日：1999-08-27
申请人： Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
发明人： Nobuto Koyama , Hua-Kang Wu , Takanari Tominaga , Eiji Nishiyama , Michio Hagiya , Tatsuji Enoki , Hiromu Ohnogi , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07C323/59 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/122 , C07C45/60 , C07C45/78 , C07C49/707 , C07C323/58 , A23V2200/224 , A23V2250/5026 , A23V2250/5024 , A23V2250/21 , A23V2250/70 , A23V2250/06 , A23V2250/204
摘要： An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为有效成分。

9. 发明授权

US06911432B2 Drugs, foods or drinks with the use of algae-derived physiologically active substances 失效
标题翻译：使用藻类来源的生理活性物质的药物，食品或饮料
公开(公告)号：US06911432B2
公开(公告)日：2005-06-28
申请号：US10228195
申请日：2002-08-27
申请人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A61K31/341 , C07G99/00 , A01N43/04
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I): These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.
摘要翻译：用于治疗，改善或预防对3,6-脱水吡喃半乳糖敏感的疾病的药物组合物由式（I）表示：这些组合物包括含有至少一种这样的化合物，其醛，其水合物和2-O-甲基化衍生物和含有上述化合物的可溶性糖化合物。这些化合物对活性氧，脂质过氧化物自由基和NO的生成表现出细胞凋亡诱导活性，制癌活性和抑制活性，这使得它们也可用作抗氧化剂和防腐剂的活性成分。

10. 发明申请

US20050119191A1 Drugs, foods or drinks with the use of algae-derived physiologically active substances 失效
标题翻译：使用藻类来源的生理活性物质的药物，食品或饮料
公开(公告)号：US20050119191A1
公开(公告)日：2005-06-02
申请号：US11034243
申请日：2005-01-13
申请人： Tatsui Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsui Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A23L1/30 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A61K31/341 , C07G99/00 , A61K31/70 , A61K31/335
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
摘要翻译：用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等，所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

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