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    • 5. 发明授权
    • Hydrofluorene derivatives
    • 氢氟芴衍生物
    • US5017724A
    • 1991-05-21
    • US532341
    • 1990-06-04
    • Yasuo OshiroTatsuyoshi TanakaYoji SakuraiSeiji Sato
    • Yasuo OshiroTatsuyoshi TanakaYoji SakuraiSeiji Sato
    • C07D207/09C07D207/26C07D207/27C07D211/26C07D211/58C07D213/38C07D213/82C07D295/096C07D295/15
    • C07D207/27C07D207/09C07D211/26C07D211/58C07D213/38C07D213/82C07D295/096C07D295/15C07C2103/18
    • Novel hydrofluorene derivatives and salts thereof represented by the formula (1) which possess excellent activities for improving anoxemic and hypoxic symptoms and syndromes accompanied therewith, therefore said derivatives are useful as cerebral activators, preventive agents for arrhythmia and heart failure caused by the shortage of oxygen and others. Furthermore, said hydrofluorene derivatives and salts thereof possess actions for scavenging active oxygen radicals, therefore, the derivatives are useful prophylactic and treating agents for various disturbances and diseases caused by the excessive formation of active oxygen radicals. In addition to the above, the hydrofluorene derivatives are useful as anti-oxidative agents for fats and oils.Yet, further, the hydrofluorene derivatives and salts thereof accelerate the uptaking of high-affinity choline in the central nerve system and/or the releasing of acetylcholine therefrom, therefore, the hydrofluorene derivatives and salts thereof are useful cholinergic nerve system activating agents.
    • 由式(1)表示的新型氢芴衍生物及其盐,其具有改善缺氧症和缺氧症状及伴随症状的优异活性,因此所述衍生物可用作脑激活剂,由氧气不足引起的心律失常和心力衰竭的预防剂 和别的。 此外,所述氢芴衍生物及其盐具有清除活性氧自由基的作用,因此,该衍生物是用于由过度形成活性氧自由基引起的各种紊乱和疾病的预防和治疗剂。 除了上述之外,氢芴衍生物可用作脂肪和油的抗氧化剂。 此外,氢芴衍生物和其盐加速了中枢神经系统中高亲和力胆碱的吸收和/或乙酰胆碱的释放,因此,氢芴衍生物及其盐是有用的胆碱能神经系统活化剂。