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1. 发明授权

US09060958B2 Tyrosinase inhibitor produced using dried earthworm powder, and method for producing same 有权
标题翻译：使用干蚯蚓粉制备的酪氨酸酶抑制剂及其制备方法
公开(公告)号：US09060958B2
公开(公告)日：2015-06-23
申请号：US14235191
申请日：2012-07-24
申请人： Yoichi Ishii , Kazuyuki Ishii
发明人： Yoichi Ishii , Kazuyuki Ishii
IPC分类号： A61K36/62 , A61K8/98 , A61Q19/02 , A61Q19/00 , A61K8/02 , A61K35/62
CPC分类号： A61K8/98 , A61K8/022 , A61K8/987 , A61K35/62 , A61Q19/00 , A61Q19/02
摘要： The present invention provides a highly safe tyrosinase inhibitor having excellent tyrosinase-inhibiting action, and a method for producing the tyrosinase inhibitor. The method for producing a tyrosinase inhibitor comprises the steps of contacting a live earthworm with hydroxycarboxylic acid powder, diluting the resulting mixture with water to adjust the pH to 2 to 5, and then leaving the resulting dilution to stand for 3 to 180 minutes, or contacting a live earthworm with an aqueous solution of hydroxycarboxylic acid having a pH of 2 to 5 and then leaving the resulting mixture to stand for 3 to 180 minutes; followed by washing the live earthworm with water, grinding the washed earthworm, and then freeze-drying the obtained ground product.
摘要翻译：本发明提供了具有优异的酪氨酸酶抑制作用的高度安全的酪氨酸酶抑制剂，以及制备酪氨酸酶抑制剂的方法。制备酪氨酸酶抑制剂的方法包括以下步骤：将活蚯蚓与羟基羧酸粉末接触，将所得混合物用水稀释以将pH调节至2至5，然后将所得稀释液静置3至180分钟，或使活蚯蚓与pH为2至5的羟基羧酸水溶液接触，然后将所得混合物静置3至180分钟; 然后用水清洗活蚯蚓，研磨洗涤的蚯蚓，然后冷冻干燥所得的研磨产物。

2. 发明申请

US20140154331A1 TYROSINASE INHIBITOR PRODUCED USING DRIED EARTHWORM POWDER, AND METHOD FOR PRODUCING SAME 有权
标题翻译：使用干地泥粉生产的酪氨酸酶抑制剂及其生产方法
公开(公告)号：US20140154331A1
公开(公告)日：2014-06-05
申请号：US14235191
申请日：2012-07-24
申请人： Yoichi Ishii , Kazuyuki Ishii
发明人： Yoichi Ishii , Kazuyuki Ishii
IPC分类号： A61K8/98
CPC分类号： A61K8/98 , A61K8/022 , A61K8/987 , A61K35/62 , A61Q19/00 , A61Q19/02
摘要： The present invention provides a highly safe tyrosinase inhibitor having excellent tyrosinase-inhibiting action, and a method for producing the tyrosinase inhibitor. The method for producing a tyrosinase inhibitor comprises the steps of contacting a live earthworm with hydroxycarboxylic acid powder, diluting the resulting mixture with water to adjust the pH to 2 to 5, and then leaving the resulting dilution to stand for 3 to 180 minutes, or contacting a live earthworm with an aqueous solution of hydroxycarboxylic acid having a pH of 2 to 5 and then leaving the resulting mixture to stand for 3 to 180 minutes; followed by washing the live earthworm with water, grinding the washed earthworm, and then freeze-drying the obtained ground product.
摘要翻译：本发明提供了具有优异的酪氨酸酶抑制作用的高度安全的酪氨酸酶抑制剂，以及制备酪氨酸酶抑制剂的方法。制备酪氨酸酶抑制剂的方法包括以下步骤：将活蚯蚓与羟基羧酸粉末接触，将所得混合物用水稀释以将pH调节至2至5，然后将所得稀释液静置3至180分钟，或使活蚯蚓与pH为2至5的羟基羧酸水溶液接触，然后将所得混合物静置3至180分钟; 然后用水清洗活蚯蚓，研磨洗涤的蚯蚓，然后冷冻干燥所得的研磨产物。

3. 发明授权

US08394417B2 Method of producing a dry earthworm powder 有权
标题翻译：生产干蚯蚓粉的方法
公开(公告)号：US08394417B2
公开(公告)日：2013-03-12
申请号：US12903615
申请日：2010-10-13
申请人： Yoichi Ishii , Kazuyuki Ishii , Hiroyuki Sumi , Etsuo Yoshida , Sayaka Ishii
发明人： Yoichi Ishii , Kazuyuki Ishii , Hiroyuki Sumi , Etsuo Yoshida , Sayaka Ishii
IPC分类号： A61K35/56
CPC分类号： A61K35/62
摘要： Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.
摘要翻译：提供了一种简单易行的生产无嗅干蚯蚓粉的方法，同时抑制蚯蚓中含有的酶的失活。在该方法中，通过研磨活蚯蚓获得的匀浆物被冷冻干燥，干燥产物在110℃以上且低于130℃的温度下进行热处理。优选地，根据本发明的方法包括进一步的在研磨步骤之前制备活蚯蚓的方法，包括以下步骤：将活蚯蚓放在灯下10-50小时; 除去形成在其皮肤上的污垢，使蚯蚓与有机酸接触30秒以下; 通过添加水稀释酸，以将酸性水溶液的pH调节至2至5范围内的pH; 在pH条件下静置蚯蚓混合物3〜180分钟; 然后用水洗蚯蚓。

4. 发明授权

US5024844A Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient 失效
标题翻译：用于生产干蚯蚓粉和抗高脂血症，抗糖尿病，抗高血压和抗低血压制剂的干燥蚯蚓粉作为活性成分的方法
公开(公告)号：US5024844A
公开(公告)日：1991-06-18
申请号：US228672
申请日：1988-08-05
申请人： Yoichi Ishii , Hisashi Mihara
发明人： Yoichi Ishii , Hisashi Mihara
IPC分类号： A61K35/56 , A61K35/62
CPC分类号： A61K35/62 , Y10S514/866 , Y10S530/855
摘要： Disclosed is a process for the production of dried earthworm powder which comprises the steps of leaving a species of living earthworms in fresh water or a slightly acidic aqueous solution until the alimentary canal thereof is freed of soil, wet-grinding the living earthworms, and freeze-drying and then vacuum-drying the resulting suspension under a vacuum of 10 mmHg or below for 10 to 100 hours while raising the temperature stepwise from -60.degree. C. to 80.degree. C. This dried earthworm powder may be combined with pharmaceutically acceptable carriers to form pharmaceutical compositions which are useful for the treatment or prevention of hyperlipemia, diabetes, hypertension and hypotension in human beings.
摘要翻译：公开了一种生产干蚯蚓粉的方法，其包括将生物蚯蚓种类留在淡水或微酸性水溶液中的步骤，直到其消化道没有土壤，湿碾生活蚯蚓，并冻结然后将所得悬浮液在10mmHg或更低的真空下真空干燥10至100小时，同时将温度逐步从-60℃升至80℃。该干燥的蚯蚓粉可与药学上可接受的载体以形成可用于治疗或预防人类中的高脂血症，糖尿病，高血压和低血压的药物组合物。

5. 发明授权

US4769357A Process for producing composite oxide catalyst 失效
标题翻译：生产复合氧化物催化剂的方法
公开(公告)号：US4769357A
公开(公告)日：1988-09-06
申请号：US017582
申请日：1987-02-24
申请人： Kohei Sarumar , Yoichi Ishii , Isamu Kobayashi
发明人： Kohei Sarumar , Yoichi Ishii , Isamu Kobayashi
IPC分类号： B01J23/16 , B01J23/887 , B01J23/888 , C07B33/00 , C07C45/35 , C07C51/25 , B01J21/06 , B01J23/72 , B01J23/84 , B01J23/88
CPC分类号： C07C51/252 , B01J23/002 , B01J23/8877 , B01J23/8885 , C07C45/35 , B01J2523/00
摘要： A process for producing a composite oxide catalyst comprising at least Sb, Mo, V and/or Nb by the steps of combining and heating the sources of required respective elements, characterized in that a composite oxide represented by the following formula, which has been heated previously at a temperature of 600.degree. to 900.degree. C., is used as at least a part of a source of Sb supply:Sb.sub.p -X.sub.q -Y.sub.r,wherein x represents at least one selected from the group consisting of Ni, Fe, Co and Bi; Y represents at least one selected from the group consisting of Al and Si; p is a numeral of 1-40, q is a numeral of 1-20 and r is a numeral of 0-10, provided that when r is 0, Ni of X is at least partly supplied by nickel carbonate.A catalyst having a large mean pore size is obtained. When the catalyst is used in an oxidation reaction such as air oxidation of acrolein, acrylic acid as the object product can be obtained in high selectivity.
摘要翻译：一种通过组合和加热所需要的各种元素的源的步骤来制备至少包含Sb，Mo，V和/或Nb的复合氧化物催化剂的方法，其特征在于由下式表示的复合氧化物，其被加热以前在600〜900℃的温度下，作为Sb供给源的至少一部分使用：Sbp-Xq-Yr，其中x表示选自Ni，Fe，Co中的至少一种和Bi Y表示选自Al和Si中的至少一种; p为1-40的数字，q为1-20，r为0-10的数字，条件是当r为0时，X的Ni至少部分由碳酸镍提供。得到平均孔径大的催化剂。当催化剂用于氧化反应如丙烯醛的空气氧化时，可以以高选择性获得丙烯酸作为目标产物。

6. 发明授权

US4254389A Pushbutton tuner having tapering portion pivotal pins 失效
标题翻译：按钮调谐器具有锥形部分枢轴销
公开(公告)号：US4254389A
公开(公告)日：1981-03-03
申请号：US58630
申请日：1979-07-18
申请人： Yasuhisa Nishikawa , Yoichi Ishii , Takao Kanai
发明人： Yasuhisa Nishikawa , Yoichi Ishii , Takao Kanai
IPC分类号： H03J5/08 , H03J5/12
CPC分类号： H03J5/12
摘要： A pushbutton tuner wherein a plurality of tilting actuating links are provided for a slide member for causing cores to move in-and-out of coils and the actuating links are adapted to engage setting pins of frequency regulating members respectively, which are provided on button slides actuatable by push buttons, respectively to effect a selection operation, which tuner is characterized in that a pivotal pin fitted in a hole formed in each of the frequency regulating members has a tapering portion and each of the setting pins also has a tapering portion at a portion where the setting pin engages the actuating link associated therewith.
摘要翻译：一种按钮调谐器，其中为滑动构件提供多个倾斜致动连杆，用于使芯线在线圈中进出并且所述致动连杆适于分别接合设置在按钮滑块上的调频构件的设定销通过按钮分别可以进行选择操作，哪个调谐器的特征在于，安装在每个频率调节构件中形成的孔中的枢轴具有锥形部分，并且每个定位销还具有锥形部分其中定位销接合与其相关联的致动连杆。

7. 发明授权

US4896193A Multicolored image forming apparatus separable for ease of maintenance 失效
标题翻译：多彩色成像设备可分离，便于维护
公开(公告)号：US4896193A
公开(公告)日：1990-01-23
申请号：US332383
申请日：1989-04-03
申请人： Kazuo Kagiura , Noriyuki Yokoo , Mototada Toriumi , Hiroyoshi Maruyama , Hidetoshi Tanaka , Yoichi Ishii
发明人： Kazuo Kagiura , Noriyuki Yokoo , Mototada Toriumi , Hiroyoshi Maruyama , Hidetoshi Tanaka , Yoichi Ishii
IPC分类号： G03G15/08 , G03G21/16
CPC分类号： G03G15/0896 , G03G21/1628 , G03G21/1647 , G03G21/1676 , G03G2221/1603 , G03G2221/1609 , G03G2221/163 , G03G2221/1648 , G03G2221/1654 , G03G2221/1657 , G03G2221/1687
摘要： An image forming apparatus comprising a first body and a second body which are openable or separable from each other. The apparatus contains a plurality of developing devices, each of which is movable between its developing position for developing a latent image on an image bearing member of the image forming apparatus and a retracted position where the developing device is retracted from the developing position. At least the developing device that is located at its developing position when the apparatus is closed, is moved away from the image bearing member in response to an operation for opening the second body relative to the first body.
摘要翻译：一种图像形成装置，包括可彼此打开或分离的第一主体和第二主体。该装置包括多个显影装置，每个显影装置可在其显影位置之间移动，用于在图像形成装置的图像承载部件上显影潜像和显影装置从显影位置缩回的缩回位置。至少当设备关闭时位于其显影位置的显影装置响应于相对于第一主体打开第二主体的操作而远离图像承载部件移动。

8. 发明授权

US5128148A Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient 失效
标题翻译：用于生产干蚯蚓粉和抗高脂血症，抗糖尿病，抗高血压和抗低血压制剂的干燥蚯蚓粉作为活性成分的方法
公开(公告)号：US5128148A
公开(公告)日：1992-07-07
申请号：US641519
申请日：1991-01-15
申请人： Yoichi Ishii , Hisashi Mihara
发明人： Yoichi Ishii , Hisashi Mihara
IPC分类号： A61K35/56 , A61K35/62
CPC分类号： A61K35/62 , Y10S514/866 , Y10S530/855
摘要： Disclosed is a process for the production of dried earthworm powder which comprises the steps of leaving a species of living earthworms in fresh water or a slightly acidic aqueous solution until the alimentary canal thereof is freed of soil, wet-grinding the living earthworms, and freeze-drying and then vacuum-drying the resulting suspension under a vacuum of 10 mmHg or below for 10 to 100 hours while raising the temperature stepwise from -60.degree. C. to 80.degree. C. This dried earthworm powder may be combined with pharmaceutically acceptable carriers to form pharmaceutical compositions which are useful for the treatment or prevention of hyperlipemia, diabetes, hypertension and hypotension in human beings.
摘要翻译：公开了一种生产干蚯蚓粉的方法，其包括将生物蚯蚓种类留在淡水或微酸性水溶液中的步骤，直到其消化道没有土壤，湿磨蚯蚓，冷冻然后将所得悬浮液在10mmHg或更低的真空下真空干燥10至100小时，同时将温度逐步从-60℃升至80℃。该干燥的蚯蚓粉可与药学上可接受的载体以形成可用于治疗或预防人类中的高脂血症，糖尿病，高血压和低血压的药物组合物。

9. 发明授权

US4604370A Process for regenerating a catalyst 失效
标题翻译：再生催化剂的方法
公开(公告)号：US4604370A
公开(公告)日：1986-08-05
申请号：US753136
申请日：1985-07-09
申请人： Kohei Sarumaru , Takeshi Shibano , Yoichi Ishii , Etsuji Yamamoto
发明人： Kohei Sarumaru , Takeshi Shibano , Yoichi Ishii , Etsuji Yamamoto
IPC分类号： C07C47/22 , B01J23/92 , B01J23/94 , B01J27/28 , B01J38/12 , C07B61/00 , C07C45/00 , C07C45/35 , C07C67/00
CPC分类号： B01J38/12 , B01J23/92 , C07C45/35 , Y02P20/584
摘要： A process for regenerating a Mo.Bi-based multi-oxide catalyst the catalytic performance of which has deteriorated as a result of its use in vapor-phase catalytic oxidation of propylene or isobutene to prepare acrolein or methacrolein, respectively, which process comprises: heating the deteriorated Mo.Bi-based multi-oxide catalyst in an atmosphere consisting essentially of air at a temperature of 380.degree. C. to 540.degree. C., so as to attain at least partial restoration of the catalytic performance thereof.
摘要翻译：一种用于再生基于Mo.Bi的多氧化物催化剂的方法，其催化性能由于其在丙烯或异丁烯的气相催化氧化中的用途而分别降低，以制备丙烯醛或异丁烯醛，该方法包括：加热在基本上由380℃至540℃的空气组成的气氛中的Mo.Bi基多氧化物催化剂劣化，从而至少部分恢复其催化性能。

10. 发明授权

US08137701B2 Method of producing a dry earthworm powder 有权
标题翻译：生产干蚯蚓粉的方法
公开(公告)号：US08137701B2
公开(公告)日：2012-03-20
申请号：US12076738
申请日：2008-03-21
申请人： Yoichi Ishii , Hiroyuki Sumi , Etsuo Yoshida
发明人： Yoichi Ishii , Hiroyuki Sumi , Etsuo Yoshida
IPC分类号： A61K35/56
CPC分类号： A61K35/62
摘要： Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C. to −35° C., keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.
摘要翻译：本发明提供一种干燥蚯蚓粉的制造方法，其不会劣化有用的药理作用，通过去除蚯蚓皮肤上的污物，同时允许蚯蚓有效排出消化道中残留的消化物而不削弱蚯蚓，这包括以下步骤：静置蚯蚓在灯下10〜50小时，除去皮肤上形成的污垢，向活蚯蚓加入有机酸，加入水快速稀释酸，将酸性水溶液的pH调节至2〜5 ，在pH条件下将蚯蚓混合物静置3〜180分钟，用水洗涤蚯蚓，将蚯蚓粉碎成匀浆，将匀浆在-18℃冷冻至-35℃，保持冷冻匀浆20 至240小时，同时在真空下对冷冻匀浆进行冷冻干燥脱气。

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