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1. 发明授权

US08094903B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08094903B2
公开(公告)日：2012-01-10
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/03
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

2. 发明申请

US20090010512A1 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US20090010512A1
公开(公告)日：2009-01-08
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： H05G1/64 , G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

3. 发明授权

US08086006B2 Method and system for evaluating image segmentation based on visibility 有权
标题翻译：基于可见度评估图像分割的方法和系统
公开(公告)号：US08086006B2
公开(公告)日：2011-12-27
申请号：US12231634
申请日：2008-09-04
申请人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T7/60 , G06T7/11 , G06T7/174 , G06T7/246 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for evaluating image segmentation is disclosed. In order to quantitatively evaluate an image segmentation technique, synthetic image data is generated and the synthetic image data is segmented to extract an object using the segmentation technique. This segmentation results in a foreground containing the extracted object and a background. The visibility of the extracted object is quantitatively measured based on the intensity distributions of the segmented foreground and background. The visibility is quantitatively measured by calculating the Jeffries-Matusita distance between the foreground and background intensity distributions. This method can be used to evaluate segmentation of vessels in fluoroscopic image sequences by coronary digital subtraction angiography (DSA).
摘要翻译：公开了一种用于评估图像分割的方法和系统。为了定量评估图像分割技术，生成合成图像数据，并且使用分割技术对合成图像数据进行分割以提取对象。该分割导致包含提取的对象和背景的前景。基于分割的前景和背景的强度分布，定量地测量提取的对象的可视性。通过计算前景和背景强度分布之间的Jeffries-Matusita距离来定量测量可见度。该方法可用于通过冠状动脉数字减影血管造影（DSA）评估荧光镜图像序列中血管的分割。

4. 发明授权

US07940971B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US07940971B2
公开(公告)日：2011-05-10
申请号：US11779405
申请日：2007-07-18
申请人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Chandan K. Reddy , Dorin Comaniciu
发明人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Chandan K. Reddy , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/34 , G06K2209/05 , Y10S128/922
摘要： A method and system for extracting motion-based layers from fluoroscopic image sequences are disclosed. Portions of multiple objects, such as anatomical structures, are detected in the fluoroscopic images. Motion of the objects is estimated between the images is the sequence of fluoroscopic images. The images in the fluoroscopic image sequence are then divided into layers based on the estimated motion. In a particular implementation, the coronary vessel tree and the diaphragm can be extracted in separate motion layers from coronary angiograph fluoroscopic image sequence.
摘要翻译：公开了一种从透视图像序列中提取基于运动的层的方法和系统。在透视图像中检测到多个对象的部分，例如解剖结构。在图像之间估计物体的运动是荧光图像的序列。然后，基于估计的运动将透视图像序列中的图像分成多个层。在特定的实施方案中，冠状动脉血管和隔膜可以与冠状动脉血管造影术透视图像序列分开提取。

5. 发明申请

US20090080729A1 Method and system for evaluating image segmentation based on visibility 有权
标题翻译：基于可见度评估图像分割的方法和系统
公开(公告)号：US20090080729A1
公开(公告)日：2009-03-26
申请号：US12231634
申请日：2008-09-04
申请人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： A61B5/00
CPC分类号： G06T7/60 , G06T7/11 , G06T7/174 , G06T7/246 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for evaluating image segmentation is disclosed. In order to quantitatively evaluate an image segmentation technique, synthetic image data is generated and the synthetic image data is segmented to extract an object using the segmentation technique. This segmentation results in a foreground containing the extracted object and a background. The visibility of the extracted object is quantitatively measured based on the intensity distributions of the segmented foreground and background. The visibility is quantitatively measured by calculating the Jeffries-Matusita distance between the foreground and background intensity distributions. This method can be used to evaluate segmentation of vessels in fluoroscopic image sequences by coronary digital subtraction angiography (DSA).
摘要翻译：公开了一种用于评估图像分割的方法和系统。为了定量评估图像分割技术，生成合成图像数据，并且使用分割技术对合成图像数据进行分割以提取对象。该分割导致包含提取的对象和背景的前景。基于分割的前景和背景的强度分布，定量地测量提取的对象的可视性。通过计算前景和背景强度分布之间的Jeffries-Matusita距离来定量测量可见度。该方法可用于通过冠状动脉数字减影血管造影（DSA）评估荧光镜图像序列中血管的分割。

6. 发明申请

US20080025588A1 System and Method For Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20080025588A1
公开(公告)日：2008-01-31
申请号：US11779405
申请日：2007-07-18
申请人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Chandan Reddy , Dorin Comaniciu
发明人： Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Chandan Reddy , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/34 , G06K2209/05 , Y10S128/922
摘要： A method and system for extracting motion-based layers from fluoroscopic image sequences are disclosed. Portions of multiple objects, such as anatomical structures, are detected in the fluoroscopic images. Motion of the objects is estimated between the images is the sequence of fluoroscopic images. The images in the fluoroscopic image sequence are then divided into layers based on the estimated motion. In a particular implementation, the coronary vessel tree and the diaphragm can be extracted in separate motion layers from coronary angiograph fluoroscopic image sequence.
摘要翻译：公开了一种从透视图像序列中提取基于运动的层的方法和系统。在透视图像中检测到多个对象的部分，例如解剖结构。在图像之间估计物体的运动是荧光图像的序列。然后，基于估计的运动将透视图像序列中的图像分成多个层。在特定的实施方案中，冠状动脉血管和隔膜可以与冠状动脉血管造影术透视图像序列分开提取。

7. 发明授权

US09524550B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US09524550B2
公开(公告)日：2016-12-20
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

8. 发明申请

US20110033102A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20110033102A1
公开(公告)日：2011-02-10
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

9. 发明授权

US08345944B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08345944B2
公开(公告)日：2013-01-01
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

10. 发明申请

US20100034446A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20100034446A1
公开(公告)日：2010-02-11
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

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