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1. 发明授权

US09524550B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US09524550B2
公开(公告)日：2016-12-20
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

2. 发明申请

US20110033102A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20110033102A1
公开(公告)日：2011-02-10
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

3. 发明授权

US08345944B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08345944B2
公开(公告)日：2013-01-01
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

4. 发明申请

US20100034446A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20100034446A1
公开(公告)日：2010-02-11
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

5. 发明授权

US08565859B2 Method and system for image based device tracking for co-registration of angiography and intravascular ultrasound images 有权
标题翻译：用于血管造影和血管内超声图像共同配准的基于图像的设备跟踪的方法和系统
公开(公告)号：US08565859B2
公开(公告)日：2013-10-22
申请号：US13171560
申请日：2011-06-29
申请人： Peng Wang , Simone Prummer , Terrence Chen , Dorin Comaniciu , Olivier Ecabert , Martin Ostermeier
发明人： Peng Wang , Simone Prummer , Terrence Chen , Dorin Comaniciu , Olivier Ecabert , Martin Ostermeier
IPC分类号： A61B5/05 , A61B8/14 , G06K9/00
CPC分类号： A61B8/0891 , A61B6/00 , A61B6/12 , A61B6/481 , A61B6/487 , A61B6/504 , A61B6/5247 , A61B8/12 , A61B8/5238 , G06T7/251 , G06T2207/10121 , G06T2207/10132
摘要： A method and system for co-registration of angiography data and intra vascular ultrasound (IVUS) data is disclosed. A vessel branch is detected in an angiogram image. A sequence of IVUS images is received from an IVUS transducer while the IVUS transducer is being pulled back through the vessel branch. A fluoroscopic image sequence is received while the IVUS transducer is being pulled back through the vessel branch. The IVUS transducer and a guiding catheter tip are detected in each frame of the fluoroscopic image sequence. The IVUS transducer detected in each frame of the fluoroscopic image sequence is mapped to a respective location in the detected vessel branch of the angiogram image. Each of the IVUS images is registered to a respective location in the detected vessel branch of the angiogram image based on the mapped location of the IVUS transducer detected in a corresponding frame of the fluoroscopic image sequence.
摘要翻译：公开了用于血管造影数据和血管内超声（IVUS）数据共同配准的方法和系统。在血管造影图像中检测血管分支。当IVUS传感器被拉回血管分支时，从IVUS换能器接收一系列IVUS图像。当IVUS传感器被拉回通过血管分支时，接收透视图像序列。在荧光镜图像序列的每个帧中检测IVUS换能器和引导导管尖端。在荧光镜像图像序列的每个帧中检测到的IVUS换能器被映射到血管造影图像的检测到的血管分支中的相应位置。基于在荧光镜像图像序列的相应帧中检测到的IVUS换能器的映射位置，将每个IVUS图像登记在血管造影图像的检测的血管分支中的相应位置。

6. 发明申请

US20120059253A1 Method and System for Image Based Device Tracking for Co-registration of Angiography and Intravascular Ultrasound Images 有权
标题翻译：用于血管造影和血管内超声图像共同配准的基于图像的设备跟踪的方法和系统
公开(公告)号：US20120059253A1
公开(公告)日：2012-03-08
申请号：US13171560
申请日：2011-06-29
申请人： Peng Wang , Simone Prummer , Terrence Chen , Dorin Comaniciu , Olivier Ecabert , Martin Ostermeier
发明人： Peng Wang , Simone Prummer , Terrence Chen , Dorin Comaniciu , Olivier Ecabert , Martin Ostermeier
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： A61B8/0891 , A61B6/00 , A61B6/12 , A61B6/481 , A61B6/487 , A61B6/504 , A61B6/5247 , A61B8/12 , A61B8/5238 , G06T7/251 , G06T2207/10121 , G06T2207/10132
摘要： A method and system for co-registration of angiography data and intra vascular ultrasound (IVUS) data is disclosed. A vessel branch is detected in an angiogram image. A sequence of IVUS images is received from an IVUS transducer while the IVUS transducer is being pulled back through the vessel branch. A fluoroscopic image sequence is received while the IVUS transducer is being pulled back through the vessel branch. The IVUS transducer and a guiding catheter tip are detected in each frame of the fluoroscopic image sequence. The IVUS transducer detected in each frame of the fluoroscopic image sequence is mapped to a respective location in the detected vessel branch of the angiogram image. Each of the IVUS images is registered to a respective location in the detected vessel branch of the angiogram image based on the mapped location of the IVUS transducer detected in a corresponding frame of the fluoroscopic image sequence.
摘要翻译：公开了用于血管造影数据和血管内超声（IVUS）数据共同配准的方法和系统。在血管造影图像中检测血管分支。当IVUS传感器被拉回血管分支时，从IVUS换能器接收一系列IVUS图像。当IVUS传感器被拉回通过血管分支时，接收透视图像序列。在荧光镜图像序列的每个帧中检测IVUS换能器和引导导管尖端。在荧光镜像图像序列的每个帧中检测到的IVUS换能器被映射到血管造影图像的检测到的血管分支中的相应位置。基于在荧光镜像图像序列的相应帧中检测到的IVUS换能器的映射位置，将每个IVUS图像登记在血管造影图像的检测的血管分支中的相应位置。

7. 发明授权

US08094903B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08094903B2
公开(公告)日：2012-01-10
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/03
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

8. 发明申请

US20090010512A1 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US20090010512A1
公开(公告)日：2009-01-08
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： H05G1/64 , G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

9. 发明申请

US20120093397A1 Method and System for Learning Based Object Detection in Medical Images 有权
标题翻译：医学图像学习对象检测方法与系统
公开(公告)号：US20120093397A1
公开(公告)日：2012-04-19
申请号：US13235747
申请日：2011-09-19
申请人： Peng Wang , Terrence Chen , Shaohua Kevin Zhou , Dorin Comaniciu , Martin Ostermeier
发明人： Peng Wang , Terrence Chen , Shaohua Kevin Zhou , Dorin Comaniciu , Martin Ostermeier
IPC分类号： G06K9/62
CPC分类号： G06K9/4614 , G06K9/6257 , G06K9/6282
摘要： Methods and Systems for training a learning based classifier and object detection in medical images is disclosed. In order to train a learning based classifier, positive training samples and negative training samples are generated based on annotated training images. Features for the positive training samples and the negative training samples are extracted. The features include an extended Haar feature set including tip features and corner features. A discriminative classifier is trained based on the extracted features.
摘要翻译：公开了用于训练医学图像中基于学习的分类器和对象检测的方法和系统。为了训练基于学习的分类器，基于注释的训练图像生成正训练样本和负训练样本。提取正训练样本和负训练样本的特征。功能包括扩展的Haar功能集，包括提示功能和角特征。基于提取的特征对歧视性分类器进行训练。

10. 发明申请

US20110064189A1 Method and System for Needle Tracking in Fluoroscopic Image Sequences 有权
标题翻译：荧光图像序列中针跟踪的方法和系统
公开(公告)号：US20110064189A1
公开(公告)日：2011-03-17
申请号：US12880319
申请日：2010-09-13
申请人： Peng Wang , Marcus Pfister , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Peng Wang , Marcus Pfister , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： A61B6/02
CPC分类号： A61B6/12
摘要： A method and system for tracking a needle in a fluoroscopic image sequence is disclosed. In order to track a needle in a fluoroscopic image sequence, the needle is initialized in a first frame of the fluoroscopic image sequence. Needle segments are detected in each subsequent frame of the fluoroscopic image sequence, and the needle is detected in each frame of the fluoroscopic image by tracking the needle from a previous frame of the fluoroscopic image sequence based on the detected needle segments in the current frame.
摘要翻译：公开了一种用于在荧光镜像图像序列中跟踪针的方法和系统。为了在透视图像序列中跟踪针，在荧光镜图像序列的第一帧中初始化针。在透视图像序列的每个随后的帧中检测针段，并且基于当前帧中检测到的针段，通过从荧光透视图像序列的先前帧跟踪针来在荧光镜图像的每个帧中检测针。

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