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1. 发明申请

US20140047851A1 BULK FREEZING OF BIOPHARMACEUTICALS 审中-公开
标题翻译：生物吸收的大容量冷冻
公开(公告)号：US20140047851A1
公开(公告)日：2014-02-20
申请号：US14008455
申请日：2012-03-27
申请人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
发明人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
IPC分类号： F25D3/10
CPC分类号： F25D3/10 , A01N1/0252 , A23L3/364 , F25D15/00 , F25D17/06 , F25D2400/38
摘要： A system and method for bulk freezing is provided. In one embodiment, the system and method for bulk freezing includes a bulk freezing container adapted to hold at least one and preferably a plurality of bags holding a biopharmaceutical liquid. The bulk freezing container includes at least a first and second shelf having corrugations wherein the second shelf is vertically arranged above the first shelf with the bags disposed between the shelves. The bags and the corrugations of the first and second shelves define a plurality of substantially parallel flow channels through which a cryogenic cold fluid or a warming fluid is passed to freeze and/or thaw the biopharmaceutical fluid. In another embodiment, the bulk freezing system and method includes a bulk freezing container with a plurality of adjacent elongated chambers adapted for holding the biopharmaceutical fluid. The adjacent elongated chambers have side walls defining a plurality of substantially parallel flow channels between the plurality of adjacent elongated chambers through which a heat transfer medium is passed for heat exchange through the side walls of the elongated chambers to the fluid within the elongated chambers.
摘要翻译：提供一种用于大容量冷冻的系统和方法。在一个实施例中，用于体积冷冻的系统和方法包括适于容纳至少一个并且优选地多个保持生物药物液体的袋的体积冷冻容器。散装冷冻容器至少包括具有波纹的第一和第二搁架，其中第二搁板垂直地布置在第一搁板的上方，袋子设置在搁架之间。第一和第二搁架的袋和波纹限定了多个基本平行的流动通道，低温冷流体或加温流体通过该流动通道冷冻和/或解冻生物药物流体。在另一个实施方案中，本体冷冻系统和方法包括具有适于保持生物药物流体的多个相邻细长室的体积冷冻容器。相邻的细长室具有在多个相邻的细长室之间限定多个基本平行的流动通道的侧壁，通过该多个相邻的细长室之间传热介质通过细长室的侧壁进行热交换，使其在细长室内的流体。

2. 发明申请

US20190195548A1 METHODS FOR PRE-CHARGING CARBON DIOXIDE SNOW 审中-公开
公开(公告)号：US20190195548A1
公开(公告)日：2019-06-27
申请号：US16223233
申请日：2018-12-18
申请人： Robert Sever , Ranko Bursac , Ying Zhou
发明人： Robert Sever , Ranko Bursac , Ying Zhou
IPC分类号： F25D3/12 , C01B32/55 , G06Q10/08 , F25D25/00 , A01N1/02
CPC分类号： F25D3/125 , A01N1/0273 , C01B32/55 , F25D25/005 , F25D2303/085 , F25D2331/8014 , F25D2331/809 , F25D2500/06 , G06Q10/0832 , G06Q10/0837
摘要： Manual and automated methods of pre-charging an empty or partially empty insulated container with CO2 snow are provided. A first location such as a charging location charges CO2 liquid into a container to create a pre-charged container with CO2 snow. The charging location prepares the pre-charged container for delivery to a second location, either by itself, or through a third party. The second location may be a clinical site, which upon receipt of the pre-charged container, loads a perishable item such as a biological sample into the pre-charged container. A user receives the pre-charged container with perishable item and removes the perishable item from the pre-charger container for testing (e.g., biological testing). Depending on the level of depletion of the CO2 snow in the pre-charged container, the user returns the depleted container to the first location or the intermediate location.

3. 发明申请

US20190185327A1 METHODS FOR AUTOMATIC FILLING, CHARGING AND DISPENSING CARBON DIOXIDE SNOW BLOCK 审中-公开
公开(公告)号：US20190185327A1
公开(公告)日：2019-06-20
申请号：US16221906
申请日：2018-12-17
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
IPC分类号： C01B32/55 , F25J1/00
CPC分类号： C01B32/55 , F25J1/0027
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.

4. 发明申请

US20220242738A1 METHODS FOR AUTOMATIC FILLING, CHARGING AND DISPENSING CARBON DIOXIDE SNOW BLOCK 有权
公开(公告)号：US20220242738A1
公开(公告)日：2022-08-04
申请号：US17725669
申请日：2022-04-21
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
IPC分类号： C01B32/55 , F25J1/00 , F25D3/12 , F17C6/00 , A61J1/00
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.

5. 发明授权

US11352262B2 Methods for automatic filling, charging and dispensing carbon dioxide snow block 有权
公开(公告)号：US11352262B2
公开(公告)日：2022-06-07
申请号：US16221906
申请日：2018-12-17
申请人： Ying Zhou , Ranko Bursac , Robert Sever
发明人： Ying Zhou , Ranko Bursac , Robert Sever
IPC分类号： F25J1/00 , C01B32/55 , F25D3/12 , F17C6/00 , A61J1/00
摘要： A method for automatically dispensing and vending carbon dioxide (CO2) snow block is disclosed. The automatic dispensing system contains multiple containers of different volumes. A user can input the volume of CO2 snow block into a controller, such as a programmable logic controller (PLC). The controller uses the inputted volume and process information to determine which container to utilize for the automated filling process. The controller can configure the selected container into a filling orientation into which liquid CO2 can flow to generate CO2 snow block. Upon detection of the completion of the fill, the container is configured into a dispensing orientation from which the CO2 snow block is released into an access region from which the user can retrieve the CO2 snow block. The control methodology may also be used to auto charge a single container located within a charging station as disclosed herein.

6. 发明授权

US11193708B2 Methods for pre-charging carbon dioxide snow 有权
公开(公告)号：US11193708B2
公开(公告)日：2021-12-07
申请号：US16223233
申请日：2018-12-18
申请人： Robert Sever , Ranko Bursac , Ying Zhou
发明人： Robert Sever , Ranko Bursac , Ying Zhou
IPC分类号： F25D3/12 , C01B32/55 , G06Q10/08 , F25D25/00 , A01N1/02
摘要： Manual and automated methods of pre-charging an empty or partially empty insulated container with CO2 snow are provided. A first location such as a charging location charges CO2 liquid into a container to create a pre-charged container with CO2 snow. The charging location prepares the pre-charged container for delivery to a second location, either by itself, or through a third party. The second location may be a clinical site, which upon receipt of the pre-charged container, loads a perishable item such as a biological sample into the pre-charged container. A user receives the pre-charged container with perishable item and removes the perishable item from the pre-charger container for testing (e.g., biological testing). Depending on the level of depletion of the CO2 snow in the pre-charged container, the user returns the depleted container to the first location or the intermediate location.

7. 发明授权

US11920862B2 Methods and apparatuses for using dry ice containers 有权
公开(公告)号：US11920862B2
公开(公告)日：2024-03-05
申请号：US16720910
申请日：2019-12-19
申请人： Robert R. Sever , Ying Zhou , Ranko Bursac
发明人： Robert R. Sever , Ying Zhou , Ranko Bursac
IPC分类号： F25D3/12 , A01N1/02 , F25D23/02
CPC分类号： F25D3/125 , F25D23/028 , A01N1/0273 , F25D2201/10 , F25D2303/083 , F25D2303/0843
摘要： Methods and apparatuses for loading, removing, accessing, positioning or preserving one or more items in a presence of dry ice are provided. The apparatus includes a tapered container that has a barrier-like structure which can partition the inner volume of the tapered container into an internal product storage volume and a dry icechamber. Each of the regions remain substantially undisturbed during handling, operation, use and transport of the tapered container. Methods for selectively introducing dry ice into the dry ice chamber of the tapered container and engaging the barrier-like structure within the tapered container can be achieved with a novel guiding assembly apparatus. The methods and apparatuses are particularly useful when loading and retrieving one or more items in the presence of dry ice for tapered containers that have single restrictive access openings and/or other characteristics which make access and handling difficult.

8. 发明申请

US20210190405A1 Methods and Apparatuses For Using Dry Ice Containers 有权
公开(公告)号：US20210190405A1
公开(公告)日：2021-06-24
申请号：US16720910
申请日：2019-12-19
申请人： Robert R. Sever , Ying Zhou , Ranko Bursac
发明人： Robert R. Sever , Ying Zhou , Ranko Bursac
IPC分类号： F25D3/12 , F25D23/02 , F25D25/00 , F17C6/00
摘要： Methods and apparatuses for loading, removing, accessing, positioning or preserving one or more items in a presence of dry ice are provided. The apparatus includes a tapered container that has a barrier-like structure which can partition the inner volume of the tapered container into an internal product storage volume and a dry icechamber. Each of the regions remain substantially undisturbed during handling, operation, use and transport of the tapered container. Methods for selectively introducing dry ice into the dry ice chamber of the tapered container and engaging the barrier-like structure within the tapered container can be achieved with a novel guiding assembly apparatus. The methods and apparatuses are particularly useful when loading and retrieving one or more items in the presence of dry ice for tapered containers that have single restrictive access openings and/or other characteristics which make access and handling difficult.

9. 发明申请

US20200300541A1 TRANSPORTABLE CONTAINER, CHARGER SYSTEM, METHOD AND KIT FOR GENERATION OF CARBON DIOXIDE SNOW BLOCK IN-SITU WITHIN THE TRANSPORTABLE CONTAINER FOR PRESERVATION OF ITEMS STORED THEREWITHIN 审中-公开
公开(公告)号：US20200300541A1
公开(公告)日：2020-09-24
申请号：US16895688
申请日：2020-06-08
申请人： Ying Zhou , Ranko Bursac , Robert R. Sever
发明人： Ying Zhou , Ranko Bursac , Robert R. Sever
IPC分类号： F25J1/00 , F25D3/12 , B65D81/38 , B65D88/12 , B65D90/34
摘要： This invention relates to a novel kit, transportable apparatus and method for generating in-situ CO2 snow block within the apparatus. An item such as a biological sample can be stored and transported within the same apparatus that is employed for creating the CO2 snow block. The apparatus is capable of preserving the sample during transport. The invention also includes a specially designed CO2 snow charger system including a charger and meshed conduit. The charger system is operated in accordance with the methods of the present invention to create the in-situ CO2 snow block within a container that can be also used for transport.

10. 发明授权

US09181521B2 Bioreactor with upward flowing impeller system for use in a mammalian cell culture process 有权
标题翻译：具有向上流动的叶轮系统的生物反应器用于哺乳动物细胞培养过程
公开(公告)号：US09181521B2
公开(公告)日：2015-11-10
申请号：US13559957
申请日：2012-07-27
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
IPC分类号： C12M1/06 , C12M1/00 , C12N1/38 , C12M1/08 , C12M1/34 , C12M1/36
CPC分类号： C12M27/20 , C12M27/02 , C12M27/24 , C12M29/06 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/38
摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.
摘要翻译：提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤细胞。使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳生物反应器容器内的介质。

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