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    • 2. 发明申请
    • BULK FREEZING OF BIOPHARMACEUTICALS
    • 生物吸收的大容量冷冻
    • US20140047851A1
    • 2014-02-20
    • US14008455
    • 2012-03-27
    • Ying ZhouAlan ChengNigel GrinterZachary FowlerRobert SeverRanko Bursac
    • Ying ZhouAlan ChengNigel GrinterZachary FowlerRobert SeverRanko Bursac
    • F25D3/10
    • F25D3/10A01N1/0252A23L3/364F25D15/00F25D17/06F25D2400/38
    • A system and method for bulk freezing is provided. In one embodiment, the system and method for bulk freezing includes a bulk freezing container adapted to hold at least one and preferably a plurality of bags holding a biopharmaceutical liquid. The bulk freezing container includes at least a first and second shelf having corrugations wherein the second shelf is vertically arranged above the first shelf with the bags disposed between the shelves. The bags and the corrugations of the first and second shelves define a plurality of substantially parallel flow channels through which a cryogenic cold fluid or a warming fluid is passed to freeze and/or thaw the biopharmaceutical fluid. In another embodiment, the bulk freezing system and method includes a bulk freezing container with a plurality of adjacent elongated chambers adapted for holding the biopharmaceutical fluid. The adjacent elongated chambers have side walls defining a plurality of substantially parallel flow channels between the plurality of adjacent elongated chambers through which a heat transfer medium is passed for heat exchange through the side walls of the elongated chambers to the fluid within the elongated chambers.
    • 提供一种用于大容量冷冻的系统和方法。 在一个实施例中,用于体积冷冻的系统和方法包括适于容纳至少一个并且优选地多个保持生物药物液体的袋的体积冷冻容器。 散装冷冻容器至少包括具有波纹的第一和第二搁架,其中第二搁板垂直地布置在第一搁板的上方,袋子设置在搁架之间。 第一和第二搁架的袋和波纹限定了多个基本平行的流动通道,低温冷流体或加温流体通过该流动通道冷冻和/或解冻生物药物流体。 在另一个实施方案中,本体冷冻系统和方法包括具有适于保持生物药物流体的多个相邻细长室的体积冷冻容器。 相邻的细长室具有在多个相邻的细长室之间限定多个基本平行的流动通道的侧壁,通过该多个相邻的细长室之间传热介质通过细长室的侧壁进行热交换,使其在细长室内的流体。