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1. 发明申请

US20080285684A1 Compact Dual Receiver Architecture for Point to Point Radio 有权
标题翻译：用于点对点无线电的紧凑型双接收机架构
公开(公告)号：US20080285684A1
公开(公告)日：2008-11-20
申请号：US11750209
申请日：2007-05-17
申请人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
发明人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
IPC分类号： H04L27/00
CPC分类号： H04L27/38 , H03D3/007 , H04L27/3845
摘要： A radio frequency receiver comprising a receiver module, an intermediate frequency (“IF”) module, a synthesizer module and a controller module. The receiver module receives a radio frequency signal and provides a baseband in-phase signal and a baseband quadrature signal eliminates a sideband of the in-phase and quadrature signals to create a first and a second signal, downconverts the first and second signal to a first and a second IF signal, and selects one of the first or second IF signals. The IF module receives the first or second IF signal, performs analog-to-digital conversion on the first or second IF signal, and demodulates the digitally converted. If signal The synthesizer module receives a programmable reference signal, downconverts the reference signal to an IF feedback signal, downconverts the reference signal to a baseband feedback signal provides the IF feedback signal to the IF module, and provides the baseband feedback signal to the receiver module. The controller module samples the digitally converted IF signal and provides the programmable reference signal to the synthesizer module to thereby provide a demodulated output signal.
摘要翻译：一种射频接收机，包括接收机模块，中频（“IF”）模块，合成器模块和控制器模块。接收器模块接收射频信号并提供基带同相信号，并且基带正交信号消除同相和正交信号的边带以产生第一和第二信号，将第一和第二信号下变频到第一和第二信号和第二IF信号，并且选择第一IF信号或第二IF信号中的一个。 IF模块接收第一或第二IF信号，在第一或第二IF信号上执行模数转换，并对数字转换进行解调。如果信号合成器模块接收到可编程参考信号，将参考信号下变频为IF反馈信号，将参考信号下变频为基带反馈信号，将IF反馈信号提供给IF模块，并将基带反馈信号提供给接收机模块。控制器模块对数字转换的IF信号进行采样，并将可编程参考信号提供给合成器模块，从而提供解调的输出信号。

2. 发明授权

US08275071B2 Compact dual receiver architecture for point to point radio 有权
标题翻译：紧凑型双接收机架构，用于点对点无线电
公开(公告)号：US08275071B2
公开(公告)日：2012-09-25
申请号：US11750209
申请日：2007-05-17
申请人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
发明人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
IPC分类号： H03K9/00 , H04L27/00
CPC分类号： H04L27/38 , H03D3/007 , H04L27/3845
摘要： A radio frequency receiver comprising a receiver module, an intermediate frequency (“IF”) module, a synthesizer module and a controller module. The receiver module receives a radio frequency signal and provides a baseband in-phase signal and a baseband quadrature signal, eliminates a sideband of the in-phase and quadrature signals to create a first and a second signal, downconverts the first and second signal to a first and a second IF signal, and selects one of the first or second IF signals. The IF module receives the first or second IF signal, performs analog-to-digital conversion on the first or second IF signal, and demodulates the digitally converted IF signal. The synthesizer module receives a programmable reference signal, downconverts the reference signal to an IF feedback signal, downconverts the reference signal to a baseband feedback signal, provides the IF feedback signal to the IF module, and provides the baseband feedback signal to the receiver module. The controller module samples the digitally converted IF signal and provides the programmable reference signal to the synthesizer module to thereby provide a demodulated output signal.
摘要翻译：一种射频接收机，包括接收机模块，中频（“IF”）模块，合成器模块和控制器模块。接收器模块接收射频信号并提供基带同相信号和基带正交信号，消除同相和正交信号的边带以产生第一和第二信号，将第一和第二信号下变频到第一和第二IF信号，并且选择第一IF信号或第二IF信号中的一个。 IF模块接收第一或第二IF信号，对第一或第二IF信号执行模数转换，并对数字转换的IF信号进行解调。合成器模块接收可编程参考信号，将参考信号下变频为IF反馈信号，将参考信号下变频为基带反馈信号，向IF模块提供IF反馈信号，并将基带反馈信号提供给接收机模块。控制器模块对数字转换的IF信号进行采样，并将可编程参考信号提供给合成器模块，从而提供解调的输出信号。

3. 发明申请

US20130089130A1 Compact Dual Receiver Architecture for Point to Point Radio 审中-公开
标题翻译：用于点对点无线电的紧凑型双接收机架构
公开(公告)号：US20130089130A1
公开(公告)日：2013-04-11
申请号：US13626813
申请日：2012-09-25
申请人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
发明人： Ying Shen , Guy Theberge , Richard Bourdeau , Luc Villeneuve , Fabio Concilio , Thanh Nguyen
IPC分类号： H03D9/00 , H04B17/00
CPC分类号： H04L27/38 , H03D3/007 , H04L27/3845
摘要： A radio frequency receiver comprising a receiver module, an intermediate frequency (“IF”) module, a synthesizer module and a controller module. The receiver module receives a radio frequency signal and provides a baseband in-phase signal and a baseband quadrature signal, eliminates a sideband of the in-phase and quadrature signals to create a first and a second signal, downconverts the first and second signal to a first and a second IF signal, and selects one of the first or second IF signals. The IF module receives the first or second IF signal, performs analog-to-digital conversion on the first or second IF signal, and demodulates the digitally converted IF signal. The synthesizer module receives a programmable reference signal, downconverts the reference signal to an IF feedback signal, downconverts the reference signal to a baseband feedback signal, provides the IF feedback signal to the IF module, and provides the baseband feedback signal to the receiver module. The controller module samples the digitally converted IF signal and provides the programmable reference signal to the synthesizer module to thereby provide a demodulated output signal.
摘要翻译：一种射频接收机，包括接收机模块，中频（IF）模块，合成器模块和控制器模块。接收器模块接收射频信号并提供基带同相信号和基带正交信号，消除同相和正交信号的边带以产生第一和第二信号，将第一和第二信号下变频到第一和第二IF信号，并且选择第一IF信号或第二IF信号中的一个。 IF模块接收第一或第二IF信号，对第一或第二IF信号执行模数转换，并对数字转换的IF信号进行解调。合成器模块接收可编程参考信号，将参考信号下变频为IF反馈信号，将参考信号下变频为基带反馈信号，向IF模块提供IF反馈信号，并将基带反馈信号提供给接收机模块。控制器模块对数字转换的IF信号进行采样，并将可编程参考信号提供给合成器模块，从而提供解调的输出信号。

4. 发明授权

US08409564B2 Rhodamine derivatives for photodynamic diagnosis and treatment 有权
标题翻译：罗丹明衍生物用于光动力学诊断和治疗
公开(公告)号：US08409564B2
公开(公告)日：2013-04-02
申请号：US10969011
申请日：2004-10-21
申请人： Denis-Claude Roy , Martin Guimond , Nestor Molfino , Luc Villeneuve
发明人： Denis-Claude Roy , Martin Guimond , Nestor Molfino , Luc Villeneuve
IPC分类号： A61K41/00 , C07D311/82 , C12N13/00
CPC分类号： A61K41/0009 , A61K41/0057 , C07D311/82 , C12N5/0087
摘要： The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of a suitable wavelength and intensity is applied.
摘要翻译：本发明涉及可光活化衍生物用于光动力学治疗用于免疫反应性细胞的选择性破坏和/或灭活而不影响正常细胞并且不对患者造成全身毒性的用途，其中实现所述衍生物的适当的细胞内水平并施加合适的波长和强度的照射。

5. 发明授权

US08383672B2 Halogenated rhodamine derivatives and applications thereof 有权
标题翻译：卤化罗丹明衍生物及其应用
公开(公告)号：US08383672B2
公开(公告)日：2013-02-26
申请号：US13157105
申请日：2011-06-09
申请人： Abdelkrim Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
发明人： Abdelkrim Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
IPC分类号： C07D311/88 , A61K31/35
CPC分类号： A61K35/28 , A61K35/14 , C07D311/82
摘要： Methods for treating a bacterial infection in a tissue sample are described. Tissue samples that are harvested from a patient may be infected with bacteria. A rhodamine compound is mixed with the infected tissue sample to form a mixture. The mixture is then exposed to radiant energy to inhibit or kill the bacteria. The exposed mixture is then transplanted into the patient. Examples of rhodamine compounds include 2′-(6-dimethylamino-3-dimethylimino-3H-xanthen-9-yl) 4′,5′-dichloro-benzoic acid methyl ester hydrochloride; 4,5-dibromorhodamine 110 2-(2-methoxy ethoxy)ethyl ester hydrobromide; acetate salt of 2,7-dibromorhodamine B hexyl ester; acetate salt of 2,7-dibromorhodamine B methyl ester; 4,5-dibromorhodamine 6G hydrobromide; rhodamine B 3-bromopropyl; acetate salt 2,7-dibromo-4′-carboxytetramethylrosamine methyl ester; 4-bromo-5-phenyl rhodamine B methyl ester chloride; 2,7-dibromo-4,5-dimethyl rhodamine B methyl ester bromide; 2-bromo-7-ethynyl rhodamine B methyl ester bromide; and 4,5-dibromo-2,7-di-n-butyl rhodamine B methyl ester bromide.
摘要翻译：描述了用于治疗组织样品中的细菌感染的方法。从患者收获的组织样品可能被细菌感染。将罗丹明化合物与感染的组织样品混合以形成混合物。然后将混合物暴露于辐射能以抑制或杀死细菌。然后将暴露的混合物移植到患者体内。罗丹明化合物的实例包括2' - （6-二甲基氨基-3-二甲基亚氨基-3H-呫吨-9-基）4'，5'-二氯 - 苯甲酸甲酯盐酸盐; 4,5-二溴罗丹胺110 2-（2-甲氧基乙氧基）乙酯氢溴酸盐; 2,7-二溴罗丹明B己基酯的乙酸盐; 乙酸盐2,7-二溴罗丹明B甲酯; 4,5-二溴罗丹明6G氢溴酸盐; 罗丹明B 3 - 溴丙基; 乙酸盐2,7-二溴-4'-羧基四甲基甲胺甲酯; 4-溴-5-苯基罗丹明B甲酯氯化物; 2,7-二溴-4,5-二甲基罗丹明B甲酯溴化物; 2-溴-7-乙炔基罗丹明B甲酯溴化物; 和4,5-二溴-2,7-二正丁基罗丹明B甲酯溴化物。

6. 发明申请

US20070098732A1 Immunologic compounds for prevention, protection, prophylaxis or treatment of immunological disorders, infections and cancer 审中-公开
标题翻译：用于预防，保护，预防或治疗免疫疾病，感染和癌症的免疫化合物
公开(公告)号：US20070098732A1
公开(公告)日：2007-05-03
申请号：US10581718
申请日：2004-12-02
申请人： Denis Roy , Marc Vaillancourt , Luc Villeneuve
发明人： Denis Roy , Marc Vaillancourt , Luc Villeneuve
IPC分类号： A61K39/00 , A61K31/365 , A61K31/353
CPC分类号： A61K31/353 , A61K31/365 , A61K35/28 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K39/0008 , A61K39/0011 , A61K41/0019 , A61K41/0057 , A61K2039/5154 , C09B11/24 , Y02A50/414 , A61K2300/00
摘要： The present invention relates to the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of vaccines for immunoprotection or immunomodulation. More particularly, the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of an immunologic compound for prevention, protection, prophylaxis or treatment of an immunological disorder, infection and/or a cancer in an individual, which comprises treatment of the individual cells or components thereof with a photoactivatable molecule selected from the group consisting of compounds I to XVIII, wherein the photoactivatable molecule is activated by a light of appropriate wavelength, thereby activating the photoactivatable molecule and causing prevention, protection, prophylaxis or treatment of the immunological disorder, infection and/or a cancer.
摘要翻译：本发明涉及PDT处理的细胞（其全部或其片段）和/或上清液在免疫保护或免疫调节疫苗的制备中的用途。更具体地说，PDT处理的细胞（其全部或其片段）和/或其上清液在制备免疫化合物中用于预防，保护，预防或治疗个体中的免疫疾病，感染和/或癌症的用途其包括用选自化合物I至XVIII的可光活化分子处理单个细胞或其组分，其中可光活化分子由适当波长的光激活，由此活化可光活化分子并引起预防，保护，预防或治疗免疫学疾病，感染和/或癌症。

7. 发明授权

US5798523A Irradiating apparatus using a scanning light source for photodynamic treatment 失效
标题翻译：使用扫描光源进行光动力处理的照射装置
公开(公告)号：US5798523A
公开(公告)日：1998-08-25
申请号：US685598
申请日：1996-07-19
申请人： Luc Villeneuve , Gerard Miller , Robert Bernier , Claude Laurendeau , Prabir Kumar Pal
发明人： Luc Villeneuve , Gerard Miller , Robert Bernier , Claude Laurendeau , Prabir Kumar Pal
IPC分类号： A61N5/10 , A61B17/00 , A61N5/01 , A61N5/06
CPC分类号： A61N5/062 , A61B2017/00057 , A61N2005/0632 , A61N2005/0642 , A61N5/01
摘要： An apparatus for irradiating a biological substance with a substantially uniform quantity of radiation energy comprises a radiation-generating device for producing radiation energy, a support structure for receiving the biological substance, and a motorized mechanism for reciprocating the radiation-generating device along a given path whereby the biological substance receives radiation energy from the radiation-generating device at each passage of the radiation-generating device. A series of sensors lie into a given plane and are subjected to radiation energy from the radiation-generating device upon each passage of that radiation-generating device for sensing and measuring the quantity of radiation energy by surface unit passing through the given plane and reaching the biological substance. Finally the radiation-generating device and the motorized mechanism are de-energized when the measured quantity of radiation energy by surface unit has reached a predetermined value.
摘要翻译：用于以基本上均匀的辐射能量照射生物物质的装置包括用于产生辐射能的辐射产生装置，用于接收生物物质的支撑结构，以及用于使辐射产生装置沿给定路径往复运动的机动化机构由此生物物质在辐射产生装置的每个通道处从辐射产生装置接收辐射能。一系列传感器位于给定的平面中，并且在该辐射产生装置每次通过时经受来自辐射产生装置的辐射能量，用于通过穿过给定平面的表面单元感测和测量辐射能量的量并达到生物物质。最后，当通过表面单元的测量的辐射能量达到预定值时，辐射产生装置和电动机构被断电。

8. 发明申请

US20110301573A1 HALOGENATED RHODAMINE DERIVATIVES AND APPLICATIONS THEREOF 有权
标题翻译：恶唑罗丹明衍生物及其应用
公开(公告)号：US20110301573A1
公开(公告)日：2011-12-08
申请号：US13157105
申请日：2011-06-09
申请人： Abdelkri Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
发明人： Abdelkri Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
IPC分类号： A61M37/00
CPC分类号： A61K35/28 , A61K35/14 , C07D311/82
摘要： Methods for treating a bacterial infection in a tissue sample are described. Tissue samples that are harvested from a patient may be infected with bacteria. A rhodamine compound is mixed with the infected tissue sample to form a mixture. The mixture is then exposed to radiant energy to inhibit or kill the bacteria. The exposed mixture is then transplanted into the patient. Examples of rhodamine compounds include 2′-(6-dimethylamino-3-dimethylimino-3H-xanthen-9-yl) 4′,5′-dichloro-benzoic acid methyl ester hydrochloride; 4,5-dibromorhodamine 110 2-(2-methoxy ethoxy)ethyl ester hydrobromide; acetate salt of 2,7-dibromorhodamine B hexyl ester; acetate salt of 2,7-dibromorhodamine B methyl ester; 4,5-dibromorhodamine 6G hydrobromide; rhodamine B 3-bromopropyl; acetate salt 2,7-dibromo-4′-carboxytetramethylrosamine methyl ester; 4-bromo-5-phenyl rhodamine B methyl ester chloride; 2,7-dibromo-4,5-dimethyl rhodamine B methyl ester bromide; 2-bromo-7-ethynyl rhodamine B methyl ester bromide; and 4,5-dibromo-2,7-di-n-butyl rhodamine B methyl ester bromide.
摘要翻译：描述了用于治疗组织样品中的细菌感染的方法。从患者收获的组织样品可能被细菌感染。将罗丹明化合物与感染的组织样品混合以形成混合物。然后将混合物暴露于辐射能以抑制或杀死细菌。然后将暴露的混合物移植到患者体内。罗丹明化合物的实例包括2' - （6-二甲基氨基-3-二甲基亚氨基-3H-呫吨-9-基）4'，5'-二氯 - 苯甲酸甲酯盐酸盐; 4,5-二溴罗丹胺110 2-（2-甲氧基乙氧基）乙酯氢溴酸盐; 2,7-二溴罗丹明B己基酯的乙酸盐; 乙酸盐2,7-二溴罗丹明B甲酯; 4,5-二溴罗丹明6G氢溴酸盐; 罗丹明B 3 - 溴丙基; 乙酸盐2,7-二溴-4'-羧基四甲基甲胺甲酯; 4-溴-5-苯基罗丹明B甲酯氯化物; 2,7-二溴-4,5-二甲基罗丹明B甲酯溴化物; 2-溴-7-乙炔基罗丹明B甲酯溴化物; 和4,5-二溴-2,7-二正丁基罗丹明B甲酯溴化物。

9. 发明申请

US20060088507A1 Rhodamine derivatives for photodynamic diagnosis and treatment 有权
公开(公告)号：US20060088507A1
公开(公告)日：2006-04-27
申请号：US10969011
申请日：2004-10-21
申请人： Denis-Claude Roy , Martin Guimond , Nestor Molfino , Luc Villeneuve
发明人： Denis-Claude Roy , Martin Guimond , Nestor Molfino , Luc Villeneuve
IPC分类号： A61K35/14 , A61K31/365
CPC分类号： A61K41/0009 , A61K41/0057 , C07D311/82 , C12N5/0087
摘要： The present invention relates to the use of the photoactivable derivatives for the photodynamic treatment for the selective destruction and/or inactivation of immunologically reactive cells without affecting the normal cells and without causing systemic toxicity for the patient, wherein appropriate intracellular levels of said derivatives are achieved and irradiation of a suitable wavelength and intensity is applied.

10. 发明申请

US20120136338A1 IMMUNOLOGIC COMPOUNDS FOR PREVENTION, PROTECTION, PROPHYLAXIS OR TREATMENT OF IMMUNOLOGICAL DISORDERS, INFECTIONS AND CANCER 审中-公开
标题翻译：用于预防，保护，预防或治疗免疫缺陷病毒，感染和癌症的免疫化学物质
公开(公告)号：US20120136338A1
公开(公告)日：2012-05-31
申请号：US13366099
申请日：2012-02-03
申请人： DENIS CLAUDE ROY , Marc Vaillancourt , Luc Villeneuve
发明人： DENIS CLAUDE ROY , Marc Vaillancourt , Luc Villeneuve
IPC分类号： A61M5/00 , A61P37/00 , A61P31/00 , A61P35/00 , A61P31/12 , A61P35/02 , A61P31/10 , A61P33/02 , A61P31/18 , A61P31/14 , A61P31/22 , A61K35/12 , A61P33/00
CPC分类号： A61K31/353 , A61K31/365 , A61K35/28 , A61K38/193 , A61K38/2013 , A61K38/21 , A61K39/0008 , A61K39/0011 , A61K41/0019 , A61K41/0057 , A61K2039/5154 , C09B11/24 , Y02A50/414 , A61K2300/00
摘要： The present invention provides for methods of treating a cancer patient. In one methods, cancer cells are harvested from a patient. A therapeutic amount of a rhodamine derivative is then added to the harvested cancer cells. The harvested cells and the rhodamine derivative are then irradiated with a suitable wavelength and intensity for the selective killing of the cancer cells. The irradiated cancer cells are then mixed with antigen presenting cells to form a mixture. The mixture of cancer and antigen presenting cells are then injected into the patient. The present invention also provides for methods of inhibiting or treating an immunological disorder, infection, or a cancer in an individual.
摘要翻译：本发明提供了治疗癌症患者的方法。在一种方法中，从患者收获癌细胞。然后将治疗量的罗丹明衍生物加入到所获得的癌细胞中。然后用合适的波长和强度照射收获的细胞和罗丹明衍生物，用于选择性杀死癌细胞。然后将照射的癌细胞与抗原呈递细胞混合以形成混合物。然后将癌症和抗原呈递细胞的混合物注射到患者体内。本发明还提供了抑制或治疗个体的免疫学障碍，感染或癌症的方法。

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