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1. 发明申请

US20180036310A1 INTRAVENOUS INFUSION DOSAGE FORM 审中-公开
公开(公告)号：US20180036310A1
公开(公告)日：2018-02-08
申请号：US15550638
申请日：2016-02-12
申请人： SUN PHARMACEUTICAL INDUSTRIES LTD.
发明人： Samarth KUMAR , Prashant KANE , Subhas Balaram BHOWMICK , Kirti GANORKAR , Nisarg Bipinchandra MISTRY , Ramaji Karshanbhai VARU
IPC分类号： A61K31/519 , A61K41/00 , A61K9/08 , B65B55/06 , A61J1/10 , B65B3/00 , B65B7/02 , A61K9/00 , A61K47/02
CPC分类号： A61K31/519 , A61J1/10 , A61K9/0019 , A61K9/08 , A61K41/0009 , A61K47/02 , A61M5/14 , B65B3/003 , B65B7/02 , B65B55/06
摘要： The present invention relates to an intravenous infusion dosage form of pemetrexed or its pharmaceutically acceptable salt, having long term stability.

2. 发明申请

US20180000965A1 SILYBIN INJECTION AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：US20180000965A1
公开(公告)日：2018-01-04
申请号：US15541556
申请日：2015-12-24
申请人： TASLY PHARMACEUTICAL GROUP CO., LTD.
发明人： Jianming CHEN , Baoan GAO , Qinqin ZHOU , Shuiping ZHOU , Nan CAI , Yuansheng ZHANG , Chan WU , Nong YU , Lina CHEN , Wenli LIU
IPC分类号： A61K47/69 , A61K47/24 , A61K47/12 , A61K47/10 , A61K41/00 , A61K9/00 , A61K31/357 , A61K9/19 , A61K9/16 , A61K9/08 , A61K47/26 , A61K47/02
CPC分类号： A61K47/6951 , A61K9/0019 , A61K9/08 , A61K9/1682 , A61K9/19 , A61K31/357 , A61K41/0009 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/26
摘要： A silybin injection contains silybin, sulfobutyl ether-β-cyclodextrin, an organic solvent for injection and may further contain a co-solvent, a lyophilization proppant, a pH regulator, water for injection and the like.

3. 发明申请

US20150343084A1 THERAPEUTIC AND DIAGNOSTIC PROBES 审中-公开
标题翻译：治疗和诊断探针
公开(公告)号：US20150343084A1
公开(公告)日：2015-12-03
申请号：US14728247
申请日：2015-06-02
申请人： LI-COR, INC.
发明人： DAVID L. DILLEY
IPC分类号： A61K47/48 , A61K49/00 , A61N5/06 , A61K41/00
CPC分类号： A61K41/0071 , A61K41/0009 , A61K47/64 , A61K47/6415 , A61K47/642 , A61K47/6849 , A61K49/0032 , A61K49/005 , A61K51/0446 , A61K51/0497 , A61K51/082 , A61K51/083 , A61K51/088 , A61M1/3618 , A61M1/3683 , A61M1/3686 , A61N5/062 , A61N2005/0658
摘要： The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.
摘要翻译：本发明提供了用于体内成像和治疗的基于纳米颗粒的探针的组合物和方法。探针可用于通过近红外范围内的非侵入性成像来跟踪病变靶细胞。此外，探针可以通过光动力学治疗诱导靶细胞的细胞死亡。

4. 发明申请

US20150343060A1 TREATMENT OF CIRCULATING TUMOR CELLS USING AN EXTRACORPOREAL DEVICE 审中-公开
标题翻译：使用超声波装置治疗循环肿瘤细胞
公开(公告)号：US20150343060A1
公开(公告)日：2015-12-03
申请号：US14728204
申请日：2015-06-02
申请人： Ll-COR, INC.
发明人： JOY L. KOVAR , HAN-WEI WANG
IPC分类号： A61K41/00 , A61M1/36
CPC分类号： A61K41/0071 , A61K41/0009 , A61K47/64 , A61K47/6415 , A61K47/642 , A61K47/6849 , A61K49/0032 , A61K49/005 , A61K51/0446 , A61K51/0497 , A61K51/082 , A61K51/083 , A61K51/088 , A61M1/3618 , A61M1/3683 , A61M1/3686 , A61N5/062 , A61N2005/0658
摘要： The present invention relates to methods and compositions for eliminating circulating tumor cells (CTCs) in a patient with or without solid tumors. In particular, the ex vivo method utilizes a photodynamic or magnetic targeting moiety that specifically binds to antigens expressed on the cell surface of CTCs.
摘要翻译：本发明涉及用于消除或不用实体瘤的患者中循环肿瘤细胞（CTC）的方法和组合物。特别地，离体方法利用特异性结合CTC细胞表面上表达的抗原的光动力或磁性靶向部分。

5. 发明申请

US20150056608A1 Method for Treating Infectious Diseases Using Emissive Energy 审中-公开
标题翻译：使用发射能量治疗传染病的方法
公开(公告)号：US20150056608A1
公开(公告)日：2015-02-26
申请号：US14381177
申请日：2013-05-21
申请人： Marv Enterprises, LLC
发明人： Mitchell S. Felder
IPC分类号： G01N33/569
CPC分类号： G01N33/569 , A61K41/0009 , G01N33/574 , G01N33/582 , G01N33/6896 , G01N2469/20
摘要： The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises methods for the extracorporeal treatment of infectious diseases that will remove infectious pathogens (leukemia cells, bacteria, viruses, or fungi causing a septicemia, metastatic cancer cells, target protein, viruses, parasites, fungi and prions) in humans by targeting such pathogens with a laser or other high-energy source of emissive radiation. More specifically, the method involves removing a bodily fluid from a patient, attaching an antibody to pathogens in the bodily fluid, sensing the antibody-pathogen moiety, using a high-powered, focused laser to destroy the antibody-pathogen moiety, removing the remains of the antibody-pathogen by filtering or other suitable mechanism(s), and returning the bodily fluid to the patient.
摘要翻译：本发明涉及感染性疾病的治疗，特别是通过体外根除病原体。本发明包括用于体外治疗感染性疾病的方法，所述感染性疾病将通过靶向这种方法去除人中感染性病原体（白血病细胞，细菌，病毒或引起败血病，转移性癌细胞，靶蛋白，病毒，寄生虫，真菌和朊病毒的真菌）病原体与激光或其他高能源的发射辐射。更具体地，该方法包括从患者身上清除身体液体，使用大功率聚焦激光器将抗体附着于体液中的病原体，感测抗体 - 病原体部分，以破坏抗体 - 病原体部分，除去残余物的抗体 - 病原体通过过滤或其他合适的机制，并将体液返回到患者。

6. 发明授权

US08303962B2 Antibacterial and antifungal peptides 有权
标题翻译：抗菌和抗真菌肽
公开(公告)号：US08303962B2
公开(公告)日：2012-11-06
申请号：US12683188
申请日：2010-01-06
申请人： Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人： Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/38 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要： This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
摘要翻译：本发明提供了新的抗微生物肽及其制剂。肽和/或制剂有效杀死或抑制各种细菌，酵母和真菌的生长和/或增殖。

7. 发明申请

US20100310461A1 BINDING OF PATHOLOGICAL FORMS OF PROTEINS USING CONJUGATED POLYELECTROLYTES 审中-公开
标题翻译：使用结合聚电解质的蛋白质病理形态的结合
公开(公告)号：US20100310461A1
公开(公告)日：2010-12-09
申请号：US12793564
申请日：2010-06-03
申请人： Peter Åsberg , Olle Inganäs , Fredrik Anghus
发明人： Peter Åsberg , Olle Inganäs , Fredrik Anghus
IPC分类号： A61K49/00 , A61K31/795 , A61P43/00 , C08G75/06
CPC分类号： A61K49/1857 , A61K41/0009 , B82Y5/00 , G01N33/6896 , G01N2800/2821 , G01N2800/2828
摘要： A method for treatment of a disease caused by aggregation of misfolded proteins including subjecting a body fluid of a patient to a separation of an aggregated misfolded protein which includes contacting both the misfolded and normal protein with a conjugated polyelectrolyte (CPE) and separating the CPE/protein complex from the other constituents of the sample.
摘要翻译：一种用于治疗由错误折叠的蛋白质聚集引起的疾病的方法，包括使患者的体液进行聚集的错误折叠的蛋白质的分离，包括将错误折叠和正常蛋白质与共轭聚电解质（CPE）接触并分离CPE / 来自样品的其他成分的蛋白质复合物。

8. 发明申请

US20100129410A1 Methods and Immunogenic Cell Preparations for Treating Antigen-Associated Diseases 失效
标题翻译：用于治疗抗原相关疾病的方法和免疫原性细胞制剂
公开(公告)号：US20100129410A1
公开(公告)日：2010-05-27
申请号：US11885871
申请日：2006-02-21
申请人： Lea Eisenbach , Arthur Machlenkin , Adrian Paz , Boaz Tirosh , Esther Tzehoval
发明人： Lea Eisenbach , Arthur Machlenkin , Adrian Paz , Boaz Tirosh , Esther Tzehoval
IPC分类号： A61K39/00 , C12N13/00 , C12N5/08 , A61P35/00
CPC分类号： C12N5/0639 , A61K35/15 , A61K39/0011 , A61K41/0009 , A61K41/0023 , A61K2039/5154
摘要： A method of inhibiting growth of, reducing or eliminating a cell population of a subject in need thereof is disclosed. The method comprises (a) thermally, mechanically and/or chemically damaging antigen-bearing cells which comprise at least one antigen characterizing cells of the cell population, with the proviso that the chemically damaging of the antigen-bearing cells is not predominantly effected using one or more antineoplastic agents, thereby generating immunogenic cells; and (b) introducing in the subject a cell aggregate which comprises the immunogenic cells and added antigen-presenting cells, thereby inducing an immune response for inhibiting growth of, reducing or eliminating the cell population of the subject.
摘要翻译：公开了抑制有需要的受试者生长，减少或消除细胞群体的方法。该方法包括（a）热，机械和/或化学损伤包含至少一种表征细胞群细胞的抗原的抗原携带细胞，附带条件是，抗原携带细胞的化学损伤不主要使用一种或更多的抗肿瘤剂，从而产生免疫原性细胞; 和（b）在受试者中引入包含免疫原性细胞和添加的抗原呈递细胞的细胞聚集体，由此诱导用于抑制或消除受试者细胞群的生长的免疫应答。

9. 发明申请

US20070248575A1 Bone graft composition 审中-公开
标题翻译：骨移植组成
公开(公告)号：US20070248575A1
公开(公告)日：2007-10-25
申请号：US11407446
申请日：2006-04-19
申请人： Jerome Connor , Qing-Qing Qiu
发明人： Jerome Connor , Qing-Qing Qiu
IPC分类号： A01K67/027 , A61K35/12
CPC分类号： A61K35/32 , A61F2002/2835 , A61K35/36 , A61K41/0009 , A61K41/0019 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/3683 , A61L2430/02
摘要： The invention provides methods of making a bone graft composition. Also featured are methods of treatment using the bone graft composition and articles of manufacture that include the bone graft composition.
摘要翻译：本发明提供了制备骨移植组合物的方法。还特征在于使用包括骨移植组合物的骨移植组合物和制品的治疗方法。

10. 发明申请

US20070238660A1 Light activated antiviral materials and devices and methods for decontaminating virus infected environments 审中-公开
标题翻译：光激活的抗病毒材料和用于去除病毒感染的环境的装置和方法
公开(公告)号：US20070238660A1
公开(公告)日：2007-10-11
申请号：US11598549
申请日：2006-11-13
申请人： Stephen Michielsen , Gordon Churchward , Jadranka Bozia , Igor Stojilokivic , Suzana Anic
发明人： Stephen Michielsen , Gordon Churchward , Jadranka Bozia , Igor Stojilokivic , Suzana Anic
IPC分类号： A01N43/42 , A01N43/00 , A01N43/84 , A01N61/00 , A01N55/02 , A01N43/16
CPC分类号： A61K41/0009 , A01N43/42 , A01N59/00 , A61K31/409 , A61K31/473 , A61K41/0019
摘要： A method of inactivating viruses, articles for inactivating viruses and methods of manufacture of such articles are disclosed. Singlet oxygen generating dyes are attached to a substrate. Upon exposure to light, singlet oxygen is generated to inactivate viruses present. In a preferred embodiment, more than one dye is used. If only one dye is used, acridine yellow G is particularly effective.
摘要翻译：公开了灭活病毒的方法，用于灭活病毒的物品及其制造方法。单线态氧发生染料附着于基底。暴露于光后，产生单线态氧以灭活存在的病毒。在优选的实施方案中，使用多于一种的染料。如果只使用一种染料，吖啶黄G是特别有效的。

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