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    • 2. 发明授权
    • Method for manufacturing hard non-gelatin pharmaceutical capsules
    • 硬质非明胶药胶囊的制造方法
    • US06752953B2
    • 2004-06-22
    • US09998317
    • 2001-12-03
    • Gan-Lin ChenChien-Yuan LeeCheng-Hsiung Liu
    • Gan-Lin ChenChien-Yuan LeeCheng-Hsiung Liu
    • C08J500
    • A61K9/4816B29C43/021B29C43/16B29C43/361B29C43/42
    • The present invention provides a method for manufacturing a non-gelatin hard capsule shell. The hard capsule shell is made by a heat-melting method which involves heating a capsule forming composition (preferably in powdery form) in a mold, followed by inserting a pestle into the mold to coat the melted capsule forming composition onto the pestle. The hard capsule shell thus formed, after hardened and dried, is removed from the pestle. This method has the advantages over the conventional “dip molding method” for not requiring the capsule forming composition to be pre-dissolved in solution so that no solvent is used in preparing the capsule forming composition. Also, by inserting a pestle into a mold, a pressure is imposed so as to ensure uniform coating of the capsule forming composition to the pestle. The present invention also provides a capsule forming composition which comprises a polymer and optionally a plasticizer and an apparatus for making the non-gelatin hard capsule shell.
    • 本发明提供一种制造非明胶硬胶囊壳的方法。 硬胶囊壳是通过加热熔融法制成的,其包括在模具中加热胶囊形成组合物(优选粉末形式),随后将杵插入模具中以将熔融的胶囊形成组合物涂覆到杵上。 这样形成的硬胶囊壳在硬化和干燥之后从研杵上取出。 该方法相对于常规的“浸渍成型方法”具有优于不需要胶囊形成组合物预溶解在溶液中的优点,使得在制备胶囊形成组合物中不使用溶剂。 此外,通过将杵插入模具中,施加压力以确保将胶囊形成组合物均匀地涂覆到研杵上。 本发明还提供了包含聚合物和任选的增塑剂的胶囊形成组合物和用于制备非明胶硬胶囊壳的装置。