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1. 发明申请

US20100159528A1 POLYMERASE STABILIZATION 审中-公开
标题翻译：聚合物稳定
公开(公告)号：US20100159528A1
公开(公告)日：2010-06-24
申请号：US12601102
申请日：2008-06-12
申请人： Yi Liu , Ryan Westberry , Scott Hamilton
发明人： Yi Liu , Ryan Westberry , Scott Hamilton
IPC分类号： C12P19/34 , C12N9/96
CPC分类号： C12N9/96 , C12N9/1252
摘要： The present invention relates to methods and compositions for providing purified thermostable enzymes, particularly thermostable DNA polymerases, that are free of exogenous detergents. The present invention also provides methods for providing such purified thermostable DNA polymerases to assays in an active form by adding one or more detergents. The present invention further provides compositions and kits comprising purified thermostable DNA polymerases for use in a variety of applications, including amplification and sequencing of nucleic acids.
摘要翻译：本发明涉及用于提供不含外源洗涤剂的纯化的热稳定酶，特别是耐热性DNA聚合酶的方法和组合物。本发明还提供了通过添加一种或多种洗涤剂来提供这种纯化的热稳定性DNA聚合酶以活性形式的测定法的方法。本发明进一步提供了包含用于各种应用的纯化的热稳定性DNA聚合酶的组合物和试剂盒，包括核酸的扩增和测序。

2. 发明授权

US11965810B2 Multiplexed on-chip impedance cytometry system and method 有权
公开(公告)号：US11965810B2
公开(公告)日：2024-04-23
申请号：US17280480
申请日：2019-09-26
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , Nathan Swami , John McGrath , Walter Varhue , Carlos Honrado , Vahid Farmehini , Yi Liu
发明人： Nathan Swami , John McGrath , Walter Varhue , Carlos Honrado , Vahid Farmehini , Yi Liu
IPC分类号： G01N15/00 , B01L3/00 , G01N15/10 , G01N15/1031
CPC分类号： G01N15/1056 , B01L3/502761 , G01N15/1031 , B01L2200/027 , B01L2200/0652 , B01L2200/10 , B01L2300/0645 , B01L2400/0424
摘要： An exemplary method and system is disclosed that facilitate the integration of multiplexed single-cell impedance cytometry in a high throughput format, which can be deployed upstream from microfluidic sample preparation and/or downstream to microfluidic cell separation. In exemplary method and system may employ impedance-based quantification of cell electrophysiology on the same microfluidic chip (i.e., “on-chip”) to provide distinguishing phenotypic information on the sample, without the need for additional sample handling, preparation or dilution steps as would be needed for other flow cytometry techniques.

3. 发明申请

US20190194385A1 Narrow Band Gap Conjugated Polymers Employing Cross-Conjugated Donors Useful in Electronic Devices 审中-公开
公开(公告)号：US20190194385A1
公开(公告)日：2019-06-27
申请号：US16327770
申请日：2017-08-23
申请人： Jason D. Azoulay , Yi Liu , Benjamin A. Zhang
发明人： Jason D. Azoulay , Yi Liu , Benjamin A. Zhang
IPC分类号： C08G61/12 , C08G83/00
CPC分类号： C08G61/126 , C08G61/122 , C08G61/123 , C08G83/00 , C08G2261/124 , C08G2261/148 , C08G2261/3223 , C08G2261/3241 , C08G2261/3243 , C08G2261/3244 , C08G2261/3246 , C08G2261/344 , C08G2261/364 , C08G2261/91 , C08G2261/92 , C08K3/045 , C08L65/00
摘要： The invention provides for new polymer compounds and methods for the preparation of modular narrow band gap conjugated compounds and polymers that incorporate exocyclic cross-conjugated donors or substituents, as well as novel monomer components of such polymers and the resulting products which comprise materials and useful electronic devices with novel functionality.

4. 发明申请

US20170212831A1 ALIGNED VARIABLE RECLAMATION 审中-公开
公开(公告)号：US20170212831A1
公开(公告)日：2017-07-27
申请号：US15326322
申请日：2015-01-23
申请人： Terry Ping-Chung LEE , XinLai YU , Yi LIU , Hewlett Packard Enterprise Development LP
发明人： Terry Ping-Chung Lee , XinLai Yu , Yi Liu
IPC分类号： G06F12/02 , G06F3/06 , G06F12/0802
CPC分类号： G06F12/023 , G06F3/0619 , G06F3/064 , G06F3/0656 , G06F3/0673 , G06F12/0802 , G06F2212/60
摘要： In one example, reclaiming obsolete regions includes a memory organized in aligned memory blocks and storing valid variables in valid regions and obsolete variables in the obsolete regions. A memory includes a buffer region to cache the memory. A controller can search the buffer region for the obsolete regions and pair with respective valid regions and determine if start addresses of the obsolete regions are memory aligned and if not aligned, to write a small portion content of a first valid region to the start address of the aligned memory block, and to write any remaining respective valid region beginning at the start address of the aligned memory block and in multiples of the aligned memory block. Upon completion of a writing, moved respective valid regions begin at the starting address of the obsolete regions and new obsolete regions begin at end addresses of the moved respective valid regions.

5. 发明授权

US09662522B2 Fire extinguishing composition containing saccharide and saccharide derivative 有权
公开(公告)号：US09662522B2
公开(公告)日：2017-05-30
申请号：US14374723
申请日：2012-08-16
申请人： Yi Liu , Junna Yao , Zhanjun Yang
发明人： Yi Liu , Junna Yao , Zhanjun Yang
IPC分类号： A62D1/06 , A62C5/00 , A62D1/00
CPC分类号： A62D1/06 , A62C5/004 , A62C5/006 , A62D1/0007
摘要： The present disclosure relates to a fire extinguishing composition containing saccharide and a saccharide derivative, comprising a saccharide derivative, a saccharide material and an auxiliary fire extinguishing agent, whose mass percentages are respectively: saccharide derivative 30%-60%, saccharide material 10%-40%, and auxiliary fire extinguishing agent 10%-30%. The fire extinguishing composition uses a pyrotechnic agent as a heat source and a power source, is heated and decomposed or reacts by using the heat of burning of the pyrotechnic agent, to generate a fire extinguishing material to be sprayed together with the fireworks agent, thereby achieving the fire extinguishing purpose. The fire extinguishing composition of the present disclosure uses a saccharide derivative and a saccharide material as primary ingredients, uses a pyrotechnic agent as a heat source and a power source, and is easily decomposed after being heated to generate non-toxic and harmless gas. The environment is not polluted after the ejection, the effective utilization rate of components is high, and the material obtained through decomposition can also extinguish fire, so as to generate a synergistic action on the pyrotechnic agent, thereby improving the fire extinguishing performance of the whole fire extinguishing composition.

6. 发明申请

US20160075878A1 Bay-Annulated Indigo (BAI) As An Excellent Electron Accepting Building Block for High Performance Organic Semiconductors 有权
公开(公告)号：US20160075878A1
公开(公告)日：2016-03-17
申请号：US14942775
申请日：2015-11-16
申请人： Yi Liu , Bo He , Andrew Pun
发明人： Yi Liu , Bo He , Andrew Pun
IPC分类号： C09B7/02 , H01L51/00
CPC分类号： C09B7/02 , C07D471/22 , H01L51/0035 , H01L51/0036 , H01L51/0068 , H01L51/0072 , H01L51/0074 , H01L51/0094 , H01L51/0558
摘要： A novel electron acceptor based on bay-annulated indigo (BAI) was synthesized and used for the preparation of a series of high performance donor-acceptor small molecules and polymers. The resulting materials possess low-lying LUMO energy level and small HOMO-LUMO gaps, while their films exhibited high crystallinity upon thermal treatment, commensurate with high field effect mobilities and ambipolar transfer characteristics.

7. 发明申请

US20150303382A1 Bay-Annulated Indigo (BAI) As An Excellent Electron Accepting Building Block for High Performance Organic Semiconductors 有权
标题翻译： Bay-Annulated Indigo（BAI）作为高性能有机半导体的优异电子接受构件
公开(公告)号：US20150303382A1
公开(公告)日：2015-10-22
申请号：US14687059
申请日：2015-04-15
申请人： Yi Liu , Bo He , Andrew Pun
发明人： Yi Liu , Bo He , Andrew Pun
IPC分类号： H01L51/00 , C07D471/22
CPC分类号： C09B7/02 , C07D471/22 , H01L51/0035 , H01L51/0036 , H01L51/0068 , H01L51/0072 , H01L51/0074 , H01L51/0094 , H01L51/0558
摘要： A novel electron acceptor based on bay-annulated indigo (BAI) was synthesized and used for the preparation of a series of high performance donor-acceptor small molecules and polymers. The resulting materials possess low-lying LUMO energy level and small HOMO-LUMO gaps, while their films exhibited high crystallinity upon thermal treatment, commensurate with high field effect mobilities and ambipolar transfer characteristics.
摘要翻译：合成了一种基于间隔靛蓝（BAI）的新型电子受体，用于制备一系列高性能供体 - 受体小分子和聚合物。所得材料具有低的LUMO能级和小的HOMO-LUMO间隙，而它们的膜在热处理时表现出高结晶度，与高场效应迁移率和双极转移特性相称。

8. 发明授权

US09160669B2 Method and device for leaky bucket speed-limitation 有权
标题翻译：漏斗速度限制的方法和装置
公开(公告)号：US09160669B2
公开(公告)日：2015-10-13
申请号：US14127862
申请日：2011-06-28
申请人： Junjie Yin , Yi Liu
发明人： Junjie Yin , Yi Liu
IPC分类号： H04L1/00 , H04L12/819
CPC分类号： H04L47/215 , H04L47/21
摘要： The disclosure discloses a method for traffic limitation by a leaky bucket, including that: during traffic-limitation of a group of packets sharing a same leaky bucket and having separate weighted priorities, the overall leaky bucket is divided into multiple sub-buckets according to priority parameters of the packets including a number of the weighted priorities and ratios between the weighted priorities; after packet information is received, parameters relevant to traffic-limitation by a leaky bucket is acquired; a total number of tokens to be added to the overall leaky bucket is calculated; token-addition is performed on the sub-buckets according to a state of the overall leaky bucket after addition of the total number of tokens and the weighted priorities corresponding to the sub-buckets; a packet is forwarded, or discarded, or marked according to a length of the packet and a number of tokens in a sub-bucket corresponding to a weighted priority, wherein in performing token-addition on the sub-buckets, after token-addition is performed on all the sub-buckets, any overrunning token is allocated to another sub-bucket not overrun with tokens. The disclosure further discloses a device for traffic limitation by a leaky bucket. With the disclosure, it is possible to limit packet traffic flexibly according to weighted priorities and improve resource utilization.
摘要翻译：本公开公开了一种泄漏桶的流量限制的方法，包括：在共享同一泄漏桶并具有单独的加权优先级的一组分组的流量限制期间，根据优先级将整个泄漏桶划分为多个子桶分组的参数包括多个加权优先级和加权优先级之间的比率; 在接收到分组信息之后，获取与泄漏桶的流量限制相关的参数; 计算要添加到总泄漏桶中的总数; 在添加总码数和对应于子桶的加权优先权之后，根据整个泄漏桶的状态在子桶上执行令牌添加; 根据分组的长度和对应于加权优先级的子桶中的令牌的数量被转发，丢弃或标记，其中在令牌添加之后在子桶上执行令牌添加是在所有子桶上执行，任何超额令牌都将分配给另一个子桶，而不会与令牌超载。本公开还公开了一种用于由泄漏桶进行交通限制的装置。通过本公开，可以根据加权优先级灵活地限制报文流量，提高资源利用率。

9. 发明授权

US09127000B2 Heterocyclic compounds and uses thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US09127000B2
公开(公告)日：2015-09-08
申请号：US14001143
申请日：2012-02-23
申请人： Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Troy Edward Wilson , Simon Fraser Campbell
发明人： Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan , Troy Edward Wilson , Simon Fraser Campbell
IPC分类号： A61K31/4745 , C07D471/04 , C07D519/00 , A61K31/5377 , A61K31/437 , A61K31/496
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , A61K31/496 , A61K31/5377 , C07D487/04 , C07D519/00
摘要： Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.
摘要翻译：本文描述了调节PI3激酶活性的杂环实体，含有杂环实体的药物组合物，以及使用这些化学实体治疗与PI3激酶活性相关的疾病和病症的方法。

10. 发明申请

US20150048004A1 Apparatus, System, and Methods for Blending Crude Oils 有权
标题翻译：用于混合原油的装置，系统和方法
公开(公告)号：US20150048004A1
公开(公告)日：2015-02-19
申请号：US14304415
申请日：2014-06-13
申请人： Yi Liu , Carl NILSSON , Vincent P. BUCHANAN
发明人： Yi Liu , Carl NILSSON , Vincent P. BUCHANAN
IPC分类号： B01F5/06 , B01F3/08
CPC分类号： B01F5/0688 , B01F3/0861 , B01F3/0865 , B01F3/10 , B01F5/0463 , B01F2003/0884 , B01F2003/105 , B01F2215/0067 , B01F2215/0431
摘要： This application includes mixing devices, methods, and systems in which a second fluid can be introduced through a second flow channel to a dispersion member for extrusion through a perforated portion of a dispersion member into a first flow channel for mixing with a first fluid. In some of the present mixing devices, methods, and systems, the second flow channel is substantially perpendicular to the first flow channel, and/or the perforated portion is disposed on a downstream portion of the dispersion member.
摘要翻译：该应用包括混合装置，方法和系统，其中第二流体可以通过第二流动通道引入分散体构件，用于通过分散构件的穿孔部分挤出到用于与第一流体混合的第一流动通道。在本发明的一些混合装置，方法和系统中，第二流动通道基本上垂直于第一流动通道，和/或穿孔部分设置在分散构件的下游部分上。

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