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1. 发明授权

US6117426A Human amine transporter polypeptide fragments 失效
标题翻译：人类胺转运蛋白多肽片段
公开(公告)号：US6117426A
公开(公告)日：2000-09-12
申请号：US139675
申请日：1998-08-25
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： A61K38/00 , A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12P21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

2. 发明授权

US5859200A Human amine transporter 失效
标题翻译：人类胺转运蛋白
公开(公告)号：US5859200A
公开(公告)日：1999-01-12
申请号：US894840
申请日：1998-01-30
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the under-expression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译： PCT No.PCT / US95 / 02645 Sec。 371日期1998年1月30日 102（e）日期1998年1月30日PCT 1995年3月1日PCT公布。公开号WO96 / 27009 日本1996年9月6日公开了一种编码这种多肽的人胺转运蛋白多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达有关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

3. 发明授权

US06630443B2 Human amine transporter antibodies 失效
标题翻译：人类胺转运蛋白抗体
公开(公告)号：US06630443B2
公开(公告)日：2003-10-07
申请号：US09502018
申请日：2000-02-11
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： C07K1618
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

4. 发明授权

US5798223A Polynucleotides encoding human amine transporter and methods of using the same 失效
标题翻译：编码人胺转运蛋白的多核苷酸及其使用方法
公开(公告)号：US5798223A
公开(公告)日：1998-08-25
申请号：US471496
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Craig A. Rosen
发明人： Yi Li , Liang Cao , Craig A. Rosen
IPC分类号： A61K38/00 , A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12P21/00 , C12N1/15 , C12N5/10
CPC分类号： C07K14/47 , A61K38/00
摘要： A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting agonists and antagonists to such polypeptide and the use of agonists and antagonists for treating diseases related to the underexpression and over-expression of the Human amine transporter of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.
摘要翻译：公开了人类胺转运蛋白多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还提供了用于检测这种多肽的激动剂和拮抗剂的方法，以及使用激动剂和拮抗剂治疗与本发明的人胺转运蛋白的低表达和过表达相关的疾病。还公开了用于检测编码多肽的核酸序列中的突变并检测多肽可溶形式的改变水平的方法。

5. 发明授权

US6090575A Polynucleotides encoding human G-protein coupled receptor GPR1 失效
标题翻译：编码人G蛋白偶联受体GPR1的多核苷酸
公开(公告)号：US6090575A
公开(公告)日：2000-07-18
申请号：US467947
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
发明人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
IPC分类号： A61K48/00 , C07K14/705 , C12N15/12 , C12N5/10 , C12N15/62
CPC分类号： C07K14/705 , A61K48/00
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

6. 发明授权

US5998164A Polynucleotides encoding human G-protein coupled receptor GPRZ 失效
标题翻译：编码人G蛋白偶联受体GPR2的多核苷酸
公开(公告)号：US5998164A
公开(公告)日：1999-12-07
申请号：US467948
申请日：1995-06-06
申请人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
发明人： Yi Li , Liang Cao , Jian Ni , Reiner Gentz , Carol J. Bult , Granger G. Sutton, III , Craig A. Rosen
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C07K14/715 , C12N15/12 , C12N15/62
CPC分类号： C07K14/7158 , C07K14/705 , A61K38/00 , A61K48/00
摘要： Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G-蛋白偶联受体或多肽和编码此类多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

7. 发明授权

US07227005B1 Vascular endothelial growth factor 2 失效
标题翻译：血管内皮生长因子2
公开(公告)号：US07227005B1
公开(公告)日：2007-06-05
申请号：US09257272
申请日：1999-02-25
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号： A61K38/24 , A61K37/27 , A61K38/00 , C07K1/00 , A01N37/18
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译：公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

8. 发明授权

US6040157A Vascular endothelial growth factor 2 失效
标题翻译：血管内皮生长因子2
公开(公告)号：US6040157A
公开(公告)日：2000-03-21
申请号：US42105
申请日：1998-03-13
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C12N1/21 , C12N15/18 , C12N5/00 , C12N15/63
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译：公开了人类VEGF2多肽，生物学活性，诊断学或治疗学的sefl片段，类似物或其衍生物，和遇到这种VEGF2多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

9. 发明申请

US20090192088A1 Vascular Endothelial Growth Factor 2 审中-公开
标题翻译：血管内皮生长因子2
公开(公告)号：US20090192088A1
公开(公告)日：2009-07-30
申请号：US12396033
申请日：2009-03-02
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号： A61K38/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12N15/09 , C07K14/475 , C07K16/22 , A61P9/00
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.
摘要翻译：公开了编码这种VEGF2多肽的人VEGF2多肽和DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断，治疗和/或预防效果。还提供了使用抗体和拮抗剂抑制VEGF2作用于治疗目的的作用的方法。

10. 发明授权

US07153827B1 Vascular endothelial growth factor 2 and methods of use 失效
标题翻译：血管内皮生长因子2及其使用方法
公开(公告)号：US07153827B1
公开(公告)日：2006-12-26
申请号：US09219442
申请日：1998-12-23
申请人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人： Jing-Shan Hu , Craig A. Rosen , Liang Cao
IPC分类号： A61K38/00 , A01N37/18 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K2319/00 , C12N2799/026
摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译：公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

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