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1. 发明授权

US08629980B2 Optical microscope and optical instrumentation 有权
标题翻译：光学显微镜和光学仪器
公开(公告)号：US08629980B2
公开(公告)日：2014-01-14
申请号：US13375388
申请日：2010-06-02
申请人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
发明人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
IPC分类号： G01J3/44
CPC分类号： G01J3/4412 , G01N21/65 , G02B21/06 , G02B21/365
摘要： The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 100 irradiates a sample 6 with a first train of optical pulses having a first optical frequency, which is generated by a first light source, and a second train of optical pulses having a second optical frequency, which is temporally synchronized with the first train of optical pulses and is generated by a second light source, and detects light scattered from the sample 6. The repetition frequency of the train of optical pulses generated by the first light source is an integral sub-multiple of the repetition frequency of the train of optical pulses generated by the second light source.
摘要翻译：本发明提供了一种光学显微镜，其防止光源系统的复杂性的增加，并且配备有即使当增加调制频率以便减少激光器的强度噪声的影响等时容易进行适当操作的光学器件该光学显微镜100照射具有由第一光源产生的具有第一光学频率的第一列光脉冲的样品6和具有与第二光频同步的第二光学频率的第二光脉冲序列第一光脉冲串，并由第二光源产生，并且检测从样品6散射的光。由第一光源产生的光脉冲序列的重复频率是该第一光源的重复频率的整数倍由第二光源产生的光脉冲序列。

2. 发明申请

US20120140217A1 OPTICAL MICROSCOPE AND OPTICAL INSTRUMENTATION 有权
标题翻译：光学显微镜和光学仪器
公开(公告)号：US20120140217A1
公开(公告)日：2012-06-07
申请号：US13375388
申请日：2010-06-02
申请人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
发明人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
IPC分类号： G01N21/65
CPC分类号： G01J3/4412 , G01N21/65 , G02B21/06 , G02B21/365
摘要： The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 100 irradiates a sample 6 with a first train of optical pulses having a first optical frequency, which is generated by a first light source, and a second train of optical pulses having a second optical frequency, which is temporally synchronized with the first train of optical pulses and is generated by a second light source, and detects light scattered from the sample 6. The repetition frequency of the train of optical pulses generated by the first light source is an integral sub-multiple of the repetition frequency of the train of optical pulses generated by the second light source.
摘要翻译：本发明提供了一种光学显微镜，其防止光源系统的复杂性的增加，并且配备有即使当增加调制频率以便减少激光器的强度噪声的影响等时容易进行适当操作的光学器件该光学显微镜100照射具有由第一光源产生的具有第一光学频率的第一列光脉冲的样品6和具有与第二光频同步的第二光学频率的第二光脉冲序列第一光脉冲串，并由第二光源产生，并且检测从样品6散射的光。由第一光源产生的光脉冲序列的重复频率是该第一光源的重复频率的整数倍由第二光源产生的光脉冲序列。

3. 发明授权

US09075284B2 Spectral width narrowing method, optical element and light source device 有权
标题翻译：光谱宽度变窄方法，光学元件和光源装置
公开(公告)号：US09075284B2
公开(公告)日：2015-07-07
申请号：US13643367
申请日：2011-04-26
申请人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
发明人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
IPC分类号： G02F1/35 , G02B6/00 , G02F1/39 , H01S3/067 , G02B6/02
CPC分类号： G02F1/395 , G02B6/02247 , G02F1/3513 , H01S3/067
摘要： The present invention provides a method for narrowing a spectral width that can also be adapted to an ultrashort optical pulse emitted from a wavelength tunable light source, and that can provide an output optical pulse with a narrow spectral width and a low noise component, and an optical element and a light source device that use the method for narrowing a spectral width. The method includes using an optical waveguide member (2) to cause a soliton effect in an input optical pulse (1) within the optical waveguide member (2), thereby narrowing a spectral width of the input optical pulse (1) to provide an output optical pulse (3), the optical waveguide member (2) having dispersion characteristics such that the average of a second-order dispersion value (β2) with respect to the input optical pulse (1) is negative, and the absolute value of the second-order dispersion value (β2) increases in a propagation direction of the input optical pulse (1).
摘要翻译：本发明提供了一种缩小光谱宽度的方法，该方法也可以适用于从波长可调谐光源发射的超短光脉冲，并且可以提供具有窄光谱宽度和低噪声分量的输出光脉冲，以及光学元件和使用这种缩小光谱宽度的方法的光源装置。该方法包括使用光波导构件（2）在光波导构件（2）内的输入光脉冲（1）中产生孤子效应，从而使输入光脉冲（1）的光谱宽度变窄以提供输出光脉冲（3），具有使二阶色散值（＆bgr; 2）相对于输入光脉冲（1）的平均值为负的色散特性的光波导元件（2），绝对值二阶色散值（＆bgr; 2）在输入光脉冲（1）的传播方向上增加。

4. 发明申请

US20130088770A1 SPECTRAL WIDTH NARROWING METHOD, OPTICAL ELEMENT AND LIGHT SOURCE DEVICE 有权
标题翻译：光谱宽度方法，光学元件和光源设备
公开(公告)号：US20130088770A1
公开(公告)日：2013-04-11
申请号：US13643367
申请日：2011-04-26
申请人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
发明人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
IPC分类号： G02F1/39 , H01S3/067
CPC分类号： G02F1/395 , G02B6/02247 , G02F1/3513 , H01S3/067
摘要： The present invention provides a method for narrowing a spectral width that can also be adapted to an ultrashort optical pulse emitted from a wavelength tunable light source, and that can provide an output optical pulse with a narrow spectral width and a low noise component, and an optical element and a light source device that use the method for narrowing a spectral width. The method includes using an optical waveguide member (2) to cause a soliton effect in an input optical pulse (1) within the optical waveguide member (2), thereby narrowing a spectral width of the input optical pulse (1) to provide an output optical pulse (3), the optical waveguide member (2) having dispersion characteristics such that the average of a second-order dispersion value (β2) with respect to the input optical pulse (1) is negative, and the absolute value of the second-order dispersion value (β2) increases in a propagation direction of the input optical pulse (1).
摘要翻译：本发明提供了一种缩小光谱宽度的方法，该方法也可以适用于从波长可调谐光源发射的超短光脉冲，并且可以提供具有窄光谱宽度和低噪声分量的输出光脉冲，以及光学元件和使用这种缩小光谱宽度的方法的光源装置。该方法包括使用光波导构件（2）在光波导构件（2）内的输入光脉冲（1）中产生孤子效应，从而使输入光脉冲（1）的光谱宽度变窄以提供输出光脉冲（3），具有使二阶色散值（＆bgr; 2）相对于输入光脉冲（1）的平均值为负的色散特性的光波导元件（2），绝对值二阶色散值（＆bgr; 2）在输入光脉冲（1）的传播方向上增加。

5. 发明授权

US09182216B2 Method for observing protein crystal 有权
标题翻译：观察蛋白质晶体的方法
公开(公告)号：US09182216B2
公开(公告)日：2015-11-10
申请号：US13825280
申请日：2011-09-20
申请人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
发明人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
IPC分类号： G01B9/02 , G01N21/47 , C07K1/30 , G01N21/17
CPC分类号： G01B9/02091 , C07K1/306 , G01N21/4795 , G01N2021/1787
摘要： Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source;a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; anda method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.
摘要翻译：提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察从超宽带超连续光源发射的光的中心波长为0.8μm波段的蛋白质晶体的方法; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。

6. 发明申请

US20130184445A1 METHOD FOR OBSERVING PROTEIN CRYSTAL 有权
标题翻译：观察蛋白水晶的方法
公开(公告)号：US20130184445A1
公开(公告)日：2013-07-18
申请号：US13825280
申请日：2011-09-20
申请人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
发明人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
IPC分类号： G01B9/02 , C07K1/30
CPC分类号： G01B9/02091 , C07K1/306 , G01N21/4795 , G01N2021/1787
摘要： Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source; a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; and a method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.
摘要翻译：提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察蛋白质晶体的方法，其中从超宽带超连续光源发射的光的中心波长为0.8μm波段; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。

7. 发明申请

US20090122317A1 Spectroscopy Method and Spectroscope 失效
标题翻译：光谱法和光谱仪
公开(公告)号：US20090122317A1
公开(公告)日：2009-05-14
申请号：US11991542
申请日：2006-09-06
申请人： Masafumi Ito , Norihiko Nishizawa , Masaru Hori , Toshio Goto , Hiroyuki Kano
发明人： Masafumi Ito , Norihiko Nishizawa , Masaru Hori , Toshio Goto , Hiroyuki Kano
IPC分类号： G01N21/31 , G02B6/26
CPC分类号： G01N21/39 , G01J3/02 , G01J3/0218 , G01J3/0224 , G01J3/10 , G01J3/42 , G01J2001/4242 , G01N2201/0697 , G02B6/2861
摘要： To achieve an apparatus capable of measuring a light absorption coefficient f a sample with high sensitivity. A ring down spectroscope uses a wavelength-variable femtosecond soliton pulse light source 1. Pulse light is input to a loop optical fiber 6 through a first light waveguide 4 and a wavelength selective switch 5. Ring down pulse light is input to a homodyne detector through the wavelength selective switch 5. On the other hand, pulse light propagating in the first light waveguide 4 is split and input to light waveguides constituting a second light waveguide 20 through an optical directional coupler 8 and a first optical switching element 12. The pulse light propagating in the second light waveguide 20 is input to the homodyne detector as reference light and used for synchronous detection. The plural light waveguides constituting the second light waveguide 20 differ in optical length in accordance with the length of the optical fiber 6, and can slightly change the optical length.
摘要翻译：实现能够以高灵敏度测量样品的光吸收系数f的装置。环形光谱仪使用波长可变飞秒激光脉冲光源1.脉冲光通过第一光波导4和波长选择开关5输入到环形光纤6中。环形脉冲光通过波长选择开关5.另一方面，在第一光波导4中传播的脉冲光通过光学定向耦合器8和第一光开关元件12被分离并输入到构成第二光波导20的光波导上。脉冲光在第二光波导20中传播的信号被输入到零差检测器作为参考光，并用于同步检测。构成第二光波导路20的多个光波导根据光纤6的长度的光学长度不同，并且可以稍微改变光学长度。

8. 发明申请

US20050226289A1 Broadband optical spectrum generating apparatus and pulsed light generating apparatus 有权
标题翻译：宽带光谱发生装置和脉冲发光装置
公开(公告)号：US20050226289A1
公开(公告)日：2005-10-13
申请号：US11156462
申请日：2005-06-21
申请人： Toshio Goto , Norihiko Nishizawa , Youta Ito
发明人： Toshio Goto , Norihiko Nishizawa , Youta Ito
IPC分类号： G02F1/365 , H01S3/00 , H01S3/067 , H01S3/13
CPC分类号： H01S3/067 , G02F1/365 , H01S3/0057 , H01S3/06725
摘要： A broadband optical spectrum generating apparatus 20 includes a ultrashort pulsed fiber laser 22 that generates pulsed light having a pulse width in the unit of picosecond to femtosecond, and broadband optical spectrum-generating optical fibers 24 that are connected with the ultrashort pulse fiber laser 22 via a lens 26 and have characteristics of normal dispersion, that is, a nonlinear coefficient of not less than 10 [W−1km−1] and a magnitude of wavelength dispersion of not greater than a value 0 [ps/km/nm] with regard to a wavelength of the pulsed light. The resulting output is super continuum that is widely broadened to a wavelength band of 1400 nm to 1750 nm and is chirped to a linear characteristic.
摘要翻译：宽带光谱发生装置20包括产生具有以皮秒为单位的脉冲宽度的脉冲光的超短脉冲光纤激光器22以及与超短脉冲光纤激光器22连接的宽带光谱产生光纤24，经由透镜26具有正常色散的特性，也就是说，非线性系数不小于10 [W -1 -1]]>，并且波长色散的大小不大于相对于脉冲光的波长的值0 [ps / km / nm]。所得到的输出是超连续谱，其广泛地扩展到1400nm至1750nm的波长带，并被啁啾成线性特征。

9. 发明授权

US07855790B2 Dimension measuring apparatus 有权
标题翻译：尺寸测量仪器
公开(公告)号：US07855790B2
公开(公告)日：2010-12-21
申请号：US12389288
申请日：2009-02-19
申请人： Norihiko Nishizawa , Masatoshi Arai , Tomohiro Aoto
发明人： Norihiko Nishizawa , Masatoshi Arai , Tomohiro Aoto
IPC分类号： G01B11/02
CPC分类号： G01B11/0608 , G01B9/0209 , G01B11/2441 , G01B2290/35
摘要： A dimension measuring apparatus includes a light beam splitting element for splitting light emitted from a white light source into measuring light flux and reference light flux, a reference light scanning optics for varying optical path length of the reference light flux, a detector for detecting interference signal produced by the light fluxes, and a controller for determining the surface height of the object from the optical path length of the reference light flux corresponding to maximum value of the interference signal. The reference light scanning optics includes a rotary member, first and second reflective elements disposed to be symmetrical with respect to the rotation axis of the rotary member, and light beam deflecting members that direct the reference light flux to be incident on the first reflective element along the direction parallel and opposite to the incident direction of the reference light flux on the second reflective element.
摘要翻译：尺寸测量装置包括用于将从白光源发射的光分解为测量光通量和参考光通量的光束分离元件，用于改变参考光通量的光程长度的参考光扫描光学器件，用于检测干涉信号的检测器由光束产生的控制器，以及控制器，用于根据与干扰信号的最大值相对应的参考光通量的光路长度确定物体的表面高度。参考光扫描光学器件包括旋转构件，设置成相对于旋转构件的旋转轴线对称设置的第一和第二反射元件以及引导参考光束入射在第一反射元件上的光束偏转构件与第二反射元件上的参考光通量的入射方向平行且相反的方向。

10. 发明授权

US06925236B2 Broadband optical spectrum generating apparatus and pulsed light generating apparatus 失效
标题翻译：宽带光谱发生装置和脉冲发光装置
公开(公告)号：US06925236B2
公开(公告)日：2005-08-02
申请号：US10231131
申请日：2002-08-30
申请人： Toshio Goto , Norihiko Nishizawa , Youta Ito
发明人： Toshio Goto , Norihiko Nishizawa , Youta Ito
IPC分类号： G02F1/365 , H01S3/00 , H01S3/067 , G02B6/00
CPC分类号： H01S3/067 , G02F1/365 , H01S3/0057 , H01S3/06725
摘要： A broadband optical spectrum generating apparatus 20 includes a ultrashort pulsed fiber laser 22 that generates pulsed light having a pulse width in the unit of picosecond to femtosecond, and broadband optical spectrum-generating optical fibers 24 that are connected with the ultrashort pulse fiber laser 22 via a lens 26 and have characteristics of normal dispersion, that is, a nonlinear coefficient of not less than 10 [W−1 km−1] and a magnitude of wavelength dispersion of not greater than a value 0 [ps/km/nm] with regard to a wavelength of the pulsed light. The resulting output is super continuum that is widely broadened to a wavelength band of 1400 nm to 1750 nm and is chirped to a linear characteristic.
摘要翻译：宽带光谱发生装置20包括产生具有以皮秒为单位的脉冲宽度的脉冲光的超短脉冲光纤激光器22以及与超短脉冲光纤激光器22连接的宽带光谱产生光纤24，经由透镜26具有正常色散的特性，也就是说，非线性系数不小于10 [W -1 -1]]>，并且波长色散的大小不大于相对于脉冲光的波长的值0 [ps / km / nm]。所得到的输出是超连续谱，其广泛地扩展到1400nm至1750nm的波长带，并被啁啾成线性特征。

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