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1. 发明授权

US09182216B2 Method for observing protein crystal 有权
标题翻译：观察蛋白质晶体的方法
公开(公告)号：US09182216B2
公开(公告)日：2015-11-10
申请号：US13825280
申请日：2011-09-20
申请人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
发明人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
IPC分类号： G01B9/02 , G01N21/47 , C07K1/30 , G01N21/17
CPC分类号： G01B9/02091 , C07K1/306 , G01N21/4795 , G01N2021/1787
摘要： Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source;a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; anda method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.
摘要翻译：提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察从超宽带超连续光源发射的光的中心波长为0.8μm波段的蛋白质晶体的方法; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。

2. 发明申请

US20130184445A1 METHOD FOR OBSERVING PROTEIN CRYSTAL 有权
标题翻译：观察蛋白水晶的方法
公开(公告)号：US20130184445A1
公开(公告)日：2013-07-18
申请号：US13825280
申请日：2011-09-20
申请人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
发明人： Norihiko Nishizawa , Hiroyoshi Matsumura , Yuusuke Mori , Shutaro Ishida , Kazuyoshi Itoh , Shigeru Sugiyama , Hiroaki Adachi , Tsuyoshi Inoue , Kazufumi Takano , Murakami Satoshi
IPC分类号： G01B9/02 , C07K1/30
CPC分类号： G01B9/02091 , C07K1/306 , G01N21/4795 , G01N2021/1787
摘要： Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source; a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; and a method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.
摘要翻译：提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察蛋白质晶体的方法，其中从超宽带超连续光源发射的光的中心波长为0.8μm波段; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。

3. 发明授权

US09075284B2 Spectral width narrowing method, optical element and light source device 有权
标题翻译：光谱宽度变窄方法，光学元件和光源装置
公开(公告)号：US09075284B2
公开(公告)日：2015-07-07
申请号：US13643367
申请日：2011-04-26
申请人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
发明人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
IPC分类号： G02F1/35 , G02B6/00 , G02F1/39 , H01S3/067 , G02B6/02
CPC分类号： G02F1/395 , G02B6/02247 , G02F1/3513 , H01S3/067
摘要： The present invention provides a method for narrowing a spectral width that can also be adapted to an ultrashort optical pulse emitted from a wavelength tunable light source, and that can provide an output optical pulse with a narrow spectral width and a low noise component, and an optical element and a light source device that use the method for narrowing a spectral width. The method includes using an optical waveguide member (2) to cause a soliton effect in an input optical pulse (1) within the optical waveguide member (2), thereby narrowing a spectral width of the input optical pulse (1) to provide an output optical pulse (3), the optical waveguide member (2) having dispersion characteristics such that the average of a second-order dispersion value (β2) with respect to the input optical pulse (1) is negative, and the absolute value of the second-order dispersion value (β2) increases in a propagation direction of the input optical pulse (1).
摘要翻译：本发明提供了一种缩小光谱宽度的方法，该方法也可以适用于从波长可调谐光源发射的超短光脉冲，并且可以提供具有窄光谱宽度和低噪声分量的输出光脉冲，以及光学元件和使用这种缩小光谱宽度的方法的光源装置。该方法包括使用光波导构件（2）在光波导构件（2）内的输入光脉冲（1）中产生孤子效应，从而使输入光脉冲（1）的光谱宽度变窄以提供输出光脉冲（3），具有使二阶色散值（＆bgr; 2）相对于输入光脉冲（1）的平均值为负的色散特性的光波导元件（2），绝对值二阶色散值（＆bgr; 2）在输入光脉冲（1）的传播方向上增加。

4. 发明申请

US20130088770A1 SPECTRAL WIDTH NARROWING METHOD, OPTICAL ELEMENT AND LIGHT SOURCE DEVICE 有权
标题翻译：光谱宽度方法，光学元件和光源设备
公开(公告)号：US20130088770A1
公开(公告)日：2013-04-11
申请号：US13643367
申请日：2011-04-26
申请人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
发明人： Norihiko Nishizawa , Yasuyuki Ozeki , Kazuyoshi Itoh
IPC分类号： G02F1/39 , H01S3/067
CPC分类号： G02F1/395 , G02B6/02247 , G02F1/3513 , H01S3/067
摘要： The present invention provides a method for narrowing a spectral width that can also be adapted to an ultrashort optical pulse emitted from a wavelength tunable light source, and that can provide an output optical pulse with a narrow spectral width and a low noise component, and an optical element and a light source device that use the method for narrowing a spectral width. The method includes using an optical waveguide member (2) to cause a soliton effect in an input optical pulse (1) within the optical waveguide member (2), thereby narrowing a spectral width of the input optical pulse (1) to provide an output optical pulse (3), the optical waveguide member (2) having dispersion characteristics such that the average of a second-order dispersion value (β2) with respect to the input optical pulse (1) is negative, and the absolute value of the second-order dispersion value (β2) increases in a propagation direction of the input optical pulse (1).
摘要翻译：本发明提供了一种缩小光谱宽度的方法，该方法也可以适用于从波长可调谐光源发射的超短光脉冲，并且可以提供具有窄光谱宽度和低噪声分量的输出光脉冲，以及光学元件和使用这种缩小光谱宽度的方法的光源装置。该方法包括使用光波导构件（2）在光波导构件（2）内的输入光脉冲（1）中产生孤子效应，从而使输入光脉冲（1）的光谱宽度变窄以提供输出光脉冲（3），具有使二阶色散值（＆bgr; 2）相对于输入光脉冲（1）的平均值为负的色散特性的光波导元件（2），绝对值二阶色散值（＆bgr; 2）在输入光脉冲（1）的传播方向上增加。

5. 发明授权

US08629980B2 Optical microscope and optical instrumentation 有权
标题翻译：光学显微镜和光学仪器
公开(公告)号：US08629980B2
公开(公告)日：2014-01-14
申请号：US13375388
申请日：2010-06-02
申请人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
发明人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
IPC分类号： G01J3/44
CPC分类号： G01J3/4412 , G01N21/65 , G02B21/06 , G02B21/365
摘要： The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 100 irradiates a sample 6 with a first train of optical pulses having a first optical frequency, which is generated by a first light source, and a second train of optical pulses having a second optical frequency, which is temporally synchronized with the first train of optical pulses and is generated by a second light source, and detects light scattered from the sample 6. The repetition frequency of the train of optical pulses generated by the first light source is an integral sub-multiple of the repetition frequency of the train of optical pulses generated by the second light source.
摘要翻译：本发明提供了一种光学显微镜，其防止光源系统的复杂性的增加，并且配备有即使当增加调制频率以便减少激光器的强度噪声的影响等时容易进行适当操作的光学器件该光学显微镜100照射具有由第一光源产生的具有第一光学频率的第一列光脉冲的样品6和具有与第二光频同步的第二光学频率的第二光脉冲序列第一光脉冲串，并由第二光源产生，并且检测从样品6散射的光。由第一光源产生的光脉冲序列的重复频率是该第一光源的重复频率的整数倍由第二光源产生的光脉冲序列。

6. 发明申请

US20120140217A1 OPTICAL MICROSCOPE AND OPTICAL INSTRUMENTATION 有权
标题翻译：光学显微镜和光学仪器
公开(公告)号：US20120140217A1
公开(公告)日：2012-06-07
申请号：US13375388
申请日：2010-06-02
申请人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
发明人： Yasuyuki Ozeki , Kazuyoshi Itoh , Fumihiro Dake , Kiichi Fukui , Shinichiro Kajiyama , Yuma Kitagawa , Norihiko Nishizawa , Kazuhiko Sumimura
IPC分类号： G01N21/65
CPC分类号： G01J3/4412 , G01N21/65 , G02B21/06 , G02B21/365
摘要： The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 100 irradiates a sample 6 with a first train of optical pulses having a first optical frequency, which is generated by a first light source, and a second train of optical pulses having a second optical frequency, which is temporally synchronized with the first train of optical pulses and is generated by a second light source, and detects light scattered from the sample 6. The repetition frequency of the train of optical pulses generated by the first light source is an integral sub-multiple of the repetition frequency of the train of optical pulses generated by the second light source.
摘要翻译：本发明提供了一种光学显微镜，其防止光源系统的复杂性的增加，并且配备有即使当增加调制频率以便减少激光器的强度噪声的影响等时容易进行适当操作的光学器件该光学显微镜100照射具有由第一光源产生的具有第一光学频率的第一列光脉冲的样品6和具有与第二光频同步的第二光学频率的第二光脉冲序列第一光脉冲串，并由第二光源产生，并且检测从样品6散射的光。由第一光源产生的光脉冲序列的重复频率是该第一光源的重复频率的整数倍由第二光源产生的光脉冲序列。

7. 发明授权

US07224255B2 Overheat protection device for movable body surface, overheat protection apparatus using the same and temperature control device 有权
标题翻译：可移动体表面过热保护装置，过热保护装置及温度控制装置
公开(公告)号：US07224255B2
公开(公告)日：2007-05-29
申请号：US10921856
申请日：2004-08-20
申请人： Yasuhiro Uehara , Kazuyoshi Itoh
发明人： Yasuhiro Uehara , Kazuyoshi Itoh
IPC分类号： H01H85/143 , H01H85/147
CPC分类号： H01H37/761
摘要： An overheat protection device for a movable body surface includes a thermal fuse having a fuse element which melts at a predetermined temperature, bridges electrodes in a pair and melts at a temperature equal to or higher than the predetermined temperature to break an electrical connection between the pair of electrodes, and a pair of long elastic bodies, to each of which one of the electrodes is electrically connected at an end or its periphery of the elastic body through a lead. At least one of pairs of upper surfaces and lower surfaces of the elastic bodies are spatially on a same plane.
摘要翻译：用于可移动体表面的过热保护装置包括具有在预定温度下熔化的熔丝元件的热熔丝，桥接一对电极并在等于或高于预定温度的温度下熔化以破坏该对之间的电连接的电极和一对长的弹性体，其中每个电极通过引线在弹性体的端部或其周边处电连接。弹性体的至少一对上表面和下表面在空间上在同一平面上。

8. 发明申请

US20050279928A1 Mass spectrometer for biological samples 失效
标题翻译：质谱仪用于生物样品
公开(公告)号：US20050279928A1
公开(公告)日：2005-12-22
申请号：US11151466
申请日：2005-06-14
申请人： Kunihiko Ohkubo , Kiichi Fukui , Kazuyoshi Itoh
发明人： Kunihiko Ohkubo , Kiichi Fukui , Kazuyoshi Itoh
IPC分类号： H01J49/16 , H01J49/40 , B01D59/44
CPC分类号： H01J49/162 , H01J49/0463
摘要： The mass spectrometer according to the present invention includes a light source for emitting pulse light including a plurality of wavelengths; an ionizer for ionizing molecules of a sample by irradiating the light from the light source to the sample; and a mass analyzer for separating ions ionized in the ionizer according to their mass to charge ratios. For the light source, one including a plurality of ultrashort pulse laser sources each emitting a wavelength different from others, and one emitting ultrashort pulse light including plural wavelengths ranging from the visible region to the infrared region generated by dispersing an ultrashort pulse light with continuous (white) spectrum can be used. Pulse lights having plural wavelengths ranging from near infrared to the ultraviolet region respectively share the role; i.e., one of them vaporizes the sample without fragmenting it, and another ionizes the vaporized sample with the single-photon process or two-photon (or multi-photon) process. This enables ionization of protein complexes as a whole contained in the sample, and enables mass analyses of them.
摘要翻译：根据本发明的质谱仪包括用于发射包括多个波长的脉冲光的光源; 电离器，用于通过将来自光源的光照射到样品上来使样品的分子离子化; 以及质量分析器，用于根据电离质量与电离比分离在离子发生器中离子化的离子。对于光源，包括多个发射不同于其他波长的超短脉冲激光源的光源，以及一个发射包括从可见光区域到红外区域的多个波长的超短脉冲光，通过分散具有连续的超短脉冲光白色）光谱。分别具有从近红外到紫外线区域的多个波长的脉冲光共同作用; 即，其中一个使样品蒸发而不使其分裂，另一个使用单光子过程或双光子（或多光子）过程将蒸发的样品电离。这使得能够将样品中包含的蛋白质复合物电离，并且能够进行质量分析。

9. 发明申请

US20070047991A1 Fixing apparatus, image forming apparatus and fixing apparatus heating method 有权
标题翻译：固定装置，成像装置和定影装置加热方法
公开(公告)号：US20070047991A1
公开(公告)日：2007-03-01
申请号：US11391337
申请日：2006-03-29
申请人： Kazuyoshi Itoh , Yasutaka Naito , Motofumi Baba , Hideaki Ohhara
发明人： Kazuyoshi Itoh , Yasutaka Naito , Motofumi Baba , Hideaki Ohhara
IPC分类号： G03G15/20
CPC分类号： G03G15/2064 , G03G15/2032 , G03G15/2039 , G03G2215/2016 , G03G2215/2035
摘要： A fixing apparatus for fixing an unfixed image on a recording material includes: a heating member having a conductive layer, that is rotatably provided; a pressure member that is rotatably provided and that is brought into press-contact with the heating member, thereby forms a fixing nip part to pass the recording material between the pressure member and the heating member; a heating unit that performs induction heating on the heating member via the conductive layer; a driving unit that rotates the heating member; and an attachment/separation unit that attaches or separates the heating member to/from the pressure member.
摘要翻译：用于将未定影图像固定在记录材料上的定影装置包括：具有可旋转地设置的导电层的加热构件; 压力构件，其被可旋转地设置并与加热构件压接，从而形成定影夹持部，以使压力构件和加热构件之间的记录材料通过; 加热单元，其经由所述导电层对所述加热构件进行感应加热; 使所述加热部件旋转的驱动部; 以及附加/分离单元，其将加热构件附接或分离到压力构件。

10. 发明申请

US20070047983A1 Heating apparatus and fixing apparatus 有权
标题翻译：加热装置和定影装置
公开(公告)号：US20070047983A1
公开(公告)日：2007-03-01
申请号：US11391338
申请日：2006-03-29
申请人： Kazuyoshi Itoh , Yasuhiro Uehara
发明人： Kazuyoshi Itoh , Yasuhiro Uehara
IPC分类号： G03G15/20
CPC分类号： G03G15/2039 , G03G15/80
摘要： A heating apparatus includes: an exciting coil provided in close vicinity of a heated body having a conductive layer; a capacitor connected serially or in parallel with the exciting coil; a switching element that generates a high frequency current by turning on/off a direct current and that supplies the high frequency current to the exciting coil and the capacitor; a specifying unit that specifies an electric value to be supplied to the exciting coil; an output unit that outputs, to the switching element, a driving signal to turn on the switching element for a period determined in correspondence with the specified electric value; a voltage detection unit that detects a flyback voltage value generated in a resonance circuit including the exciting coil and the capacitor; and an abnormality detection unit that detects an abnormality in the heated body based on the detected flyback voltage value.
摘要翻译：一种加热装置，包括：设置在具有导电层的被加热体附近的励磁线圈; 与励磁线圈串联或并联连接的电容器; 开关元件，其通过接通/断开直流电而产生高频电流，并将高频电流提供给励磁线圈和电容器; 指定单元，其指定要提供给所述励磁线圈的电值; 输出单元，向所述开关元件输出驱动信号，以将所述开关元件接通一定时间，所述周期与所述指定电值相对应; 电压检测单元，其检测在包括所述励磁线圈和所述电容器的谐振电路中产生的回扫电压值; 以及异常检测单元，其基于检测到的反激电压值来检测加热体的异常。

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