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1. 发明授权

US5877167A Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives 失效
标题翻译：抑制鞘氨醇-1-磷酸及其衍生物的细胞运动性的方法
公开(公告)号：US5877167A
公开(公告)日：1999-03-02
申请号：US797926
申请日：1997-02-12
申请人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic motility and/or chemoinvasion, a method of inhibiting phagokinetic activity of tumor cells and neutrophils, a method of inhibiting tumor cell metastasis and a method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising contacting the cells or administering to a host in need of treatment an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives is also described.
摘要翻译：一种抑制肿瘤细胞趋化运动和/或化学侵蚀的方法，抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法，抑制肿瘤细胞转移的方法以及抑制由于运动和侵入嗜中性粒细胞血管壁引起的炎症的方法，包括使细胞接触或向需要治疗的宿主施用抑制量的选自鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1-磷酸的模拟物的药剂，或衍生物和药学上可接受的盐。还描述了制备鞘氨醇-1-磷酸酯及其衍生物的方法。

2. 发明授权

US5260288A Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives 失效
标题翻译：通过鞘氨醇-1-磷酸酯及其衍生物抑制细胞运动的方法
公开(公告)号：US5260288A
公开(公告)日：1993-11-09
申请号：US863179
申请日：1992-04-03
申请人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
摘要翻译：一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或其衍生物，以及药学上可接受的盐。抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物，磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药剂的药学上可接受的盐。鞘氨醇-1-磷酸及其衍生物的制备方法。

3. 发明授权

US5663404A Sphingosine-1-phosphate essentially free of L-threo isomer 失效
标题翻译：基本上不含L-苏式异构体的鞘氨醇-1-磷酸
公开(公告)号：US5663404A
公开(公告)日：1997-09-02
申请号：US371866
申请日：1995-01-12
申请人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173 , C07F9/09
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
摘要翻译：一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或其衍生物，以及药学上可接受的盐。抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物，磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药物的药学上可接受的盐。鞘氨醇-1-磷酸及其衍生物的制备方法。

4. 发明授权

US5391800A Method for inhibition of cell motility by sphingosine-1-phosphate, its derivatives and mimetics and method of synthesizing sphingosine-1-phosphate and its derivatives 失效
标题翻译：鞘氨醇-1-磷酸及其衍生物和模拟物抑制细胞运动性的方法及合成鞘氨醇-1-磷酸酯及其衍生物的方法
公开(公告)号：US5391800A
公开(公告)日：1995-02-21
申请号：US104504
申请日：1993-08-09
申请人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
摘要翻译：一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或其衍生物，以及药学上可接受的盐。抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物，磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药剂的药学上可接受的盐。鞘氨醇-1-磷酸及其衍生物的制备方法。

5. 发明授权

US5627171A Sphingosine-1-phosphate/trimethylsphingosine composition 失效
标题翻译：鞘氨醇-1-磷酸/三甲基鞘氨醇组合物
公开(公告)号：US5627171A
公开(公告)日：1997-05-06
申请号：US225796
申请日：1994-04-11
申请人： Yong S. Park , Yasuyuki Igarashi , Sen-itiroh Hakomori
发明人： Yong S. Park , Yasuyuki Igarashi , Sen-itiroh Hakomori
IPC分类号： A61K9/127 , A61K31/66 , A61K31/14
CPC分类号： A61K9/1272 , A61K31/66
摘要： Sphingosine-1-phosphate/N,N,N-trimethylsphingosine composition to modulate cell growth.
摘要翻译：鞘氨醇-1-磷酸/ N，N，N-三甲基鞘氨醇组成调节细胞生长。

6. 发明授权

US5331014A Effect of N,N,N-trimethylsphingosine on protein kinase-C activity; melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation 失效
标题翻译： N，N，N-三甲基鞘氨醇对蛋白激酶C活性的影响; 体外黑素瘤细胞生长; 体内转移潜能和人血小板聚集
公开(公告)号：US5331014A
公开(公告)日：1994-07-19
申请号：US81383
申请日：1993-06-30
申请人： Satoshi Kimura , Yasuyuki Igarashi , Sen-itiroh Hakomori , Mohammad N. Ahmad , Hirofumi Okoshi , Kazuko Handa
发明人： Satoshi Kimura , Yasuyuki Igarashi , Sen-itiroh Hakomori , Mohammad N. Ahmad , Hirofumi Okoshi , Kazuko Handa
IPC分类号： A61K31/13 , A61K31/133 , A61P7/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C215/40 , A61K31/14
CPC分类号： C07C215/40
摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
摘要翻译： PCT No.PCT / US91 / 09196 Sec。 371日期：1993年6月30日 102（e）日期1993年6月30日PCT 1991年12月23日PCT PCT。公开号WO92 / 12119 本发明涉及一种新型化合物，其组合物和药物，以及抑制细胞增殖，血小板聚集（各种因素诱导）和抑制肿瘤细胞恶性表型的方法，例如具有转移性的那些，并使用所述化合物，组合物或药物调节细胞粘附分子的表达和功能。 N，N，N-三甲基鞘氨醇对相关化合物显示出优异的细胞增殖抑制和抗转移活性。

7. 发明授权

US5876715A Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof 失效
标题翻译：结合导致E-选择素依赖性细胞翻滚的新型碳水化合物配体（髓磷脂）的抗体及其用途
公开(公告)号：US5876715A
公开(公告)日：1999-03-02
申请号：US635849
申请日：1996-04-22
申请人： Kazuko Handa , Mary Ellen K. Salyan , Mark R. Stroud , Sen-itiroh Hakomori
发明人： Kazuko Handa , Mary Ellen K. Salyan , Mark R. Stroud , Sen-itiroh Hakomori
IPC分类号： A61P29/00 , C07H3/06 , C07H15/10 , A61K39/395 , C07K16/00
CPC分类号： C07H15/10 , C07H3/06
摘要： The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.
摘要翻译：本发明涉及特异性结合髓鞘蛋白的抗体，其包含非分支的多聚乳糖胺，其包含至少10个单糖并且具有末端α2-> 3唾液酸化和内部α1→3岩藻糖基化，除了倒数第二个N-乙酰氨基葡萄糖残基之外的各种N-乙酰葡糖胺残基。本发明还涉及使用这种抗体抑制细胞在另一个细胞上的E-选择蛋白依赖性滚动的方法，其中一个细胞表达结合抗体的髓鞘蛋白。

8. 发明授权

US5418129A Blood treatment method 失效
标题翻译：血液处理方法
公开(公告)号：US5418129A
公开(公告)日：1995-05-23
申请号：US803065
申请日：1991-12-06
申请人： Edward Nudelman , Anil Singhal , Henrik Clausen , Sen-itiroh Hakomori , Kazuo Muroi , Toshio Suda , Hisao Nojiri
发明人： Edward Nudelman , Anil Singhal , Henrik Clausen , Sen-itiroh Hakomori , Kazuo Muroi , Toshio Suda , Hisao Nojiri
IPC分类号： A61K38/00 , C07K16/30 , C12P21/08 , A01N1/02 , A61K39/395 , C07K15/28
CPC分类号： C07K16/30 , A61K38/00
摘要： A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension comprising a mixture of tumor cell membrane and at least one purified lactonized tumor-associated ganglioside; (3) boosting the host with an immunogen comprising a lactone of a tumor associated ganglioside adsorbed on or incorporated into a carrier; (4) fusing immunized cells from the host with myeloma cells to form hybridoma cells; (5) selecting hybridoma cells that produce antibody that binds to the ganglioside of step (3); (6) culturing the selected hybridoma cells; and (7) recovering the antibody.
摘要翻译：一种产生与肿瘤相关神经节苷脂结合的单克隆抗体的方法，所述方法包括：（1）用肿瘤细胞免疫宿主; （2）用包含肿瘤细胞膜和至少一种经内化的内源性肿瘤相关神经节苷脂的混合物的悬浮液加强宿主; （3）用包含吸附在载体上或结合到载体中的肿瘤相关神经节苷脂的内酯的免疫原来加强宿主; （4）将来自宿主的免疫细胞与骨髓瘤细胞融合以形成杂交瘤细胞; （5）选择产生与步骤（3）的神经节苷脂结合的抗体的杂交瘤细胞; （6）培养所选择的杂交瘤细胞; 和（7）回收抗体。

9. 发明授权

US5230900A Antibody-mediated and ligand-mediated targeting of differentiation-inducers to tumor cells 失效
标题翻译：抗体介导和配体介导的分化诱导剂靶向肿瘤细胞
公开(公告)号：US5230900A
公开(公告)日：1993-07-27
申请号：US730513
申请日：1991-07-12
申请人： Sen-itiroh Hakomori , Michiro Otaka , Anil Singhal
发明人： Sen-itiroh Hakomori , Michiro Otaka , Anil Singhal
IPC分类号： A61K9/127 , A61K9/16 , A61K47/48
CPC分类号： A61K47/48007 , A61K9/1271 , A61K9/167 , Y10S424/812 , Y10S436/829
摘要： The present invention relates to compositions which mediate antibody and ligand targeting of differentiation-inducers to tumor cells and methods for employing the same.
摘要翻译：本发明涉及将肿瘤细胞分化诱导剂的抗体和配体靶向的组合物及其应用方法。

10. 发明申请

US20110142844A1 Anti-Extended Type I Glycosphingolipid Antibody, Derivatives Thereof And Use 有权
标题翻译：抗扩展型I型糖鞘抗体，其衍生物及其用途
公开(公告)号：US20110142844A1
公开(公告)日：2011-06-16
申请号：US12299013
申请日：2008-09-07
申请人： Tong-Hsuan Chang , Jerry Ting , Tsai-Hsia Hong , Mei-Chun Yang , Liahng-Yirn Liu , Shu-Yen Chang , Ying-Jin Chen , Jaw-Yuan Wen , Kazuko Handa , Sen-itiroh Hakomori
发明人： Tong-Hsuan Chang , Jerry Ting , Tsai-Hsia Hong , Mei-Chun Yang , Liahng-Yirn Liu , Shu-Yen Chang , Ying-Jin Chen , Jaw-Yuan Wen , Kazuko Handa , Sen-itiroh Hakomori
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/732 , C07K2317/734
摘要： Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.
摘要翻译：提供了特异性结合延长的I型链糖鞘脂的那些抗体的人抗体和抗原结合部分。

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