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1. 发明授权

US07033994B2 Medicinal compositions for preventing and treating hemorrhagic diseases associating thrombopathy 失效
公开(公告)号：US07033994B2
公开(公告)日：2006-04-25
申请号：US10168727
申请日：2000-12-21
申请人： Tatsuya Araki , Kazuhiko Tomokiyo , Yasushi Nakatomi , Kaori Teshima , Tomoko Watanabe , Tomohiro Nakagaki
发明人： Tatsuya Araki , Kazuhiko Tomokiyo , Yasushi Nakatomi , Kaori Teshima , Tomoko Watanabe , Tomohiro Nakagaki
IPC分类号： A61K38/00 , A61K35/14 , A61K35/16
CPC分类号： A61K38/37 , Y10S514/802 , Y10S514/834
摘要： The present invention provides a pharmaceutical composition for treatment and prevention of bleeding disorders caused by platelet disorders, not caused by defect in blood coagulation factors or von Willebrand Factor but caused by reduction of circulating platelet count or platelet dysfunction, said composition comprising a hemostatic effective amount of Factor VIII and/or von Willebrand Factor. Also provided is a method for treating said bleeding, comprising administering a hemostatic effective amount of Factor VIII and/or von Willebrand Factor to patients suffering from bleeding disorders caused by platelet disorders.

2. 发明授权

US06881721B2 Medicinal compositions for treating and preventing diseases based on abnormal blood coagulation 有权
标题翻译：基于异常血液凝固治疗和预防疾病的药物组合物
公开(公告)号：US06881721B2
公开(公告)日：2005-04-19
申请号：US10168371
申请日：2000-12-21
申请人： Yasushi Nakatomi , Kazuhiko Tomokiyo , Tatsuya Araki , Kaori Teshima , Tomoko Watanabe , Tomohiro Nakagaki
发明人： Yasushi Nakatomi , Kazuhiko Tomokiyo , Tatsuya Araki , Kaori Teshima , Tomoko Watanabe , Tomohiro Nakagaki
IPC分类号： A61K38/43 , A61K38/48 , A61P7/04 , A61K38/00
CPC分类号： A61K38/4846
摘要： The present invention provides a pharmaceutical composition for treatment and prevention of hemorrhage associated with blood coagulation disorders, comprising activated Factor VII (FVIIa) and Factor X (FX) as an active ingredient. The pharmaceutical composition of the present invention contains no components causative side effects, is safe, highly efficacious, and easy to manage hemostasis. The pharmaceutical composition can be used for hemostatic management of patients suffering from hemorrhage associated with blood coagulation disorders, for example, disorders (including deficiency) of blood coagulation factors, especially caused by inhibitors (antibodies) against blood coagulation factors.
摘要翻译：本发明提供了用于治疗和预防与凝血障碍相关的出血的药物组合物，其包含活化因子VII（FVIIa）和因子X（FX）作为活性成分。本发明的药物组合物不含成分副作用，安全，高效，易于止血。药物组合物可以用于与血液凝固障碍相关的出血患者的止血管理，例如血液凝固因子的紊乱（包括缺乏），特别是由针对凝血因子的抑制剂（抗体）引起的。

3. 发明授权

US08580235B2 Hair cosmetic 有权
标题翻译：头发化妆品
公开(公告)号：US08580235B2
公开(公告)日：2013-11-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
IPC分类号： A61K8/49 , A61K8/86 , A61K31/704 , A61Q5/00 , A61Q5/02
CPC分类号： A61Q5/02 , A61K8/4966 , A61K8/86 , A61Q5/00 , A61Q5/06 , A61Q5/12 , A61Q17/04
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译：本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品其中。具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。

4. 发明申请

US20120269755A1 Lip Cosmetics 审中-公开
标题翻译：唇妆
公开(公告)号：US20120269755A1
公开(公告)日：2012-10-25
申请号：US13514309
申请日：2010-12-10
申请人： Tomo Osawa , Tomoko Ikeda , Yoshiharu Tsuji , Tomoko Watanabe , Noriko Tomita
发明人： Tomo Osawa , Tomoko Ikeda , Yoshiharu Tsuji , Tomoko Watanabe , Noriko Tomita
IPC分类号： A61K8/37 , A61Q1/06
CPC分类号： A61K8/84 , A61K8/375 , A61K8/39 , A61K8/585 , A61K8/891 , A61Q1/04 , A61Q1/06
摘要： The present invention provides a lip cosmetic that has excellent secondary adhesion resistance effect immediately after the application and is excellent in gloss and stability. The lip cosmetic of the present invention is characterized by comprising the following (a) and (b), wherein the blending quantity of (b) is 20 to 70 mass %: (a) 5 to 20 mass % of a polyglyceryl isostearate wherein the addition mole number of glycerin is 4 to 10, and the number of isostearic acid residues is 1 to 4; and (b) (b1) 20 to 70 mass % of a methyl phenyl silicone, (b2) 0 to 45 mass % of a pentaerythritol ester.
摘要翻译：本发明提供了一种在施用后立即具有优异的二次粘合性效果并且光泽和稳定性优异的唇部化妆品。本发明的唇部化妆品的特征在于包含以下（a）和（b），其中（b）的配合量为20〜70质量％：（a）5〜20质量％的聚甘油异硬脂酸酯，其中，甘油的加成摩尔数为4〜10，异硬脂酸残基数为1〜4; 和（b）（b1）20〜70质量％的甲基苯基硅氧烷，（b2）0〜45质量％的季戊四醇酯。

5. 发明授权

US4902551A Process for treating copper surface 失效
标题翻译：处理铜表面的方法
公开(公告)号：US4902551A
公开(公告)日：1990-02-20
申请号：US224911
申请日：1988-07-27
申请人： Akishi Nakaso , Toshiro Okamura , Haruo Ogino , Tomoko Watanabe , Yuko Kimura
发明人： Akishi Nakaso , Toshiro Okamura , Haruo Ogino , Tomoko Watanabe , Yuko Kimura
IPC分类号： B32B15/04 , C23C18/40 , C23C22/63 , C23C22/83 , H05K1/00 , H05K1/03 , H05K3/02 , H05K3/28 , H05K3/38 , H05K3/42 , H05K3/46
CPC分类号： C23C22/63 , B32B15/04 , C23C18/40 , C23C22/83 , H05K3/022 , H05K3/385 , H05K3/4652 , H05K1/0366 , H05K1/0393 , H05K2201/0355 , H05K2203/0315 , H05K2203/1157 , H05K3/281 , H05K3/427 , Y10S428/901 , Y10T156/1057 , Y10T29/49165 , Y10T428/24322
摘要： Adhesion of copper to a resin layer is improved by reducing a copper oxide layer with an aqueous aldehyde solution (a) while applying a potential of -1000 mV to -400 mV to the copper oxide layer, (b) after contacting with a metal piece made of copper or a metal nobler than copper, or (c) after contacting with an aqueous solution of alkali borohydride.

6. 发明授权

US06964975B2 Isoxazole and thiazole compounds and use thereof as medicine 失效
标题翻译：异恶唑和噻唑化合物及其作为药物的用途
公开(公告)号：US06964975B2
公开(公告)日：2005-11-15
申请号：US10204173
申请日：2001-02-19
申请人： Akihiro Ueno , Rika Nagao , Tomoko Watanabe , Hideo Ohta , Mikio Yagi
发明人： Akihiro Ueno , Rika Nagao , Tomoko Watanabe , Hideo Ohta , Mikio Yagi
IPC分类号： A61P9/10 , A61P13/12 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D261/14 , C07D275/02 , C07D275/03 , C07D413/04 , C07D413/12 , A61K31/42 , A61K31/422
CPC分类号： C07D275/03 , C07D261/14 , C07D413/04 , C07D413/12
摘要： The present invention relates to novel isoxazole and thiazole compounds having an excellent lysophosphatidic acid (LPA) receptor antagonistic activity represented by general formula [1] or salts thereof: wherein R1 and R2 represents an optionally substituted alkyl group or the like; R3 represents a hydrogen atom or the like; R4 represent a group selected from the group consisting of (I) optionally substituted phenyl, aryl, or heterocycle, (II) substituted or nonsubstituted alkyl, and (III) substituted or nonsubstituted alkenyl, alternatively, R3 and R4 may form a ring structure together with a carbon atom to which they bind; and X represents an oxygen atom or a sulfur atom, provided that, when R3 is a hydrogen atom, R4 represents a group other than methyl, and the use thereof as a medicine.
摘要翻译：本发明涉及具有由通式[1]表示的极好的溶血磷脂酸（LPA）受体拮抗作用或其盐的异恶唑和噻唑化合物，其中R1和R2表示任选取代的烷基等; R3表示氢原子等; R 4表示选自（I）任选取代的苯基，芳基或杂环，（II）取代或未取代的烷基和（III）取代或未取代的烯基的基团，或者，R3和R4可以一起形成环结构与它们结合的碳原子; 并且X表示氧原子或硫原子，条件是当R 3为氢原子时，R 4表示甲基以外的基团，以及作为药物的用途。

7. 发明授权

US06266070B1 Character pattern generator, character generating method, and storage medium therefor 失效
标题翻译：字符图案生成器，字符生成方法及其存储介质
公开(公告)号：US06266070B1
公开(公告)日：2001-07-24
申请号：US09178671
申请日：1998-10-26
申请人： Yutaka Shigi , Yuka Yabuuchi , Tomoko Watanabe , Yoshimi Asai
发明人： Yutaka Shigi , Yuka Yabuuchi , Tomoko Watanabe , Yoshimi Asai
IPC分类号： G06F1500
CPC分类号： G06T11/203
摘要： A character pattern generator includes: an input section for inputting an input information that contains a character code, a character style, and a character size of a character pattern to be generated; a character information storing section for storing, for each character code, a character information containing a stroke configuration information composed of skeleton coordinate data of strokes constituting the character pattern; a bit map font generating section for reading, from the character information storing section, the stroke configuration information contained in the character information based on the input information input by the input section and for generating a bit map font based on the skeleton coordinate data of the stroke configuration information that has been read; and an output section for outputting, as a character pattern, the bit map font generated by the bit map font generating section.
摘要翻译：字符图形生成器包括：输入部，其输入包含要生成的字符图案的字符代码，字符样式和字符尺寸的输入信息; 字符信息存储部分，用于针对每个字符代码存储包含由构成字符图案的笔画的骨架坐标数据组成的笔画配置信息的字符信息; 位图字体产生部分，用于根据输入部分输入的输入信息，从字符信息存储部分读取包含在字符信息中的笔划配置信息，并且基于所述字符信息存储部分的骨架坐标数据生成位图字体已阅读的笔画配置信息; 以及输出部分，用于输出由位图字体生成部分生成的位图字体作为字符图形。

8. 发明申请

US20120070398A1 Hair Cosmetic 审中-公开
标题翻译：头发化妆品
公开(公告)号：US20120070398A1
公开(公告)日：2012-03-22
申请号：US13263109
申请日：2010-03-31
申请人： Tanemasa Nagano , Tomoko Watanabe , Shigeru Iwai
发明人： Tanemasa Nagano , Tomoko Watanabe , Shigeru Iwai
IPC分类号： A61K8/41 , A61Q5/12
CPC分类号： A61Q5/12 , A61K8/342 , A61K8/361 , A61K8/368 , A61K8/41 , A61K8/466 , A61Q5/00
摘要： To provide means for improving sensation of hair in application of a hair cosmetic composition, particularly a hair conditioner, after washing of the hair. The present inventors have found that the object can be attained by a hair cosmetic composition containing the following ingredients (1) to (4): (1) a hydroxyetheramine compound represented by formula (I) in an amount of 0.01 to 10 mass % with respect to the hair cosmetic composition: wherein R1 represents a C6 to C24 linear or branched alkyl group or alkenyl group, R2 represents a C2 to C6 linear or branched hydroxyalkylene or hydroxyalkylenyl group, and R3 and R4, which are identical to or different from each other, each represent a hydrogen atom or a C1 to C6 linear alkyl group; (2) a higher alcohol and/or a higher fatty acid in an amount of 0.1 to 20 mass % with respect to the hair cosmetic composition; (3) an organic acid having an aromatic ring skeleton; and (4) water.
摘要翻译：为了提供在洗发后，改善头发化妆品组合物，特别是头发护发素在使用中改善头发感觉的方法。本发明人已经发现，通过含有以下成分（1）〜（4）的毛发化妆品可以实现上述目的：（1）由式（I）表示的羟基醚胺化合物的量为0.01〜10质量％关于毛发化妆品组合物：其中R1表示C6〜C24直链或支链烷基或烯基，R2表示C2〜C6直链或支链羟基亚烷基或羟烷基，R3和R4各自相同或不同另外，各自表示氢原子或C1〜C6直链烷基; （2）相对于毛发化妆品组合物为0.1〜20质量％的高级醇和/或高级脂肪酸; （3）具有芳环骨架的有机酸; 和（4）水。

9. 发明申请

US20110110877A1 Hair Cosmetic 有权
标题翻译：头发化妆品
公开(公告)号：US20110110877A1
公开(公告)日：2011-05-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
IPC分类号： A61K8/49 , A61K8/86 , A61Q5/00 , A61Q5/02
CPC分类号： A61Q5/02 , A61K8/4966 , A61K8/86 , A61Q5/00 , A61Q5/06 , A61Q5/12 , A61Q17/04
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译：本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品其中。具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。

10. 发明申请

US20090326151A1 HAIR COSMETIC 审中-公开
标题翻译：头发化妆品
公开(公告)号：US20090326151A1
公开(公告)日：2009-12-31
申请号：US12306887
申请日：2007-06-29
申请人： Hideki Shimizu , Tomoko Watanabe , Tomoyuki Kawasoe , Taizo Fujiyama , Toshiki Origuchi , Shintaro Ogawa , Yoshitaka Nakayama
发明人： Hideki Shimizu , Tomoko Watanabe , Tomoyuki Kawasoe , Taizo Fujiyama , Toshiki Origuchi , Shintaro Ogawa , Yoshitaka Nakayama
IPC分类号： C08F8/30
CPC分类号： A61Q5/06 , A61K8/87 , A61K8/898 , A61K8/899 , C08G18/0823 , C08G18/12 , C08G18/6625 , C08G18/3893
摘要： Provided is a hair cosmetic that can exhibit hair styling capability, natural finishing capability, and hair style retentivity respectively at superior levels.The hair cosmetic contains a urethane-modified acrylic polymer having a structure in which a urethane polymer chain is bonded to an acrylic polymer chain through a linkage segment having a silicon-oxygen bond, in which the acrylic polymer chain is a residue of an acrylic polymer derived at least from an acrylic monomer (A) and a compound (B1) and/or a compound (B2), where the compound (B1) has a hydrolyzable silicon-containing group and an ethylenically unsaturated bond-containing group, and the compound (B2) has a hydrolyzable silicon-containing group and a mercapto group, and the urethane polymer chain is a residue of a urethane polymer (C) having a hydrolyzable silicon-containing group. The linkage segment in the urethane-modified acrylic polymer is preferably a silicone polymer chain.
摘要翻译：本发明提供一种能够分别具有发型能力，自然整理能力和发型保持性的头发化妆品。毛发化妆品含有氨基甲酸酯改性的丙烯酸类聚合物，其具有通过具有硅 - 氧键的连接链段将氨基甲酸酯聚合物链与丙烯酸聚合物链结合的结构，其中丙烯酸类聚合物链是丙烯酸聚合物的残基至少从丙烯酸类单体（A）和化合物（B1）和/或化合物（B2）得到的化合物（B1），其中化合物（B1）具有可水解的含硅基团和含烯属不饱和键的基团，化合物（B2）具有可水解的含硅基团和巯基，氨基甲酸酯聚合物链是具有可水解的含硅基团的氨基甲酸酯聚合物（C）的残基。氨基甲酸酯改性丙烯酸类聚合物中的连接段优选为有机硅聚合物链。

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