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1. 发明授权

US6143763A Carbostyril derivatives 失效
标题翻译：卡波他汀衍生物
公开(公告)号：US6143763A
公开(公告)日：2000-11-07
申请号：US849664
申请日：1997-05-29
申请人： Yasuo Koga , Yoshito Kihara , Minoru Okada , Takao Nishi , Yoshihiro Inoue , Yukio Kimura , Hiroyoshi Hidaka , Norio Fukuda
发明人： Yasuo Koga , Yoshito Kihara , Minoru Okada , Takao Nishi , Yoshihiro Inoue , Yukio Kimura , Hiroyoshi Hidaka , Norio Fukuda
IPC分类号： C07D215/22 , C07D215/227 , A61K31/4704
CPC分类号： C07D215/227
摘要： A carbostyril derivative of the formula (1): ##STR1## wherein A is lower alkylene, R is H, halogen or lower alkoxy, R.sup.1 and R.sup.2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R.sup.3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R.sup.3 are H, R.sup.1 and R.sup.2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.
摘要翻译： PCT No.PCT / JP96 / 02892 Sec。 371日期：1998年5月29日 102（e）日期1998年5月29日PCT提交1996年10月4日PCT公布。公开号WO97 / 12869 日期：1997年04月10日式（1）的喹诺酮衍生物：其中A为低级亚烷基，R为H，卤素或低级烷氧基，R1和R2各自为低级烷基，任选被OH，低级烷氧基，苯基 - 低级烷氧基或低级烷酰氧基; 任选被OH，羟基 - 低级烷氧基或低级烷酰氧基取代的环烷基; 或氨基任选被低级烷基或环烷基取代，R 3是H，低级烷基，低级烯基或羟基 - 低级烷基，并且喹诺酮环的3-和4-位之间的键是单或双，条件是当R和 R3是H，R1和R2不应该是未取代的低级烷基或未取代的环烷基或其盐，其显示抗血栓形成活性，内膜增厚抑制活性，血小板质量分解活性和增加脑中血流的活性，外周血管，因此可用作预防或治疗各种缺血性疾病的药物。

2. 发明授权

US08883792B2 Substituted isoquinoline derivative 有权
标题翻译：取代的异喹啉衍生物
公开(公告)号：US08883792B2
公开(公告)日：2014-11-11
申请号：US13995300
申请日：2011-12-21
申请人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
发明人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
IPC分类号： C07D401/12 , C07D217/04 , A61K31/4725 , C07D217/02 , C07D417/12 , C07D405/12 , C07D409/12 , C07D217/22
CPC分类号： C07D217/04 , C07D217/02 , C07D217/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides a novel isoquinoline-6-sulfonamide derivative that is useful as a medicine. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt, wherein R1 and R2 each independently represent a hydrogen atom, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like; R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, an optionally substituted alkanoyl group, or the like; and A represents a linear or branched alkylene group having 2 to 6 carbon atoms.
摘要翻译：本发明提供了可用作药物的新型异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或衍生物或其盐的溶剂合物，其中R1和R2各自独立地表示氢原子等; R3和R4各自独立地表示氢原子，烷基等; R5表示氢原子，任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的环烷基，任选取代的烷酰基等; A表示碳原子数2〜6的直链或支链亚烷基。

3. 发明申请

US20130274269A1 NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE 有权
标题翻译：新型取代的异喹啉衍生物
公开(公告)号：US20130274269A1
公开(公告)日：2013-10-17
申请号：US13995300
申请日：2011-12-21
申请人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
发明人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
IPC分类号： C07D217/04 , C07D405/12 , C07D417/12 , C07D401/12
CPC分类号： C07D217/04 , C07D217/02 , C07D217/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides a novel isoquinoline-6-sulfonamide derivative that is useful as a medicine. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt, wherein R1 and R2 each independently represent a hydrogen atom, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like; R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, an optionally substituted alkanoyl group, or the like; and A represents a linear or branched alkylene group having 2 to 6 carbon atoms.
摘要翻译：本发明提供了可用作药物的新型异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或衍生物或其盐的溶剂合物，其中R1和R2各自独立地表示氢原子等; R3和R4各自独立地表示氢原子，烷基等; R5表示氢原子，任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的环烷基，任选取代的烷酰基等; A表示碳原子数2〜6的直链或支链亚烷基。

4. 发明申请

US20120035159A1 SUBSTITUTED ISOQUINOLINE DERIVATIVE 有权
标题翻译：取代的异喹啉衍生物
公开(公告)号：US20120035159A1
公开(公告)日：2012-02-09
申请号：US13265246
申请日：2010-06-18
申请人： Hiroyoshi Hidaka , Kouichi Takahashi , Yoshihiro Inoue , Kengo Sumi , Ryohei Nakamura
发明人： Hiroyoshi Hidaka , Kouichi Takahashi , Yoshihiro Inoue , Kengo Sumi , Ryohei Nakamura
IPC分类号： A61K31/551 , C07D217/04 , A61K31/4709 , C07D245/02 , C07D413/12 , A61P25/28 , C07D401/12 , A61K31/497 , C07D255/00 , A61P27/06 , A61P9/00 , C07D243/08 , A61K31/5377
CPC分类号： A61K31/407 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D217/02 , C07D401/12 , C07D487/08
摘要： The present invention provides an isoquinoline-6-sulfonamide derivative that is useful as a novel pharmaceutical agent. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt: wherein X and Y each independently represent a direct bond, NH, CH═CH, O, or S; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like, or R3 and R4 together form an alkylene group or an alkenylene group, which may be bridged between two carbon atoms to an arbitrary position; and l, m, and n represent an integer number of 1 to 4.
摘要翻译：本发明提供可用作新型药剂的异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或其衍生物或盐的溶剂合物：其中X和Y各自独立地表示直接键，NH，CH = CH，O ，或S; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，烷基等; R 3和R 4各自独立地表示氢原子，烷基等，或者R 3和R 4一起形成可以在两个碳原子之间桥接到任意位置的亚烷基或亚烯基; l，m和n表示1〜4的整数。

5. 发明授权

US08951997B2 Substituted isoquinoline derivative 有权
标题翻译：取代的异喹啉衍生物
公开(公告)号：US08951997B2
公开(公告)日：2015-02-10
申请号：US13265246
申请日：2010-06-18
申请人： Hiroyoshi Hidaka , Kouichi Takahashi , Yoshihiro Inoue , Kengo Sumi , Ryohei Nakamura
发明人： Hiroyoshi Hidaka , Kouichi Takahashi , Yoshihiro Inoue , Kengo Sumi , Ryohei Nakamura
IPC分类号： C07D403/12 , A61K31/47 , A61K31/551 , A61K31/407 , A61K31/4725 , A61K31/496 , A61K31/5377 , C07D217/02 , C07D401/12 , C07D487/08
CPC分类号： A61K31/407 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D217/02 , C07D401/12 , C07D487/08
摘要： The present invention provides an isoquinoline-6-sulfonamide derivative that is useful as a novel pharmaceutical agent. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt: wherein X and Y each independently represent a direct bond, NH, CH═CH, O, or S; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like, or R3 and R4 together form an alkylene group or an alkenylene group, which may be bridged between two carbon atoms to an arbitrary position; and l, m, and n represent an integer number of 1 to 4.
摘要翻译：本发明提供可用作新型药剂的异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或其衍生物或盐的溶剂合物：其中X和Y各自独立地表示直接键，NH，CH = CH，O ，或S; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，烷基等; R 3和R 4各自独立地表示氢原子，烷基等，或者R 3和R 4一起形成可以在两个碳原子之间桥接到任意位置的亚烷基或亚烯基; l，m和n表示1〜4的整数。

6. 发明申请

US20150041446A1 WELDING CARRIAGE 有权
标题翻译：焊接运输
公开(公告)号：US20150041446A1
公开(公告)日：2015-02-12
申请号：US14383412
申请日：2012-04-10
申请人： Yoshihiro Inoue
发明人： Yoshihiro Inoue
IPC分类号： B23K37/02 , B23K9/025
CPC分类号： B23K37/0241 , B23K9/02 , B23K9/0216 , B23K9/025 , B23K9/0256 , B23K9/12 , B23K37/02 , B23K37/0211 , B23K37/0264 , B23K37/0282 , B23K37/0294
摘要： A welding carriage traveling with a welding torch mounted thereon includes: a carriage body; and a torch supporting part disposed between the front and rear ends of carriage body and supporting a tip of the welding torch in a state of positioning on a side surface side of the carriage body and facing diagonally downward. The torch supporting part includes a torch swinging unit and a weaving unit. The torch swinging unit includes a torch swinging mechanism which swings the tip of the welding torch in a forward and rearward direction of the carriage body, and thereby moves tip close to the welding line. The weaving unit includes a weaving mechanism which operates so as to integrally rotate a unit case and a torch mounting bar of the torch swinging unit about a screw, thereby to cause the welding torch to perform a weaving operation.
摘要翻译：用安装在其上的焊炬行进的焊接车架包括：车体; 以及设置在滑架主体的前端和后端之间的炬支撑部分，并且在定位在滑架主体的侧表面侧并面向对角地向下的状态下支撑焊炬的尖端。割炬支撑部件包括割炬摆动单元和编织单元。割炬摆动单元包括一个割炬摆动机构，其在滑架主体的前后方向摆动焊炬的尖端，从而使尖端靠近焊接线。编织单元包括一个织造机构，其操作以围绕螺丝将单元壳体和割炬摆动单元的割炬安装杆整体旋转，从而使焊炬进行编织操作。

7. 发明授权

US08770895B2 Cutting insert, cutting tool, and method of cutting workpiece using them 有权
标题翻译：切削刀片，切削刀具及使用它们切割工件的方法
公开(公告)号：US08770895B2
公开(公告)日：2014-07-08
申请号：US13575935
申请日：2011-01-26
申请人： Yoshihiro Inoue
发明人： Yoshihiro Inoue
IPC分类号： B23B27/00 , B23B27/04
CPC分类号： B23B27/045 , B23B2200/323 , B23B2205/02 , B23B2270/54 , Y10T82/10 , Y10T407/2268 , Y10T407/23 , Y10T407/24 , Y10T407/245 , Y10T407/25
摘要： A cutting insert having excellent chip discharge performance is provided. In the cutting insert of the present invention, a bottom surface of a concave groove 21 includes a first bottom surface 211 continuous with a cutting edge part 5, and a second bottom surface 212 which is located on a side further remote from the cutting edge part 5 than the first bottom surface 211, and is located at a lower position than a virtual extension line L1 of an end portion of the first bottom surface 211 on a side remote from the cutting edge part 5. Further, a pair of inclined surfaces 23 are located on a side further remote from the cutting edge part 5 than the end portion of the first bottom surface 211 on the side remote from the cutting edge part 5 in a top view. Therefore, the diameter of generated chips decreases by the fact that the chips are curled while sinking in space formed at a lower position than the virtual extension line L1 of the first bottom surface 211. Consequently, the chip discharge direction is stabilized, thus achieving satisfactory chip discharge performance.
摘要翻译：提供了具有优异的排屑性能的切削刀片。在本发明的切削刀片中，凹槽21的底面包括与切削刃部5连续的第一底面211和位于更远离切削刃部的一侧的第二底面212 5位于比第一底面211的远离切削刃部5的一侧的第一底面211的端部的虚拟延伸线L1的下方位置。此外，一对倾斜面23 位于远离切割边缘部分5的一侧，比顶视图中远离切割边缘部分5的一侧的第一底部表面211的端部。因此，由于芯片在与形成在比第一底面211的虚拟延伸线L1低的位置形成的空间中卷曲的同时，产生的芯片的直径减小。因此，芯片排出方向稳定，从而达到满意芯片放电性能。

8. 发明授权

US08461518B2 Method of collecting calibration data in radiation tomography apparatus 失效
标题翻译：辐射断层摄影仪中收集校准数据的方法
公开(公告)号：US08461518B2
公开(公告)日：2013-06-11
申请号：US13145786
申请日：2009-01-23
申请人： Tetsuro Mizuta , Yoshihiro Inoue , Masaharu Amano , Kazumi Tanaka , Atsushi Ohtani
发明人： Tetsuro Mizuta , Yoshihiro Inoue , Masaharu Amano , Kazumi Tanaka , Atsushi Ohtani
IPC分类号： G01D18/00
CPC分类号： G01T1/1644 , G01T1/1648 , G01T1/2985
摘要： This invention has one object to provide a method of collecting calibration data in radiation tomography apparatus that allows reliable collection of calibration data with a wide detector ring. In order to achieve this purpose, in the method of collecting calibration data in radiation tomography apparatus according to this invention, the number of coincidence events is obtained while the phantom that emits annihilation gamma-ray pairs moves as to pass through an inner hole of the detector ring. Such configuration dose not need the phantom having a width equal or larger than the detector ring, and may realize reliable collection of calibration data. Moreover, it may be considered that annihilation gamma-ray pairs have been emitted in uniform property without depending on positions of the detector ring. As a result, calibration data that is more suitable for removal of a image artifact may be obtained.
摘要翻译：本发明的一个目的是提供一种在放射线断层摄影装置中收集校准数据的方法，其允许使用宽的检测器环可靠地收集校准数据。为了实现这一目的，在根据本发明的放射线断层摄影装置中收集校准数据的方法中，获得符合事件的数量，同时发出湮灭伽马射线对的体模移动通过探测器环。这种配置不需要具有等于或大于检测器环的宽度的体模，并且可以实现校准数据的可靠收集。此外，可以认为，湮没伽马射线对已经以均匀的性质发射，而不依赖于检测器环的位置。结果，可以获得更适合去除图像伪像的校准数据。

9. 发明授权

US08122992B2 Impact member for a saddle-type vehicle, and vehicle incorporating same 有权
标题翻译：用于鞍式车辆的冲击件，以及结合其的车辆
公开(公告)号：US08122992B2
公开(公告)日：2012-02-28
申请号：US12717711
申请日：2010-03-04
申请人： Yoshihiro Inoue , Kenichi Misaki , Kazuyoshi Kuroki , Hiroshi Furuse , Sunao Kawano
发明人： Yoshihiro Inoue , Kenichi Misaki , Kazuyoshi Kuroki , Hiroshi Furuse , Sunao Kawano
IPC分类号： B60K5/00
CPC分类号： B62J27/00
摘要： A saddle-type vehicle is provided with an impact member for deflecting a front wheel sideways in the event of a collision. The saddle-type vehicle includes a body frame having a head pipe for rotatably supporting a steering shaft for the front wheel, main frames extending rearwards from the head pipe, and an engine operatively mounted to the main frames. The impact member is disposed in front of a lower portion of the engine. The impact member includes a support part, which extends forwardly from the engine, and a load-receiving deflector plate mounted to the support part and which is inclined away from a vehicle width direction.
摘要翻译：鞍式车辆设置有冲击构件，用于在碰撞的情况下侧向偏转前轮。鞍式车辆包括主体框架，其具有用于可旋转地支撑前轮转向轴的头管，从头管向后延伸的主框架和可操作地安装到主框架的发动机。冲击构件设置在发动机的下部的前方。冲击构件包括从发动机向前延伸的支撑部分和安装到支撑部分并且远离车辆宽度方向倾斜的载荷接收偏转板。

10. 发明申请

US20110288397A1 MEDICAL DIAGNOSTIC IMAGING APPARATUS 有权
标题翻译：医学诊断成像装置
公开(公告)号：US20110288397A1
公开(公告)日：2011-11-24
申请号：US13147419
申请日：2009-02-03
申请人： Yoshihiro Inoue , Masaharu Amano , Kazumi Tanaka , Tetsuro Mizuta , Atsushi Ohtani
发明人： Yoshihiro Inoue , Masaharu Amano , Kazumi Tanaka , Tetsuro Mizuta , Atsushi Ohtani
IPC分类号： A61B6/00
CPC分类号： A61B6/0457 , A61B6/037 , A61B6/4417 , A61B6/5235
摘要： Provided is a medical image diagnosis apparatus which requires a small area for installation, has a short length in an axial direction of the apparatus, can reduce a problem of the strength of a top plate, and can simultaneously carry out dynamic PET-imaging of the entire body. A top plate (61) on which an examinee lies is moved through a tunnel of a CT gantry (2) and a PET gantry (3) to execute CT imaging and PET imaging. A PET unit consisting of a plurality (e.g. seven) of PET units (32) has a length of 2 m in the axis direction, the visual field thereof covers the whole body and the whole body can be simultaneously subjected to dynamic PET-imaging. For the maintenance of the PET gantry (3), the diagnosis apparatus is separated at an arbitrary PET unit (32) to be maintained, the apparatus slides on a rail (31) in the axis direction and is separated for maintenance operation. Accordingly, a large space for maintenance is not required and the area for installation is small.
摘要翻译：提供一种医疗图像诊断装置，其需要小的安装区域，在装置的轴向具有短的长度，可以减少顶板的强度的问题，并且可以同时进行动态PET成像全身受检者所在的顶板（61）通过CT机架（2）和PET机架（3）的隧道移动，以执行CT成像和PET成像。由多个（例如七个）PET单元（32）组成的PET单元在轴线方向上具有2m的长度，其视野覆盖整个身体，并且全身可以同时进行动态PET成像。为了维护PET龙门架（3），诊断装置在任意的PET单元（32）处被分离以保持，该装置在轨道（31）上在轴向上滑动并被分离用于维护操作。因此，不需要大的维护空间，并且安装区域小。

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