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1. 发明授权

US6009373A Ship track and underwater conditions indicating system 失效
标题翻译：船舶轨道和水下条件指示系统
公开(公告)号：US6009373A
公开(公告)日：1999-12-28
申请号：US127139
申请日：1993-09-27
申请人： Yasuhiro Shimojima , Genji Mori , Takashi Yoshioka , Toshio Ozaki , Hiroyuki Hamato , Itsuo Makino
发明人： Yasuhiro Shimojima , Genji Mori , Takashi Yoshioka , Toshio Ozaki , Hiroyuki Hamato , Itsuo Makino
IPC分类号： G01S7/62 , G01S15/02 , G01S15/89 , G01C21/00
CPC分类号： G01S15/89 , G01S15/025 , G01S7/6281
摘要： A ship track and underwater conditions indicating system for displaying a ship track and the underwater conditions under the ship track at the same time on the screen of an indicator, and for associating the two resultant pictures with each other. The ship track and the underwater conditions are respectively displayed on two corresponding portions of the face of the indicator by dividing the screen into two parts. Also, the ship track or the underwater conditions are selectively indicated on the whole screen of an indicator at different times.
摘要翻译：一种用于在指示器的屏幕上同时显示船舶轨道和船舶轨道下的水下条件的船舶轨道和水下条件指示系统，并且用于将两张结果图片相互关联。船舶轨迹和水下条件分别显示在指示器表面的两个对应部分上，将屏幕分为两部分。此外，在不同时间，在指示器的整个屏幕上选择性地指示船舶轨道或水下条件。

2. 发明申请

US20110028717A1 AZAINDOLE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY 审中-公开
标题翻译：具有PGD2受体拮抗活性的氨基衍生物
公开(公告)号：US20110028717A1
公开(公告)日：2011-02-03
申请号：US12904647
申请日：2010-10-14
申请人： Akira Kugimiya , Itsuo Makino , Naohiro Onodera
发明人： Akira Kugimiya , Itsuo Makino , Naohiro Onodera
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases.A compound of the general formula (I) wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a 3- to 8-membered nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═N— etc.; R1, R2, R3, R4 and R5 are independently a hydrogen atom or a halogen atom etc.; R6 is optionally substituted C1-C6 alkyloxy etc.; R7 is independently a halogen atom etc.; R8 is optionally substituted C1-C6 alky etc.; R9 is carboxy etc.; M is sulfonyl etc.; Y is a single bond etc.; L1, L2 and L3 are a single bond or alkylene optionally containing one or two heteroatoms etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明产生具有DP受体拮抗活性的氮杂吲哚衍生物和包含所述化合物作为活性成分的药物组合物，并进一步提供治疗过敏性疾病的治疗剂。通式（I）的化合物，其中环A是芳族碳环等; 环B为3〜8元含氮非芳族杂环等; -X 1 = X 2 -X 3 = X 4 - 的式为-C（R 1）= C（R 2）-C（R 3）= N-等的式 R1，R2，R3，R4和R5独立地是氢原子或卤素原子等; R6是任选取代的C 1 -C 6烷氧基等; R7独立地为卤素原子等; R8是任选取代的C 1 -C 6烷基等; R9是羧基等。 M是磺酰基等。 Y是单键等; L1，L2和L3是任选含有一个或两个杂原子等的单键或亚烷基; n为0等 q为0等; 其药学上可接受的盐或水合物。

3. 发明授权

US4564623A Aminoalkylbenzene derivatives 失效
标题翻译：氨基烷基苯衍生物
公开(公告)号：US4564623A
公开(公告)日：1986-01-14
申请号：US573685
申请日：1984-01-25
申请人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
发明人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doteuchi , Koichi Otani
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/18 , C07C233/20 , C07C233/22 , C07C233/60 , C07C233/69 , C07C235/20 , C07C235/48 , C07C235/72 , C07C237/08 , C07C237/32 , C07C237/42 , C07C239/00 , C07C261/04 , C07C301/00 , C07C311/18 , C07C313/00 , C07C323/29 , C07C323/39 , C07C323/41 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/48 , C07C327/50 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D307/68 , C07D333/38 , C07D335/06 , C07D498/04 , C07D207/04
CPC分类号： C07D213/81 , C07C323/29 , C07D207/16 , C07D207/28 , C07D213/82 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/096 , C07D295/15 , C07D333/38 , C07D335/06 , Y10S514/927
摘要： An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;Y is oxo, thioxo, or cyanoimino;a is an integer of 1 to 3;b is an integer of 0 to 3;c is an integer of 1 to 4;R.sup.1 is alkyl;R.sup.2 is hydrogen or alkyl; orR.sup.1 and R.sup.2 taken together represent pyrrolidinyl;R is hydrogen, cycloaklkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R.sup.3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy;R.sup.4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; orR.sup.3 and R.sup.4 taken together represent alkylidene or aralkylidene);with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H.sub.2 blockers, especially peptic ulcer remedies, are provided via several routes.

4. 发明授权

US07842692B2 Azaindole derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的阿维醇衍生物
公开(公告)号：US07842692B2
公开(公告)日：2010-11-30
申请号：US11989132
申请日：2006-07-20
申请人： Akira Kugimiya , Itsuo Makino , Naohiro Onodera
发明人： Akira Kugimiya , Itsuo Makino , Naohiro Onodera
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases.A compound of the general formula (I) wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a 3- to 8-membered nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═N— etc.; R1, R2, R3, R4 and R5 are independently a hydrogen atom or a halogen atom etc.; R6 is optionally substituted C1-C6 alkyloxy etc.; R7 is independently a halogen atom etc.; R8 is optionally substituted C1-C6 alkyl etc.; R9 is carboxy etc.; M is sulfonyl etc.; Y is a single bond etc.; L1, L2 and L3 are a single bond or alkylene optionally containing one or two heteroatoms etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明产生具有DP受体拮抗活性的氮杂吲哚衍生物和包含所述化合物作为活性成分的药物组合物，并进一步提供治疗过敏性疾病的治疗剂。通式（I）的化合物，其中环A是芳族碳环等; 环B为3〜8元含氮非芳族杂环等; -X 1 = X 2 -X 3 = X 4 - 的式为-C（R 1）= C（R 2）-C（R 3）= N-等的式 R1，R2，R3，R4和R5独立地是氢原子或卤素原子等; R6是任选取代的C 1 -C 6烷氧基等; R7独立地为卤素原子等; R8是任选取代的C 1 -C 6烷基等; R9是羧基等。 M是磺酰基等。 Y是单键等; L1，L2和L3是任选含有一个或两个杂原子等的单键或亚烷基; n为0等 q为0等; 其药学上可接受的盐或水合物。

5. 发明授权

US4482566A Substituted aminoalkylbenzene type lower acylamides 失效
标题翻译：取代氨基烷基苯型低级酰基酰胺
公开(公告)号：US4482566A
公开(公告)日：1984-11-13
申请号：US277161
申请日：1981-06-25
申请人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doeteuchi , Koichi Otani
发明人： Kentaro Hirai , Teruyuki Ishiba , Shigeru Matsutani , Itsuo Makino , Toshio Fujishita , Masami Doeteuchi , Koichi Otani
IPC分类号： C07D295/18 , A61K31/16 , A61K31/165 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/18 , C07C233/20 , C07C233/22 , C07C233/60 , C07C233/69 , C07C235/20 , C07C235/48 , C07C235/72 , C07C237/08 , C07C237/32 , C07C237/42 , C07C239/00 , C07C261/04 , C07C301/00 , C07C311/18 , C07C313/00 , C07C323/29 , C07C323/39 , C07C323/41 , C07C325/00 , C07C327/40 , C07C327/46 , C07C327/48 , C07C327/50 , C07D207/16 , C07D207/28 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/90 , C07D249/10 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D307/68 , C07D333/38 , C07D335/06 , C07D498/04 , C07D207/04 , A61K31/135 , C07C103/34 , C07C103/37
CPC分类号： C07D213/81 , C07C323/29 , C07D207/16 , C07D207/28 , C07D213/82 , C07D257/04 , C07D261/18 , C07D271/06 , C07D295/096 , C07D295/15 , C07D333/38 , C07D335/06 , Y10S514/927
摘要： An aminoalkylbenzene derivative of the formula: ##STR1## [wherein A is oxygen or sulfur;Y is oxo, thioxo, or cyanoimino;a is an integer of 1 to 3;b is an integer of 0 to 3;c is an integer of 1 to 4;R.sup.1 is alkyl;R.sup.2 is hydrogen or alkyl; orR.sup.1 and R.sup.2 taken together represent pyrrolidinyl;R is hydrogen, cycloalkyl, trihaloalkyl, alkoxy, dialkylamino, aryl, aroyl, heterocyclic group, or a group of the formula: ##STR2## (wherein R.sup.3 is hydrogen, halogen, amino, alkyl, alkylamino, dialkylamino, alkylthio, or aryloxy;R.sup.4 is hydrogen, alkyl, alkenyl, aryl, or heterocyclic group; orR.sup.3 and R.sup.4 taken together represent alkylidene or aralkylidene);with the proviso that the above aryl, aroyl, and heterocyclic group can be substituted by 1 to 3 substituents] and its pharmaceutically acceptable acid addition salts being useful as histamine H.sub.2 blockers, especially peptic ulcer remedies, are provided via several routes.

6. 发明授权

US4374842A 4,1-Benzoxazepines and compositions 失效
标题翻译： 4,1-苯并氧氮杂和组合物
公开(公告)号：US4374842A
公开(公告)日：1983-02-22
申请号：US250299
申请日：1981-04-02
申请人： Kentaro Hirai , Shigeru Matsutani , Itsuo Makino , Teruyuki Ishiba
发明人： Kentaro Hirai , Shigeru Matsutani , Itsuo Makino , Teruyuki Ishiba
IPC分类号： C07D267/14 , C07D498/04 , A61K31/55 , C07D498/14
CPC分类号： C07D267/14
摘要： 4,1-Benzoxazepines of the following formula are central nervous system drugs: ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.5 alkyl; X is hydrogen, halogen, or nitro; Y is phenyl, 2-halophenyl, 4-halophenyl, 2-trifluoromethylphenyl, or pyridyl; and ##STR2## is a group of the formula: ##STR3## (wherein Q is oxygen, sulfur, or hydrazono, with a proviso that, when Y is phenyl or 2-halophenyl and R is hydrogen, Q is neither oxygen nor sulfur;R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.5 alkyl, C.sub.1 to C.sub.5 alkylthio, 5- or 6-membered heterocycle or C.sub.1 to C.sub.5 alkyl substituted by a substituent selected from the group consisting of halogen, hydroxy, mercapto, C.sub.1 to C.sub.5 alkoxy, C.sub.1 to C.sub.5 alkanoyloxy, C.sub.1 to C.sub.5 alkylthio, C.sub.7 to C.sub.9 aralkyldithio, C.sub.2 to C.sub.10 dialkylamino, C.sub.3 to C.sub.15 dialkylaminoalkoxy, C.sub.3 to C.sub.15 dialkylaminoalkylthio, and 5- or 6-membered heterocycle;R.sup.2 is C.sub.1 to C.sub.5 alkyl;and R.sup.3 is C.sub.1 to C.sub.5 alkyl or C.sub.3 to C.sub.10 dialkylaminoalkyl;with a proviso that when R.sup.1 is C.sub.1 to C.sub.5 alkyl and R is hydrogen, Y is neither phenyl nor 2-halophenyl).
摘要翻译：下式的4,1-苯并氧氮杂是中枢神经系统药物：其中R是氢或C1至C5烷基; X是氢，卤素或硝基; Y是苯基，2-卤代苯基，4-卤代苯基，2-三氟甲基苯基或吡啶基; 并且是下列基团：其中Q是氧，硫或亚肼基，条件是当Y是苯基或2-卤代苯基且R是氢时，Q是氧还不硫; R1是氢，卤素，C1至C5烷基，C1至C5烷硫基，5-或6-元杂环或被选自卤素，羟基，巯基，C1的取代基取代的C1至C5烷基 C 1-5烷酰氧基，C 1至C 5烷硫基，C 7至C 9芳烷基二硫代，C 2至C 10二烷基氨基，C 3至C 15二烷基氨基烷氧基，C 3至C 15二烷基氨基烷硫基以及5-或6-元杂环; R 2为C 1至C 5烷基; 并且R 3为C 1至C 5烷基或C 3至C 10二烷基氨基烷基;条件是当R 1为C 1至C 5烷基且R为氢时，Y不为苯基或2-卤代苯基）。

7. 发明授权

US4297280A 4,1-Benzoxazepines 失效
标题翻译： 4,1-苯并氧氮杂
公开(公告)号：US4297280A
公开(公告)日：1981-10-27
申请号：US91814
申请日：1979-11-06
申请人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino
发明人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino
IPC分类号： A61K31/395 , A61K31/4196 , A61K31/55 , A61K31/553 , A61K31/554 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/20 , A61P25/22 , C07D249/08 , C07D249/10 , C07D267/14 , C07D273/00 , C07D281/10 , C07D285/36 , C07D498/04 , C07D513/04 , C07D521/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/10 , C07D267/14 , C07D273/00 , C07D285/36 , C07D513/04
摘要： 4,1-Benzoxazepines and thia analogs thereof of the formula: ##STR1## (wherein --A--B-- is the following group: ##STR2## (wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.3 alkyl, or C.sub.7 to C.sub.9 aralkyl;R.sup.2 is C.sub.1 to C.sub.3 alkyl or C.sub.1 to C.sub.3 .alpha.-aminoalkyl;R.sup.3 is C.sub.2 to C.sub.6 dialkylamino;R.sup.4 is C.sub.2 to C.sub.6 dialkylamino or C.sub.5 to C.sub.7 alkylpiperazino;R.sup.5 is C.sub.1 to C.sub.3 alkyl; andQ is oxygen or sulfur);D is oxygen or sulfur;X is halogen or nitro;Y is hydrogen or halogen; andZ is hydrogen, C.sub.1 to C.sub.3 alkoxy, or C.sub.3 to C.sub.9 dialkylaminoalkoxy;with the proviso that when --A--B-- is ##STR3## Z is not hydrogen.) useful as novel central nervous system drugs are prepared by various synthetic routes.
摘要翻译：（其中-AB-是下列基团：其中R 1是氢，C 1至C 3烷基或C 7至C 9芳烷基） ; R2是C1-C3烷基或C1-C3α-氨基烷基; R3是C2-C6二烷基氨基; R4是C2-C6二烷基氨基或C5-C7烷基哌嗪基; R5是C1-C3烷基; Q是氧或硫）; D 是氧或硫; X是卤素或硝基; Y是氢或卤素; Z是氢，C 1至C 3烷氧基或C 3至C 9二烷基氨基烷氧基;条件是当-AB-不是氢时。）作为新型中枢神经系统药物通过各种合成途径制备。

8. 发明授权

US06595315B1 Underwater detecting apparatus, depth measuring apparatus and display apparatus 有权
标题翻译：水下检测装置，深度测量装置及显示装置
公开(公告)号：US06595315B1
公开(公告)日：2003-07-22
申请号：US09662627
申请日：2000-09-15
申请人： Hiroyasu Fujimoto , Hiroshi Nagano , Makoto Obuchi , Itsuo Makino
发明人： Hiroyasu Fujimoto , Hiroshi Nagano , Makoto Obuchi , Itsuo Makino
IPC分类号： G01S1500
CPC分类号： G01S15/96 , G01S7/6218 , G01S7/6272 , G01S7/64 , G01S15/08 , G01S15/87
摘要： A screen on which water depth information obtained from an echo signal is historically displayed and a screen on which fish school detection information obtained from an echo signal is displayed, are displayed side by side on a display screen of a display instrument or either one is displayed by switching. Thus, a large amount of information is displayed on a limited space of a small display instrument efficiently and effectively and to be easy to see. Further, when a water depth value becomes a set value of an alarm water depth mark or less, an alarm is displayed on the display screen of the display instrument, and an alarm is given by sound. At the same time as this, the brilliance of the display screen is raised to the maximum brilliance to make the screen brighter, so that the contents of the alarm are made easy to see. Thus, quick measures can be taken in an emergency. Moreover, after a mode is set to a help mode by a mode switch, when any one of keys in an operation portion is pushed, guidance of the function, operation procedure, and the like of the pushed key is displayed on a display portion. Thus, the guidance as to the key can be displayed by a simple operation in a help mode.
摘要翻译：历史上显示从回波信号获得的水深信息的屏幕和显示从回波信号获得的鱼学校检测信息的屏幕并排地显示在显示器具的显示屏幕上或者显示通过切换。因此，在小型显示装置的有限空间中有效且高效地显示大量的信息并且易于看见。此外，当水深值成为报警水深标记的设定值以下时，在显示装置的显示画面上显示报警，并且通过声音给出报警。与此同时，显示屏的亮度提高到最大的亮度，使屏幕更亮，使报警的内容变得容易看清。因此，在紧急情况下可以采取快速措施。此外，在通过模式切换将模式设置为帮助模式之后，当按下操作部中的任何一个键时，在显示部分上显示所推动的键的功能，操作过程等的引导。因此，可以通过在帮助模式中的简单操作来显示关于键的指导。

9. 发明授权

US4341704A 4,1-Benzoxazepines and thia analogs thereof 失效
标题翻译： 4,1-苯并氧氮杂及其类似物
公开(公告)号：US4341704A
公开(公告)日：1982-07-27
申请号：US276632
申请日：1981-06-23
申请人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino
发明人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino
IPC分类号： A61K31/395 , A61K31/4196 , A61K31/55 , A61K31/553 , A61K31/554 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/20 , A61P25/22 , C07D249/08 , C07D249/10 , C07D267/14 , C07D273/00 , C07D281/10 , C07D285/36 , C07D498/04 , C07D513/04 , C07D521/00
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D249/10 , C07D267/14 , C07D273/00 , C07D285/36 , C07D513/04
摘要： 4,1-Benzoxazepines and thia analogs thereof of the formula: ##STR1## (wherein --A--B-- is the following group: ##STR2## (wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.3 alkyl, or C.sub.7 to C.sub.9 aralkyl;R.sup.2 is C.sub.1 to C.sub.3 alkyl or C.sub.1 to C.sub.3 .alpha.-aminoalkyl;R.sup.3 is C.sub.2 to C.sub.6 dialkylamino;R.sup.4 is C.sub.2 to C.sub.6 dialkylamino or C.sub.5 to C.sub.7 alkylpiperazino;R.sup.5 is C.sub.1 to C.sub.3 alkyl; andQ is oxygen or sulfur);D is oxygen or sulfur;X is halogen or nitro;Y is hydrogen or halogen; andZ is hydrogen, C.sub.1 to C.sub.3 alkoxy, or C.sub.3 to C.sub.9 dialkylaminoalkoxy;with the proviso that when --A--B-- is ##STR3## Z is not hydrogen.) useful as novel central nervous system drugs are prepared by various synthetic routes.
摘要翻译：（其中-AB-是下列基团：其中R 1是氢，C 1至C 3烷基或C 7至C 9芳烷基） ; R2是C1-C3烷基或C1-C3α-氨基烷基; R3是C2-C6二烷基氨基; R4是C2-C6二烷基氨基或C5-C7烷基哌嗪基; R5是C1-C3烷基; Q是氧或硫）; D 是氧或硫; X是卤素或硝基; Y是氢或卤素; Z是氢，C 1至C 3烷氧基或C 3至C 9二烷基氨基烷氧基;条件是当-AB-不是氢时。）作为新型中枢神经系统药物通过各种合成途径制备。

10. 发明授权

US4318858A Thioethylamide derivatives 失效
标题翻译：硫代乙酰胺衍生物
公开(公告)号：US4318858A
公开(公告)日：1982-03-09
申请号：US212222
申请日：1980-12-02
申请人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino , Masami Doteuchi , Koichi Otani
发明人： Kentaro Hirai , Shigeru Matsutani , Teruyuki Ishiba , Itsuo Makino , Masami Doteuchi , Koichi Otani
IPC分类号： C07D333/16 , A61K31/34 , A61K31/341 , A61P43/00 , C07D307/52 , C07D307/68 , C07D333/20 , C07D333/38 , C07D405/12 , C07D409/12 , C07D207/04 , C07D333/18
CPC分类号： C07D307/68 , C07D307/52 , C07D333/20 , C07D333/38 , Y10S514/927
摘要： A compound of the formula: ##STR1## [wherein R is dimethylamino or 1-pyrrolidinyl;R.sup.1 and R.sup.2 each is hydrogen or C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, C.sub.1 -C.sub.3 alkyl (optionally substituted by one member selected from the group consisting of cyano, C.sub.1 -C.sub.3 alkoxy, phenyl, and 5- or 6-membered heterocyclic group), C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.5 alkenyl (optionally substituted by one member selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, phenyl, and phenoxy), C.sub.6 -C.sub.10 aryl (optionally substituted by one or two members selected from the group consisting of hydroxy, halogen, nitro, sulfamoyl, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkanoyl, C.sub.2 -C.sub.4 alkoxycarbonyl, C.sub.2 -C.sub.4 dialkylamino, and C.sub.1 -C.sub.3 alkanesulfonyl), or 5- or 6-membered heterocyclic group (optionally substituted by one member selected from the group consisting of oxo, halogen, C.sub.1 -C.sub.3 alkyl, and C.sub.1 -C.sub.3 alkoxy);and X is oxygen or sulfur]and its pharmaceutically acceptable acid addition salts is useful as histamine H.sub.2 blockers.
摘要翻译：下式的化合物：其中R是二甲基氨基或1-吡咯烷基; R1和R2各自为氢或C1-C3烷基; R 3是氢，C 1 -C 3烷基（任选地被选自氰基，C 1 -C 3烷氧基，苯基和5-或6-元杂环基中的一个取代），C 3 -C 6环烷基，C 2 -C 5烯基（任选地被选自C 1 -C 3烷氧基，苯基和苯氧基的一个取代基取代），C 6 -C 10芳基（任选被一个或两个选自羟基，卤素，硝基，氨磺酰基，C1- C 3烷基，C 1 -C 3烷氧基，C 1 -C 3烷酰基，C 2 -C 4烷氧基羰基，C 2 -C 4二烷基氨基和C 1 -C 3烷磺酰基）或5或6元杂环基（任选被一个选自的氧代，卤素，C 1 -C 3烷基和C 1 -C 3烷氧基）; 并且X是氧或硫]，其药学上可接受的酸加成盐可用作组胺H2阻断剂。

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