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1. 发明授权

US08895508B2 Methods for corneal endothelial proliferation using bFGF sustained-release gelatin hydrogel particles 有权
标题翻译：使用bFGF缓释明胶水凝胶颗粒进行角膜内皮增殖的方法
公开(公告)号：US08895508B2
公开(公告)日：2014-11-25
申请号：US13386844
申请日：2009-07-24
申请人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
发明人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
IPC分类号： A61K38/18 , A61K9/00 , A61K9/06 , A61K47/42
CPC分类号： A61K38/1825 , A61K9/0048 , A61K9/06 , A61K47/42
摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.
摘要翻译：本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。

2. 发明申请

US20120190621A1 CORNEAL ENDOTHELIAL CELL PROLIFERATION PROMOTER 有权
标题翻译：角膜内皮细胞增殖促进剂
公开(公告)号：US20120190621A1
公开(公告)日：2012-07-26
申请号：US13386844
申请日：2009-07-24
申请人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
发明人： Yasuhiko Tabata , Shigeru Kinoshita , Noriko Koizumi , Yuji Sakamoto , Naoki Okumura , Hiroaki Takahashi
IPC分类号： A61K38/18 , A61P27/02
CPC分类号： A61K38/1825 , A61K9/0048 , A61K9/06 , A61K47/42
摘要： The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated.
摘要翻译：本发明的目的在于提供角膜内皮细胞增殖促进剂和与角膜内皮损伤相关的疾病的治疗剂，其被施用于前房。通过形成bFGF缓释明胶水凝胶颗粒，其中bFGF携带在明胶水凝胶上，以持续的方式释放bFGF。因此，可以通过将含有bFGF缓释明胶水凝胶颗粒的制剂给予前房来持续加速角膜内皮细胞的增殖，并且可以治疗与角膜内皮损伤有关的疾病。

3. 发明授权

US10052411B2 Methods of treating corneal related diseases by corneal endothelial preparation which enables cells to grow in vivo 有权
公开(公告)号：US10052411B2
公开(公告)日：2018-08-21
申请号：US12161433
申请日：2007-01-18
申请人： Noriko Koizumi , Shigeru Kinoshita , Yuji Sakamoto
发明人： Noriko Koizumi , Shigeru Kinoshita , Yuji Sakamoto
IPC分类号： A61K48/00 , A01N63/00 , C12N5/07 , C12N5/071 , C12N5/16 , C12N5/0793 , C12N5/0789 , A61L27/38 , A61L27/24
CPC分类号： A61L27/3839 , A61L27/24 , A61L27/3808 , A61L2430/16
摘要： The present invention provides a graft more suitable for the transplantation of corneal endothelial cells and an application method thereof. Specifically, the present invention provides a corneal endothelial preparation capable of cell proliferation in vivo, which contains a substrate and a corneal endothelial cell layer cultured on the substrate, and a treatment method of a disease selected from the group consisting of bullous keratopathy, corneal edema, corneal leukoma and corneal endothelial inflammation, which includes a step of transplanting the preparation to patients. As the substrate, collagen is used.

4. 发明申请

US20100233240A1 CORNEAL ENDOTHELIAL PREPARATION WHICH ENABLES CELLS TO GROW IN VIVO 审中-公开
标题翻译：角膜内皮细胞在体内生长的脊髓内皮制剂
公开(公告)号：US20100233240A1
公开(公告)日：2010-09-16
申请号：US12161433
申请日：2007-01-18
申请人： Noriko Koizumi , Shigeru Kinoshita , Yuji Sakamoto
发明人： Noriko Koizumi , Shigeru Kinoshita , Yuji Sakamoto
IPC分类号： A61F2/14 , A61K35/44 , A61P27/02
CPC分类号： A61L27/3839 , A61L27/24 , A61L27/3808 , A61L2430/16
摘要： The present invention provides a graft more suitable for the transplantation of corneal endothelial cells and an application method thereof. Specifically, the present invention provides a corneal endothelial preparation capable of cell proliferation in vivo, which contains a substrate and a corneal endothelial cell layer cultured on the substrate, and a treatment method of a disease selected from the group consisting of bullous keratopathy, corneal edema, corneal leukoma and corneal endothelial inflammation, which includes a step of transplanting the preparation to patients. As the substrate, collagen is used.
摘要翻译：本发明提供了更适合于角膜内皮细胞移植的移植物及其应用方法。具体地说，本发明提供能够在体内进行细胞增殖的角膜内皮制剂，该角膜内皮制剂含有在底物上培养的底物和角膜内皮细胞层，以及选自下组的疾病的治疗方法：大疱性角膜病，角膜水肿，角膜白血病和角膜内皮炎症，其中包括将制剂移植到患者中的步骤。作为底物，使用胶原。

5. 发明申请

US20120288482A1 THERAPEUTIC AGENT (Y-39983) FOR CORNEAL ENDOTHELIAL DYSFUNCTION 审中-公开
标题翻译：治疗药物（Y-39983）用于角膜内膜功能障碍
公开(公告)号：US20120288482A1
公开(公告)日：2012-11-15
申请号：US13519682
申请日：2010-12-28
申请人： Hiroaki Takahashi , Yuji Sakamoto , Tetsuo Kida , Takeshi Tarui
发明人： Hiroaki Takahashi , Yuji Sakamoto , Tetsuo Kida , Takeshi Tarui
IPC分类号： A61K31/437 , A61K35/44 , A61P27/02
CPC分类号： A61K31/437 , A61K9/0048 , A61K9/08 , C12N5/0621 , C12N2501/999
摘要： The present invention aims to provide a means for effectively and conveniently treating diseases wherein corneal endothelial cells poor in proliferative capacity in vivo are damaged. The present invention provides a therapeutic agent for corneal endothelial dysfunction containing (R)-(+)-N-(1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide or a pharmacologically acceptable salt thereof (compound (Ia)) as active ingredient, an agent for promoting adhesion of corneal endothelial cells, containing compound (Ia), a culture medium for corneal endothelial cells, containing the agent for promoting adhesion, an implant for corneal endothelial keratoplasty, containing corneal endothelial cells, scaffold and compound (Ia), and a production method of a corneal endothelial preparation, including a step of cultivating corneal endothelial cells using the culture medium.
摘要翻译：本发明旨在提供一种有效且方便地治疗疾病的手段，其中体内增殖能力差的角膜内皮细胞被破坏。本发明提供了含有（R） - （+） - N-（1H-吡咯并[2,3-b]吡啶-4-基）-4-（1-氨基乙基）苯甲酰胺的角膜内皮功能障碍的治疗剂 -3983>或其药理学上可接受的盐（化合物（Ia））作为活性成分，用于促进角膜内皮细胞粘附的试剂，含有化合物（Ia），用于角膜内皮细胞的培养基，其含有促进粘附的试剂，用于角膜内皮角膜移植术的植入物，其包含角膜内皮细胞，支架和化合物（Ia），以及角膜内皮制剂的制备方法，包括使用培养基培养角膜内皮细胞的步骤。

6. 发明授权

US08876698B2 Pressing member, endoscopic treatment system, and endoscopic suturing device 有权
标题翻译：压片，内窥镜治疗系统和内窥镜缝合装置
公开(公告)号：US08876698B2
公开(公告)日：2014-11-04
申请号：US11996447
申请日：2006-07-21
申请人： Yuji Sakamoto , Tsutomu Okada , Satoshi Miyamoto
发明人： Yuji Sakamoto , Tsutomu Okada , Satoshi Miyamoto
IPC分类号： A61B1/00 , A61B1/04 , A61B17/04 , A61B17/3205 , A61B17/062 , A61B18/14 , A61B17/29 , A61B17/02 , A61B17/06 , A61B17/00
CPC分类号： A61B17/32056 , A61B17/0218 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/062 , A61B17/29 , A61B18/1477 , A61B18/1492 , A61B2017/00269 , A61B2017/00292 , A61B2017/00296 , A61B2017/00557 , A61B2017/0409 , A61B2017/0417 , A61B2017/0451 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2017/2926 , A61B2018/1407 , A61B2018/141 , A61B2018/1425
摘要： An endoscopic treatment system 1 of the present invention includes an overtube 2 that is inserted into the body of a patient. An endoscope 7 and a suturing device 8 are inserted into the overtube 2. The overtube 2 has a long and flexible tube main body 3, and a chamber 4 is provided at the distal end of the tube main body 3. The chamber 4 has a lateral hole 10 formed on the lateral surface thereof. The width of the lateral hole 10 is set such that a lesion can be drawn into the lateral hole 10 while preventing other organs on the periphery of the lesion from being drawn into the lateral hole 10.
摘要翻译：本发明的内窥镜治疗系统1包括插入患者体内的外套管2。内窥镜7和缝合装置8插入到外套管2中。外套管2具有长且柔性的管主体3，并且在管主体3的远端设置有腔室4.腔室4具有形成在其侧表面上的横向孔10。侧孔10的宽度被设定为使病变能够被拉入侧孔10，同时防止病变周围的其他器官被吸入侧孔10。

7. 发明授权

US08419631B2 Endoscope apparatus with forward viewing and side viewing 有权
标题翻译：具有前视和侧视的内窥镜装置
公开(公告)号：US08419631B2
公开(公告)日：2013-04-16
申请号：US13052599
申请日：2011-03-21
申请人： Seigo Kase , Yasuhito Kura , Yuji Sakamoto
发明人： Seigo Kase , Yasuhito Kura , Yuji Sakamoto
IPC分类号： A61B1/04 , A61B1/012
CPC分类号： G02B23/243 , A61B1/00091 , A61B1/00177 , A61B1/00181 , A61B1/0615 , A61B1/126 , G02B23/2469 , G02B23/2476
摘要： An endoscope includes a side viewing observation section and a forward viewing observation section provided on a distal end side of an insertion portion which is inserted into an observation target for acquiring subject images of an observation target in a circumferential direction and an insertion direction of the insertion portion, respectively, a shielding section located within a viewing field of the side viewing observation section for shielding light from the subject entering the side viewing observation section and a protruding member protruding from the insertion portion arranged in a shielding region formed by the shielding section. The protruding member includes at least a cleaning nozzle for cleaning the forward viewing observation section and/or the side viewing observation section.
摘要翻译：内窥镜包括侧视观察部和设置在插入部的前端侧的前视观察观察部，该观察对象被插入观察对象物，用于获取观察对象在圆周方向上的被摄体图像和插入方向分别位于侧观察观察部分的观察区域内的屏蔽部分，用于屏蔽来自进入侧视观察部分的被摄体的光，以及从布置在由屏蔽部分形成的屏蔽区域中的插入部突出的突出部件。所述突出构件至少包括用于清洁前视观察部和/或侧视观察部的清洗喷嘴。

8. 发明授权

US07575548B2 Endoscopic treatment instrument, endoscopic treatment system and supporting adaptor 有权
标题翻译：内镜治疗仪，内镜治疗系统及配套适配器
公开(公告)号：US07575548B2
公开(公告)日：2009-08-18
申请号：US11208388
申请日：2005-08-19
申请人： Shotaro Takemoto , Tetsuya Yamamoto , Yoshio Onuki , Koichi Kawashima , Yuji Sakamoto
发明人： Shotaro Takemoto , Tetsuya Yamamoto , Yoshio Onuki , Koichi Kawashima , Yuji Sakamoto
IPC分类号： A61B1/00
CPC分类号： A61B1/018 , A61B1/00087 , A61B1/0014 , A61B17/00234 , A61B90/50 , A61B2017/00296
摘要： In an endoscopic treatment instrument having a plurality of sheaths, a supporting member for directly and indirectly supporting the plurality of sheaths, and a connecting member for directly/indirectly bringing the sheaths and an endoscope in a connected state are provided. The supporting member constrains a relative position of the plurality of sheaths and the connecting member can change the connecting state. Therefore, when an operator changes the connecting state of the connecting member, the positional relation of the endoscope and the plurality of sheaths can be changed, while the positional relation of the plurality of sheaths is still constrained. Accordingly, for example, left and right sheaths can be easily exchanged.
摘要翻译：在具有多个护套的内窥镜处理器械中，设置有用于直接和间接地支撑多个护套的支撑构件，以及用于直接/间接地使护套和连接状态的内窥镜的连接构件。支撑构件限制多个护套的相对位置，并且连接构件可以改变连接状态。因此，当操作者改变连接构件的连接状态时，可以改变内窥镜与多个护套的位置关系，同时多个护套的位置关系仍受到限制。因此，例如，左右护套可以容易地更换。

9. 发明授权

US5445353A Support device for animal clamp 失效
标题翻译：动物夹具支撑装置
公开(公告)号：US5445353A
公开(公告)日：1995-08-29
申请号：US129171
申请日：1993-10-12
申请人： Yuji Sakamoto
发明人： Yuji Sakamoto
IPC分类号： A61D3/00 , F16M13/00
CPC分类号： A61D3/00
摘要： This is a device for supporting an animal clamp (100) fixing a small laboratory animal in a specified position with respect to a testing apparatus (300). A base board (2) is fixed to the testing apparatus (300). An elevating board (4) is raised or lowered by jacks (31, 32) installed between it and base board (2), and a clamp mounting board (8) is tilted by jack (61) and sliding member (62) installed between it and elevating board (4).As a result, the height position and inclination angle of the animal clamp (100) mounted on the clamp mounting board (8) are determined, and they may be finely adjusted by properly manipulating the jacks (31, 32, 61). The animal clamp (100) does not slip off the clamp mounting board (8) because of the clamp slip preventive flange piece (7).
摘要翻译： PCT No.PCT / JP92 / 00151 Sec。 371日期：1993年10月12日 102（e）日期1993年10月12日PCT提交1992年2月13日PCT公布。公开号WO93 / 15689 日期为1993年8月19日。这是一种用于支持将小型实验室动物固定在相对于测试装置（300）的指定位置的动物夹具（100）的装置。基板（2）固定在测试装置（300）上。升降板（4）由安装在其与基板（2）之间的插座（31,32）升高或降低，夹具安装板（8）由插座（61）和滑动构件（62）它和升降板（4）。结果，确定安装在夹具安装板（8）上的动物夹具（100）的高度位置和倾斜角度，并且可以通过适当地操纵插孔（31,32,61）来精细地调节它们。由于夹具防滑法兰片（7），动物夹具（100）不会从夹具安装板（8）上滑落。

10. 发明授权

US5157660A Communication system including portable terminals and fixed terminals 失效
标题翻译：通信系统包括便携式终端和固定终端
公开(公告)号：US5157660A
公开(公告)日：1992-10-20
申请号：US586242
申请日：1990-09-21
申请人： Hiroshi Kuwahara , Nobuo Tsukamoto , Kumiko Takikawa , Yuji Sakamoto , Shirou Tanabe
发明人： Hiroshi Kuwahara , Nobuo Tsukamoto , Kumiko Takikawa , Yuji Sakamoto , Shirou Tanabe
IPC分类号： H04M1/00 , H04M1/253 , H04M3/42 , H04M11/02 , H04Q11/04 , H04W84/16
CPC分类号： H04W84/16 , H04M3/42 , H04Q11/0428 , H04M11/022 , H04M3/42229
摘要： A communication system including a plurality of portable terminal apparatuses each capable of calling a partner terminal apparatus via a radio channel and a plurality of fixed terminal apparatuses each being connected via an ISDN interface to a time-division switch and each being connectable to the portable terminal in which when two portable terminals having an established cell are respectively attached to two fixed terminal apparatuses arbitrarily selected, the state of the call is automatically transferred to the two fixed terminal apparatuses so that the speech can be achieved between the fixed terminal apparatuses without conducting another call establishing procedure.
摘要翻译：一种通信系统，包括多个便携式终端装置，每个便携式终端装置能够通过无线电信道呼叫对方终端装置，以及多个固定终端装置，每个固定终端装置经由ISDN接口连接到时分开关，并且每个可连接到便携终端其中当具有建立小区的两个便携式终端分别附加到任意选择的两个固定终端设备时，呼叫的状态被自动传送到两个固定终端设备，使得可以在固定终端设备之间实现语音而不进行另一个呼叫建立程序。

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