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1. 发明授权

US07972800B2 Screening method for binding property or signal transduction alterations 有权
标题翻译：结合性质或信号转导改变的筛选方法
公开(公告)号：US07972800B2
公开(公告)日：2011-07-05
申请号：US12428877
申请日：2009-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

2. 发明申请

US20060216286A1 Novel screening method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20060216286A1
公开(公告)日：2006-09-28
申请号：US10552014
申请日：2004-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

3. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

4. 发明申请

US20050089866A1 Novel screening method 失效
标题翻译：新型筛选方法
公开(公告)号：US20050089866A1
公开(公告)日：2005-04-28
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

5. 发明申请

US20080160033A1 Novel Screening Method 审中-公开
标题翻译：新型筛选方法
公开(公告)号：US20080160033A1
公开(公告)日：2008-07-03
申请号：US10542408
申请日：2004-01-15
申请人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
发明人： Yasuaki Ito , Ryo Fujii , Shuji Hinuma , Shoji Fukusumi , Minoru Maruyama
IPC分类号： A61K39/395 , G01N33/68 , C07H21/04 , C07K14/705 , C12N5/06 , A61P5/00 , A61P35/00 , A61P31/12 , A61P3/00 , C12P21/02 , C12N15/63 , A61K31/711 , G01N33/566
CPC分类号： C07K14/723 , A61K31/711 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein comprising the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 8, or a salt thereof, and a fatty acid, a compound or its salt that changes the binding property of the receptor protein or a salt thereof to the fatty acid can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1，SEQ ID NO：3或SEQ ID NO：8表示的氨基酸序列相同或基本相同的G蛋白偶联受体蛋白或其盐，和脂肪酸可以有效地筛选改变受体蛋白质或其盐与脂肪酸的结合性的化合物或其盐。

6. 发明授权

US06538107B1 G protein coupled receptor protein production, and use thereof 失效
标题翻译： G蛋白偶联受体蛋白质的产生及其用途
公开(公告)号：US06538107B1
公开(公告)日：2003-03-25
申请号：US09461436
申请日：1999-12-14
申请人： Shuji Hinuma , Yasuaki Ito , Ryo Fujii
发明人： Shuji Hinuma , Yasuaki Ito , Ryo Fujii
IPC分类号： C07K14435
CPC分类号： C12Q1/6876 , C07K14/705 , C07K14/70571 , C07K14/723 , C12Q1/6809 , C12Q1/6883
摘要： DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above G protein coupled receptor proteins, processes for producing the above G protein coupled receptor proteins, methods of determining ligands for the above G protein coupled receptor proteins, methods of screening compounds that inhibit the binding between the ligand and the G protein coupled receptor proteins or screening kits therefor, compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compounds or salts thereof, and antibodies against the above protein coupled receptor proteins or partial peptides thereof are provided.
摘要翻译：提供了有效筛选编码G蛋白偶联受体蛋白的DNA片段的DNA引物。与与编码对应于或接近第一跨膜结构域或第六跨膜结构域的氨基酸序列的核苷酸序列（同源的）的核苷酸序列互补的引物，每个已知的各种G蛋白偶联受体蛋白被设计和合成。还提供了使用上述DNA引物扩增G蛋白偶联受体蛋白质编码DNA的方法，以及新的靶向G蛋白偶联受体蛋白质编码DNA。可以有效地进行DNA文库的筛选。人类垂体腺或来自扁桃体的小鼠胰腺衍生的G蛋白偶联受体蛋白等，或其盐，其部分肽，编码上述G蛋白偶联受体蛋白质的DNA，用于产生上述G蛋白偶联受体蛋白质的方法，确定上述G蛋白偶联受体蛋白质的配体的方法，筛选抑制配体和G蛋白偶联受体蛋白质或其筛选试剂盒之间的结合的化合物的方法，通过上述筛选方法获得的化合物或其盐或筛选试剂盒提供含有上述化合物或其盐的药物组合物和针对上述蛋白质偶联受体蛋白质或其部分肽的抗体。

7. 发明授权

US07517661B2 Methods of screening for ligands for FPRL2 失效
标题翻译：筛选FPRL2配体的方法
公开(公告)号：US07517661B2
公开(公告)日：2009-04-14
申请号：US10554234
申请日：2004-04-22
申请人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
发明人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要： The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
摘要翻译：使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽，所述配体肽包含由SEQ ID NO： SEQ ID NO：3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。

8. 发明申请

US20070009513A1 Novel method of screening 失效
标题翻译：新型筛选方法
公开(公告)号：US20070009513A1
公开(公告)日：2007-01-11
申请号：US10554234
申请日：2004-04-22
申请人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
发明人： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC分类号： A61K39/395 , G01N33/567 , G01N33/53
CPC分类号： G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要： The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
摘要翻译：使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽，所述配体肽包含由SEQ ID NO： SEQ ID NO：3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。

9. 发明申请

US20050153289A1 Method of analyzing gene expression 审中-公开
标题翻译：分析基因表达的方法
公开(公告)号：US20050153289A1
公开(公告)日：2005-07-14
申请号：US10498848
申请日：2002-12-13
申请人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
发明人： Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
IPC分类号： A61K38/17 , A61P35/00 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/68 , C07H21/04 , C07K14/42 , C07K16/30 , G01N33/574
CPC分类号： A61K38/1709 , C07K14/4726 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/689 , G01N2333/705 , G01N2333/726
摘要： The present invention intends to provide a method for analyzing gene expression, a novel use for a receptor protein and the like. Specifically, the present invention provides a method for analyzing gene expression, which is characterized by identifying genes, which are characteristically promoted or suppressed in certain cells or tissues by quantitatively analyzing the individual expressed amounts of a plural number of genes collectively, an assay kit employed in the method and the like. The present invention also provides a method of screening compounds or salts thereof which alter the binding properties of a novel G protein coupled receptor protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 9 or a salt thereof with a ligand, characterized by the use of the protein or salt thereof and a protein (such as a lectin) showing an affinity for a sugar chain which is one of the ligands.
摘要翻译：本发明意在提供分析基因表达的方法，受体蛋白质的新用途等。具体地说，本发明提供一种分析基因表达的方法，其特征在于通过定量分析多个基因的个体表达量来统一地鉴定某些细胞或组织中特征性促进或抑制的基因，所用的测定试剂盒在该方法等中。本发明还提供一种筛选化合物或其盐的方法，其改变新型G蛋白偶联受体蛋白的结合性质，其包含与SEQ ID NO：9所示的氨基酸序列相同或基本上相同的氨基酸序列或盐其特征在于使用蛋白质或其盐和显示对作为配体之一的糖链的亲和性的蛋白质（例如凝集素）。

10. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

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