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1. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

2. 发明授权

US07192723B2 G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译： G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US07192723B2
公开(公告)日：2007-03-20
申请号：US10719587
申请日：2003-11-21
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K7/08 , C07K14/47 , G01N33/566
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

3. 发明授权

US07662574B2 Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion 失效
标题翻译： G蛋白偶联受体及其识别配体在鉴定影响催乳素分泌的化合物中的应用
公开(公告)号：US07662574B2
公开(公告)日：2010-02-16
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

4. 发明申请

US20080131976A1 Novel G protein coupled receptor protein, DNA its ligand 失效
标题翻译：新型G蛋白偶联受体蛋白，DNA的配体
公开(公告)号：US20080131976A1
公开(公告)日：2008-06-05
申请号：US11976414
申请日：2007-10-24
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
摘要翻译：本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选改变结合的化合物的方法/试剂盒配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物或其G蛋白偶联受体蛋白质的抗体。

5. 发明授权

US07608409B2 Screening assay using G-protein coupled receptor protein OT7T175 失效
标题翻译：使用G蛋白偶联受体蛋白OT7T175的筛选试验
公开(公告)号：US07608409B2
公开(公告)日：2009-10-27
申请号：US11976414
申请日：2007-10-24
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K14/705 , G01N33/53
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
摘要翻译：本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选改变结合的化合物的方法/试剂盒配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物或其G蛋白偶联受体蛋白质的抗体。

6. 发明授权

US06699965B1 Peptides that activate the G-protein coupled receptor protein, 0T7T175 失效
标题翻译：激活G蛋白偶联受体蛋白的肽，0T7T175
公开(公告)号：US06699965B1
公开(公告)日：2004-03-02
申请号：US09830428
申请日：2001-04-26
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Tetsuya Ohtaki , Kimiko Kanehashi , Chieko Kitada
IPC分类号： C07K1400
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.
摘要翻译： G起源于大鼠脑干和人脑或其盐附近的蛋白质偶联受体蛋白质，或其肽片段或其酰胺，酯或其盐; 配体; 用于筛选能够改变配体与G蛋白偶联受体蛋白质的结合性质的化合物的方法/试剂盒; 通过上述筛选获得的化合物或其盐; 针对G蛋白偶联受体蛋白的抗体等

7. 发明授权

US07419956B2 Isolated physiologically active peptide and use thereof 失效
标题翻译：分离的生理活性肽及其用途
公开(公告)号：US07419956B2
公开(公告)日：2008-09-02
申请号：US11304129
申请日：2005-12-15
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

8. 发明授权

US07314754B2 Polynucleotide encoding the hOT7T175 G protein coupled receptor 失效
标题翻译：编码hOT7T175 G蛋白偶联受体的多核苷酸
公开(公告)号：US07314754B2
公开(公告)日：2008-01-01
申请号：US10771417
申请日：2004-02-05
申请人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani
发明人： Takuya Watanabe , Yasuko Terao , Yasushi Shintani
IPC分类号： C07H21/04 , C12N7/01 , C12N15/09 , C12N15/00 , C07K14/705 , C12N15/10 , C12P21/02
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： The present invention relates to a polynucleotide encoding a human brain-derived G protein coupled receptor protein. The human brain-derived G protein coupled receptor protein is useful: (1) for determination of a ligand to the receptor protein, (2) as an agent for the prevention and/or treatment of diseases associated with dysfunction of the receptor protein, (3) as a genetic diagnostic agent, (4) for quantification of a ligand to the receptor protein, (5) for screening of a compound that alters the binding property between the receptor protein and a ligand, (6) as an agent for the prevention and/or treatment of various diseases, comprising a compound that alters the binding property between the receptor protein and a ligand, (7) for quantification of the receptor protein, (8) for neutralization by antibodies to the receptor protein and (9) for preparation of a non-human animal bearing the DNA encoding the receptor protein.
摘要翻译：本发明涉及编码人脑源G蛋白偶联受体蛋白质的多核苷酸。人类脑源性G蛋白偶联受体蛋白质可用于：（1）用于测定受体蛋白质的配体，（2）作为预防和/或治疗与受体蛋白质功能障碍有关的疾病的药剂（ 3）作为遗传诊断剂，（4）用于定量受体蛋白质的配体，（5）用于筛选改变受体蛋白质和配体之间的结合性质的化合物，（6）作为预防和/或治疗各种疾病，包括改变受体蛋白质和配体之间的结合性质的化合物，（7）用于定量受体蛋白质的化合物，（8）用于通过受体蛋白质的抗体中和，以及（9）用于制备携带编码受体蛋白的DNA的非人动物。

9. 发明授权

US07045299B2 Physiologically active peptide and use thereof 失效
标题翻译：生理活性肽及其用途
公开(公告)号：US07045299B2
公开(公告)日：2006-05-16
申请号：US10333192
申请日：2001-07-17
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
IPC分类号： G01N33/53 , C12P2/06 , C07K14/00 , C07K2/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

10. 发明申请

US20060088915A1 Novel physiologically active peptide and use thereof 失效
标题翻译：新型生理活性肽及其用途
公开(公告)号：US20060088915A1
公开(公告)日：2006-04-27
申请号：US11304129
申请日：2005-12-15
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

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