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1. 发明申请

US20070203241A1 Antiviral treatments 审中-公开
标题翻译：抗病毒治疗
公开(公告)号：US20070203241A1
公开(公告)日：2007-08-30
申请号：US11705546
申请日：2007-02-12
申请人： Yarlagadda Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Kilpatrick
发明人： Yarlagadda Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Kilpatrick
IPC分类号： A61K31/195
CPC分类号： A61K31/215 , A61K9/0019 , A61K9/006 , A61K31/195 , A61K31/196 , A61K45/06
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译：本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。

2. 发明申请

US20070244193A1 Intramuscular antiviral treatments 审中-公开
标题翻译：肌内抗病毒治疗
公开(公告)号：US20070244193A1
公开(公告)日：2007-10-18
申请号：US11476401
申请日：2006-06-28
申请人： Yarlagadda S. Babu , Pooran Chand , Shanta Bantia , Shane Arnold
发明人： Yarlagadda S. Babu , Pooran Chand , Shanta Bantia , Shane Arnold
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译：本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。

3. 发明申请

US20110015264A1 INTRAMUSCULAR ANTIVIRAL TREATMENTS 审中-公开
标题翻译：内分泌抗病毒治疗
公开(公告)号：US20110015264A1
公开(公告)日：2011-01-20
申请号：US12749030
申请日：2010-03-29
申请人： Yarlagadda S. Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
发明人： Yarlagadda S. Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
IPC分类号： A61K31/215 , A61K31/195 , C07C61/06 , A61P31/16
CPC分类号： A61K31/195
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译：本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。

4. 发明授权

US08778997B2 Antiviral treatments 有权
标题翻译：抗病毒治疗
公开(公告)号：US08778997B2
公开(公告)日：2014-07-15
申请号：US13103562
申请日：2011-05-09
申请人： Yarlagadda Sudhakara Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
发明人： Yarlagadda Sudhakara Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
IPC分类号： A61K31/215 , A61K31/196 , A61P31/12 , A61P31/16 , A61K31/195
CPC分类号： A61K31/215 , A61K9/0019 , A61K9/006 , A61K31/195 , A61K31/196 , A61K45/06
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译：本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。

5. 发明申请

US20120059057A1 ANTIVIRAL TREATMENTS 有权
标题翻译：抗病毒治疗
公开(公告)号：US20120059057A1
公开(公告)日：2012-03-08
申请号：US13103562
申请日：2011-05-09
申请人： Yarlagadda Sudhakara Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
发明人： Yarlagadda Sudhakara Babu , Pooran Chand , Shanta Bantia , Shane Arnold , John Michael Kilpatrick
IPC分类号： A61K31/215 , A61P31/12 , A61P31/16 , A61K31/196
CPC分类号： A61K31/215 , A61K9/0019 , A61K9/006 , A61K31/195 , A61K31/196 , A61K45/06
摘要： The invention provides unit dosage forms, kits, and methods useful for treating viral infections.
摘要翻译：本发明提供了用于治疗病毒感染的单位剂量形式，试剂盒和方法。

6. 发明授权

US06503745B1 Cyclopentane and cyclopentene compounds and use for detecting influenza virus 有权
标题翻译：环戊烷和环戊烯化合物，用于检测流感病毒
公开(公告)号：US06503745B1
公开(公告)日：2003-01-07
申请号：US09831140
申请日：2001-05-07
申请人： Pooran Chand , Yarlagadda S. Babu , Shanta Bantia
发明人： Pooran Chand , Yarlagadda S. Babu , Shanta Bantia
IPC分类号： C12N914
CPC分类号： C07D495/04 , C07C271/34 , C07C279/16 , C07C2601/08 , G01N33/56983
摘要： New cyclopentane and cyclopentene compounds are provided along with their use in method for detecting influenza virus.
摘要翻译：提供新的环戊烷和环戊烯化合物及其在检测流感病毒的方法中的用途。

7. 发明申请

US20070099942A1 AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases 有权
公开(公告)号：US20070099942A1
公开(公告)日：2007-05-03
申请号：US11157867
申请日：2005-06-22
申请人： Yarlagadda Babu , Pooran Chand , Ajit Ghosh , Pravin Kotian , V. Kumar
发明人： Yarlagadda Babu , Pooran Chand , Ajit Ghosh , Pravin Kotian , V. Kumar
IPC分类号： A61K31/519 , C07D487/02 , C07F7/02
CPC分类号： C07D487/04 , C07D491/048 , C07F9/6561
摘要： Compounds represented by the formula: , and pharmaceutically acceptable salts thereof and prodrugs thereof; wherein R1 is H, CH3, C2H5, C3H7 R2 is H, CH3, C2H5, C3H7, CH═CH2, CH2—OH, CH2F, CF3 R′2 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O—C(O)CH(NH2)alkyl R3 is H, CH3, C2H5, C3H7 R′3 is H, OH, NH2, NH-alkyl, F, N3, OCH3, O—C(O)CH(NH2)alkyl R4 is H, CH3, C2H5, C3H7 At least one of R2, R3, or R4 has to be other than H, when X═NH in B R6 is H, CH3, C2H5, R7 is selected from H, alkyl, alkenyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl, aminoacids, CH2CH2SC(O)alkyl; and B is represented by the following structure: X is independently NR6, O, S, R8 and R9 independently is H, NH2, OH, SH, F, Cl, Br, I, aryl, heterocycle, alkyl, alkene, alkyne, S-alkyl, S-aryl, S(O)-alkyl, SO2-alkyl, SO2NH2, SO2NH-alkyl, SO2NH-aryl, NH-alkyl, NH-aryl, N(alkyl)2, N(aryl)2, O-alkyl, O-aryl, O-heterocycle, NH-(CH2)n-aryl, NH—C(O)-alkyl, NH—C(O)-aryl are useful for inhibiting viral RNA polymerases and treating patients suffering from diseases caused by various RNA viruses.

8. 发明申请

US20060165655A1 Therapeutic furopyrimidines and thienopyrimidines 有权
标题翻译：治疗性呋喃嘧啶和噻吩并嘧啶
公开(公告)号：US20060165655A1
公开(公告)日：2006-07-27
申请号：US11332858
申请日：2006-01-16
申请人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
发明人： Yarlagadda Babu , Pooran Chand , Minwan Wu , Pravin Kotian , V. Kumar , Tsu-Hsing Lin , Yahya El-Kattan , Ajit Ghosh
IPC分类号： A61K38/21 , A61K31/675 , A61K31/7076
CPC分类号： C07D495/04 , A61K31/675 , A61K31/7076 , A61K38/212 , A61K38/2292 , C07D491/048 , C07D493/04 , C07F9/6561 , C07H7/06 , C07H19/22 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.
摘要翻译：本发明提供了本文所述的式I，II和III的化合物，以及包含该化合物的药物组合物，以及可用于制备化合物的合成方法和中间体。式I，II和III的化合物可用作抗病毒剂和/或作为抗癌剂。

9. 发明申请

US20050033051A1 Nucleosides preparation thereof and use as inhibitors of rna viral polymerases 审中-公开
标题翻译：核苷的制备及用作rna病毒聚合酶的抑制剂
公开(公告)号：US20050033051A1
公开(公告)日：2005-02-10
申请号：US10496116
申请日：2002-11-14
申请人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Minwan Wu
发明人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Minwan Wu
IPC分类号： A61K31/13 , A61K31/575 , A61K31/66 , A61K31/662 , A61K31/663 , A61K31/704 , A61K31/7056 , A61K36/28 , A61K38/20 , A61K38/21 , A61P31/14 , A61P31/16 , A61P31/20 , A61P43/00 , C07F9/10 , C07F9/6512 , C07F9/6561 , C07F9/02
CPC分类号： C07F9/65616 , A61K31/13 , A61K31/66 , A61K36/28 , A61K38/20 , A61K38/208 , A61K38/21 , A61K38/212 , C07F9/10 , C07F9/6512 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： Compounds represented by the formula (I) R is H, OH, alkyl, O-alkyl, CH2—O-alkyl, (CH2)nOH, (CH2)nNH2, (CH2)nCONH2, (CH2)nOOOH; R1 is H, OH, alkyl, O-alkyl, CH2—O-alkyl, C6H11, CH2OH; R2 is H, alkyl, OH, CH2OH, CH2—O-alkyl, CH(OH)-alkyl, CH(OH)CH2OH, CH2-halogen; R3 and R4 independently is H, OH, alkyl; Z is OR5, OR6, or aminoacids and esters thereof R5 and R6 independently is H, alkyl, aryl, pivaloyloxymethyl, C(R7)2OC(O) X (R8)a formula (II), R7 independently is —H, C1-C12 alkyl, C5-C12 aryl, C2-C12 alkenyl, C2-C12 alkynyl, C7-C12 alkenylaryl, C7-C12 alkynylaryl, or C6-C12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or —OR9; R9 is C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl or C5-C12 aryl; provided that at least one R8 is not H; and a is 1 when X is CH2, or direct bond, or 1 or 2 when X is N with the proviso that when a is 2 and X is N, (a) two N-linked R groups can be taken together to form a carbocyclic or oxygen containing heterocycle, (b) one N-linked R8 additionally can be —OR9 or (c) both N-linked R8 groups can be —H; R10 is H or C1-C8 alkyl; R11 is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl n is 1-5 m is 0 to 5 X is S, N(R8) or direct bond Y is O, S, N (R8), and CHR1 B is selected from the group consisting of adenine, guanine, cytosine, uracil, thymine, modified purines and pyrimidines such as inosin-9-yl, 2-amino-purin-9-yl, 2amino-6-chloro-purin-9-yl, 2-6-diamino-purin-9-yl, 3-carboxamido-1, 2, 4-triazol-1-yl, 3-deaza-adenin-9-yl, 3-deaza-guanin-9-yl, 3-deaza-inosin-9-yl, 3-deaza-2-amino-purin-9-yl, 3-deaza-2-amino-6-chloro-purin-9-yl, 3-deaza-2, 6-diamino-purin-9-yl, 7-deaza-adenin-9-yl, 7-deaza-guanin-9-yl, 7-deaza-inosin-9-yl, 7-deaza-2-amino-purin-9-yl, 7-deaza-2-amino-6-chloro-purin-9-yl, 7-deaza-2-6-diamino-purin-9-yl, 7-deaza-8-aza-adenin-9-yl, 7-deaza-8-aza-guanin-9-yl, 7-deaza-8-aza-inosnin-9-yl, 7-deaza-8-aza-2-amino-purin-9-yl, 7-deaza-8-aza-2-amino-6-chloro-purin-9-yl, 7-deaza-8-aza-2-6-diamino-purin-9-yl, -8-aza-adenin-9-yl,-8-aza-guanin-9-yl, -8-aza-inosnin-9-yl, -8-aza-2-amino-purin-9-yl, -8-aza-2-amino-6-chloro-purin-9-yl, -8-aza-2-6-diamino-purin-9-yl, 5-aza-thymin-1-yl, 5-aza-cytosin-1-yl, 5-aza-uracil-1-yl, 6-aza-thymin-1-yl, 6-aza-cytosin-1-yl, 6-aza-uracil-1-yl, 2-thiouracil-1-yl, 4-thiouracil-1-yl, 2 thiocytosine-1-yl, uracil-5-yl, 2-thiouracil-5-yl, 4-thiouracil-5-yl, substituted pyridine derivatives such as 6-azauracil, and azacyzosine. In general, attachment may be at different positions in the ring at nitrogen or carbon. These B ring systems may be substituted with halo, alkyl, substituted alkyl (F, Cl, Br, I, OH), NH2, N3, aryl, substituted aryl (F, Cl, Br, I, OH, NH2), aralkyl; and pharmaceutically acceptable salts thereof and prodrugs thereof are provided.
摘要翻译：由式（I）R表示的化合物是H，OH，烷基，O-烷基，CH 2 -O-烷基，（CH 2）n OH，（CH 2）n NH 2，（CH 2）n CONH 2，（CH 2） R 1是H，OH，烷基，O-烷基，CH 2 -O-烷基，C 6 H 11，CH 2 OH; R 2是H，烷基，OH，CH 2 OH，CH 2 -O-烷基，CH（OH） - 烷基，CH（OH）CH 2 OH， R 3和R 4独立地是H，OH，烷基; Z为OR 5，OR 6或其氨基酸及其酯R 5和R 6独立地为H，烷基，芳基，新戊酰氧基甲基，C（R 7）2 OC（O）X（R 式（II）中，R 7独立地是-H，C 1 -C 12烷基，C 5 -C 12芳基，C 2 -C 12烯基，C 2 -C 12炔基，C 7 -C 12链烯基芳基，C 7 -C 12炔基芳基或 C 6 -C 12烷芳基，其中任何一个是未取代的或被1或2个卤素，氰基，叠氮基，硝基或-OR 9取代。 R 9是C 1 -C 12烷基，C 2 -C 12烯基，C 2 -C 12炔基或C 5 -C 12芳基; 条件是至少一个R 8不是H; 当X为CH 2或直接键合时，a为1，X为N时为1或2，条件是当a为2且X为N时，（a）两个N-连接的R基团可以一起形成碳环或含氧杂环，（b）一个N-连接的R 8另外可以是-OR 9或（c）两个N-连接的R 8基团可以是-H; R 10是H或C 1 -C 8烷基; R 11选自H，烷基，烯基，炔基，芳基，酰氧基烷基和新戊酰氧基烷基

10. 发明申请

US20060122391A1 Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases 有权
公开(公告)号：US20060122391A1
公开(公告)日：2006-06-08
申请号：US11269819
申请日：2005-11-09
申请人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Minwan Wu
发明人： Yarlagadda Babu , Pooran Chand , Yahya El-Kattan , Minwan Wu
IPC分类号： C07F9/6512
CPC分类号： C07F9/65616 , A61K36/28 , A61K38/208 , A61K38/212 , C07F9/6512 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： Compounds represented by the formula: A is (CH2)nR2, —CH═CH2, CH2—CH═CH2, O(CH2)nR2, CH(OH)CH3, CH(OH)CH2OH, CH2—CH(OH)CH3, CH2CH(OH)CH2OH, or CH(OH)CH(OH)CH3, R,R1 individually is H, NH2OH, Cl, Br, I, aryl, substituted aryl, heterocycle, NR3R4, OR3 or SR3, R2 is H, OH, F, N3, NH2, CO2H, SH, alkyl, substituted alkyl, S-alkyl, O-acyl, CONH2, or CONH-alkyl, n is 1-3, y is O, S or NH, W is O or S, Z, Z′ individually is OR3, OR4, O(CH2)m—O—(CH2)xCH3, NH—CH(alkyl)CO2R3, alkyl, substituted alkyl, OCH2CH2S—C(O)CH3, OCH2CH2S—C(O)CH(CH3)2, OCH2CH2S—C(O)C(CH3)3, OCH2CH2—SC(O)aryl, OCH2CH2—S—S—OCH2CH2OH, OCH2OC(O)C(CH3)3, OCH2—O—C(O)OCH(CH3)2, or OCH2—O—C(O)CH(CH3)2 R3, R4 individually is H, alkyl, substituted alkyl, aryl, or substituted aryl; Both R3 and R4 can form a monocyclic ring of 4-7 atoms with N or optionally a further heteroatom in the ring; m is 1-3, x is 0-19; and pharmaceutically acceptable salts thereof and prodrugs thereof are provided.

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