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1. 发明申请

US20130013020A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20130013020A1
公开(公告)日：2013-01-10
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

2. 发明申请

US20120165895A1 Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification 审中-公开
标题翻译：心脏起搏反应分类中不被捕获的内在歧视
公开(公告)号：US20120165895A1
公开(公告)日：2012-06-28
申请号：US13411852
申请日：2012-03-05
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.
摘要翻译：心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

3. 发明申请

US20080228093A1 Systems and methods for enhancing cardiac signal features used in morphology discrimination 审中-公开
标题翻译：用于增强形态学鉴别中使用的心脏信号特征的系统和方法
公开(公告)号：US20080228093A1
公开(公告)日：2008-09-18
申请号：US11717482
申请日：2007-03-13
申请人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
发明人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
IPC分类号： A61B5/0464
CPC分类号： A61B5/04525 , A61B5/0464 , A61B5/7203 , A61B5/7264 , A61N1/371
摘要： Methods and devices used to classify cardiac events based on morphological analysis of sensed signals are described. A signal comprising a cardiac signal component and a noise signal component is sensed. The sensed signal is processed to preferentially alter morphology of the cardiac signal component. The altered morphology of the cardiac signal component enhances detection of one or more features of the cardiac signal component. The features of the cardiac signal component are detected and the cardiac event is classified using the detected features. Processing the sensed signal may involve the use of adaptable signal processing parameters. For example, the signal processing parameters may be selected to accentuate one or more desirable features of the cardiac signal component or to mitigate one or more undesirable features of the cardiac signal component.
摘要翻译：描述了基于感测信号的形态学分析来分类心脏事件的方法和装置。检测包括心脏信号分量和噪声信号分量的信号。处理感测到的信号以优先改变心脏信号分量的形态。心脏信号分量改变的形态增强了对心脏信号分量的一个或多个特征的检测。检测心脏信号分量的特征，并使用检测到的特征对心脏事件进行分类。处理感测信号可能涉及使用适应性信号处理参数。例如，可以选择信号处理参数以强调心脏信号分量的一个或多个期望特征或减轻心脏信号分量的一个或多个不期望的特征。

4. 发明申请

US20080140145A1 Selection of cardiac signal features detected in multiple classification intervals for cardiac pacing response classification 有权
公开(公告)号：US20080140145A1
公开(公告)日：2008-06-12
申请号：US12070004
申请日：2008-02-14
申请人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
发明人： Scott A. Meyer , Yanting Dong , Kevin John Stalsberg
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/7264 , A61N1/362 , A61N1/371
摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.

5. 发明申请

US20100036449A1 Adaptive Windowing for Cardiac Waveform Discrimination 有权
标题翻译：心脏波形鉴别的自适应窗口
公开(公告)号：US20100036449A1
公开(公告)日：2010-02-11
申请号：US12538297
申请日：2009-08-10
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , Eric Keith Enrooth , Derek Daniel Bohn
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , Eric Keith Enrooth , Derek Daniel Bohn
IPC分类号： A61N1/08
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/0472 , A61B5/7217
摘要： Cardiac devices and methods provide adaptation of detection windows used to determine a cardiac response to pacing. Adapting a detection window involves sensing a cardiac signal indicative of a particular type of cardiac pacing response, and detecting a feature of the sensed cardiac signal. The cardiac response detection window associated with the type of cardiac pacing response is preferentially adjusted based on the location of the detected cardiac feature. Preferential adjustment of the detection window may involve determining a direction of change between the detection window and the detected feature. The detection window may be adapted more aggressively in a more preferred direction and less aggressively in a less preferred direction.
摘要翻译：心脏装置和方法提供用于确定对起搏的心脏反应的检测窗口的适应。适应检测窗口包括感测指示特定类型的心脏起搏反应的心脏信号，以及检测感测到的心脏信号的特征。基于检测到的心脏特征的位置优先调整与心脏起搏响应类型相关联的心脏响应检测窗口。检测窗口的优先调整可以包括确定检测窗口和检测到的特征之间的变化方向。检测窗口可以在更优选的方向上更积极地改变，并且在较不优选的方向上较不积极地适配。

6. 发明申请

US20090105780A1 Pacing Output Determination Based on Selected Capture Threshold Values 有权
标题翻译：基于所选捕获阈值的起搏输出确定
公开(公告)号：US20090105780A1
公开(公告)日：2009-04-23
申请号：US12341617
申请日：2008-12-22
申请人： John Michael Voegele , Clayton Scott Foster , David William Yost , Scott A. Meyer , Yanting Dong , Kevin John Stalsberg , Derek Daniel Bohn , Eric Keith Enrooth
发明人： John Michael Voegele , Clayton Scott Foster , David William Yost , Scott A. Meyer , Yanting Dong , Kevin John Stalsberg , Derek Daniel Bohn , Eric Keith Enrooth
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： Approaches for adjusting the pacing energy delivered by a pacemaker are provided. Adjusting the pacing energy involves performing a plurality of capture threshold tests, each capture threshold test measuring a capture threshold of the heart. One or more measured captured thresholds are selected, including at least one capture threshold that is higher relative to other measured capture thresholds acquired by the plurality of capture threshold tests. The pacing energy is adjusted based on the one or more selected capture thresholds.
摘要翻译：提供了调节由起搏器提供的起搏能量的方法。调整起搏能量包括执行多个捕获阈值测试，每个捕获阈值测试测量心脏的捕获阈值。选择一个或多个测量的捕获阈值，包括相对于通过多个捕获阈值测试获取的其他测量的捕获阈值更高的捕获阈值。基于一个或多个选择的捕获阈值来调整起搏能量。

7. 发明授权

US08565879B2 Method and apparatus for pacing safety margin 有权
标题翻译：起搏安全幅度的方法和装置
公开(公告)号：US08565879B2
公开(公告)日：2013-10-22
申请号：US13071680
申请日：2011-03-25
申请人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
发明人： Amy Jean Brisben , Shibaji Shome , Kenneth N. Hayes , Yanting Dong , Aaron R. McCabe , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/08
CPC分类号： A61N1/36585 , A61N1/3712
摘要： An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture.
摘要翻译：一种装置包括心脏信号感测电路，起搏治疗电路和控制器电路。控制器电路包括安全裕度计算电路。控制器电路使用第一能级开始向心脏传送起搏刺激能量，通过以下至少一种来改变能量水平：a）从第一能量级增加能量直到检测到起搏刺激能量引起稳定的捕获，或 b）减少来自第一能级的能量，直到检测到刺激能量不能诱导捕获，并且继续改变刺激能量水平，直到确认捕获稳定或捕获失败为止。安全裕度计算电路使用与诱发反应相关联的参数的确定的稳定性以及与捕获的稳定捕获或间歇性故障相对应的能量水平的确定范围中的至少一个来计算起搏刺激能量的安全裕度。

8. 发明授权

US08290591B2 Methods and systems for managing fusion and noise in cardiac pacing response classification 有权
标题翻译：用于管理心脏起搏反应分类中的融合和噪声的方法和系统
公开(公告)号：US08290591B2
公开(公告)日：2012-10-16
申请号：US12822480
申请日：2010-06-24
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

9. 发明授权

US08145310B2 Non-captured intrinsic discrimination in cardiac pacing response classification 有权
标题翻译：心脏起搏反应分类中未被捕获的内在区别
公开(公告)号：US08145310B2
公开(公告)日：2012-03-27
申请号：US12217652
申请日：2008-07-07
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.
摘要翻译：心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

10. 发明授权

US08831727B2 Methods and systems for managing fusion and noise in cardiac pacing response classification 有权
标题翻译：用于管理心脏起搏反应分类中的融合和噪声的方法和系统
公开(公告)号：US08831727B2
公开(公告)日：2014-09-09
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/362 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

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