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1. 发明申请

US20110264158A1 HIS-BUNDLE CAPTURE VERIFICATION AND MONITORING 有权
标题翻译：验证和监控
公开(公告)号：US20110264158A1
公开(公告)日：2011-10-27
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

2. 发明授权

US08565880B2 His-bundle capture verification and monitoring 有权
标题翻译： His-bundle捕获验证和监控
公开(公告)号：US08565880B2
公开(公告)日：2013-10-22
申请号：US13094416
申请日：2011-04-26
申请人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
发明人： Yanting Dong , Allan C. Shuros , Jiang Ding , Scott A. Meyer , Shibaji Shome
IPC分类号： A61N1/36
CPC分类号： A61N1/371 , A61B5/0031 , A61B5/04525 , A61B5/7264 , A61N1/3712 , A61N1/37247
摘要： This document discusses, among other things, a system and method for generating a stimulation energy to provide His-bundle stimulation for a cardiac cycle, receiving electrical information from the heart over at least a portion of the cardiac cycle, determining a characteristic of at least a portion of the received electrical information for the cardiac cycle, and classifying the cardiac cycle using the determined characteristic.
摘要翻译：本文件尤其涉及用于产生刺激能量以提供心跳周期的His束刺激的系统和方法，在心脏周期的至少一部分上从心脏接收电信息，确定至少一个特征所接收的用于心动周期的电信息的一部分，并且使用所确定的特征对心动周期进行分类。

3. 发明授权

US08805497B2 Titrated intermittent pacing therapy 有权
标题翻译：滴定间歇起搏治疗
公开(公告)号：US08805497B2
公开(公告)日：2014-08-12
申请号：US12573533
申请日：2009-10-05
申请人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
发明人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's heart rate or exertion level to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。这里描述了一种方法和系统，其使用患者心率或运动水平的测量来控制间歇性预激发起搏的占空比。

4. 发明授权

US08929983B2 Reverse hysteresis and mode switching for intermittent pacing therapy 有权
标题翻译：间歇性起搏治疗的反向滞后和模式切换
公开(公告)号：US08929983B2
公开(公告)日：2015-01-06
申请号：US12615050
申请日：2009-11-09
申请人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
发明人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用。描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。

5. 发明申请

US20100121402A1 REVERSE HYSTERESIS AND MODE SWITCHING FOR INTERMITTENT PACING THERAPY 有权
标题翻译：用于间歇性治疗的逆向滞后和模式切换
公开(公告)号：US20100121402A1
公开(公告)日：2010-05-13
申请号：US12615050
申请日：2009-11-09
申请人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
发明人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用。描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。

6. 发明申请

US20100087887A1 TITRATED INTERMITTENT PACING THERAPY 有权
标题翻译：治疗间歇性间歇性治疗
公开(公告)号：US20100087887A1
公开(公告)日：2010-04-08
申请号：US12573533
申请日：2009-10-05
申请人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
发明人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's heart rate or exertion level to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。这里描述了一种方法和系统，其使用患者心率或运动水平的测量来控制间歇性预激发起搏的占空比。

7. 发明申请

US20100016916A1 APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION 审中-公开
标题翻译：用于治疗角膜移植和感染的装置和方法
公开(公告)号：US20100016916A1
公开(公告)日：2010-01-21
申请号：US12504593
申请日：2009-07-16
申请人： Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Allan C. Shuros , Scott A. Meyer , Robert Shipley , Jason J. Hamann
发明人： Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Allan C. Shuros , Scott A. Meyer , Robert Shipley , Jason J. Hamann
IPC分类号： A61N1/368
CPC分类号： A61N1/36564 , A61N1/36528 , A61N1/36571 , A61N1/368
摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for different purposes. The system delivers electrical stimulation to modulate myocardial strain for anti-atherosclerosis therapy and/or to provide therapy for myocardial infarction (MI). In one embodiment, a medical device for treating atherosclerosis is provided. The medical device includes a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals. The device also includes a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas. According to various embodiments, a controller communicates with the sensing circuit and controls the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to induce myocardial strain changes. The stimulation is targeted to attenuate or prevent atherosclerosis associated with the CAD, according to various embodiments.
摘要翻译：起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。起搏系统接收一组输入，并为不同目的提供优化的心脏保护起搏。该系统提供电刺激以调节用于抗动脉粥样硬化治疗的心肌应变和/或提供心肌梗塞（MI）治疗。在一个实施方案中，提供了用于治疗动脉粥样硬化的医疗装置。医疗设备包括感测电路，用于接收感测到的信号，以使用感测到的信号来识别冠状动脉疾病（CAD）或CAD风险区域。该装置还包括起搏器电路，其适于将电信号通过至少一个电极传递到与所识别的区域相邻的心肌靶。根据各种实施例，控制器与感测电路通信并控制起搏器电路，以向心肌靶标提供间歇性电刺激，以诱导由于诱发心肌应变变化而在血管上延伸的时间段。根据各种实施方案，刺激旨在减弱或预防与CAD相关的动脉粥样硬化。

8. 发明申请

US20120239106A1 HIS CAPTURE VERIFICATION USING ELECTRO-MECHANICAL DELAY 有权
标题翻译：使用电子机械延迟的捕获验证
公开(公告)号：US20120239106A1
公开(公告)日：2012-09-20
申请号：US13404814
申请日：2012-02-24
申请人： Barun Maskara , Jiang Ding , Shantha Arcot-Krishnamurthy , Allan C. Shuros
发明人： Barun Maskara , Jiang Ding , Shantha Arcot-Krishnamurthy , Allan C. Shuros
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译：可以向His束提供刺激能量以激活自然心脏收缩机制。间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。

9. 发明授权

US08954147B2 Timing for His-bundle pacing 有权
标题翻译：他的束起搏的时间
公开(公告)号：US08954147B2
公开(公告)日：2015-02-10
申请号：US13277617
申请日：2011-10-20
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding
IPC分类号： A61N1/365 , A44C15/00
CPC分类号： A44C15/00 , A61N1/365 , Y10T24/10
摘要： An A-H delay can be specified, such as by computing the A-H delay using a measured cardiovascular physiologic parameter. The A-H delay can be used for specifying timing between a paced or sensed atrial contraction and a His-bundle pacing time.
摘要翻译：可以指定A-H延迟，例如通过使用测量的心血管生理参数计算A-H延迟。 A-H延迟可用于指定节奏或感觉到的心房收缩与His束起搏时间之间的时间。

10. 发明授权

US08489204B2 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US08489204B2
公开(公告)日：2013-07-16
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

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