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1. 发明申请

US20070160533A1 Pharmacokinetic modulation and compositions for modified Fn3 polypeptides 有权
标题翻译：用于修饰的Fn3多肽的药代动力学调节和组合物
公开(公告)号：US20070160533A1
公开(公告)日：2007-07-12
申请号：US11482641
申请日：2006-07-07
申请人： Yan Chen , Elena Getmanova , Martin Wright , Alan Harris , Ai Lim , Jochem Gokemeijer
发明人： Yan Chen , Elena Getmanova , Martin Wright , Alan Harris , Ai Lim , Jochem Gokemeijer
IPC分类号： A61K51/00 , A61K38/17 , C07K14/705
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

2. 发明申请

US20070148126A1 Inhibitors of type 2 vascular endothelial growth factor receptors 有权
标题翻译： 2型血管内皮生长因子受体的抑制剂
公开(公告)号：US20070148126A1
公开(公告)日：2007-06-28
申请号：US11448171
申请日：2006-06-05
申请人： Yan Chen , Elena Getmanova , Martin Wright , Alan Harris , Ai Lim , Jochem Gokemeijer
发明人： Yan Chen , Elena Getmanova , Martin Wright , Alan Harris , Ai Lim , Jochem Gokemeijer
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

3. 发明申请

US20060270697A1 Treatment method 审中-公开
公开(公告)号：US20060270697A1
公开(公告)日：2006-11-30
申请号：US11500651
申请日：2006-08-08
申请人： Alan Harris , Paul Medeiros
发明人： Alan Harris , Paul Medeiros
IPC分类号： A61K31/473
CPC分类号： A61K31/47 , A61K31/4545 , A61K31/473 , A61K2300/00 , A61K31/445
摘要： Methods of treating and/or preventing a cardiovascular disease in a human suffering from an allergic and/or inflammatory condition or cardiovascular disease by administrating an effective amount of loratadine, in combination with an effective amount of montelukast, for such treating and/or preventing are disclosed.

4. 发明授权

US6066616A Somatostatin analogue composition and use in treating breast cancer 失效
标题翻译：生长抑素类似物组合物和用于治疗乳腺癌
公开(公告)号：US6066616A
公开(公告)日：2000-05-23
申请号：US22079
申请日：1998-02-11
申请人： Thomas Cavanak , Alan Harris
发明人： Thomas Cavanak , Alan Harris
IPC分类号： A61K9/08 , A61K9/00 , A61K31/19 , A61K38/00 , A61K38/04 , A61K38/27 , A61K38/31 , A61K47/02 , A61K47/12 , A61K51/08 , A61P35/00 , C07K14/575 , C07K14/655
CPC分类号： C07K14/6555 , A61K38/31 , A61K47/12 , A61K9/0019 , A61K2123/00 , Y10S514/806 , Y10S930/16 , Y10S930/26
摘要： The invention provides a pharmaceutical composition comprising a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better tolerated when administered by injection.
摘要翻译：本发明提供包含生长抑素类似物的药物组合物及其在治疗乳腺癌中的用途。除了生长抑素类似物之外，药物组合物优选含有乳酸，并且当通过注射施用时，其耐受性更好。

5. 发明授权

US5753618A Somatostatin analogue composition and use in treating breast cancer 失效
标题翻译：生长抑素类似物组合物和用于治疗乳腺癌
公开(公告)号：US5753618A
公开(公告)日：1998-05-19
申请号：US471706
申请日：1995-06-06
申请人： Thomas Cavanak , Alan Harris
发明人： Thomas Cavanak , Alan Harris
IPC分类号： A61K9/08 , A61K9/00 , A61K31/19 , A61K38/00 , A61K38/04 , A61K38/27 , A61K38/31 , A61K47/02 , A61K47/12 , A61K51/08 , A61P35/00 , C07K14/575 , C07K14/655 , A61K38/12
CPC分类号： C07K14/6555 , A61K38/31 , A61K47/12 , A61K9/0019 , A61K2123/00 , Y10S514/806 , Y10S930/16 , Y10S930/26
摘要： The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better tolerated when administered by injection.
摘要翻译：本发明提供含有生长抑素类似物的药物组合物及其在治疗乳腺癌中的用途。除了生长抑素类似物之外，药物组合物优选含有乳酸，并且当通过注射施用时，其耐受性更好。

6. 发明授权

US5482931A Stabilized pharmaceutical peptide compositions 失效
标题翻译：稳定的药物肽组合物
公开(公告)号：US5482931A
公开(公告)日：1996-01-09
申请号：US84563
申请日：1993-06-29
申请人： Alan Harris , Birgitta Tennhammar-Ekman
发明人： Alan Harris , Birgitta Tennhammar-Ekman
IPC分类号： A61K9/08 , A61K9/00 , A61K38/00 , A61K38/08 , A61K38/11 , A61K47/18 , C07K7/16 , C07K14/00
CPC分类号： A61K47/186 , A61K38/11 , A61K9/0019 , A61K9/0043
摘要： Disclosed is a stabilized aqueous composition for administration to a patient comprising a biologically active peptide, a buffer, a quaternary amine-type preservative or disinfectant, and an osmotic pressure-controlling agent, which composition can be stored and used at room temperature. The buffer stabilizes the pH of the composition between about 4 and 6. The preferred buffer contains citrate and/or phosphate, and the preferred preservative or disinfectant is benzalkonium chloride. The composition protects the peptide contained therein from adhering to container surfaces, particularly in containers made of polymeric materials.
摘要翻译：公开了用于给予患者的稳定的含水组合物，其包含生物活性肽，缓冲剂，季胺型防腐剂或消毒剂和渗透压控制剂，所述组合物可以在室温下储存和使用。缓冲液将组合物的pH稳定在约4和6之间。优选的缓冲液含有柠檬酸盐和/或磷酸盐，优选的防腐剂或消毒剂是苯扎氯铵。组合物保护其中所含的肽不粘附到容器表面，特别是在由聚合材料制成的容器中。

7. 外观设计

USD733686S1 Handheld battery operated blower 有权
标题翻译：手持电池供电鼓风机
公开(公告)号：USD733686S1
公开(公告)日：2015-07-07
申请号：US29430730
申请日：2012-08-29
申请人： Alan Harris
设计人： Alan Harris

8. 发明申请

US20130052045A1 Handheld Battery Operated Blower 审中-公开
标题翻译：手持式电动鼓风机
公开(公告)号：US20130052045A1
公开(公告)日：2013-02-28
申请号：US13597956
申请日：2012-08-29
申请人： Alan Harris
发明人： Alan Harris
IPC分类号： F04D25/08
CPC分类号： F04D25/084
摘要： A handheld electric blower for stimulating and accelerating a fire includes: a hollow, generally cylindrical shaped body having a tapered, open front tip and an open rear end; a turbine blade positioned within the body; an electric motor positioned within the body and operationally coupled to the turbine blade; an adjustable baffle positioned within the front tip of the body; and a baffle control provided on an external surface of the body to adjust the position of the baffle to decrease or increase the flow of air through the body. Activation of the electric motor causes the turbine blade to rotate, thereby drawing air into the open rear end of the body and directing the air out of the tip.
摘要翻译：用于刺激和加速火的手持式电动鼓风机包括：中空的大致圆柱形的主体，其具有锥形的敞开的前端和敞开的后端; 位于体内的涡轮叶片; 定位在所述主体内并且可操作地联接到所述涡轮叶片的电动机; 位于身体前端的可调挡板; 以及设置在主体的外表面上的挡板控制，以调节挡板的位置以减少或增加穿过身体的空气流。电动机的激活导致涡轮叶片旋转，从而将空气吸入主体的敞开的后端并将空气引导出尖端。

9. 发明申请

US20110155152A1 Tobacco Treatment 审中-公开
标题翻译：烟草治疗
公开(公告)号：US20110155152A1
公开(公告)日：2011-06-30
申请号：US12997679
申请日：2009-05-28
申请人： Alan Harris , Steve Hemsley
发明人： Alan Harris , Steve Hemsley
IPC分类号： A24B15/26 , A24B15/24
CPC分类号： A24B15/24 , A24B15/20 , B01D11/023 , B01D11/0288
摘要： This invention provides a method for removing undesirable constituents from tobacco which includes extracting tobacco material in an aqueous or organic solvent and filtering the product of the extraction using a horizontal belt filter. The extract and insoluble tobacco residue may be further treated enzymically, chemically or otherwise to remove a complement of undesirable constituents. The extract and insoluble tobacco residue are recombined to form a regenerated tobacco material that is less harmful when combusted than the original material.
摘要翻译：本发明提供一种从烟草中除去不需要的成分的方法，其中包括在水性或有机溶剂中萃取烟草材料，并使用水平带式过滤器过滤萃取产物。提取物和不溶性烟草残余物可以进一步通过酶学，化学或其它方式进行处理以除去不希望的成分的补体。将提取物和不溶性烟草残渣重新组合以形成再生烟草材料，其与原始材料相比燃烧时的危害较小。

10. 发明授权

US07242318B2 Event detection and transmission system 有权
标题翻译：事件检测和传输系统
公开(公告)号：US07242318B2
公开(公告)日：2007-07-10
申请号：US10769206
申请日：2004-01-29
申请人： Alan Harris
发明人： Alan Harris
IPC分类号： H04Q9/00
CPC分类号： H04L67/125 , A61B5/0022 , G01D9/005 , G06F19/00 , G16H40/67 , H04L67/04 , H04W52/0261 , H04W74/06 , Y10S128/903 , Y10S128/904
摘要： The present invention concerns a data acquisition and transfer device comprising a sensor responsive to change of predetermined nature, and a transmitter for transmitting over the mobile phone network data concerning the occurrence of such a change to a receiver station. Such devices can be used in monitoring patients compliance when undergoing drug trials and can form part of a system which polls the device for changes and keeps a record of all transmissions.
摘要翻译：本发明涉及一种数据采集和传送装置，包括响应于预定性质变化的传感器，以及用于通过移动电话网发送关于发生这种改变的接收站的数据的发射机。这种装置可用于在进行药物试验时监测患者的依从性，并且可以形成轮询该装置以进行变化并保持所有传输记录的系统的一部分。

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