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1. 发明授权

US06864050B2 Single-phase amplification of nucleic acids 有权
标题翻译：核酸的单相扩增
公开(公告)号：US06864050B2
公开(公告)日：2005-03-08
申请号：US09373984
申请日：1999-08-16
申请人： Xing Su , Rolfe C. Anderson
发明人： Xing Su , Rolfe C. Anderson
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q2565/501 , C12Q2600/158 , C12Q2525/173 , C12Q2525/143
摘要： The amplification of nucleic acids in a single phase can reliably provide products at relatively low cost and labor. A single-phase amplification can also increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof. A single-phase amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.
摘要翻译：单相中核酸的扩增可以以相对较低的成本和劳动力可靠地提供产品。单相扩增还可以增加核酸的量，同时保留各个核酸种类或其部分的相对丰度。可以在基因表达监测系统中分析单相扩增核酸制剂，优选涉及核酸探针阵列。

2. 发明授权

US5856174A Integrated nucleic acid diagnostic device 失效
公开(公告)号：US5856174A
公开(公告)日：1999-01-05
申请号：US589027
申请日：1996-01-19
申请人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
发明人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/0059 , B01F15/0238 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L7/52 , G01N35/1095 , B01F13/005 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , B01L3/502715 , B01L3/502753 , B01L9/527 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

3. 发明授权

US06830936B2 Integrated nucleic acid diagnostic device 失效
标题翻译：集成核酸诊断装置
公开(公告)号：US06830936B2
公开(公告)日：2004-12-14
申请号：US09751658
申请日：2000-12-31
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： G01N3510
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。与一个或多个样品分析操作结合进行或多次采样和准备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

4. 发明授权

US06326211B1 Method of manipulating a gas bubble in a microfluidic device 有权
标题翻译：在微流体装置中操纵气泡的方法
公开(公告)号：US06326211B1
公开(公告)日：2001-12-04
申请号：US09523417
申请日：2000-03-10
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： G01N100
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

5. 发明授权

US06197595B1 Integrated nucleic acid diagnostic device 有权
标题翻译：集成核酸诊断装置
公开(公告)号：US06197595B1
公开(公告)日：2001-03-06
申请号：US09294700
申请日：1999-04-19
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： G01N110
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

6. 发明授权

US06043080A Integrated nucleic acid diagnostic device 有权
标题翻译：集成核酸诊断装置
公开(公告)号：US06043080A
公开(公告)日：2000-03-28
申请号：US210025
申请日：1998-12-11
申请人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
发明人： Robert J. Lipshutz , Richard P. Rava , Rolfe C. Anderson , Stephen P. A. Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10 , C12Q1/68
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/0059 , B01F15/0238 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L7/52 , G01N35/1095 , B01F13/005 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , B01L3/502715 , B01L3/502753 , B01L9/527 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。

7. 发明授权

US5922591A Integrated nucleic acid diagnostic device 失效
公开(公告)号：US5922591A
公开(公告)日：1999-07-13
申请号：US671928
申请日：1996-06-27
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10
CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/0059 , B01F15/0238 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L7/52 , G01N35/1095 , B01F13/005 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , B01L3/502715 , B01L3/502753 , B01L9/527 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

8. 发明申请

US20100168561A1 Intraoperative Tissue Mapping and Dissection Systems, Devices, Methods, and Kits 审中-公开
标题翻译：术中组织图和解剖系统，装置，方法和试剂盒
公开(公告)号：US20100168561A1
公开(公告)日：2010-07-01
申请号：US12519495
申请日：2007-12-18
申请人： Rolfe C. Anderson
发明人： Rolfe C. Anderson
IPC分类号： A61B5/05
CPC分类号： A61B17/3403 , A61B17/22004 , A61B17/32 , A61B18/02 , A61B18/042 , A61B18/14 , A61B90/36 , A61B90/39 , A61B90/98 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00411 , A61B2090/3933 , A61B2090/3937 , A61B2090/395 , A61B2090/3954 , A61B2090/3975 , A61B2090/3987 , A61N1/05 , A61N1/36014
摘要： Intraoperative devices are described that assist the surgeon in identifying the location and characteristics of tissues and structures. Devices are also described that have the added capability of marking the location of the identified tissues and structures. This invention also includes devices that can selectively ablate adjacent tissues while avoiding damage and trauma to the identified tissues and structures by combining ablation with sensing, where sensing of either tissue properties, markings made by another device or surgeon, or a reference probe can be used. Devices are also described that protect tissue in the proximity of reference markings or probes by closed loop inhibition of the ablation process. The devices, systems, methods and kits described are adapted and configured to facilitate locating a target structure or target tissue within a body of a mammal, including nerves, peripheral nerves, blood vessels, and tubes such as the ureter. The devices, systems and methods may discriminate between different tissues by exploiting the electrical, mechanical, and physiological properties of the body.
摘要翻译：描述了术中装置，其帮助外科医生识别组织和结构的位置和特征。还描述了具有标记所识别的组织和结构的位置的附加能力的装置。本发明还包括能够选择性地烧蚀邻近组织的装置，同时通过将消融与感测组合来消除识别的组织和结构的损伤和创伤，其中可以使用任何组织性质，由另一装置或外科医生制造的标记或参考探针的感测。还描述了通过消融过程的闭环抑制来保护参考标记或探针附近的组织的装置。所描述的装置，系统，方法和试剂盒被适配和构造成便于将目标结构或靶组织定位在哺乳动物的体内，包括神经，外周神经，血管和诸如输尿管的管。装置，系统和方法可以通过利用身体的电气，机械和生理特性来区分不同的组织。

9. 发明授权

US06403317B1 Electronic detection of hybridization on nucleic acid arrays 有权
标题翻译：电子检测核酸阵列杂交
公开(公告)号：US06403317B1
公开(公告)日：2002-06-11
申请号：US09535142
申请日：2000-03-24
申请人： Rolfe C. Anderson
发明人： Rolfe C. Anderson
IPC分类号： C12Q168
CPC分类号： C12Q1/6825 , C12Q1/6837 , G01N15/1031 , G01N21/1717 , G01N25/4846 , G01N2015/0065 , C12Q2565/107 , C12Q2527/101
摘要： A method of detecting locations on a nucleic acid probe array at which hybridization occurs between targets in a fluid sample and nucleic acid probes disposed on a surface of the nucleic acid probe array, comprising: measuring the temperature at a plurality of locations on the surface of the nucleic acid probe array; applying an oscillating level of energy to the surface of the nucleic acid probe array, thereby causing the temperature at the surface of the nucleic acid probe array to oscillate; and detecting a decreased range of temperature oscillation at least one of the plurality of locations on the nucleic acid probe array, thereby indicating an increased heat capacity caused by latent heat of hybridization between at least one target in the fluid sample and at least one nucleic acid probe disposed on a surface of the nucleic acid probe array.
摘要翻译：一种检测核酸探针阵列上的位置的方法，其中在流体样品中的靶和设置在核酸探针阵列的表面上的核酸探针之间发生杂交，包括：测量表面上多个位置处的温度核酸探针阵列; 向核酸探针阵列的表面施加振荡水平的能量，从而使核酸探针阵列表面的温度振荡; 以及检测所述核酸探针阵列上的所述多个位置中的至少一个的温度振荡范围的降低，从而表明由所述流体样品中的至少一个靶与至少一个核酸之间的杂交潜热引起的增加的热容量探针设置在核酸探针阵列的表面上。

10. 发明授权

US06168948A Miniaturized genetic analysis systems and methods 失效
标题翻译：小型遗传分析系统和方法
公开(公告)号：US06168948A
公开(公告)日：2001-01-02
申请号：US09005985
申请日：1998-01-12
申请人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
发明人： Rolfe C. Anderson , Robert J. Lipshutz , Richard P. Rava , Stephen P. A. Fodor
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/069 , B01L2300/0883 , B01L2300/16 , B01L2400/0481 , B01L2400/0487 , Y10S366/03
摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system which includes a nucleic acid extraction zone including nucleic acid binding sites.
摘要翻译：本发明提供了一种小型化的综合核酸诊断装置和系统，其包括包含核酸结合位点的核酸提取区。

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