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1. 发明授权

US07321792B1 Pacing therapy and acupuncture 失效
标题翻译：起搏治疗和针灸
公开(公告)号：US07321792B1
公开(公告)日：2008-01-22
申请号：US10392619
申请日：2003-03-19
申请人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
发明人： Xiaoyi Min , Gene A. Bornzin , Mark W. Kroll , Xing Pei
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/3962 , A61H39/002 , A61H39/02 , A61N1/37252 , A61N1/3925 , Y10S128/907
摘要： Exemplary methods, devices and/or systems for detecting one or more needs and for requesting the delivery of power to one or more acupoints. Other methods, devices and/or systems are also disclosed.
摘要翻译：用于检测一个或多个需求并请求向一个或多个穴位传递电力的示例性方法，装置和/或系统。还公开了其它方法，装置和/或系统。

2. 发明授权

US07308307B1 Implantable single-chamber atrial pacing device providing active ventricular far field sensing and rate limit 有权
标题翻译：可植入的单室心房起搏装置，提供主动心室远场感测和速率限制
公开(公告)号：US07308307B1
公开(公告)日：2007-12-11
申请号：US10792207
申请日：2004-03-02
申请人： Xing Pei , Mark W. Kroll
发明人： Xing Pei , Mark W. Kroll
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/365
摘要： A maximum pacing rate is dynamically established during single-chamber atrial pacing of a heart by a rate control system within a single-chamber or dual-chamber cardiac stimulation device which paces the atria of a heart on demand at the end of an escape interval. The system includes a detector that detects an atrial activation of the heart and an R wave of the heart corresponding to the detected atrial activation. The system further includes a rate limit circuit that determines a minimum RA interval and extends the escape interval to an extended escape interval to end with the minimum RA interval.
摘要翻译：在单室或双室心脏刺激装置中的速率控制系统在心脏的单室心房起搏期间动态地建立最大起搏速率，其在逃逸间隔结束时根据需要对心脏的心房进行起搏。该系统包括检测心脏的心房激活和对应于检测到的心房激活的心脏的R波的检测器。所述系统还包括速率限制电路，其确定最小RA间隔并且将逃生间隔延伸到扩展逃逸间隔以最小RA间隔结束。

3. 发明授权

US07933649B1 Implantable cardiac stimulation device and method for measuring intrinsic activity metrics in multi-site pacing 有权
标题翻译：可植入式心脏刺激装置和多站点起搏测量内在活动指标的方法
公开(公告)号：US07933649B1
公开(公告)日：2011-04-26
申请号：US11222722
申请日：2005-09-08
申请人： Adam F. Atherton , Xing Pei
发明人： Adam F. Atherton , Xing Pei
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/365
摘要： An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
摘要翻译：可植入的心脏刺激装置提供内在的心脏活动指标的测量，同时维持心脏起搏。所述装置包括脉搏发生器，其将起搏脉冲输送到心脏的相应腔室的第一腔室;以及感测电路，其响应于起搏脉冲感测心脏的相应腔室的第二腔室的传导诱发反应以提供代表传导诱发反应的电信号。该装置还包括测量电路，其测量电信号的度量以接近第二室的本征电特征的对应度量。

4. 发明申请

US20090281588A1 DETERMINING ATRIAL TIME PERIODS IN CONJUNCTION WITH REAL-TIME TESTING 审中-公开
标题翻译：确定与实时测试相关的ATRIAL时间段
公开(公告)号：US20090281588A1
公开(公告)日：2009-11-12
申请号：US12118423
申请日：2008-05-09
申请人： Xing Pei
发明人： Xing Pei
IPC分类号： A61N1/365
CPC分类号： A61N1/36507 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/371 , A61N1/37247 , A61N1/37264
摘要： Time periods such as PVAB and PVARP are defined based on data acquired during real-time tests. For example, data may be collected during a real-time test that determines a sensing threshold or during a real-time test that determines a capture threshold. Time period information may then be derived based on correlations between the timing of far-field events and/or retrograde conduction derived from the acquired data and the timing of sensed or paced ventricular events. In some cases, the derived time period information may be used to provide timing recommendations for initial programming of an implantable device.
摘要翻译：基于实时测试中获取的数据定义PVAB和PVARP等时间段。例如，可以在确定感测阈值的实时测试期间或在确定捕获阈值的实时测试期间收集数据。然后可以基于远场事件的定时和/或从获取的数据导出的逆行传导与感测或起搏的心室事件的定时之间的相关性来导出时间段信息。在一些情况下，可以使用导出的时间段信息来提供用于可植入装置的初始编程的定时建议。

5. 发明授权

US07587243B1 System and method for verifying capture and/or event sensing during manual threshold evaluations of an implantable cardiac stimulation device 有权
标题翻译：用于在可植入心脏刺激装置的手动阈值评估期间验证捕获和/或事件感测的系统和方法
公开(公告)号：US07587243B1
公开(公告)日：2009-09-08
申请号：US11430785
申请日：2006-05-08
申请人： Xing Pei
发明人： Xing Pei
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/0006 , A61B5/04525 , A61N1/37247
摘要： A system verifies the occurrence of a cardiac event during a manual evaluation of a pacing and/or sensing parameter of an implantable cardiac stimulation device. The system comprises a template generator that generates an electrogram template standard characterizing the cardiac event, an event marker pattern generator that generates a marker pattern standard representing a desired sequence of cardiac events including the cardiac event, and a sensing circuit that senses cardiac activity to provide an evaluation electrogram signal responsive to evaluation of the pacing and/or sensing parameter. The template generator generates an evaluation electrogram and the event marker pattern generator generates an evaluation marker pattern from the evaluation electrogram signal. A cardiac event verifier verifies the occurrence of the cardiac event when the evaluation electrogram matches the electrogram template standard and the evaluation marker pattern matches the marker pattern standard.
摘要翻译：在手动评估可植入心脏刺激装置的起搏和/或感测参数期间，系统验证心脏事件的发生。该系统包括生成表征心脏事件的电描记图模板标准的模板发生器，产生表示包括心脏事件的所需心脏事件序列的标记图案标准的事件标记图案生成器，以及感测心脏活动以提供心脏事件的感测电路响应于对起搏和/或感测参数的评估的评估电描记图信号。模板生成器生成评估电图，事件标记图案生成器从评估电描记信号生成评估标记图案。当评估电描记图与电描记图模板标准匹配并且评估标记图案与标记图案标准匹配时，心脏事件验证器验证心脏事件的发生。

6. 发明授权

US08521279B2 Implantable cardiac stimulation device and method for measuring intrinsic activity metrics in multi-site pacing 有权
标题翻译：可植入式心脏刺激装置和多站点起搏测量内在活动指标的方法
公开(公告)号：US08521279B2
公开(公告)日：2013-08-27
申请号：US13049677
申请日：2011-03-16
申请人： Adam F. Atherton , Xing Pei
发明人： Adam F. Atherton , Xing Pei
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/365
摘要： An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
摘要翻译：可植入的心脏刺激装置提供内在的心脏活动指标的测量，同时维持心脏起搏。所述装置包括脉搏发生器，其将起搏脉冲输送到心脏的相应腔室的第一腔室;以及感测电路，其响应于起搏脉冲感测心脏的相应腔室的第二腔室的传导诱发反应以提供代表传导诱发反应的电信号。该装置还包括测量电路，其测量电信号的度量以接近第二室的本征电特征的对应度量。

7. 发明授权

US08498706B2 Capture threshold and lead condition analysis 有权
公开(公告)号：US08498706B2
公开(公告)日：2013-07-30
申请号：US12496539
申请日：2009-07-01
申请人： Xing Pei , Robert E. Smith , Paul A. Levine
发明人： Xing Pei , Robert E. Smith , Paul A. Levine
IPC分类号： A61N1/37
CPC分类号： A61N1/08 , A61N1/056 , A61N1/0563 , A61N1/368 , A61N1/3682 , A61N1/3702 , A61N1/371 , A61N1/3712 , A61N1/372 , A61N1/3962 , A61N2001/083
摘要： An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.

8. 发明申请

US20110166617A1 Implantable Cardiac Stimulation Device and Method for Measuring Intrinsic Activity Metrics in Multi-Site Pacing 有权
标题翻译：可植入心脏刺激装置和多站点起搏测量内在活动指标的方法
公开(公告)号：US20110166617A1
公开(公告)日：2011-07-07
申请号：US13049677
申请日：2011-03-16
申请人： Adam F. Atherton , Xing Pei
发明人： Adam F. Atherton , Xing Pei
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/365
摘要： An implantable cardiac stimulation device provides measurement of intrinsic heart activity metrics while sustaining pacing of the heart. The device includes a pulse generator that delivers pacing pulses to a first chamber of corresponding chambers of a heart, and a sensing circuit that senses a conducted evoked response of a second chamber of the corresponding chambers of the heart in response to the pacing pulse to provide an electrical signal representing the conducted evoked response. The device further includes a measuring circuit that measures a metric of the electrical signal to approximate a corresponding metric of an intrinsic electrical feature of the second chamber.
摘要翻译：可植入的心脏刺激装置提供内在的心脏活动指标的测量，同时维持心脏起搏。所述装置包括脉搏发生器，其将起搏脉冲输送到心脏的相应腔室的第一腔室;以及感测电路，其响应于起搏脉冲感测心脏的相应腔室的第二腔室的传导诱发反应以提供代表传导诱发反应的电信号。该装置还包括测量电路，其测量电信号的度量以接近第二室的本征电特征的对应度量。

9. 发明申请

US20090281587A1 SYSTEM AND METHOD FOR DETECTING HIDDEN ATRIAL EVENTS FOR USE WITH AUTOMATIC MODE SWITCHING WITHIN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于在可移植医疗设备中使用自动模式切换检测隐藏事件的系统和方法
公开(公告)号：US20090281587A1
公开(公告)日：2009-11-12
申请号：US12116450
申请日：2008-05-07
申请人： Xing Pei
发明人： Xing Pei
IPC分类号： A61N1/362
CPC分类号： A61N1/3704 , A61B5/04525 , A61B5/046 , A61N1/3622 , A61N1/3688
摘要： Techniques are provided for detecting atrial events that might be hidden due to the operation of a post-ventricular atrial blanking (PVAB) interval or other atrial channel blanking interval. In one example, candidate atrial events are identified within signals occurring during the PVAB interval. Then, a determination is made as to whether the candidate atrial event is a true atrial event based on a comparison of characteristics of the candidate atrial event with characteristics of prior known atrial events within the patient. By comparing the characteristics of the “hidden” event with the characteristics of prior known atrial events within the patient, a quick and accurate determination can be made whether the event should be counted as a P-wave. In this manner, hidden atrial arrhythmias can be detected and mode switch oscillations can be reduced or eliminated.
摘要翻译：提供技术用于检测可能由于室后心房消隐（PVAB）间隔或其他心房通道消隐间隔的操作而被隐藏的心房事件。在一个示例中，在PVAB间隔期间发生的信号内识别候选心房事件。然后，基于候选心房事件的特征与患者内先前已知的心房事件的特征的比较，确定候选心房事件是否为真心房事件。通过将“隐藏”事件的特征与患者以前已知的心房事件的特征进行比较，可以快速准确地确定事件是否应该被计为P波。以这种方式，可以检测到隐藏的心房心律失常，并且可以减少或消除模式切换振荡。

10. 发明授权

US07574259B1 Capture threshold and lead condition analysis 有权
标题翻译：捕获阈值和引导条件分析
公开(公告)号：US07574259B1
公开(公告)日：2009-08-11
申请号：US10987731
申请日：2004-11-12
申请人： Xing Pei , Robert E. Smith , Paul A. Levine
发明人： Xing Pei , Robert E. Smith , Paul A. Levine
IPC分类号： A61N1/37
CPC分类号： A61N1/08 , A61N1/056 , A61N1/0563 , A61N1/368 , A61N1/3682 , A61N1/3702 , A61N1/371 , A61N1/3712 , A61N1/372 , A61N1/3962 , A61N2001/083
摘要： An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括使用双极电极配置执行捕获阈值评估，确定捕获阈值评估的最大能量值是否发生捕获，并且如果没有发生捕获，则对与双极性相关联的引线执行引线阻抗测试电极配置。这种测试可能旨在检测绝缘缺陷和/或导体缺陷。还公开了其它示例性方法，装置，系统等。

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