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1. 发明授权

US08731665B1 Posture detection using pressure and other physiologic sensors 有权
标题翻译：使用压力和其他生理传感器的姿势检测
公开(公告)号：US08731665B1
公开(公告)日：2014-05-20
申请号：US11923286
申请日：2007-10-24
申请人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61N1/36535
摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.
摘要翻译：提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

2. 发明授权

US07272443B2 System and method for predicting a heart condition based on impedance values using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的阻抗值来预测心脏病的系统和方法
公开(公告)号：US07272443B2
公开(公告)日：2007-09-18
申请号：US11014276
申请日：2004-12-15
申请人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0538 , A61N1/3627 , A61N1/371
摘要： Techniques are provided for predicting the onset of a heart condition within a patient based on impedance measurements. Briefly, overloads in fluid levels in the thorax and in ventricular myocardial mass within the patient are detected based on impedance signals sensed using implanted electrodes. The onset of certain heart conditions is then predicted based on the overloads. For example, pulmonary edema arising due to diastolic heart failure is predicted based on the detection of on-going overloads in both fluid levels and ventricular mass. Ventricular hypertrophy is detected based on an on-going ventricular mass overload without a sustained fluid overload. Various other heart conditions may also be predicted based on specific combinations of recent or on-going overloads. Evoked response is exploited to corroborate the predictions. Appropriate warning signals are generated and preemptive therapy is initiated.
摘要翻译：提供了基于阻抗测量来预测患者心脏病状发作的技术。简单地说，基于使用植入电极感测到的阻抗信号来检测患者胸部液位水平和心室心肌质量的过载。然后基于过载来预测某些心脏状况的发作。例如，由于舒张性心力衰竭引起的肺水肿基于检测流体水平和心室质量中的持续过载而被预测。基于正在进行的心室质量超载而无持续的流体超载检测出心室肥大。还可以基于最近或正在进行的过载的特定组合来预测各种其他心脏状况。被诱发的反应被利用来证实预测。产生适当的警告信号并开始抢先治疗。

3. 发明授权

US06937900B1 AC/DC multi-axis accelerometer for determining patient activity and body position 有权
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06937900B1
公开(公告)日：2005-08-30
申请号：US10205188
申请日：2002-07-24
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Alan B. Vogel , Joseph J. Florio , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

4. 发明授权

US06741885B1 Implantable cardiac device for managing the progression of heart disease and method 有权
标题翻译：用于管理心脏疾病进展的植入式心脏装置和方法
公开(公告)号：US06741885B1
公开(公告)日：2004-05-25
申请号：US09908179
申请日：2001-07-17
申请人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61N1/36514
摘要： An implantable cardiac device detects a progression or regression in heart disease such as congestive heart failure. An activity sensor and a respiration sensor generate raw signals indicative of the patient's activity level and respiration level. Degradation or improvement of the patient's activity and respiration over a predetermined time corresponds to an indication of the progression or regression of the heart disease. A processor coupled to the sensors is programmed to process the raw sensor signals over the predetermined time and stores the processed sensor signals in a memory having a data storage area. A telemetry circuit coupled to the memory is configured to transmit the stored sensor signals to an external monitor for subsequent display. The processor further controls pacing of the heart, adjusts pacing therapy responsive to the process signals, and process the raw respiration signals when the patient is in a number of different active states.
摘要翻译：可植入的心脏装置检测心脏病的进展或消退，例如充血性心力衰竭。活动传感器和呼吸传感器产生指示患者的活动水平和呼吸水平的原始信号。在预定时间内降低或改善患者的活动和呼吸对应于心脏病的进展或消退的指征。耦合到传感器的处理器被编程为在预定时间内处理原始传感器信号，并将经处理的传感器信号存储在具有数据存储区域的存储器中。耦合到存储器的遥测电路被配置为将存储的传感器信号发送到外部监视器用于随后的显示。处理器进一步控制心脏的起搏，响应于过程信号调整起搏治疗，并且当患者处于多个不同的活动状态时处理原始呼吸信号。

5. 发明授权

US06512953B2 System and method for automatically verifying capture during multi-chamber stimulation 有权
标题翻译：在多室刺激下自动验证捕获的系统和方法
公开(公告)号：US06512953B2
公开(公告)日：2003-01-28
申请号：US09844189
申请日：2001-04-26
申请人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
发明人： Joseph J. Florio , Euljoon Park , Kerry Bradley , Gene A. Bornzin
IPC分类号： A61N1365
CPC分类号： A61N1/3712 , A61N1/3627
摘要： A system and corresponding method are provided to reliably detect capture during multi-chamber stimulation, and to further monitor the progression of congestive heart failure. The system provides a method by which intracardiac electrogram (IEGM) characteristics representing single-chamber capture and bi-ventricular capture are stored in memory and displayed. The annotation of the displayed waveforms is such that events associated with loss of capture, single-chamber capture, and bi-ventricular capture are clearly marked for ready interpretation by the physician. In a first situation, a stimulation pulse is followed by a time delay window and a subsequent depolarization complex that represents intrinsic responses of the chambers that have not been captured. In a second situation, a stimulation pulse is followed almost immediately by an evoked response that represents capture of one chamber, and a subsequent depolarization complex that represents an intrinsic response of one chamber that has not been captured. In a third situation, a stimulation pulse is almost immediately followed by an evoked response that represents simultaneous capture of two chambers.
摘要翻译：提供了一种系统和相应的方法来可靠地检测多室刺激期间的捕获，并进一步监测充血性心力衰竭的进展。该系统提供了一种表示单室捕获和双心室捕获的心内电图（IEGM）特征存储在存储器中并显示的方法。显示的波形的注释使得与丢失捕获，单室捕获和双心室捕获相关联的事件被清楚地标记以供医师准备解释。在第一种情况下，刺激脉冲之后是时间延迟窗口和随后的去极化复合体，其表示未被捕获的室的内在响应。在第二种情况下，刺激脉冲几乎立即被跟随表示一个腔室的捕获的诱发反应，以及后续的去极化复合体，其表示一个未被捕获的腔室的固有响应。在第三种情况下，刺激脉冲几乎紧随其后，表示同时捕获两个腔室的诱发反应。

6. 发明授权

US5991661A System and method for measuring cardiac activity 失效
标题翻译：用于测量心脏活动的系统和方法
公开(公告)号：US5991661A
公开(公告)日：1999-11-23
申请号：US954326
申请日：1997-10-17
申请人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
发明人： Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device, such as a pacemaker or an implantable cardioverter-defibrillator, that includes an accelerometer-based activity sensor that processes one or more signals from the activity sensor to obtain parameters that are indicative of the heartbeat of the patient. The implantable cardiac stimulation device determines when the patient is at rest and the activity sensor provides a signal that corresponds to the acceleration of the sensor due to the heartbeat of the patient. This acceleration signal is integrated over time once to provide a contractility parameter, which is indicative of the contractility of the heart and is integrated over time twice to provide a displacement parameter, which is indicative of the displacement of the heart wall during the heartbeat. This displacement parameter is thereby indicative of the volume of blood pumped by the heart. A microprocessor uses either the contractility parameter, the displacement parameter or both to modify the delivery of therapeutic stimulation pulses to the heart.
摘要翻译：可植入心脏刺激装置，例如起搏器或植入式心律转复除颤器，其包括基于加速度计的活动传感器，其处理来自活动传感器的一个或多个信号以获得指示患者心跳的参数。可植入心脏刺激装置确定患者何时休息，并且活动传感器提供对应于由于患者心跳引起的传感器的加速度的信号。该加速度信号随着时间一度被积分以提供收缩性参数，其表示心脏的收缩性并且随时间积分两次以提供位移参数，其指示在心跳期间心脏壁的位移。因此，该位移参数指示由心脏泵送的血液的体积。微处理器使用收缩性参数，位移参数或两者来修改对心脏的治疗刺激脉冲的递送。

7. 发明授权

US08306623B2 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US08306623B2
公开(公告)日：2012-11-06
申请号：US13149507
申请日：2011-05-31
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

8. 发明申请

US20110282226A1 CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
标题翻译：用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统
公开(公告)号：US20110282226A1
公开(公告)日：2011-11-17
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

9. 发明授权

US07945326B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US07945326B1
公开(公告)日：2011-05-17
申请号：US11684677
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

10. 发明授权

US07546157B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
标题翻译：使用由可植入医疗装置感测到的内部心脏信号来模拟表面EKG的系统和方法
公开(公告)号：US07546157B1
公开(公告)日：2009-06-09
申请号：US10735948
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0402 , A61N1/3702
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测的远场心室信号与在心室中感测到的远场心房信号组合，或者通过组合近场在心房中感测到的信号在心室感测到近场信号。在另一示例中，使用选择性地放大或衰减使用单个电极对感测的单个信号的部分的技术来执行仿真，例如通过衰减相对于该场的远场部分的心房单极信号的近场部分相同的信号或通过将相对于心室部分的交叉室信号的心房部分衰减到相同的信号。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。

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