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1. 发明申请

US20060095081A1 Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权
标题翻译：通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置
公开(公告)号：US20060095081A1
公开(公告)日：2006-05-04
申请号：US11116970
申请日：2005-04-28
申请人： Xiaohong Zhou , Thomas Mullen , Michael Hill , Steve Laporte , Gary King
发明人： Xiaohong Zhou , Thomas Mullen , Michael Hill , Steve Laporte , Gary King
IPC分类号： A61N1/18
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译：根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。

2. 发明申请

US20070276453A1 METHOD AND APPARATUS TO MINIMIZE THE EFFECTS OF A CARDIAC INSULT 审中-公开
标题翻译：减轻心脏病的效果的方法和装置
公开(公告)号：US20070276453A1
公开(公告)日：2007-11-29
申请号：US11837811
申请日：2007-08-13
申请人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
发明人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou , Rahul Mehra
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided to peripheral nerves, intrinsic cardiac nerves, sympathetic ganglia, cranial nerves, and may generally be directed to the vertebral column, or within the chest wall of the patient.
摘要翻译：提供了一种用于保护心脏组织免受侮辱的方法和装置。所述方法包括识别呃等的发生，例如心脏病发作，并且响应于识别侮辱的发生而向患者身体中的一个或多个预定神经传递电刺激。刺激可以提供给外周神经，内在的心脏神经，交感神经节，颅神经，并且通常可以被引导到脊柱或患者的胸壁内。

3. 发明申请

US20070213773A1 Closed-Loop Neuromodulation for Prevention and Treatment of Cardiac Conditions 审中-公开
标题翻译：闭环神经调节预防和治疗心脏病症
公开(公告)号：US20070213773A1
公开(公告)日：2007-09-13
申请号：US11748847
申请日：2007-05-15
申请人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou
发明人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/36585
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the patient's body, and then the physiologic response of the patient is monitored to determine the efficacy of the stimulation.
摘要翻译：公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。该方法包括将电刺激递送到患者体内神经系统的一个或多个预定部分; 并监测身体的一个或多个生理指标以确定递送的治疗是否有效。也就是说，使用闭环反馈控制器对患者身体的预选区域施加电刺激，然后监测患者的生理反应以确定刺激的功效。

4. 发明授权

US10692391B2 Instructional support platform for interactive learning environments 有权
公开(公告)号：US10692391B2
公开(公告)日：2020-06-23
申请号：US16551889
申请日：2019-08-27
申请人： Gary King , Eric Mazur , Kelly Miller , Brian Lukoff
发明人： Gary King , Eric Mazur , Kelly Miller , Brian Lukoff
IPC分类号： G09B5/02 , G09B7/02 , G06N20/00 , G06N20/20 , G06N5/00 , G06N7/00 , G06F40/40 , G06F40/169 , G09B5/12
摘要： In various embodiments, subject matter for improving discussions in connection with an educational resource is identified and summarized by analyzing annotations made by students assigned to a discussion group to identify high-quality annotations likely to generate responses and stimulate discussion threads, identifying clusters of high-quality annotations relating to the same portion or related portions of the educational resource, extracting and summarizing text from the annotations, and combining, in an electronically represented document, the extracted and summarized text and (i) at least some of the annotations and the portion or portions of the educational resource or (ii) clickable links thereto.

5. 发明授权

US08954520B2 Systems and methods for managing user-specific modifications to shared content on an individual basis 有权
标题翻译：在个别基础上管理对共享内容的用户特定修改的系统和方法
公开(公告)号：US08954520B2
公开(公告)日：2015-02-10
申请号：US13393204
申请日：2011-11-11
申请人： Nick Triantos , Abraham Benjamin de Waal , Gary King
发明人： Nick Triantos , Abraham Benjamin de Waal , Gary King
IPC分类号： G06F15/16 , G06Q10/10
CPC分类号： H04L51/046 , G06F3/04842 , G06Q10/103
摘要： System and methods for managing content modification messages are provided. In some embodiments, a request to send a modification message to a second user is received from a first user. The request to send the modification message pertains to a modification made to a first user-specific version corresponding to the first user and represented by a first delta. The modification message comprising a second delta is generated. The modification message includes second instructions to modify a second user-specific version to include the modification within the second user-specific version by resolving the first delta and the first user-specific version to the second user-specific version. A message indicator for the modification message is provides to a client device of the second user. The message indicator identifies the first user as the sender of the modification message.
摘要翻译：提供了管理内容修改消息的系统和方法。在一些实施例中，从第一用户接收向第二用户发送修改消息的请求。发送修改消息的请求涉及对应于第一用户并由第一增量表示的对第一用户特定版本的修改。生成包括第二增量的修改消息。修改消息包括通过将第一增量和第一用户特定版本解析为第二用户特定版本来修改第二用户特定版本以将修改包括在第二用户特定版本内的第二指令。用于修改消息的消息指示符被提供给第二用户的客户端设备。消息指示符将第一个用户标识为修改消息的发送者。

6. 发明申请

US20080058878A1 THERAPEUTIC METHOD WITH PAIN RELIEF 有权
标题翻译：疼痛缓解的治疗方法
公开(公告)号：US20080058878A1
公开(公告)日：2008-03-06
申请号：US11930767
申请日：2007-10-31
申请人： Gary King
发明人： Gary King
IPC分类号： A61N1/34 , A61N1/32 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/36007 , A61N1/36071
摘要： A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and/or direct current pulses at or near the second site. Timex varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be defibrillation of the patient's atria or defibrillation of the patient's ventricles, and the undesired side effect may be pain.
摘要翻译：通过在患者体内的第一部位进行治疗活化的组织产生期望的效果，并且通过施加高频刺激和/或使患者的身体内的第二部位阻止组织的激活或动作电位的传导来减少相应的不期望的副作用，和/ 或在第二位置处或附近的直流脉冲。可以在高频阻塞信号之前或之后使用Timex变化的DC脉冲。高频刺激可以在治疗激活期间开始并且在治疗激活期间继续。高频刺激可以以相对低的幅度开始，并且幅度可能逐渐增加。期望的效果可以是患者心房的除颤或患者心室的除颤，并且不期望的副作用可能是疼痛。

7. 发明申请

US20060259099A1 Shifting between electrode combinations in electrical stimulation device 有权
公开(公告)号：US20060259099A1
公开(公告)日：2006-11-16
申请号：US11401100
申请日：2006-04-10
申请人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
发明人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

8. 发明申请

US20060167525A1 Method of stimulating multiple sites 审中-公开
标题翻译：刺激多个部位的方法
公开(公告)号：US20060167525A1
公开(公告)日：2006-07-27
申请号：US11038656
申请日：2005-01-19
申请人： Gary King
发明人： Gary King
IPC分类号： A61N1/18 , A61N1/34
CPC分类号： A61N1/0553 , A61N1/36071
摘要： A method of stimulating two sites of neurological tissue. A lead is implanted in or near the spinal column. The lead has a first set of at least two electrodes and a second set of at least first, second and third electrodes. The first and second electrodes are positioned on opposite sides of an imaginary longitudinal axis that passes through the center of the third electrode. The placement of the first set of electrodes is at a higher vertebral level than the placement of the second set of electrodes.
摘要翻译：刺激神经组织两个部位的方法。将铅植入脊柱或脊柱附近。引线具有至少两个电极的第一组和至少第一，第二和第三电极的第二组。第一和第二电极位于通过第三电极的中心的虚拟纵向轴线的相对侧上。第一组电极的放置位置比第二组电极放置的椎体水平高。

9. 发明申请

US20060079937A1 Technique for adjusting the locus of excitation of electrically excitable tissue 失效
公开(公告)号：US20060079937A1
公开(公告)日：2006-04-13
申请号：US11273310
申请日：2005-11-14
申请人： Gary King , Robert Leinders , Greg Hrdlicka , Michael Baudino
发明人： Gary King , Robert Leinders , Greg Hrdlicka , Michael Baudino
IPC分类号： A61N1/32 , A61N1/00
CPC分类号： A61N1/36164 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36017 , A61N1/36071 , A61N1/36167
摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

10. 发明授权

US10438498B2 Instructional support platform for interactive learning environments 有权
公开(公告)号：US10438498B2
公开(公告)日：2019-10-08
申请号：US15365019
申请日：2016-11-30
申请人： Gary King , Eric Mazur , Kelly Miller , Brian Lukoff
发明人： Gary King , Eric Mazur , Kelly Miller , Brian Lukoff
IPC分类号： G09B5/02 , G09B7/02 , G06N20/00 , G06F17/24 , G06F17/28 , G09B5/12
摘要： In various embodiments, subject matter for improving discussions in connection with an educational resource is identified and summarized by analyzing annotations made by students assigned to a discussion group to identify high-quality annotations likely to generate responses and stimulate discussion threads, identifying clusters of high-quality annotations relating to the same portion or related portions of the educational resource, extracting and summarizing text from the annotations, and combining, in an electronically represented document, the extracted and summarized text and (i) at least some of the annotations and the portion or portions of the educational resource or (ii) clickable links thereto.

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