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1. 发明申请

US20060229687A1 Shifting between electrode combinations in electrical stimulation device 审中-公开
标题翻译：在电刺激装置中的电极组合之间移动
公开(公告)号：US20060229687A1
公开(公告)日：2006-10-12
申请号：US11352389
申请日：2006-02-10
申请人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
发明人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/36071
摘要： In general, the invention is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. The stimulation pulses of the first and second electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, thereby allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find the most efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.
摘要翻译：通常，本发明涉及用于在两个电极组合之间移动的技术。第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。第一和第二电极组合的刺激脉冲在时间上交付给患者。以这种方式，本发明提供了从第一电极组合到第二电极组合的平滑的逐渐变化，从而允许患者保持对刺激的连续感知。在编程期间可以使用本文描述的移位技术来在不同的电极组合之间移动以找到最有效的电极组合。另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

2. 发明申请

US20060259099A1 Shifting between electrode combinations in electrical stimulation device 有权
公开(公告)号：US20060259099A1
公开(公告)日：2006-11-16
申请号：US11401100
申请日：2006-04-10
申请人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
发明人： Steven Goetz , Andrew Houchins , Jeffrey Keacher , Gary King , Kenneth Heruth , Roy Testerman , Michael Lee , Nathan Torgerson , Joseph Nolan
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

3. 发明申请

US20070245318A1 Rule-based stimulation program search 有权
标题翻译：基于规则的刺激程序搜索
公开(公告)号：US20070245318A1
公开(公告)日：2007-10-18
申请号：US11402657
申请日：2006-04-12
申请人： Steven Goetz , Donald Johnson , Andrew Houchins , Jeffrey Keacher , Theodore Stone , Kenneth Heruth , Gary King , Roy Testerman
发明人： Steven Goetz , Donald Johnson , Andrew Houchins , Jeffrey Keacher , Theodore Stone , Kenneth Heruth , Gary King , Roy Testerman
IPC分类号： G06F9/44
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36132 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63 , G16H50/20
摘要： Techniques that involve application of one or more rules to a “parent” program to generate a plurality of different “child” programs are described. Each of the rules may define a respective electrode configuration modification, and each child program may be a variation of the parent based on a modification of the electrode configuration of the parent according to one of the rules. The systems or devices may generate further generations of child programs from a previous generation child program using the same one or more rules. The child programs may be provided to a user, so that the user may test the efficacy of the new programs, assisting the user in identifying desirable programs. The child programs may be relatively minor variations of the parent program, and the user may “fine tune” a generally desirable parent program by testing the child programs.
摘要翻译：描述涉及将一个或多个规则应用于“父”程序以生成多个不同的“子”程序的技术。每个规则可以限定相应的电极配置修改，并且每个子程序可以是基于根据规则之一的父母的电极配置的修改的父母的变体。系统或设备可以使用相同的一个或多个规则从上一代子程序生成更多代的子程序。子程序可以被提供给用户，使得用户可以测试新程序的功效，帮助用户识别期望的程序。子程序可能是父程序的相对小的变化，并且用户可以通过测试子程序来“微调”通常期望的父程序。

4. 发明申请

US20070073357A1 Peripheral nerve field stimulation and spinal cord stimulation 有权
标题翻译：外周神经刺激和脊髓刺激
公开(公告)号：US20070073357A1
公开(公告)日：2007-03-29
申请号：US11450144
申请日：2006-06-09
申请人： Ethan Rooney , Carl Wahlstrand , Gary King , Thomas Cross , Jeffrey Evanson , Kenneth Heruth , Paul Wacnik
发明人： Ethan Rooney , Carl Wahlstrand , Gary King , Thomas Cross , Jeffrey Evanson , Kenneth Heruth , Paul Wacnik
IPC分类号： A61N1/32
CPC分类号： A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/0558 , A61N1/36021 , A61N1/37205 , A61N1/37211 , A61N1/375 , A61N1/3756
摘要： Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
摘要翻译：描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

5. 发明申请

US20070073356A1 Combination therapy including peripheral nerve field stimulation 有权
标题翻译：组合疗法包括周围神经域刺激
公开(公告)号：US20070073356A1
公开(公告)日：2007-03-29
申请号：US11450133
申请日：2006-06-09
申请人： Ethan Rooney , Carl Wahlstrand , Gary King , Thomas Cross , Jeffrey Evanson , Kenneth Heruth , Paul Wacnik
发明人： Ethan Rooney , Carl Wahlstrand , Gary King , Thomas Cross , Jeffrey Evanson , Kenneth Heruth , Paul Wacnik
IPC分类号： A61N1/32
CPC分类号： A61N1/36021 , A61M5/14 , A61M5/142 , A61M2205/054 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/0558 , A61N1/36017 , A61N1/36071 , A61N1/37211 , A61N1/375
摘要： Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
摘要翻译：描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

6. 发明申请

US20070021801A1 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US20070021801A1
公开(公告)日：2007-01-25
申请号：US11374852
申请日：2006-03-14
申请人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
发明人： Kenneth Heruth , Mark Lent , Ruchika Singhal , Michael Schendel , Gary King
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

7. 发明申请

US20080071327A1 CONTROLLING THERAPY BASED ON SLEEP QUALITY 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US20080071327A1
公开(公告)日：2008-03-20
申请号：US11691430
申请日：2007-03-26
申请人： Keith Miesel , Kenneth Heruth , Jonathan Werder , Steve LaPorte , Nina Graves
发明人： Keith Miesel , Kenneth Heruth , Jonathan Werder , Steve LaPorte , Nina Graves
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

8. 发明申请

US20060129221A1 Tunneling guide 审中-公开
标题翻译：隧道指南
公开(公告)号：US20060129221A1
公开(公告)日：2006-06-15
申请号：US11069187
申请日：2005-03-01
申请人： Kenneth Heruth
发明人： Kenneth Heruth
IPC分类号： A61N1/05
CPC分类号： A61L29/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/45 , A61M2025/0056 , A61M2025/0057
摘要： An implantable tunneling guide capable of releasing one or more therapeutic agents is described. The tunneling guide has a body member defining a lumen. The lumen is configured to receive at least a portion of a therapy delivery element, such as a catheter, a lead, or a lead extension. One or more therapeutic agents are disposed on, in, or about the body member.
摘要翻译：描述了能够释放一种或多种治疗剂的可植入隧道导管。隧道引导件具有限定管腔的主体构件。该管腔构造成容纳至少一部分治疗递送元件，例如导管，引线或引线延伸部。一个或多个治疗剂设置在身体构件上，内部或周围。

9. 发明申请

US20060039946A1 Drug eluting medical device 审中-公开
标题翻译：药物洗脱医疗器械
公开(公告)号：US20060039946A1
公开(公告)日：2006-02-23
申请号：US10975253
申请日：2004-10-28
申请人： Kenneth Heruth , Mark Lent
发明人： Kenneth Heruth , Mark Lent
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61K9/0024 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61L2300/61 , A61M37/00 , A61M2025/0057 , A61N1/0534 , A61N1/0536 , A61N1/0551 , A61N1/36071
摘要： Medical devices configured to be implanted in two or more tissues simultaneously are discussed. A therapeutic agent is disposed on, in, or about at least a portion of an external surface of a medical device configured to be placed in one tissue, but not on, in or about a surface configured to be placed in another tissue. The therapeutic agent may be disposed on or in a polymeric material, which is disposed on or about at least a portion of an external surface of first portion the medical device. Such targeted placement of polymeric material may allow for the therapeutic agent to be eluted in an appropriate tissue and may allow for decreased undesired effects.
摘要翻译：讨论了被配置为同时植入在两个或更多个组织中的医疗装置。治疗剂设置在医疗装置的外表面的至少一部分上，或者围绕被配置成放置在一个组织中但不在其上或周围的配置为放置在另一组织中的表面上。治疗剂可以设置在聚合物材料上或聚合物材料中，聚合物材料设置在医疗装置的第一部分的外表面的至少一部分上或周围。聚合材料的这种靶向放置可以使治疗剂在适当的组织中洗脱并且可以减少不期望的效果。

10. 发明申请

US20050209513A1 Collecting sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集睡眠质量信息
公开(公告)号：US20050209513A1
公开(公告)日：2005-09-22
申请号：US10826925
申请日：2004-04-15
申请人： Kenneth Heruth , Keith Miesel
发明人： Kenneth Heruth , Keith Miesel
IPC分类号： A61B5/0476 , A61B5/11 , A61M5/142 , A61M5/172 , A61N1/05 , A61N1/34 , A61N1/36 , A61N1/365 , A61N1/372 , A61N1/00 , A61B5/00 , A61B5/02 , A61B5/08
CPC分类号： A61N1/36139 , A61B3/113 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/1116 , A61B5/1118 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61M5/14276 , A61M5/1723 , A61N1/36071 , A61N1/36078 , A61N1/36135 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/3702 , A61N1/37247
摘要： At least one of a medical device, such as an implantable medical device, and a programming device determines values for one or more metrics that indicate the quality of a patient's sleep. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. In some embodiments, determined sleep quality metric values are associated with a current therapy parameter set. In some embodiments, a programming device presents sleep quality information to a user based on determined sleep quality metric values values. A clinician, for example, may use the sleep quality information presented by the programming device to evaluate the effectiveness of therapy delivered to the patient by the medical device, to adjust the therapy delivered by the medical device, or to prescribe a therapy not delivered by the medical device in order to improve the quality of the patient's sleep.
摘要翻译：诸如可植入医疗设备的医疗设备和编程设备中的至少一个确定了指示患者睡眠质量的一个或多个度量的值。睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。在一些实施例中，确定的睡眠质量度量值与当前治疗参数组相关联。在一些实施例中，编程设备基于确定的睡眠质量度量值值向用户呈现睡眠质量信息。例如，临床医生可以使用编程设备呈现的睡眠质量信息来评估由医疗设备递送给患者的治疗的有效性，以调整由医疗设备递送的治疗，或者开出不由医疗器械为了提高病人的睡眠质量。

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