会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF PEPTIDASES IN MACROPHAGE AND MACROPHAGE-LIKE CELLS
    • 用于调节巨噬细胞和巨噬细胞样细胞中肽活性的方法和组合物
    • US20090217402A1
    • 2009-08-27
    • US11914881
    • 2006-05-18
    • Kenneth BernsteinXiao Shen
    • Kenneth BernsteinXiao Shen
    • A01K67/00C12N15/00C12N5/00A61K35/12A61K39/00C12N15/63
    • C12N15/1138C12N9/48
    • Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects, methods are provided for enhancing or suppressing the immune function of a host by increasing or decreasing, respectively, expression of a target peptidase in host macrophage and macrophage-like cells. Such methods for enhancing or suppressing the immune function of a host by increasing or inhibiting (suppressing or silencing) expression of a target peptidase in host macrophage and macrophage-like cells find use in methods for treating and/or preventing a number of diseases and conditions, including cancer, viral and/or bacterial infection, Alzheimer's disease, tissue transplant rejection, autoimmune diseases, and chronic inflammatory diseases. The invention also provides compositions and research tools related to these methods, including vectors for increasing or inhibiting the expression of a peptidase in macrophage and macrophage-like cells, macrophage and macrophage-like cells transfected with these vectors, genetically modified mice that over-express a target peptidase or in which expression of a target peptidase has been disrupted, and selective modulators of peptidase activity in macrophages as well as methods for identifying and using such modulators.
    • 提供了用于调节巨噬细胞和巨噬细胞样细胞的活性的方法和组合物,特别是通过调节这些细胞的肽酶活性。 在某些方面,通过分别增加或减少宿主巨噬细胞和巨噬细胞样细胞中靶肽酶的表达来提供用于增强或抑制宿主免疫功能的方法。 通过增加或抑制(抑制或沉默)宿主巨噬细胞和巨噬细胞样细胞中靶肽酶的表达来增强或抑制宿主的免疫功能的这些方法可用于治疗和/或预防多种疾病和病症 ,包括癌症,病毒和/或细菌感染,阿尔茨海默病,组织移植排斥,自身免疫疾病和慢性炎性疾病。 本发明还提供了与这些方法相关的组合物和研究工具,包括用于增加或抑制巨噬细胞和巨噬细胞样细胞中巨噬细胞和巨噬细胞样细胞,巨噬细胞和巨噬细胞样细胞表达的载体的载体,用于过表达的转基因小鼠 目标肽酶或靶蛋白酶的表达已被破坏,以及巨噬细胞中肽酶活性的选择性调节剂以及用于鉴定和使用这些调节剂的方法。