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1. 发明申请

US20130134183A1 LIQUID DELIVERY SYSTEM 审中-公开
标题翻译：液体输送系统
公开(公告)号：US20130134183A1
公开(公告)日：2013-05-30
申请号：US13695222
申请日：2011-04-20
申请人： Jacobus Simon Petrus Van Diepen , Christopher Leonard Padain , Xianzhi Zhou
发明人： Jacobus Simon Petrus Van Diepen , Christopher Leonard Padain , Xianzhi Zhou
IPC分类号： B67D1/00 , B65D88/54
CPC分类号： A47K5/1217 , A47K5/1202
摘要： A liquid delivery system comprising a base unit (2) comprising a liquid inlet in an upwardly facing surface, a liquid duct leading from the inlet to a liquid outlet above the liquid inlet; a pump for pumping the liquid from the inlet to the outlet; a motor to drive the pump; and a shroud extending upwardly in a manner which surrounds the inlet, the system further comprising a vessel (1) received within the shroud in an inverted configuration with its outlet lowermost and in communication with the fluid inlet, the vessel (1) having a refill opening (20) towards the end opposite to the outlet.
摘要翻译：一种液体输送系统，包括基本单元（2），该基座单元（2）包括在向上表面中的液体入口，从入口通向液体入口上方的液体出口的液体管道; 用于将液体从入口泵送到出口的泵; 驱动泵的电机; 以及以围绕所述入口的方式向上延伸的护罩，所述系统还包括容纳在所述护罩内的倒置构造的容器（1），其出口最下部并与所述流体入口连通，所述容器（1）具有填充物开口（20）朝向与出口相对的端部。

2. 发明申请

US20130020275A1 Bottle With A Secure Cap 审中-公开
标题翻译：带安全帽的瓶子
公开(公告)号：US20130020275A1
公开(公告)日：2013-01-24
申请号：US13382285
申请日：2010-07-12
申请人： Xianzhi Zhou , Christopher Leonard Padain
发明人： Xianzhi Zhou , Christopher Leonard Padain
IPC分类号： B65D41/47 , A47K5/12
CPC分类号： B65D55/024 , B65D41/485
摘要： A bottle (1) with a secure cap (7), comprising a bottle having an open neck (2) and a first retaining flange (3) around at least a portion of the neck; and a push-on cap (7) fitted over the neck (2), the cap having an outlet with a valve (32) for controlling flow through the outlet and a second retaining flange (9) positioned so that, upon placement of the cap (7) on the bottle (1), the first and second retaining flanges (3,9) deflect relatively to one another as they pass and snap back into place once they have passed with a shoulder (41) of the first retaining flange engaging a shoulder (131) on the second retaining flange to hold the cap securely on the bottle.
摘要翻译：一种具有固定帽（7）的瓶子（1），包括一个具有开口颈部（2）的瓶子和围绕颈部的至少一部分的第一保持凸缘（3）; 以及安装在所述颈部（2）上的推盖（7），所述盖具有带阀（32）的出口，用于控制通过所述出口的流动;以及第二保持凸缘（9），所述第二保持凸缘（9）第一和第二保持凸缘（3,9）在瓶子（1）上的帽（7）上时，一旦它们通过并且第一保持凸缘（3,9）的肩部（41）穿过第一和第二保持凸缘将肩部（131）接合在第二保持凸缘上，以将盖子牢固地保持在瓶子上。

3. 发明授权

US08662356B2 Dispenser and refill unit 有权
标题翻译：分配器和补充单元
公开(公告)号：US08662356B2
公开(公告)日：2014-03-04
申请号：US13129164
申请日：2009-11-17
申请人： Christopher Leonard Padain , Jacobus Simon Petrus Van Diepen , Xianzhi Zhou , Dong Xiao You
发明人： Christopher Leonard Padain , Jacobus Simon Petrus Van Diepen , Xianzhi Zhou , Dong Xiao You
IPC分类号： G01F11/00
CPC分类号： A47K5/1217 , A47K5/1202
摘要： A dispenser including a base unit with an actuation mechanism for dispensing liquid and a refill unit insertible into the base unit in an inverted configuration with its outlet lowermost for the supply of liquid to the base unit. The refill unit includes an annular wall projecting into the refill unit and defining an outlet from the refill unit, the annular wall being closable at its innermost end by a valve element biased onto the annular wall. The base unit includes a hollow spigot and an annular seal surrounding and spaced from the top of the spigot whereby insertion of the refill unit into the base unit causes the spigot to enter the annular wall and to lift the valve element from the annular wall to define a flow path from the refill unit, and the annular seal to seal between the spigot and the annular wall.
摘要翻译：一种分配器，包括具有用于分配液体的致动机构的基座单元和以倒置构型插入到基座单元中的再填充单元，其出口最下部用于向基座单元供应液体。再填充单元包括突出到再填充单元中的环形壁，并且限定了来自再填充单元的出口，环形壁在其最内端被偏置在环形壁上的阀元件封闭。基座单元包括中空的插口和环形密封件，该环形密封件围绕并与该插口的顶部间隔开，从而将再填充单元插入基座单元中，使得插口进入环形壁并将阀元件从环形壁提升以限定来自再填充单元的流动路径和环形密封件以在插口和环形壁之间进行密封。

4. 发明授权

US08881957B2 Relief valve 有权
标题翻译：泄压阀
公开(公告)号：US08881957B2
公开(公告)日：2014-11-11
申请号：US13129165
申请日：2009-11-16
申请人： Xianzhi Zhou , Dong Xiao You
发明人： Xianzhi Zhou , Dong Xiao You
IPC分类号： B65B3/18 , B65D90/22 , B65D51/16 , F16K17/08 , F16K15/14
CPC分类号： B65D51/165 , B65D2205/00 , F16K15/145 , F16K17/085 , F16K17/087 , Y10T137/7895 , Y10T137/7897
摘要： A relief valve (60) for a liquid container, the valve comprising a substantially conical body (50) extending into the container, and tapering inwardly away from an external wall of the container, at least one air inlet passage (62) through the substantially conical body; and a flexible diaphragm (53) extending over the conical body, being attached at its outer periphery around the substantially conical body and having a central opening surrounding the substantially conical body above the air inlet passage so as to seal the air inlet passage until the pressure within the container falls below a predetermined level.
摘要翻译：一种用于液体容器的安全阀（60），所述阀包括延伸进入所述容器的基本上圆锥形的本体（50），并且从所述容器的外壁向内逐渐变细，至少一个空气入口通道（62）圆锥体以及在圆锥体上延伸的柔性隔膜（53），其周围围绕基本上圆锥形的主体附接在其外周边，并且具有围绕空气入口通道上方的基本上圆锥形的主体的中心开口，以便密封空气入口通道，直到压力在容器内下降到预定水平以下。

5. 发明授权

US06953577B2 Human methionine aminopeptidase type 3 失效
标题翻译：人甲硫氨酸氨肽酶3型
公开(公告)号：US06953577B2
公开(公告)日：2005-10-11
申请号：US10299867
申请日：2002-11-19
申请人： Carolyn J. Sympson , Rajeev Aurora , Stanton B. Dotson , Ronald B. Frazier , Cynthia L. Woods , Hamideh Zakeri , Xianzhi Zhou
发明人： Carolyn J. Sympson , Rajeev Aurora , Stanton B. Dotson , Ronald B. Frazier , Cynthia L. Woods , Hamideh Zakeri , Xianzhi Zhou
IPC分类号： A61K38/00 , A61K39/00 , C12N9/48 , A01N63/00 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12Y304/11018 , A61K38/00 , A61K39/00 , C12N9/48
摘要： Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine aminopeptidase type-3 (MetAP-3), has a substrate specificity which is similar to MetAP-1 and MetAP-2, although it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. MetAP-3 also preferentially localizes to mitochondria, unlike MetAP-1 and MetAP-2, which accumulate in the cytoplasm. One embodiment of the present invention relates to human cDNAs encoding polypeptides comprising MetAP-3. Other embodiments of the invention relate to nucleic acid molecules derived from these cDNAs, including complements, homologues, and fragments thereof, and methods of using these nucleic acid molecules, to generate polypeptides and fragments thereof. Other embodiments of the invention relate to antibodies directed against polypeptides comprising MetAP-3, and methods to screen for compounds or compositions that preferentially or specifically effect the activity of polypeptides comprising MetAP-3.
摘要翻译：甲硫氨酸氨基肽酶催化从新生多肽链共转移氨基末端甲硫氨酸残基。称为甲硫氨酸氨基肽酶-3型（MetAP-3）的新发现的酶具有与MetAP-1和MetAP-2相似的底物特异性，尽管它不被万古霉素（Metap-2的不可逆抑制剂）抑制。 MetAP-3也优先定位于线粒体，不同于MetAP-1和MetAP-2，其积聚在细胞质中。本发明的一个实施方案涉及编码包含MetAP-3的多肽的人cDNA。本发明的其它实施方案涉及衍生自这些cDNA的核酸分子，包括其互补序列，同系物及其片段，以及使用这些核酸分子的方法来产生其多肽及其片段。本发明的其它实施方案涉及针对包含MetAP-3的多肽的抗体，以及筛选优先或特异性影响包含MetAP-3的多肽的活性的化合物或组合物的方法。

6. 发明申请

US20120187152A1 Fluid Delivery System 有权
标题翻译：流体输送系统
公开(公告)号：US20120187152A1
公开(公告)日：2012-07-26
申请号：US13382283
申请日：2010-07-06
申请人： Xianzhi Zhou , Dong Xiaoyou
发明人： Xianzhi Zhou , Dong Xiaoyou
IPC分类号： B65D88/54 , B67D7/58
CPC分类号： A47K5/1204 , B05B11/3097
摘要： A fluid delivery system comprising a pump arranged to draw fluid, in use, from a reservoir (1) and dispense it through a dispensing tube (4), the pump comprising a cylinder (21) in which a piston (22) is reciprocally movable; an inlet into the cylinder; a one-way inlet valve (17) for controlling flow through the inlet; an outlet from the cylinder and leading to the dispensing tube; and an outlet valve (27) controlling flow through the outlet, wherein the piston is arranged to selectively contact the outlet valve to maintain it open during the initial portion of its downstroke and to allow it to close for the remainder of the downstroke.
摘要翻译：一种流体输送系统，包括泵，该泵设置成在使用中从储存器（1）中抽出流体并将其分配通过分配管（4），所述泵包括气缸（21），活塞（22）可往复运动 ; 进入气缸的入口; 用于控制通过入口的流动的单向入口阀（17）; 来自气缸的出口并通向分配管; 以及控制通过所述出口的流量的出口阀（27），其中所述活塞被布置成选择性地接触所述出口阀，以在其下行程的初始部分期间保持其打开，并且允许所述活塞关闭所述下行程的其余部分。

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