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1. 发明申请

US20060045807A1 Detection of biospecific interactions using amplified differential time domain spectroscopy signal 有权
标题翻译：使用扩增的差分时域光谱信号检测生物特异性相互作用
公开(公告)号：US20060045807A1
公开(公告)日：2006-03-02
申请号：US10515607
申请日：2003-05-22
申请人： Xi-Cheng Zhang , Samuel Mickan , Abdellah Menikh
发明人： Xi-Cheng Zhang , Samuel Mickan , Abdellah Menikh
IPC分类号： G01N21/41 , G01N33/48
CPC分类号： G01N33/54373 , G01N21/3577 , G01N21/3586
摘要： A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tethered and untethered target molecules; (3) detecting the radiation impinged on the tethered molecule to form a reference signal and the radiation impinged on the sample to form a sample signal; and (4) comparing the reference signal with the sample signal to generate a specimen signal indicative of an association between the selected tethered and target molecules. The method will detect whether a selected tethered molecule and the desired target exhibit any affinity or, in cases where the affinity is known, will detect the presence of the target molecule in a sample. Also provided is an apparatus for detecting specific associations between a tethered molecule and an untethered target molecule.
摘要翻译：一种用于检测系留分子和无束缚靶分子之间的特异性关联的方法。该方法包括：（1）选择拴系分子; （2）将THz辐射交替地撞击到束缚分子上，并且包含拴系和无束缚的靶分子的样品; （3）检测入射到束缚分子上的辐射，形成一个参考信号，射入该样本上的辐射，形成一个采样信号; 和（4）将参考信号与采样信号进行比较以产生指示所选择的系留分束和目标分子之间的关联的样本信号。该方法将检测所选择的束缚分子和所需靶标是否表现出任何亲和力，或者在已知亲和力的情况下将检测样品中目标分子的存在。还提供了一种用于检测系留分子和无束缚靶分子之间的特异性关联的装置。

2. 发明授权

US07368280B2 Detection of biospecific interactions using amplified differential time domain spectroscopy signal 有权
标题翻译：使用扩增的差分时域光谱信号检测生物特异性相互作用
公开(公告)号：US07368280B2
公开(公告)日：2008-05-06
申请号：US10515607
申请日：2003-05-22
申请人： Xi-Cheng Zhang , Samuel Peter Mickan , Abdellah Menikh
发明人： Xi-Cheng Zhang , Samuel Peter Mickan , Abdellah Menikh
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/54373 , G01N21/3577 , G01N21/3586
摘要： A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tethered and untethered target molecules; (3) detecting the radiation impinged on the tethered molecule to form a reference signal and the radiation impinged on the sample to form a sample signal; and (4) comparing the reference signal with the sample signal to generate a specimen signal indicative of an association between the selected tethered and target molecules. The method will detect whether a selected tethered molecule and the desired target exhibit any affinity or, in cases where the affinity is known, will detect the presence of the target molecule in a sample. Also provided is an apparatus for detecting specific associations between a tethered molecule and an untethered target molecule.
摘要翻译：一种用于检测系留分子和无束缚靶分子之间的特异性关联的方法。该方法包括：（1）选择拴系分子; （2）将THz辐射交替地撞击到束缚分子上，并且包含拴系和无束缚的靶分子的样品; （3）检测入射到束缚分子上的辐射，形成一个参考信号，射入该样本上的辐射，形成一个采样信号; 和（4）将参考信号与采样信号进行比较以产生指示所选择的系留分束和目标分子之间的关联的样本信号。该方法将检测所选择的束缚分子和所需靶标是否表现出任何亲和力，或者在已知亲和力的情况下将检测样品中目标分子的存在。还提供了一种用于检测系留分子和无束缚靶分子之间的特异性关联的装置。

3. 发明授权

US07608417B2 Cell electro-physiological sensor and method of manufacturing the same 有权
标题翻译：细胞电生理传感器及其制造方法
公开(公告)号：US07608417B2
公开(公告)日：2009-10-27
申请号：US11272892
申请日：2005-11-14
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
IPC分类号： C12Q1/02
CPC分类号： G01N33/48728
摘要： A cell electro-physiological sensor includes a sensor chip including a partition board having a first surface and a second surface opposite to the first surface, a member for forming a first region provided on the first surface of the partition board, and a member for forming a second region provided on the second surface of the partition board. The partition board has a through-hole provided therein, the through-hole having a first opening which opens to the first surface, a second opening which opens to the second surface, and a wall. The first region contacts the first opening of the through-hole. The first region is arranged to contain cell suspension. The atomic ratio of carbon at the first surface of the partition board is not greater than 15 atomic percent of the composition of the first surface. The cell electro-physiological sensor causes the cell to be tightly held at the first opening of the through-hole in the partition board, thereby measuring a potential of the cell efficiently.
摘要翻译：细胞电生理传感器包括传感器芯片，其包括具有第一表面和与第一表面相对的第二表面的隔板，用于形成设置在隔板的第一表面上的第一区域的构件和用于形成设置在隔板的第二表面上的第二区域。分隔板具有设置在其中的通孔，该通孔具有通向第一表面的第一开口，通向第二表面的第二开口和壁。第一区域接触通孔的第一开口。第一个区域被设置成包含细胞悬浮液。分隔板的第一表面处的碳的原子比不大于第一表面的组成的15原子％。细胞电生理传感器使细胞紧密地保持在隔板的通孔的第一开口处，从而有效地测量细胞的电位。

4. 发明申请

US20070108478A1 Cell electro-physiological sensor and method of manufacturing the same 有权
标题翻译：细胞电生理传感器及其制造方法
公开(公告)号：US20070108478A1
公开(公告)日：2007-05-17
申请号：US11272892
申请日：2005-11-14
申请人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
发明人： Masaya Nakatani , Hiroshi Ushio , Soichiro Hiraoka , Abdellah Menikh
IPC分类号： H01L23/58
CPC分类号： G01N33/48728
摘要： A cell electro-physiological sensor includes a sensor chip including a partition board having a first surface and a second surface opposite to the first surface, a member for forming a first region provided on the first surface of the partition board, and a member for forming a second region provided on the second surface of the partition board. The partition board has a through-hole provided therein, the through-hole having a first opening which opens to the first surface, a second opening which opens to the second surface, and a wall. The first region contacts the first opening of the through-hole. The first region is arranged to contain cell suspension. The atomic ratio of carbon at the first surface of the partition board is not greater than 15 atomic percent of the composition of the first surface. The cell electro-physiological sensor causes the cell to be tightly held at the first opening of the through-hole in the partition board, thereby measuring a potential of the cell efficiently.
摘要翻译：细胞电生理传感器包括传感器芯片，其包括具有第一表面和与第一表面相对的第二表面的隔板，用于形成设置在隔板的第一表面上的第一区域的构件和用于形成设置在隔板的第二表面上的第二区域。分隔板具有设置在其中的通孔，该通孔具有通向第一表面的第一开口，通向第二表面的第二开口和壁。第一区域接触通孔的第一开口。第一个区域被设置成包含细胞悬浮液。分隔板的第一表面处的碳的原子比不大于第一表面的组成的15原子％。细胞电生理传感器使细胞紧密地保持在隔板的通孔的第一开口处，从而有效地测量细胞的电位。

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