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1. 发明授权

US07368280B2 Detection of biospecific interactions using amplified differential time domain spectroscopy signal 有权
标题翻译：使用扩增的差分时域光谱信号检测生物特异性相互作用
公开(公告)号：US07368280B2
公开(公告)日：2008-05-06
申请号：US10515607
申请日：2003-05-22
申请人： Xi-Cheng Zhang , Samuel Peter Mickan , Abdellah Menikh
发明人： Xi-Cheng Zhang , Samuel Peter Mickan , Abdellah Menikh
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/54373 , G01N21/3577 , G01N21/3586
摘要： A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tethered and untethered target molecules; (3) detecting the radiation impinged on the tethered molecule to form a reference signal and the radiation impinged on the sample to form a sample signal; and (4) comparing the reference signal with the sample signal to generate a specimen signal indicative of an association between the selected tethered and target molecules. The method will detect whether a selected tethered molecule and the desired target exhibit any affinity or, in cases where the affinity is known, will detect the presence of the target molecule in a sample. Also provided is an apparatus for detecting specific associations between a tethered molecule and an untethered target molecule.
摘要翻译：一种用于检测系留分子和无束缚靶分子之间的特异性关联的方法。该方法包括：（1）选择拴系分子; （2）将THz辐射交替地撞击到束缚分子上，并且包含拴系和无束缚的靶分子的样品; （3）检测入射到束缚分子上的辐射，形成一个参考信号，射入该样本上的辐射，形成一个采样信号; 和（4）将参考信号与采样信号进行比较以产生指示所选择的系留分束和目标分子之间的关联的样本信号。该方法将检测所选择的束缚分子和所需靶标是否表现出任何亲和力，或者在已知亲和力的情况下将检测样品中目标分子的存在。还提供了一种用于检测系留分子和无束缚靶分子之间的特异性关联的装置。

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