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1. 发明授权

US08691865B2 Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers 有权
标题翻译：取代的八氢环戊二烯并[C]吡咯-4-胺作为钙通道阻断剂
公开(公告)号：US08691865B2
公开(公告)日：2014-04-08
申请号：US13114829
申请日：2011-05-24
申请人： Xenia B. Searle , Ming C. Yeung , Stanley DiDomenico , Andrew O. Stewart , Daria Darczak , Michael Schrimpf , Michael J. Rozema
发明人： Xenia B. Searle , Ming C. Yeung , Stanley DiDomenico , Andrew O. Stewart , Daria Darczak , Michael Schrimpf , Michael J. Rozema
IPC分类号： A61K31/40 , C07D209/00 , C07D209/44
CPC分类号： C07D209/52 , C07D209/02 , C07D209/44
摘要： The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

2. 发明申请

US20110281870A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS 有权
标题翻译：新的取代的OCTAHYDROCYCLOPENTA [C]吡咯烷-4-胺作为钙通道阻断剂
公开(公告)号：US20110281870A1
公开(公告)日：2011-11-17
申请号：US13114829
申请日：2011-05-24
申请人： Xenia B. Searle , Ming C. Yeung , Stanley DiDomenico , Andrew O. Stewart , Daria Darczak , Michael Schrimpf , Michael J. Rozema
发明人： Xenia B. Searle , Ming C. Yeung , Stanley DiDomenico , Andrew O. Stewart , Daria Darczak , Michael Schrimpf , Michael J. Rozema
IPC分类号： A61K31/403 , C07D209/52 , C07D401/14 , A61K31/443 , C07D401/04 , C07D417/04 , A61K31/433 , C07D417/14 , C07D495/04 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/454 , C07D413/04 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/28 , A61P25/16 , A61P13/02 , A61P13/10 , A61P11/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/06 , A61P25/30 , A61P17/00 , A61P35/00 , A61P3/10 , A61P15/08 , A61P15/00 , C07D403/12
CPC分类号： C07D209/52 , C07D209/02 , C07D209/44
摘要： The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

3. 发明申请

US20100130558A1 NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS 有权
标题翻译：新的取代的OCTAHYDROCYCLOPENTA [C]吡咯烷-4-胺作为钙通道阻断剂
公开(公告)号：US20100130558A1
公开(公告)日：2010-05-27
申请号：US12625754
申请日：2009-11-25
申请人： Andrew O. Stewart , Xenia B. Searle , Daria Darczak , Ming C. Yeung , Stanley DiDomenico, JR.
发明人： Andrew O. Stewart , Xenia B. Searle , Daria Darczak , Ming C. Yeung , Stanley DiDomenico, JR.
IPC分类号： A61K31/4439 , C07D209/02 , C07D401/12 , C07D209/52 , A61K31/403 , A61P25/00
CPC分类号： C07D209/02
摘要： The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

4. 发明授权

US08129417B2 Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers 有权
标题翻译：取代的八氢环戊二烯并[C]吡咯-4-胺作为钙通道阻断剂
公开(公告)号：US08129417B2
公开(公告)日：2012-03-06
申请号：US12625754
申请日：2009-11-25
申请人： Andrew O. Stewart , Xenia B. Searle , Daria Darczak , Ming Clinton Yeung , Stanley DiDomenico
发明人： Andrew O. Stewart , Xenia B. Searle , Daria Darczak , Ming Clinton Yeung , Stanley DiDomenico
IPC分类号： A61K31/4439 , A61K31/403 , C07D401/04 , C07D209/52
CPC分类号： C07D209/02
摘要： The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有式（I）化合物的钙通道抑制剂，其中L1，L2，R1，R2和R3如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

5. 发明授权

US06831193B2 Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors 有权
标题翻译：抑制P2X3和P2X2 / 3含有受体的三取代-N - [（1S）-1,2,3,4-四氢-1-萘基]苯甲酰胺
公开(公告)号：US06831193B2
公开(公告)日：2004-12-14
申请号：US10141989
申请日：2002-05-10
申请人： Chih-Hung Lee , Richard J. Perner , Daniel P. Larson , John R. Koenig , Arthur R. Gomtsyan , Guo Zhu Zheng , Stanley DiDomenico , Andrew O. Stewart , Erol K. Bayburt
发明人： Chih-Hung Lee , Richard J. Perner , Daniel P. Larson , John R. Koenig , Arthur R. Gomtsyan , Guo Zhu Zheng , Stanley DiDomenico , Andrew O. Stewart , Erol K. Bayburt
IPC分类号： C07C22900
CPC分类号： C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
摘要： Compounds of formula (I) are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
摘要翻译：式（I）化合物是可用于治疗疼痛，尿失禁和膀胱过度活动的新型P2X3和P2X2 / P2X3拮抗剂。

6. 发明授权

US08404719B2 Substituted piperidinylcarbonylbenzenesulfonamides as calcium channel blockers 有权
标题翻译：取代的哌啶基羰基苯磺酰胺作为钙通道阻断剂
公开(公告)号：US08404719B2
公开(公告)日：2013-03-26
申请号：US13323029
申请日：2011-12-12
申请人： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
发明人： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
IPC分类号： A61K31/445
CPC分类号： C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

7. 发明申请

US20100197693A1 NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS 有权
标题翻译：新型苯并呋喃二胺作为钙通道阻断剂
公开(公告)号：US20100197693A1
公开(公告)日：2010-08-05
申请号：US12687465
申请日：2010-01-14
申请人： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
发明人： Qingwei Zhang , Andrew O. Stewart , Zhiren Xia
IPC分类号： A61K31/4985 , C07D487/04 , C07D401/00 , A61K31/4545 , A61P25/00 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/16 , A61P9/12 , A61P11/06
CPC分类号： C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

8. 发明授权

US07235661B2 Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权
标题翻译：用于治疗性功能障碍的稠合双环芳香化合物
公开(公告)号：US07235661B2
公开(公告)日：2007-06-26
申请号：US11395807
申请日：2006-03-31
申请人： Marlon D. Cowart , Steven P. Latshaw , Sherry L. Nelson , Andrew O. Stewart
发明人： Marlon D. Cowart , Steven P. Latshaw , Sherry L. Nelson , Andrew O. Stewart
IPC分类号： C07D495/04 , C07D513/04 , A61K31/496 , A61K31/506
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1, are as described in the specification.
摘要翻译：本发明涉及式（I）化合物用于治疗性功能障碍的用途和含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B < / SUB>，如说明书中所述。

9. 发明授权

US5863946A Iminoxyderivatives of fenamates as inhibitors of prostaglandin biosynthesis 失效
标题翻译：作为前列腺素生物合成抑制剂的灭火剂的亚硝基衍生物
公开(公告)号：US5863946A
公开(公告)日：1999-01-26
申请号：US660046
申请日：1996-06-06
申请人： Clint D. W. Brooks , Richard A. Craig , Teodozyj Kolasa , Andrew O. Stewart
发明人： Clint D. W. Brooks , Richard A. Craig , Teodozyj Kolasa , Andrew O. Stewart
IPC分类号： C07C251/58 , C07D257/04 , A61K31/195
CPC分类号： C07D257/04 , C07C251/58
摘要： Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is absent or is selected from optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, optionally substituted alkenylene, and ##STR2## or R.sup.2 and A together define a saturated 5- to 8-membered optionally substituted carbocyclic or heterocyclic ring to which the group Z is attached; Z is selected from (a) hydrogen, (b) COM wherein M is selected from the group consisting of --OR.sup.5, a pharmaceutically acceptable cation, --NR.sup.7 R.sup.8, and a pharmaceutically acceptable, metabolically cleavable group, (c) --OR.sup.3, (d) tetrazolyl, (e) --CH(OR.sup.3)--CH.sub.2 OR.sup.9, (f) --CH(OR.sup.3)--CH.sub.2 --CH.sub.2 OR.sup.9, (g) --CH(OR.sup.3)--CH(OR.sup.9)--CH.sub.2 OR.sup.10, and (h) .dbd.N--OR.sup.3 ; and R.sup.1, R.sup.2, R.sup.3, R.sup.9, and R.sup.10 are independently selected from (a) hydrogen, (b) alkyl, and (c) optionally substituted phenyl, are prostaglandin biosynthesis inhibitors and are useful in the treatment of inflammatory disease states. Also disclosed are prostaglandin inhibiting compositions, a method of inhibiting prostaglandin biosynthesis in a mammal.
摘要翻译：具有式“IMAGE”的化合物或其药学上可接受的盐，其中Y选自卤素，烷基和卤代烷基; n为0,1,2或3; X不存在或是亚烷基; A不存在或选自任选取代的亚烷基，任选取代的亚环烷基，任选取代的亚环烷基，其中一个或两个碳原子被一个或两个独立地选自O，S和N的杂原子，任选取代的亚烯基取代，以及

10. 发明授权

US5843968A Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis 失效
标题翻译：对称双杂芳基甲氧基 - 苯基烷基羧酸盐作为白三烯生物合成的抑制剂
公开(公告)号：US5843968A
公开(公告)日：1998-12-01
申请号：US958301
申请日：1997-10-27
申请人： Clint D. W. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
发明人： Clint D. W. Brooks , Pramila Bhatia , Teodozyj Kolasa , Andrew O. Stewart , David E. Gunn , Richard A. Craig
IPC分类号： C07D239/26 , A61K31/4184 , A61K31/421 , A61K31/4402 , A61K31/454 , A61K31/47 , A61K31/498 , A61K31/506 , A61P37/08 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D417/14 , A61K31/38 , A61K31/405 , A61K31/42 , A61K31/425
CPC分类号： C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D277/64
摘要： Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d) --NR.sup.6 SO.sub.2 R.sup.9, (e) --NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
摘要翻译：具有下式的化合物：其中W在每次出现时相同，并且选自任选取代的喹啉基，任选取代的苯并噻唑基，任选取代的苯并恶唑基，任选取代的苯并咪唑基，任选取代的喹喔啉基，任选取代的吡啶基，任选取代的嘧啶基，取代的噻唑基; R1和R2独立地选自氢，烷基，卤代烷基，烷氧基，卤素; R3是价键或选自氢和烷基; X是价键或选自亚烷基，烯基和亚炔基; 并且Z选自（a）COM，（b）CH = NOA-COM，（c）CH2-ON = A-COM其中A选自亚烷基和亚环烷基，M选自（a）药学上可接受的代谢可裂解基团，（b）-OR6，（c）-NR7R8，（d）-NR6SO2R9，（e）-NH-四唑基，（f）甘氨酰抑制白三烯生物合成，可用于治疗过敏性和炎性疾病状态。还公开了白三烯生物合成抑制组合物和抑制白三烯生物合成的方法。

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