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1. 发明申请

US20100234345A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS 有权
标题翻译：新型化合物作为CANNABINOID受体配体
公开(公告)号：US20100234345A1
公开(公告)日：2010-09-16
申请号：US12612504
申请日：2009-11-04
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/397 , C07D275/03 , A61K31/425 , C07D275/04 , A61K31/428 , C07D413/02 , A61K31/5377 , C07D277/02 , A61K31/426 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/437 , C07D215/00 , A61K31/4709 , C07D417/02 , A61K31/454 , A61K31/497 , A61P29/00 , A61P25/00 , A61P35/00 , A61P37/00 , A61P11/00 , A61P9/00
CPC分类号： C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

2. 发明申请

US20100093814A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF 有权
标题翻译：新化合物作为CANNABINOID受体配体及其用途
公开(公告)号：US20100093814A1
公开(公告)日：2010-04-15
申请号：US12274105
申请日：2008-11-19
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , C07D277/28 , A61P25/00
CPC分类号： C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法使用这些化合物和组合物治疗病症和病症。本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a，R x和n如说明书中所定义，包含这些化合物的组合物和方法使用这些化合物和组合物治疗病症和病症。

3. 发明授权

US07528134B2 Acetamides and benzamides that are useful in treating sexual dysfunction 有权
标题翻译：可用于治疗性功能障碍的乙酰胺和苯甲酰胺
公开(公告)号：US07528134B2
公开(公告)日：2009-05-05
申请号：US10444687
申请日：2003-05-23
申请人： Pramila A. Bhatia , Jerome F. Daanen , Ahmed A. Hakeem , Teodozyj Kolasa , Mark A. Matulenko , Kathleen H. Mortell , Meena V. Patel , Andrew O. Stewart , Xueqing Wang , Zhiren Xia , Henry Q. Zhang
发明人： Pramila A. Bhatia , Jerome F. Daanen , Ahmed A. Hakeem , Teodozyj Kolasa , Mark A. Matulenko , Kathleen H. Mortell , Meena V. Patel , Andrew O. Stewart , Xueqing Wang , Zhiren Xia , Henry Q. Zhang
IPC分类号： A61K31/501 , A61K31/497
CPC分类号： C07D213/82 , A61K31/40 , A61K31/41 , A61K31/445 , A61K31/4453 , A61K31/4523 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D213/74 , C07D213/85 , C07D235/30 , C07D239/42 , C07D277/38 , C07D277/82 , C07D295/13 , C07D295/15 , C07D295/155 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要翻译：本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。

4. 发明申请

US20090105306A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS 有权
标题翻译：新化合物作为CANNABINOID受体配体
公开(公告)号：US20090105306A1
公开(公告)日：2009-04-23
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： A61K31/433 , C07D417/02 , C07D285/12 , C07D405/02 , C07D413/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61K31/443 , A61K31/422 , A61K31/4155
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译：本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

5. 发明申请

US20090023789A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS 有权
标题翻译：新型化合物作为CANNABINOID受体配体
公开(公告)号：US20090023789A1
公开(公告)日：2009-01-22
申请号：US12100731
申请日：2008-04-10
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/425 , C07D275/02 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00
CPC分类号： A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

6. 发明申请

US20060189639A1 Antagonists of the mGlu receptor and uses thereof 审中-公开
标题翻译： mGlu受体的拮抗剂及其用途
公开(公告)号：US20060189639A1
公开(公告)日：2006-08-24
申请号：US11333035
申请日：2006-01-17
申请人： Andrew Stewart , Guo Zheng , Teodozyj Kolasa , Pramila Bhatia , Jerome Daanen , Steven Latshaw , Xueqing Wang
发明人： Andrew Stewart , Guo Zheng , Teodozyj Kolasa , Pramila Bhatia , Jerome Daanen , Steven Latshaw , Xueqing Wang
IPC分类号： A61K31/519 , C07D498/14
CPC分类号： C07D493/14 , C07D495/14
摘要： The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.
摘要翻译：本发明公开了通式（I）的化合物，其中X 1 -X 4 -X 3和R 1 -R 3 >如说明书中所定义。本发明还公开了在有需要的宿主哺乳动物中治疗疼痛，神经变性和惊厥状态的方法，以及包括那些化合物的药物组合物。

7. 发明授权

US07022728B2 Benzimidazoles that are useful in treating male sexual dysfunction 有权
标题翻译：苯并咪唑可用于治疗男性性功能障碍
公开(公告)号：US07022728B2
公开(公告)日：2006-04-04
申请号：US10094265
申请日：2002-03-08
申请人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
发明人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde
IPC分类号： A61K31/415 , A61K31/495 , A61K31/50
CPC分类号： A61K31/496
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
摘要翻译：本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途。

8. 发明授权

US06960589B2 Benzimidazoles that are useful in treating sexual dysfunction 有权
标题翻译：可用于治疗性功能障碍的苯并咪唑
公开(公告)号：US06960589B2
公开(公告)日：2005-11-01
申请号：US10236812
申请日：2002-09-06
申请人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde , Kenneth M. Engstrom
发明人： Marlon D. Cowart , Pramila A. Bhatia , Jerome F. Daanen , Andrew O. Stewart , Meena V. Patel , Teodozyj Kolasa , Jorge D. Brioni , Jeffrey Rohde , Kenneth M. Engstrom
IPC分类号： A61K31/496 , C07D401/12 , C07D403/12 , A61P15/00
CPC分类号： C07D401/12 , A61K31/496 , C07D403/12
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein L is C1-4 alkyl; RA, RB, RC, RD, and RE, are as described in the specification; Z is selected from the group consisting of N, C and CH; and A is aryl and heteroaryl as described in the specification.
摘要翻译：本发明涉及式（I）化合物用于治疗性功能障碍的用途，以及含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中L为C 1-4 烷基; R A，R B，R C，R D和R E，，如说明书所述; Z选自N，C和CH; 并且A是如说明书中所述的芳基和杂芳基。

9. 发明授权

US06323231B1 Use of &agr;1A adrenoceptor agonists with &agr;1B and &agr;1D antagonism for the treatment of stress urinary incontinence 失效
标题翻译：使用α1A肾上腺素能受体激动剂与α1B和α1D拮抗剂治疗压力性尿失禁
公开(公告)号：US06323231B1
公开(公告)日：2001-11-27
申请号：US09788198
申请日：2001-02-16
申请人： Jorge D. Brioni , Michael E. Brune , Steven A. Buckner , Teodozyj Kolasa , James P. Sullivan
发明人： Jorge D. Brioni , Michael E. Brune , Steven A. Buckner , Teodozyj Kolasa , James P. Sullivan
IPC分类号： A61K31415
CPC分类号： A61K31/4174 , A61K31/00
摘要： The following disclosure relates to a method of treating incontinence with a compound having a specific &agr;1A adrenoceptor profile.
摘要翻译：以下公开内容涉及用具有特定α1A肾上腺素受体概况的化合物治疗失禁的方法。

10. 发明授权

US5750558A Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis 失效
标题翻译：吲哚和茚化合物的肟衍生物作为前列腺素生物合成的抑制剂
公开(公告)号：US5750558A
公开(公告)日：1998-05-12
申请号：US660048
申请日：1996-06-06
申请人： Clint D. W. Brooks , Teodozyj Kolasa , Wendy Lee , Andrew O. Stewart
发明人： Clint D. W. Brooks , Teodozyj Kolasa , Wendy Lee , Andrew O. Stewart
IPC分类号： C07C317/32 , C07D209/14 , C07D257/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D417/14 , A61K31/40
CPC分类号： C07D257/04 , C07C317/32 , C07D209/14 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D417/14 , C07C2102/08
摘要： Described herein are compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein L is selected from the group consisting of ##STR2## R.sup.2 is selected from (a) ##STR3## R.sup.3 is selected from optionally substituted phenyl, and optionally substituted pyridyl; Y is selected from halogen, alkyl, haloalkyl, alkoxy, pyridylmethoxy, thiazolylmethoxy, benzothiazolylmethoxy, quinolylmethoxy, and optionally substituted quinolylmethoxy; W is selected from hydrogen, alkyl, hydroxyalkyl, and hydroxy; A is absent or is selected from optionally substituted alkylene optionally substituted cycloalkylene, optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, and ##STR4## and X is absent or is alkylene; Z is selected from (a) hydrogen, (b) COM wherein M is selected from (b-1) a pharmaceutically acceptable metabolically cleavable group, (b-2)--OR.sup.10,(b-3)--O(CH.sub.2).sub.w --CH(OR.sup.12)--CH.sub.2 OR.sup.13, and (b-4)--NR.sup.15 R.sup.16 (c)--OR.sup.17, (d) tetrazolyl, (e)--CH(OR.sup.17)--CH.sub.2 OR.sup.18,(f)--CH(OR.sup.17)--CH.sub.2 --CH.sub.2 OR.sup.18, (g)--CH(OR.sup.17)--CH(OR.sup.18)--CH.sub.2 OR.sup.19, and (h).dbd.N--OR.sup.17 ; and R.sup.1 and R.sup.4 selected from (a) hydrogen, (b) alkyl, and (c) optionally substituted phenyl, are prostaglandin biosynthesis inhibitors and are useful in the treatment of inflammatory disease states. Also disclosed are prostaglandin inhibiting compositions, and a method of inhibiting prostaglandin biosynthesis in a mammal.
摘要翻译：本文描述的是具有式“IMAGE”的化合物或其药学上可接受的盐，其中L选自由下列组成的组：R 2选自（a）图像（b）图像（c）（d）R 3选自任选取代的苯基和任选取代的吡啶基; Y选自卤素，烷基，卤代烷基，烷氧基，吡啶基甲氧基，噻唑基甲氧基，苯并噻唑基甲氧基，喹啉基甲氧基和任选取代的喹啉基甲氧基; W选自氢，烷基，羟基烷基和羟基; A不存在或选自任选取代的亚烷基任选取代的亚环烷基，任选取代的亚环烷基，其中一个或两个碳原子被一个或两个独立地选自O，S和N的杂原子替代，并且X不存在或者是亚烷基; Z选自（a）氢，（b）COM，其中M选自（b-1）可药用代谢裂解基团，（b-2）-OR10，（b-3）-O（CH2）w- CH（OR 12）-CH 2 OR 13和（b-4）-NR 15 R 16（c）-OR 17，（d）四唑基，（e）-CH（OR 17）-CH 2 OR 18，（f）-CH（OR 17）（g）-CH（OR 17）-CH（OR 18）-CH 2 OR 19，和（h）= N-OR 17; 并且选自（a）氢，（b）烷基和（c）任选取代的苯基的R 1和R 4是前列腺素生物合成抑制剂，并且可用于治疗炎性疾病状态。还公开了前列腺素抑制组合物和抑制哺乳动物中前列腺素生物合成的方法。

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