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1. 发明申请

US20070003970A1 PAK 2: modulators of lymphocyte activation 审中-公开
标题翻译： PAK 2：淋巴细胞活化的调节剂
公开(公告)号：US20070003970A1
公开(公告)日：2007-01-04
申请号：US11512788
申请日：2006-08-29
申请人： X. Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
发明人： X. Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
IPC分类号： C12Q1/68 , G01N33/567 , A61K48/00
CPC分类号： C12N9/1205 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/56972
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码PAK2的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节PAK2调节淋巴细胞活化的试剂，包括小有机分子，肽，环肽，抗体，脂质，反义核酸和核酶的方法; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

2. 发明授权

US07118854B2 PAK2: modulators of lymphocyte activation 有权
标题翻译： PAK2：淋巴细胞活化调节剂
公开(公告)号：US07118854B2
公开(公告)日：2006-10-10
申请号：US09967624
申请日：2001-09-28
申请人： X. Charlene Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
发明人： X. Charlene Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
IPC分类号： C12Q1/70 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/56972
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码PAK2的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节PAK2调节淋巴细胞活化的试剂，包括小有机分子，肽，环肽，抗体，脂质，反义核酸和核酶的方法; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

3. 发明申请

US20080260719A1 EDG: Modulators of lymphocyte activation and migration 审中-公开
标题翻译： EDG：淋巴细胞激活和迁移的调节剂
公开(公告)号：US20080260719A1
公开(公告)日：2008-10-23
申请号：US11636370
申请日：2006-12-06
申请人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
发明人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
IPC分类号： A61K39/395 , C12Q1/02 , A61K31/164 , A61K38/16 , C40B30/06 , A61P37/00
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
摘要翻译：本发明涉及淋巴细胞活化和迁移的调控。更具体地，本发明涉及编码EDG家族GPCR蛋白质的核酸，例如参与调节淋巴细胞活化和迁移的EDG-1,2,3,4,5,6,7或8。本发明还涉及用于鉴定和使用通过调节EDG GPCR和EDG来调节淋巴细胞活化或迁移的包括小有机分子，抗体，肽，环肽，核酸，反义核酸，鞘脂类似物和核酶的试剂的方法相关信号转导; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。

4. 发明授权

US07521192B2 EDG: modulators of lymphocyte activation and migration 失效
公开(公告)号：US07521192B2
公开(公告)日：2009-04-21
申请号：US09971228
申请日：2001-10-03
申请人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
发明人： X. Charlene Liao , Esteban Masuda , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Ying-Ping Jiang , Collin Spencer
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.

5. 发明申请

US20050130117A1 Modulators of lymphocyte activation and migration 审中-公开
标题翻译：淋巴细胞激活和迁移的调节剂
公开(公告)号：US20050130117A1
公开(公告)日：2005-06-16
申请号：US10491545
申请日：2002-10-02
申请人： Cong Davis , X. Liao , Esteban Masuda , Jorge Pardo , Haoran Zhao
发明人： Cong Davis , X. Liao , Esteban Masuda , Jorge Pardo , Haoran Zhao
IPC分类号： C12N15/85 , C12Q1/00 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/505 , G01N2500/00
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLCγ1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-Rα, integrinα2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A α, centractin α, moesin, TIMP3, and RNH. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, siRNA, and ribozymes, that modulate lymphocyte activation or migration; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
摘要翻译：本发明涉及淋巴细胞活化和迁移的调节。更具体地，本发明涉及编码图1中所列的核酸和蛋白质的核酸。 7，其涉及淋巴细胞活化和迁移的调节，例如A-raf-1，Lck，Zap70，Syk，PLCgamma1，PAG，SHP / PTP1C，CSK，核仁素，SLAP，PAK2，TRAC1，TCPTP / PTPN2，EDG1 ，IL10-Ralpha，integrinalpha2，烯醇化酶1a，PRSM1，CLN2，P2X5b，6PFKL，DUSP1，KIAA0251，GG2-1，GRB7，SH2-B，STAT1，TCF19，HFP101S，RERE，SudD，Ku70，SCAMP2，Fibulin-5， KIAA1228，来自克隆2108068的Est，波形蛋白，丝氨酸Aα，分心α，莫辛，TIMP3和RNH。本发明还涉及用于鉴定和使用调节淋巴细胞活化或迁移的试剂（包括小有机分子，抗体，肽，环肽，核酸，反义核酸，siRNA和核酶）的方法; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。

6. 发明授权

US4655018A Roof paver element and system 失效
标题翻译：屋顶摊铺机元件和系统
公开(公告)号：US4655018A
公开(公告)日：1987-04-07
申请号：US696710
申请日：1985-01-31
申请人： Jorge Pardo
发明人： Jorge Pardo
IPC分类号： E04D3/04 , E04D11/00 , E04D13/04 , E04B1/70
CPC分类号： E04D13/0477 , E04D11/00 , E04D3/04 , Y10T403/559
摘要： A roof paver system includes a plurality of roof paver elements having alternating dovetail-shaped and tapered grooves and an upper surface having raised portions to generate vortexes for preventing wind from lifting the elements and to provide a safety tread. Connecting members are provided in some of the dovetail grooves to interconnect the roof paver elements and further prevent their displacement. The tapered grooves break the vacuum between the roof paver elements and the molds in which they are formed. Clips are provided to mate with outwardly projecting toes on the roof paver elements in perimeter courses to align and anchor them, and elongate battens, which are dovetail-shaped in cross section, are received in the dovetail grooves and include openings for receiving thin elements transverse to the battens to engage the concrete elements at the ends of the grooves.
摘要翻译：屋顶摊铺机系统包括具有交替的燕尾形和锥形槽的多个屋顶摊铺机元件和具有凸起部分的上表面，以产生用于防止风抬起元件并提供安全胎面的涡流。连接构件设置在一些燕尾槽中以互连屋顶摊铺单元并进一步防止其移动。锥形槽破坏屋顶摊铺机元件与其形成的模具之间的真空。提供夹子以在周边路线上与屋顶摊铺机元件上的向外突出的脚趾配合以对准和锚定它们，并且横截面为燕尾形的细长条状物被容纳在燕尾槽中，并且包括用于接收薄元件的开口以将混凝土元件接合在槽的端部。

7. 发明授权

US4909970A Biaxial concrete masonry casting method 失效
标题翻译：双轴混凝土砌筑施工方法
公开(公告)号：US4909970A
公开(公告)日：1990-03-20
申请号：US298342
申请日：1989-01-17
申请人： Jorge Pardo
发明人： Jorge Pardo
IPC分类号： B28B7/18 , B28B7/30 , E04B2/42
CPC分类号： B28B7/183 , B28B7/303 , E04B2/42
摘要： Methods for biaxially (or triaxially) casting concrete masonry ("CM") products like CM blocks which have twin cavities formed by a pair of face shells and three webs interconnecting same with the twin cavities extending in the direction of the axis of casting of the CM block include using in the mold cavity one or more main mold cores which incorporate structure for extending and retracting a plunger or the like to provide one or more temporary mold cores laterally extending into the mold cavity from one or more main mold cores along a second axis which is normal to the axis of casting during certain selected phases of the CM casting process so as to form openings extending through one or more webs in the direction of the second axis.
摘要翻译：双轴（或三轴）铸造混凝土砌体（“CM”）产品的方法，如具有由一对面罩形成的双腔的CM块，以及与沿着铸造轴线的轴线方向延伸的双腔相连的三个腹板 CM块包括在模腔中使用一个或多个主模芯，其包括用于延伸和缩回柱塞等的结构，以提供从一个或多个主模芯沿着第二个侧向延伸到模腔中的一个或多个临时模芯轴，其在CM铸造工艺的某些选定阶段期间垂直于铸造轴线，以便形成沿着第二轴线的方向延伸穿过一个或多个腹板的开口。

8. 发明授权

US4909717A Biaxial concrete masonry casting apparatus 失效
公开(公告)号：US4909717A
公开(公告)日：1990-03-20
申请号：US336548
申请日：1989-04-10
申请人： Jorge Pardo
发明人： Jorge Pardo
IPC分类号： B28B7/18 , B28B7/30 , E04B2/42
CPC分类号： E04B2/42 , B28B7/183 , B28B7/303
摘要： The biaxial CM casting apparatus utilizes one or more main mold cores having an automatically extensible and retractable plunger or like structure extending laterally into the mold cavity from the one or more main mold cores along an axis substantially orthogonal to the axis of casting during certain selected phases of the CM casting process to form one or more openings or other structural changes in the casted concrete which openings or changes extend in the direction of a second axis normal to the casting axis.

9. 发明授权

US06397555B1 Interlocking blocks of precise height 有权
标题翻译：具有精确高度的联锁块
公开(公告)号：US06397555B1
公开(公告)日：2002-06-04
申请号：US09521216
申请日：2000-03-08
申请人： Jorge Pardo
发明人： Jorge Pardo
IPC分类号： E04B104
CPC分类号： B28B7/00 , E04B2/18 , E04B2/24 , E04B2002/0206 , Y10S264/64
摘要： An interlocking block for constructing walls without mortar at bed joints includes an inner wall, an outer wall, and a web arrangement connecting the walls, wherein upper and lower surfaces of the block when in use are formed in contact with walls of a mold, and the block is slipped from the mold in a direction parallel to the mold walls. Interlocking recesses and ridges are formed in one piece with the walls of the block. The web is minimal in cross-sectional area and is positioned at one end of the block and between the top and bottom to create large empty volumes defining vertical and horizontal passages. The block can include one or more intermediate walls parallel to the inner and outer walls and additional webs to connect the intermediate walls to the inner and outer walls.
摘要翻译：用于在床接头处构造没有灰浆的墙壁的互锁块包括内壁，外壁和连接壁的腹板布置，其中在使用中的块的上表面和下表面形成为与模具的壁接触，以及该块从模具沿与模具壁平行的方向滑动。联锁凹槽和脊与块的壁形成一体。纤维网的横截面积最小，并且位于块体的一端并且在顶部和底部之间，以产生限定垂直和水平通道的大的空体积。该块可以包括平行于内壁和外壁的一个或多个中间壁和用于将中间壁连接到内壁和外壁的附加腹板。

10. 发明授权

US5274968A Building block for use with flashing and arrangement for weeping condensation 失效
标题翻译：用于闪烁和布置用于哭泣冷凝的构件
公开(公告)号：US5274968A
公开(公告)日：1994-01-04
申请号：US881601
申请日：1992-05-15
申请人： Jorge Pardo
发明人： Jorge Pardo
IPC分类号： E04B1/64 , E04B1/70 , E04C1/39 , E04D13/14
CPC分类号： E04B1/703 , E04B1/644 , E04B1/7053 , E04C1/39 , E04C1/392 , E04D13/1415 , E04D2013/1422
摘要： A construction unit includes weep openings through a front wall, side walls, and a center web, and at least one slot extending parallel to a rear wall to receive a flashing member, the slot being defined at least partially by the rear wall. An insert member having an insect screen is positioned in each of the weep openings of the front wall.
摘要翻译：施工单元包括通过前壁，侧壁和中心腹板的阻塞开口，以及至少一个平行于后壁延伸以容纳闪光构件的槽，该槽至少部分地由后壁限定。具有昆虫屏幕的插入构件定位在前壁的每个下流开口中。

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