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    • 3. 发明申请
    • Modulators of lymphocyte activation and migration
    • 淋巴细胞激活和迁移的调节剂
    • US20050130117A1
    • 2005-06-16
    • US10491545
    • 2002-10-02
    • Cong DavisX. LiaoEsteban MasudaJorge PardoHaoran Zhao
    • Cong DavisX. LiaoEsteban MasudaJorge PardoHaoran Zhao
    • C12N15/85C12Q1/00C12Q1/68G01N33/50
    • G01N33/505G01N2500/00
    • The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLCγ1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-Rα, integrinα2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A α, centractin α, moesin, TIMP3, and RNH. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, siRNA, and ribozymes, that modulate lymphocyte activation or migration; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
    • 本发明涉及淋巴细胞活化和迁移的调节。 更具体地,本发明涉及编码图1中所列的核酸和蛋白质的核酸。 7,其涉及淋巴细胞活化和迁移的调节,例如A-raf-1,Lck,Zap70,Syk,PLCgamma1,PAG,SHP / PTP1C,CSK,核仁素,SLAP,PAK2,TRAC1,TCPTP / PTPN2,EDG1 ,IL10-Ralpha,integrinalpha2,烯醇化酶1a,PRSM1,CLN2,P2X5b,6PFKL,DUSP1,KIAA0251,GG2-1,GRB7,SH2-B,STAT1,TCF19,HFP101S,RERE,SudD,Ku70,SCAMP2,Fibulin-5, KIAA1228,来自克隆2108068的Est,波形蛋白,丝氨酸Aα,分心α,莫辛,TIMP3和RNH。 本发明还涉及用于鉴定和使用调节淋巴细胞活化或迁移的试剂(包括小有机分子,抗体,肽,环肽,核酸,反义核酸,siRNA和核酶)的方法; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。