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1. 发明申请

US20070003970A1 PAK 2: modulators of lymphocyte activation 审中-公开
标题翻译： PAK 2：淋巴细胞活化的调节剂
公开(公告)号：US20070003970A1
公开(公告)日：2007-01-04
申请号：US11512788
申请日：2006-08-29
申请人： X. Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
发明人： X. Liao , Peter Chu , Jorge Pardo , Congfen Li , Haoran Zhao , Jun Wu
IPC分类号： C12Q1/68 , G01N33/567 , A61K48/00
CPC分类号： C12N9/1205 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/56972
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码PAK2的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节PAK2调节淋巴细胞活化的试剂，包括小有机分子，肽，环肽，抗体，脂质，反义核酸和核酶的方法; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

2. 发明授权

US06645246B1 Intraocular lens with surrounded lens zone 有权
标题翻译：带镜头区的人工晶状体
公开(公告)号：US06645246B1
公开(公告)日：2003-11-11
申请号：US09657325
申请日：2000-09-07
申请人： Joseph I. Weinschenk, III , Charles X. Liao , Massoud Ghazizadeh
发明人： Joseph I. Weinschenk, III , Charles X. Liao , Massoud Ghazizadeh
IPC分类号： A61F216
CPC分类号： A61F2/1629 , A61F2/1613 , A61F2/1648 , A61F2250/0053
摘要： An intraocular lens for use in a mammalian eye includes an optic adapted to focus light toward a retina of the mammalian eye and, in cooperation with the mammalian eye, to provide accommodation, the optic including a first portion adapted to move in response to the action of the mammalian eye; and a second portion surrounded by the first portion, and having a higher index of refraction than the first portion and/or being less deformable than the first portion in response to forces exerted by the mammalian eye.
摘要翻译：用于哺乳动物眼睛的人工晶状体包括适于将光聚焦到哺乳动物眼睛的视网膜的光学器件，并且与哺乳动物眼睛协作以提供适应，所述光学元件包括适于响应于动作移动的第一部分的哺乳动物眼睛; 以及第二部分，其被第一部分包围，并且响应于哺乳动物眼睛施加的力，具有比第一部分更高的折射率和/或比第一部分更小的可变形性。

3. 发明申请

US20050130117A1 Modulators of lymphocyte activation and migration 审中-公开
标题翻译：淋巴细胞激活和迁移的调节剂
公开(公告)号：US20050130117A1
公开(公告)日：2005-06-16
申请号：US10491545
申请日：2002-10-02
申请人： Cong Davis , X. Liao , Esteban Masuda , Jorge Pardo , Haoran Zhao
发明人： Cong Davis , X. Liao , Esteban Masuda , Jorge Pardo , Haoran Zhao
IPC分类号： C12N15/85 , C12Q1/00 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/505 , G01N2500/00
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLCγ1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-Rα, integrinα2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A α, centractin α, moesin, TIMP3, and RNH. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, siRNA, and ribozymes, that modulate lymphocyte activation or migration; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
摘要翻译：本发明涉及淋巴细胞活化和迁移的调节。更具体地，本发明涉及编码图1中所列的核酸和蛋白质的核酸。 7，其涉及淋巴细胞活化和迁移的调节，例如A-raf-1，Lck，Zap70，Syk，PLCgamma1，PAG，SHP / PTP1C，CSK，核仁素，SLAP，PAK2，TRAC1，TCPTP / PTPN2，EDG1 ，IL10-Ralpha，integrinalpha2，烯醇化酶1a，PRSM1，CLN2，P2X5b，6PFKL，DUSP1，KIAA0251，GG2-1，GRB7，SH2-B，STAT1，TCF19，HFP101S，RERE，SudD，Ku70，SCAMP2，Fibulin-5， KIAA1228，来自克隆2108068的Est，波形蛋白，丝氨酸Aα，分心α，莫辛，TIMP3和RNH。本发明还涉及用于鉴定和使用调节淋巴细胞活化或迁移的试剂（包括小有机分子，抗体，肽，环肽，核酸，反义核酸，siRNA和核酶）的方法; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。

4. 发明授权

US06599317B1 Intraocular lens with a translational zone 有权
标题翻译：具有平移区的人工晶状体
公开(公告)号：US06599317B1
公开(公告)日：2003-07-29
申请号：US09657251
申请日：2000-09-07
申请人： Joseph I. Weinschenk, III , Charles X. Liao , Massoud Ghazizadeh
发明人： Joseph I. Weinschenk, III , Charles X. Liao , Massoud Ghazizadeh
IPC分类号： A61F216
CPC分类号： B29D11/026 , A61F2/1613 , A61F2/1629 , A61F2/1648 , A61F2250/0053 , A61L27/16 , A61L2430/16 , C08L33/16
摘要： An intraocular lens (IOL) for use in a mammalian eye includes an optic adapted to focus light toward a retina of the mammalian eye and, in cooperation with the mammalian eye, to provide accommodation, the optic including a first portion adapted to move in response to the action of the mammalian eye; and a second portion secured to the first portion and having a higher index of refraction than the first portion and/or being positioned generally anterior of the first portion.
摘要翻译：用于哺乳动物眼睛的眼内透镜（IOL）包括适于将光聚焦到哺乳动物眼睛的视网膜的光学器件，并且与哺乳动物眼睛协作以提供适应，该光学元件包括适于响应于移动的第一部分对哺乳动物眼睛的作用; 以及固定到第一部分并且具有比第一部分更高的折射率和/或大体位于第一部分前方的第二部分。

5. 发明申请

US20060147978A1 Methods and compositions for screening for altered cellular phenotypes 审中-公开
公开(公告)号：US20060147978A1
公开(公告)日：2006-07-06
申请号：US11361631
申请日：2006-02-24
申请人： James Lorens , Todd Kinsella , Esteban Masuda , Yasumichi Hitoshi , X. Liao , Denise Pearsall , Annabelle Friera , Peter Chu
发明人： James Lorens , Todd Kinsella , Esteban Masuda , Yasumichi Hitoshi , X. Liao , Denise Pearsall , Annabelle Friera , Peter Chu
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： C12N15/1079 , C07K14/70578 , C07K2319/00 , C12N15/63 , C12N2510/00 , C12Q1/6897 , G01N33/5008 , G01N33/5023 , G01N33/5047 , G01N2500/10
摘要： The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more particularly, relates to screening libraries of candidate bioactive agents, for example, nucleic acids and peptides, in cells using an regulatable expression system to enrich for a subpopulation of cells having an altered phenotype due to the presence of a candidate bioactive agent.

6. 发明申请

US20050170434A1 Modulators of lymphocyte activation, mkk3b compositions and methods of use 有权
标题翻译：淋巴细胞活化调节剂，mkk3b组成和使用方法
公开(公告)号：US20050170434A1
公开(公告)日：2005-08-04
申请号：US10495901
申请日：2002-11-18
申请人： Alan Fu , Jun Wu , X. Liao , Helena Mancebo
发明人： Alan Fu , Jun Wu , X. Liao , Helena Mancebo
IPC分类号： A61K38/00 , A61K48/00 , C07K16/40 , C12N9/12 , C12Q1/48 , G01N33/50 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/485 , A61K38/00 , A61K48/00 , C07K16/40 , C12N9/1205 , G01N33/5047 , G01N33/505 , G01N33/5052
摘要： The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating lymphocyte activation.
摘要翻译：本发明提供用于调节淋巴细胞活化的组合物和方法。提供编码能够调节淋巴细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与淋巴细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节淋巴细胞活化的生物活性剂的测定法。

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