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1. 发明授权

US07569375B2 Alcohol dehydrogenases with increased solvent and temperature stability 有权
标题翻译：醇脱氢酶具有增加的溶剂和温度稳定性
公开(公告)号：US07569375B2
公开(公告)日：2009-08-04
申请号：US10666205
申请日：2003-09-18
申请人： Wolfgang Stampfer , Birgit Kosjek , Wolfgang Kroutil , Kurt Faber , Jürgen Eck , Frank Niehaus
发明人： Wolfgang Stampfer , Birgit Kosjek , Wolfgang Kroutil , Kurt Faber , Jürgen Eck , Frank Niehaus
IPC分类号： C12N9/04 , C12N15/00 , C12P21/04 , C12N1/20 , C12Q1/00 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/0006 , C12P7/04 , C12P41/002
摘要： The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.
摘要翻译：本发明涉及显示可从红球菌获得的醇脱氢酶活性的生物催化剂，它们的制备，它们在仲醇氧化中的用途和/或还原酮，以及编码这些醇脱氢酶的核酸和用编码的核酸转化的微生物这些生物催化剂及其用于生产生物催化剂或氧化仲醇和/或还原酮的用途。

2. 发明申请

US20090221046A1 BIOCATALYTIC RACEMISATION OF ALPHA-HYDROXYKETONES 有权
标题翻译： ALPHA-羟基酮的生物化学结构
公开(公告)号：US20090221046A1
公开(公告)日：2009-09-03
申请号：US12278464
申请日：2007-01-31
申请人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
发明人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemisation of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译：通过在乳杆菌的乙酰丁酰消旋酶存在下温育所述α-羟基酮来使光学活性的α-羟基酮消旋化的方法。

3. 发明授权

US08153408B2 Biocatalytic racemisation of alpha-hydroxyketones 有权
标题翻译： α-羟基酮的生物催化外消旋化
公开(公告)号：US08153408B2
公开(公告)日：2012-04-10
申请号：US12278464
申请日：2007-01-31
申请人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
发明人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译：通过在乳杆菌的乙偶姻消旋酶存在下温育所述α-羟基酮来使光学活性α-羟基酮外消旋化的方法。

4. 发明申请

US20090098623A1 PROCESS FOR THE RACEMIZATION OF OPTICALLY ACTIVE SECONDARY ALCOHOLS WITH THE USE OF ALCOHOL DEHYDROGENASE 有权
标题翻译：使用酒精脱氢酶的光活性二级醇的研制方法
公开(公告)号：US20090098623A1
公开(公告)日：2009-04-16
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P7/04
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译：通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。类。

5. 发明授权

US07795004B2 Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases 有权
标题翻译：使用两种醇脱氢酶使光学活性仲醇外消旋化的方法
公开(公告)号：US07795004B2
公开(公告)日：2010-09-14
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P41/00
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译：通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。类。

6. 发明申请

US20150111254A1 METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE 有权
标题翻译：用于生产亚麻酸的方法或使用阿兰生产的化合物
公开(公告)号：US20150111254A1
公开(公告)日：2015-04-23
申请号：US14390133
申请日：2013-03-25
申请人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
发明人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
IPC分类号： C12P13/06
CPC分类号： C12P13/06 , C12P13/005
摘要： The problem addressed by the invention is solved in a first aspect by a method for producing alanine or a compound produced using alanine, having the steps of (a) providing a cell which expresses a recombinant alanine dehydrogenase or a variant thereof, (b) cultivating the cell under aerobic conditions in the presence of an inorganic nitrogen source in an aqueous phase, and (c) bringing the cell into contact with an organic phase, said cell being a prokaryotic or a lower eukaryotic cell.
摘要翻译：本发明解决的问题在第一方面通过一种制备丙氨酸或使用丙氨酸生产的化合物的方法来解决，该方法具有以下步骤：（a）提供表达重组丙氨酸脱氢酶的细胞或其变体，（b）培养在有氧条件下在无水氮源存在下在水相中，和（c）使细胞与有机相接触，所述细胞是原核或低等真核细胞。

7. 发明授权

US09273291B2 Enzymatic alkene cleavage 有权
标题翻译：酶切烯烃裂解
公开(公告)号：US09273291B2
公开(公告)日：2016-03-01
申请号：US14241210
申请日：2012-08-09
申请人： Aashrita Rajagopalan , Wolfgang Kroutil , Markus Schober
发明人： Aashrita Rajagopalan , Wolfgang Kroutil , Markus Schober
IPC分类号： C12P7/24 , C12N9/02 , C07H21/04
CPC分类号： C12N9/0073 , C12N9/0069 , C12P7/24 , C12Y114/13069
摘要： The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.
摘要翻译：本发明涉及一种酶，其包含或包含根据SEQ ID NO： ID号1或SEQ。 ID No.2，其制备方法及其在乙烯基芳族化合物的氧化裂解中作为催化剂的用途。

8. 发明申请

US20150064756A1 ENZYMATIC ALKENE CLEAVAGE 有权
公开(公告)号：US20150064756A1
公开(公告)日：2015-03-05
申请号：US14241210
申请日：2012-08-09
申请人： Aashrita Rajagopalan , Wolfgang Kroutil , Markus Schober
发明人： Aashrita Rajagopalan , Wolfgang Kroutil , Markus Schober
IPC分类号： C12N9/02 , C12P7/24
CPC分类号： C12N9/0073 , C12N9/0069 , C12P7/24 , C12Y114/13069
摘要： The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.
摘要翻译：本发明涉及一种酶，其包含或包含根据SEQ ID NO： ID号1或SEQ。 ID No.2，其制备方法及其在乙烯基芳族化合物的氧化裂解中作为催化剂的用途。

9. 发明申请

US20110070630A1 METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES 审中-公开
标题翻译：促进剂混合物的制备方法
公开(公告)号：US20110070630A1
公开(公告)日：2011-03-24
申请号：US12866612
申请日：2009-03-26
申请人： Christian Gruber , Wolfgang Kroutil , Constance Voss , Jan Pfeffer , Uwe Dingerdissen
发明人： Christian Gruber , Wolfgang Kroutil , Constance Voss , Jan Pfeffer , Uwe Dingerdissen
IPC分类号： C12P41/00
CPC分类号： C12P41/002 , C12N9/0006 , C12P7/02
摘要： The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors.
摘要翻译：本发明涉及通过立体选择性醇脱氢酶及其辅因子通过氧化和还原反应的组合将仲醇的对映异构体混合物酶促脱水化的方法，其中光学活性仲醇的一种对映异构体具有形式上的选择性氧化相应的酮，其随后被选择性地还原成光学对映体，而还原形式的辅因子被提供用于通过另外的酶的还原反应，其特征在于具有相反立体选择性和不同辅因子选择性的两种醇脱氢酶和两个相应的不同的辅因子被用于氧化和还原反应，并且氧化的和还原的辅因子与另外的酶在平行的酶反应中相互转化，通过选择th可以控制两个对映异构体之一的旋转方向使用两种醇脱氢酶或使用另外的酶对两种辅因子的选择性差异。

10. 发明申请

US20100184174A1 PROCESS FOR THE OXIDATIVE CLEAVAGE OF VINYLAROMATICS USING PEROXIDASES OR LACCASES 审中-公开
标题翻译：使用过氧化物或薄荷脂的乙烯基氧化物的氧化过程
公开(公告)号：US20100184174A1
公开(公告)日：2010-07-22
申请号：US12668640
申请日：2008-07-09
申请人： Wolfgang Kroutil , Miguel Lara
发明人： Wolfgang Kroutil , Miguel Lara
IPC分类号： C12P7/24 , C12P7/26
CPC分类号： C12P7/24
摘要： The invention relates to a method for the oxidative cleavage of vinyl aromatics of the formula (1) characterized in that (a) compound(s) of the formula (1) is/are oxidized to aldehydes and ketones of the formulas (2) and (3), respectively, in the presence of molecular oxygen using at least one enzyme selected from peroxidases and laccases as a catalyst, according to the following general reaction scheme: wherein n is an integer of 0 to 5; the R1 are selected from saturated or unsaturated hydrocarbon groups with 1 to 10 carbon atoms, wherein carbon atoms are optionally substituted by heteroatoms and are optionally further substituted, amino, C1-6 alkylamino and C1-6 dialkylamino groups, halogens, hydroxy and cyano, wherein two of the substituents R1 may be linked to form a ring; R2 and R3 are each independently hydrogen or one of the options for R1, wherein R2 and/or R3 may be linked with R1 to form a ring, in which case R2 and R3 may each represent a chemical bond.
摘要翻译：本发明涉及一种式（1）的乙烯基芳族化合物的氧化裂解方法，其特征在于（a）式（1）化合物被氧化成式（2）和（II）的醛和酮（3），分别使用选自过氧化物酶和漆酶的至少一种酶作为催化剂，在分子氧存在下，根据以下一般反应方案：其中n为0至5的整数; R1选自具有1至10个碳原子的饱和或不饱和烃基，其中碳原子任选被杂原子取代，并且任选地被进一步取代，氨基，C 1-6烷基氨基和C 1-6二烷基氨基，卤素，羟基和氰基，其中两个取代基R 1可以连接形成环; R 2和R 3各自独立地为氢或R 1的选择之一，其中R 2和/或R 3可以与R 1连接形成环，在这种情况下，R 2和R 3可各自表示化学键。

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