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1. 发明申请

US20110070630A1 METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES 审中-公开
标题翻译：促进剂混合物的制备方法
公开(公告)号：US20110070630A1
公开(公告)日：2011-03-24
申请号：US12866612
申请日：2009-03-26
申请人： Christian Gruber , Wolfgang Kroutil , Constance Voss , Jan Pfeffer , Uwe Dingerdissen
发明人： Christian Gruber , Wolfgang Kroutil , Constance Voss , Jan Pfeffer , Uwe Dingerdissen
IPC分类号： C12P41/00
CPC分类号： C12P41/002 , C12N9/0006 , C12P7/02
摘要： The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors.
摘要翻译：本发明涉及通过立体选择性醇脱氢酶及其辅因子通过氧化和还原反应的组合将仲醇的对映异构体混合物酶促脱水化的方法，其中光学活性仲醇的一种对映异构体具有形式上的选择性氧化相应的酮，其随后被选择性地还原成光学对映体，而还原形式的辅因子被提供用于通过另外的酶的还原反应，其特征在于具有相反立体选择性和不同辅因子选择性的两种醇脱氢酶和两个相应的不同的辅因子被用于氧化和还原反应，并且氧化的和还原的辅因子与另外的酶在平行的酶反应中相互转化，通过选择th可以控制两个对映异构体之一的旋转方向使用两种醇脱氢酶或使用另外的酶对两种辅因子的选择性差异。

2. 发明申请

US20080048422A1 Safety Device for a Motor Vehicle Having a Front-End Structure 审中-公开
标题翻译：具有前端结构的机动车辆的安全装置
公开(公告)号：US20080048422A1
公开(公告)日：2008-02-28
申请号：US11578129
申请日：2005-03-30
申请人： Guenter Eichhorn , Mario Gassmann , Christian Gruber , Rudolf Mayer , Harald Muehleisen , Andreas Richter
发明人： Guenter Eichhorn , Mario Gassmann , Christian Gruber , Rudolf Mayer , Harald Muehleisen , Andreas Richter
IPC分类号： B60R21/09 , B62D25/08
CPC分类号： B60T7/065 , B60T13/567
摘要： In a motor vehicle having a front-end structure, a front bulkhead separates the front-end structure from an interior space, and a braking unit fixed to the front bulkhead has a master brake cylinder and a brake booster. The braking unit is pivotable about a pivot axis which runs through the front bulkhead, with an arrangement for pivoting the braking unit being arranged at a distance from the pivot axis and interacting with components arranged in the front-end structure in the event of a vehicle collision. In order to reliably reduce the risk of injury to a driver of a motor vehicle in the footwell region in the event of a vehicle collision, a transmitting element is provided to prevent a relative movement between the arrangement for pivoting the braking unit and the pivot axis.
摘要翻译：在具有前端结构的机动车辆中，前隔板将前端结构与内部空间分离，固定在前隔板上的制动单元具有主制动缸和制动助力器。制动单元可围绕穿过前隔板的枢转轴线枢转，具有用于使制动单元枢转的装置，其布置在与枢转轴线一定距离处并且在车辆的情况下与布置在前端结构中的部件相互作用碰撞。为了在车辆碰撞的情况下可靠地降低在脚部空间区域中的机动车辆的驾驶员受伤的风险，提供传动元件以防止用于枢转制动单元的装置与枢转轴线之间的相对运动。

3. 发明授权

US08442726B2 Method and device for lessening the consequences of an accident on a vehicle occupant 有权
标题翻译：减轻车祸事故后果的方法和装置
公开(公告)号：US08442726B2
公开(公告)日：2013-05-14
申请号：US13533162
申请日：2012-06-26
申请人： Markus Zimmermann , Christian Gruber
发明人： Markus Zimmermann , Christian Gruber
IPC分类号： B60R22/00
CPC分类号： B60N2/4221 , B60N2/427 , B60N2/4279 , B60R21/0134 , B60R2021/01034 , B60R2021/01272
摘要： A method and device are provided for lessening the consequences of an accident affecting a vehicle occupant in the event of a collision of the vehicle with an obstruction. Before the collision, the absolute speed of the vehicle occupant relative to the obstruction is reduced independently of the traveling speed of the vehicle by way of a reduction of the vehicle occupant's speed relative to the vehicle, without the vehicle occupant experiencing a first displacement movement against the vehicle movement direction beyond his initial destination-related traveling position.
摘要翻译：提供一种方法和装置，用于减轻在车辆与障碍物碰撞的情况下影响车辆乘客的事故的后果。在碰撞之前，车辆乘员相对于障碍物的绝对速度通过相对于车辆的车辆乘员的速度的降低而与车辆的行进速度无关地降低，而车辆乘客经历了针对车辆移动方向超出他的初始目的地相关行驶位置。

4. 发明申请

US20060127936A1 Compositions and methods for labeling of nucleic acid molecules 审中-公开
公开(公告)号：US20060127936A1
公开(公告)日：2006-06-15
申请号：US11330358
申请日：2006-01-12
申请人： Christian Gruber , Po-Jen Shih
发明人： Christian Gruber , Po-Jen Shih
IPC分类号： C12Q1/68 , C12N9/22 , C07H21/04
CPC分类号： C12P19/34 , C12Q1/68 , C12Q1/6813 , C12Q1/6816 , C12Q1/6844 , C12Q1/6862 , G01N27/44726 , C12Q2563/107 , C12Q2521/107 , C12Q2527/149
摘要： The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics.

5. 发明授权

US06848644B2 Belt tensioner 失效
标题翻译：皮带张紧器
公开(公告)号：US06848644B2
公开(公告)日：2005-02-01
申请号：US10358918
申请日：2003-02-05
申请人： Walter Eberle , Christian Gruber , Markus Woldrich
发明人： Walter Eberle , Christian Gruber , Markus Woldrich
IPC分类号： B60R22/44 , B60R22/46
CPC分类号： B60R22/44 , B60R22/46 , B60R22/4628 , B60R2022/4473 , B60R2022/4666 , B60R2022/468 , B60R2022/4685
摘要： In a belt tensioner of a seat belt in a vehicle, in particular a motor vehicle, a retraction device, which is driven by a motor and has a retraction force that is controllable as a function of parameters, is provided for retracting the belt.
摘要翻译：在车辆中的安全带的带张紧器中，特别是机动车辆中，提供由电动机驱动且具有作为参数的函数可控制的收缩力的收回装置，用于缩回带。

6. 发明申请

US20090098623A1 PROCESS FOR THE RACEMIZATION OF OPTICALLY ACTIVE SECONDARY ALCOHOLS WITH THE USE OF ALCOHOL DEHYDROGENASE 有权
标题翻译：使用酒精脱氢酶的光活性二级醇的研制方法
公开(公告)号：US20090098623A1
公开(公告)日：2009-04-16
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P7/04
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译：通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。类。

7. 发明授权

US5943753A Plant for producing a hot-rolled product 失效
标题翻译：用于生产热轧产品的设备
公开(公告)号：US5943753A
公开(公告)日：1999-08-31
申请号：US168078
申请日：1998-10-08
申请人： Bernhard Buchsbaum , Karl Christian Gruber
发明人： Bernhard Buchsbaum , Karl Christian Gruber
IPC分类号： B21B1/46 , B23P17/00
CPC分类号： B21B1/466 , Y10T29/5184
摘要： There is disclosed a plant for producing a hot-rolled product from a cast strand comprising two or several continuous casters and a rolling mill associated therewith and respective guide sections for transporting a strand piece separated from the cast strand. A pivotable or laterally displaceable guide section is each provided in at least one line of the rolling mill and in a line not registering with the former, of the continuous caster. The guide sections are capable of being aligned in a mutually registering position. In order to reach a high plant availability, at least one pivotable and/or laterally displaceable guide section is provided with two or several guide parts each serving to receive strand pieces and capable of being alternately aligned to register with the line of the rolling mill. In one position of this guide section, a pivotable and/or laterally displaceable guide section of an adjacently arranged line of a continuous caster is alignable to register with one of the guide parts of the guide section including two or several guide parts and, in this position, a second guide part of this guide section is aligned to register with the line of the rolling mill.
摘要翻译：公开了一种用于从包括两个或多个连续脚轮的铸造线材和与其相关联的轧制机的铸造线材生产热轧产品的设备，以及用于输送从铸造线材分离的线材片材的各自的引导部分。在连续铸造机的轧机的至少一条直线和不与前者对准的一条线中分别设置有可枢转或横向移动的导向部分。引导部分能够在相互对准的位置对准。为了达到高的设备可用性，至少一个可枢转和/或横向移位的引导部分设置有两个或几个引导部件，每个引导部件用于接收绞合片并且能够交替对齐以与轧机的线对准。在该引导部分的一个位置中，连续脚轮的相邻布置的线的可枢转和/或横向移动的引导部分可对准，以与包括两个或几个引导部分的引导部分的引导部分中的一个对准，并且在该位置，该引导部分的第二引导部分对齐以与轧机的线对准。

8. 发明申请

US20120265407A1 Method and Device for Lessening the Consequences of an Accident on a Vehicle Occupant 有权
标题翻译：减轻车辆乘客事故后果的方法和装置
公开(公告)号：US20120265407A1
公开(公告)日：2012-10-18
申请号：US13533162
申请日：2012-06-26
申请人： Markus ZIMMERMANN , Christian GRUBER
发明人： Markus ZIMMERMANN , Christian GRUBER
IPC分类号： B60R21/0134
CPC分类号： B60N2/4221 , B60N2/427 , B60N2/4279 , B60R21/0134 , B60R2021/01034 , B60R2021/01272
摘要： A method and device are provided for lessening the consequences of an accident affecting a vehicle occupant in the event of a collision of the vehicle with an obstruction. Before the collision, the absolute speed of the vehicle occupant relative to the obstruction is reduced independently of the traveling speed of the vehicle by way of a reduction of the vehicle occupant's speed relative to the vehicle, without the vehicle occupant experiencing a first displacement movement against the vehicle movement direction beyond his initial destination-related traveling position.
摘要翻译：提供一种方法和装置，用于减轻在车辆与障碍物碰撞的情况下影响车辆乘客的事故的后果。在碰撞之前，车辆乘员相对于障碍物的绝对速度通过相对于车辆的车辆乘员的速度的降低而与车辆的行进速度无关地降低，而车辆乘客经历了针对车辆移动方向超出他的初始目的地相关行驶位置。

9. 发明授权

US07795004B2 Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases 有权
标题翻译：使用两种醇脱氢酶使光学活性仲醇外消旋化的方法
公开(公告)号：US07795004B2
公开(公告)日：2010-09-14
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P41/00
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译：通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。类。

10. 发明授权

US06332255B1 Process for producing a hot-rolled product and plant for carrying out the process 失效
标题翻译：用于生产用于进行该工艺的热轧产品和设备的方法
公开(公告)号：US06332255B1
公开(公告)日：2001-12-25
申请号：US09166964
申请日：1998-10-06
申请人： Bernhard Buchsbaum , Karl Christian Gruber
发明人： Bernhard Buchsbaum , Karl Christian Gruber
IPC分类号： B21B1500
CPC分类号： B21B1/466 , Y10T29/49991 , Y10T29/5184
摘要： In a process for producing a hot-rolled product by continuously casting a strand, separating a strand piece from the strand, thermally influencing the strand piece by temperature equalization and/or strand piece heating and hot-rolling the strand piece, continuous casting takes place at two or several continuous casters. The strand pieces are rolled in a rolling mill associated with these continuous casters, to which the strand pieces are conducted by diverting the strand pieces into the line of the rolling mill from at least one of the continuous casters whose line does not register with the line of the rolling mill. In order to reach a higher plant availability, thermal influence of the strand pieces to be diverted is effected during the diversion of the strand pieces after their emergence from the continuous caster line and prior to their introduction into the rolling mill line while completely clearing the continuous caster lines and the rolling mill line.
摘要翻译：在通过连续铸造线材来生产热轧产品的过程中，将股线从股线分离，通过温度均衡和/或绞线片加热和/或绞合片加热来热影响绞合片，并且连续铸造发生连续铸造在两个或几个连续脚轮。绞合片在与这些连续脚轮相关联的轧机中轧制，通过将线段从线不与线对准的连续脚轮中的至少一个转向到轧机的线中，从而将绞合片传导到所述轧机上的轧机。为了达到更高的设备可用性，在从连续的连铸机线路出来之前和引入轧制机生产线之前，在股线片段的引流过程中，进行转向的绞合片材的热影响，同时完全清除连续的脚轮线和轧机线。

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