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1. 发明授权

US06630149B1 Blister containing a transdermal therapeutic system and a single dose form of administration 失效
标题翻译：含有透皮治疗系统和单剂量给药形式的泡罩
公开(公告)号：US06630149B1
公开(公告)日：2003-10-07
申请号：US09743540
申请日：2001-03-23
申请人： Wolfgang Schaefer , Hanshermann Franke , Bodo Asmussen
发明人： Wolfgang Schaefer , Hanshermann Franke , Bodo Asmussen
IPC分类号： A61K970
CPC分类号： A61K9/703 , A61J1/035 , A61J7/04 , B65D75/327
摘要： A form of administration for medical active agents in the form of a blister is characterized in that it contains a transdermal therapeutic system and at least one single dose form of the active agent next to each other.
摘要翻译：以泡罩形式的医用活性剂的给药形式的特征在于其含有透皮治疗系统和至少一种单剂量形式的活性剂彼此相邻。

2. 发明授权

US11612571B2 Transdermal therapeutic system for administering water-soluble peptides and polypeptides 有权
公开(公告)号：US11612571B2
公开(公告)日：2023-03-28
申请号：US12525888
申请日：2008-01-19
申请人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
发明人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
IPC分类号： A61K9/70 , A61K31/135
摘要： The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.

3. 发明授权

US08051983B2 Peelable, child-resistant package for film-shaped drug forms 有权
标题翻译：可剥皮，防儿童包装用于膜状药物形式
公开(公告)号：US08051983B2
公开(公告)日：2011-11-08
申请号：US11664083
申请日：2005-09-10
申请人： Michael Simon , Markus Krumme , Karin Ludwig , Bodo Asmussen
发明人： Michael Simon , Markus Krumme , Karin Ludwig , Bodo Asmussen
IPC分类号： B65D83/04 , B65D85/42
CPC分类号： B65D50/06 , B65D75/5805 , B65D2215/04 , B65D2575/362
摘要： A package for flat, pliable objects, such as for wafer-shaped or film-shaped drug forms. The package has a carrier layer, a cover layer which is detachably connected to the carrier layer, and a first surface region wherein the carrier layer is not connected to the cover layer and is completely surrounded by a margin area. A cavity, enclosed on all sides, is formed for accommodating an object. The package has a second surface region wherein the carrier layer is not connected to the cover layer. At least one perforation line extends at least partially within the second surface region, and is provided both in the carrier layer and in the cover layer.Severing the perforation line forms a free edge of the cover layer which serves as a gripping aid and enables manual removal of the cover layer from the carrier layer. The disclosure further covers a process for packaging flat, pliable objects by forming the above-described package.
摘要翻译：用于扁平，柔韧物体的包装，例如用于晶片形或胶片形药物形式。封装具有载体层，可拆卸地连接到载体层的覆盖层和其中载体层未连接到覆盖层并且被边缘区域完全包围的第一表面区域。形成为封闭在各个侧面上的空腔，用于容纳物体。封装具有第二表面区域，其中载体层未连接到覆盖层。至少一个穿孔线至少部分地在第二表面区域内延伸，并且被设置在载体层和覆盖层中。切割穿孔线形成覆盖层的自由边缘，其用作夹持助剂并且能够从载体层手动去除覆盖层。本公开还包括通过形成上述包装来包装扁平的柔韧物体的方法。

4. 发明申请

US20070190117A1 Buccal formulations of galanthamine and uses thereof 审中-公开
标题翻译：雪花胺的颊配方及其用途
公开(公告)号：US20070190117A1
公开(公告)日：2007-08-16
申请号：US10569160
申请日：2004-04-23
申请人： Bodo Asmussen , Joachim Moormann
发明人： Bodo Asmussen , Joachim Moormann
IPC分类号： A61K9/70 , A61K31/55
CPC分类号： A61K9/0056 , A61K9/006 , A61K31/55 , Y02A50/465
摘要： Film-shaped medicaments for buccal administration of galanthamine or of a salt or derivative thereof comprise at least one layer which contains a cholinergic active agent acting on the central nervous system or a combination of at least two such active agents, the said substance(s) being selected from the group comprising galanthamine, pharmaceutically acceptable salts of galanthamine, galanthamine derivatives and their pharmaceutically acceptable salts.
摘要翻译：用于颊内施用雪花胺或其盐或衍生物的片状药物包含至少一层，其含有作用于中枢神经系统的胆碱能活性剂或至少两种此类活性剂的组合，所述物质选自加兰他敏组，加兰他敏的药学上可接受的盐，雪花胺衍生物及其药学上可接受的盐。

5. 发明授权

US06436937B1 Use of desoxypeganine in the treatment of Alzheimer's dementia 失效
标题翻译：使用脱氧胆碱治疗阿尔茨海默病的痴呆症
公开(公告)号：US06436937B1
公开(公告)日：2002-08-20
申请号：US09913638
申请日：2001-08-16
申请人： Bodo Asmussen , Thomas Hille , Hans-Rainer Hoffmann , Klaus Opitz
发明人： Bodo Asmussen , Thomas Hille , Hans-Rainer Hoffmann , Klaus Opitz
IPC分类号： A61P2528
CPC分类号： A61K31/519 , Y10S514/906
摘要： The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.
摘要翻译：本发明涉及一种用去氧胆酸和/或脱氧焦虑素的药学上可接受的酸加成盐治疗阿尔茨海默氏痴呆的装置和方法。

6. 发明授权

US5869652A Process for producing active substances from unused or discarded devices for the transdermal administration 失效
标题翻译：用于经皮给药的未使用或丢弃的装置产生活性物质的方法
公开(公告)号：US5869652A
公开(公告)日：1999-02-09
申请号：US983029
申请日：1998-01-02
申请人： Bodo Asmussen , Hans-Rainer Hoffmann , Walter Muller
发明人： Bodo Asmussen , Hans-Rainer Hoffmann , Walter Muller
IPC分类号： A61G12/00 , A61K9/70 , B09B3/00 , C07D223/14 , C07C217/70
CPC分类号： B09B3/0075 , A61K9/7023 , B09B2220/14
摘要： In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom.
摘要翻译： PCT No.PCT / EP96 / 02734 Sec。 371日期1998年1月2日 102（e）1998年1月2日PCT PCT 1996年6月24日PCT公布。出版物WO97 / 02100 日期1997年1月23日在用于再次处理用于透皮施用活性物质或其工艺废物的装置的方法中，将含活性物质的组分引入溶液中并从中回收活性物质。

7. 发明授权

US4254099A Pharmaceutical tablet composition 失效
标题翻译：药片组合物
公开(公告)号：US4254099A
公开(公告)日：1981-03-03
申请号：US80900
申请日：1979-10-01
申请人： Bodo Asmussen , Georg A. Ulex
发明人： Bodo Asmussen , Georg A. Ulex
IPC分类号： A61K9/14 , A61K9/20 , A61K31/705 , A61K47/00
CPC分类号： A61K9/143 , A61K9/2009
摘要： A pharmaceutical tablet composition for oral administration is disclosed which provides for accelerated release <> of a finely divided active ingredient contained therein which is only slightly soluble . The tablet composition is characterized as containing a micro-dispersed, amorphous, porous silica having a primary particle size of between about 1 and 15 .mu.m, a BET surface of between about 350 and 450 m.sup.2/ g, and a pore volume of between about 1.4 and 1.7 ml/g. A method of producing the tablet composition is also disclosed.
摘要翻译：公开了用于口服给药的药物片剂组合物，其提供其中包含的细分活性成分的加速释放，其仅在温血动物的胃肠道中微溶。片剂组合物的特征在于含有初级粒度为约1至15μm，BET表面积为约350至450m 2 / g之间的微分散，无定形多孔二氧化硅，孔体积为约 1.4和1.7ml / g。还公开了制备片剂组合物的方法。

8. 发明授权

US08997991B2 Wafer vial with inert intermediate layers 有权
标题翻译：具有惰性中间层的晶片小瓶
公开(公告)号：US08997991B2
公开(公告)日：2015-04-07
申请号：US12065649
申请日：2006-08-25
申请人： Bodo Asmussen , Markus Krumme
发明人： Bodo Asmussen , Markus Krumme
IPC分类号： B65D75/00 , B65D57/00
CPC分类号： B65D57/00
摘要： The invention relates to a packaging unit comprising a container and hygroscopic or humidity softenable film-like materials. For this purpose, said film-like materials are stacked in the container and a separating material which is chemically inert and physically stable with respect thereto is arranged at time between said film-like materials. Each time, said separating material is brought into contact with two film-like materials and does not adheres or adheres less strongly to at least one film-like material that to the other film-like material. Said invention makes it possible to develop a packaging unit provided with a container which guarantees a reliable individual withdrawal of the hygroscopic film-like materials.
摘要翻译：本发明涉及包括容器和吸湿或可湿软化的膜状材料的包装单元。为此目的，将所述薄膜状材料堆叠在容器中，并且在所述薄膜状材料之间的时间布置了化学惰性且相对于其物理稳定的分离材料。每次，所述分离材料与两个膜状材料接触，并且不会对至少一种类似于薄膜的材料的膜状材料强烈地粘附或粘附。所述发明使得可以开发设置有容器的包装单元，其确保吸湿膜状材料的可靠的单独抽出。

9. 发明授权

US08647314B2 Gingival wafer 有权
标题翻译：牙龈晶圆
公开(公告)号：US08647314B2
公开(公告)日：2014-02-11
申请号：US12736109
申请日：2009-02-27
申请人： Bodo Asmussen , Michael Simon
发明人： Bodo Asmussen , Michael Simon
IPC分类号： A61M35/00
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/2072
摘要： Strip-shaped forms of administration for administering an active ingredient via the mucous membrane of the gums.
摘要翻译：带状形式的给药用于通过牙龈的粘膜施用活性成分。

10. 发明授权

US08262604B2 Single-use injector with at least one draw hook 有权
标题翻译：一次性注射器至少有一个拉钩
公开(公告)号：US08262604B2
公开(公告)日：2012-09-11
申请号：US12455964
申请日：2009-06-10
申请人： Bodo Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
发明人： Bodo Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2033 , A61M5/24 , A61M5/3007 , A61M5/31515 , A61M2005/2073 , A61M2005/2488 , A61M2005/2492 , A61M2005/312
摘要： A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.
摘要翻译：公开了一种一次性注射器，其包括壳体（10），其布置有至少一个机械弹簧能量存储器（50），至少一个活塞 - 气缸单元（100），其至少可以有效地填充至少一定的至少一个活塞致动柱塞（60）和至少一个触发单元（80）。弹簧能量储存器包括至少一个预张紧弹簧元件。弹簧加载的活塞致动冲头（60）具有至少一个保持杆或钩（62），其可以至少在某些区域中横向移动，并且借助于支撑部分支撑张紧的弹簧能量储存在壳体的至少一个搁置表面。当致动发生时，触发单元（80）释放支撑部分以允许其移动远离静止表面。

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