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1. 发明授权

US5281342A Method and apparatus for the separation of blood into its components 失效
标题翻译：用于将血液分离成其组分的方法和装置
公开(公告)号：US5281342A
公开(公告)日：1994-01-25
申请号：US932130
申请日：1992-08-19
申请人： Wolfgang Biesel , Johannes Geibel , Henning Brass
发明人： Wolfgang Biesel , Johannes Geibel , Henning Brass
IPC分类号： G01N33/48 , A61M1/02 , A61M1/36 , B01D43/00 , B01D21/26
CPC分类号： B01D43/00 , A61M1/3693 , Y10S210/929
摘要： The invention concerns a process and a device for more efficiently obtaining a highly pure fraction of thrombocytes during density centrifugation of blood, which no longer has to be filtered before infusion into a patient for leukocytes contained therein, in order to prevent immunization of the recipient. The invention is based on a two-stage density separation, wherein in a first stage a separation is made between cells and thrombocyte-rich plasma, and the thrombocyte-rich plasma is not separated into a thrombocyte concentrate and thrombocyte-poor plasm until a second stage. During the first separation, the position of the phase boundary is changed cyclically in the first separation stage. Through alternating the phase boundary in the first stage, it becomes possible for the first time in the second stage to obtain highly pure thrombocyte concentrations with minimally low leukocyte contamination from the transferred thrombocyte-rich plasma without loss of efficiency.
摘要翻译：本发明涉及一种方法和装置，用于在血液密度离心过程中更有效地获得高纯度级分的凝血细胞，而在血液密度离心之前，为了防止接受者的免疫，不再需要在向患者输入白细胞之前将其过滤。本发明基于两阶段密度分离，其中在第一阶段中，在细胞和富血小板富集血浆之间进行分离，并且富血小板血浆不分离成血细胞浓缩物和血小板减少的血浆，直至第二阶段。在第一分离期间，相位边界的位置在第一分离阶段中循环地改变。通过在第一阶段交替相边界，可以在第二阶段中第一次获得高度纯净的血细胞浓度，并且不会损失有效的血小板转移的血浆细胞血浆的低白细胞污染。

2. 发明授权

US5814279A Centrifuge having marker elements 失效
标题翻译：具有标记元素的离心机
公开(公告)号：US5814279A
公开(公告)日：1998-09-29
申请号：US597443
申请日：1996-02-02
申请人： Wolfgang Biesel , Stefan Kreber , Henning Brass , Friedrich Witthaus , Artur Meisberger
发明人： Wolfgang Biesel , Stefan Kreber , Henning Brass , Friedrich Witthaus , Artur Meisberger
IPC分类号： G01N33/48 , B04B5/02 , B04B5/04 , B04B13/00 , B04B15/00 , G01N1/10 , G01N15/04 , G01N21/07
CPC分类号： G01N15/042 , B04B13/00 , B04B5/0407 , B04B2013/006 , Y10T436/111666 , Y10T436/25375
摘要： A centrifuge has a drive unit, a separation chamber which can be inserted into the drive unit, and a scanning device for recognizing the position of the separation chamber which is rotated by the drive unit. The separation chamber is constructed as a disposable chamber and is provided with a marker element which is arranged in a scanning region extending annularly around the rotation axis of the chamber. The position of a phase boundary window is detected by sensing the position of the marker with a phase boundary detector portion of the scanning device whereby the chamber can be inserted into the drive unit in any position.
摘要翻译：离心机具有驱动单元，能够插入到驱动单元中的分离室，以及用于识别由驱动单元旋转的分离室的位置的扫描装置。分离室被构造为一次性室，并且设置有标记元件，该标记元件布置在围绕室的旋转轴线环形延伸的扫描区域中。通过用扫描装置的相边界检测器部分感测标记的位置来检测相边界窗口的位置，从而可以在任何位置将腔室插入到驱动单元中。

3. 发明申请

US20100329910A1 Roller pump 有权
标题翻译：滚筒泵
公开(公告)号：US20100329910A1
公开(公告)日：2010-12-30
申请号：US12801561
申请日：2010-06-15
申请人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
发明人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
IPC分类号： F04B43/12 , F16L33/00
CPC分类号： F04B43/1253
摘要： The invention relates to a roller pump consisting of a stator with a pump bed formed therein and a rotor for acting on a hose inserted into the pump bed in arcuate form. In accordance with the invention, the ends of the tube guided out of the pump bed cross.
摘要翻译：本发明涉及一种由在其中形成有泵床的定子和用于以弓形形式插入到泵床中的软管作用的转子组成的滚子泵。根据本发明，从泵床引出的管的端部交叉。

4. 发明授权

US5298171A Method and apparatus for separation of blood into its components 失效
标题翻译：将血液分离成其组分的方法和装置
公开(公告)号：US5298171A
公开(公告)日：1994-03-29
申请号：US927101
申请日：1992-08-07
申请人： Wolfgang Biesel
发明人： Wolfgang Biesel
IPC分类号： A61M1/02 , A61M1/36 , B01D21/30 , B01D21/26
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/3669 , A61M2202/0429
摘要： In a separation device for separation of blood into its components, the hematocrit value of the blood to be separated plays a significant role relative to the sedimentation of cellular blood components. Since in blood processing, particularly in the intraoperative area, significant fluctuations of the incoming hematocrit value may occur, for example, due to infused volume expander, irrigation solutions, anticoagulant additives, etc., it is useful for maintenance of a blood separation working with constant values, particularly a constant hematocrit value of the erythrocyte fraction, to take the preset hematocrit value of the blood to be separated into account. According to the invention, the rate of blood flow through the separation device is automatically adjusted as a function of the hematocrit value of the incoming blood.
摘要翻译：在用于将血液分离成其组分的分离装置中，待分离血液的血细胞比容值相对于细胞血液成分的沉降起着重要作用。由于在血液处理方面，特别是在术中区域，例如由于输注体积扩张器，灌注溶液，抗凝血剂添加剂等引起的血细胞比容值的显着波动可能发生，因此维持血液分离工作是有用的恒定值，特别是红细胞分数的恒定血细胞比容值，以考虑要分离的血液的预设血细胞比容值。根据本发明，通过分离装置的血液流量的速率被自动调整为进入血液的血细胞比容值的函数。

5. 发明授权

US08734138B2 Roller pump 有权
标题翻译：滚筒泵
公开(公告)号：US08734138B2
公开(公告)日：2014-05-27
申请号：US12801561
申请日：2010-06-15
申请人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
发明人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
IPC分类号： F04B43/08 , F04B43/12 , F04B45/06
CPC分类号： F04B43/1253
摘要： The invention relates to a roller pump consisting of a stator with a pump bed formed therein and a rotor for acting on a hose inserted into the pump bed in arcuate form. In accordance with the invention, the flow paths associated with the ends of the tube guided out of the pump bed cross.
摘要翻译：本发明涉及一种由在其中形成有泵床的定子和用于以弓形形式插入到泵床中的软管作用的转子组成的滚子泵。根据本发明，与引导出泵床的管的端部相关联的流动路径交叉。

6. 发明授权

US07758324B2 Roller pump 有权
标题翻译：滚筒泵
公开(公告)号：US07758324B2
公开(公告)日：2010-07-20
申请号：US11596353
申请日：2005-05-12
申请人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
发明人： Manfred Baumann , Berthold Breitkopf , Elmar Huegel , Herbert Neubauer , Thomas Nuernberger , Jochen Schneider , Gerhard Spengler , Ralf Wamsiedler , Wolfgang Biesel , Christian Busse , Marco Caronna , Joerg Jonas , Reinhold Reiter , Joern Apel , Martin Lauer
IPC分类号： F04B43/08 , F04B43/12 , F04B43/06
CPC分类号： F04B43/1253
摘要： A roller pump includes a stator with a pump bed formed therein, and a rotor for acting on a hose inserted into the pump bed in arcuate form. The ends of the hose are guided out of the pump bed in a crossed configuration.
摘要翻译：滚子泵包括定子，其中形成有泵床，转子用于作用在以弓形形式插入泵床中的软管上。软管的端部以交叉配置被引导出泵床。

7. 发明授权

US5449022A Hose arrangement for a sealess centrifuge having hoses comprised of layers of different hardness 失效
标题翻译：用于密封离心机的软管布置，其具有由不同硬度的层组成的软管
公开(公告)号：US5449022A
公开(公告)日：1995-09-12
申请号：US220120
申请日：1994-03-30
申请人： Friedrich Witthaus , Carlo Lay , Wolfgang Biesel
发明人： Friedrich Witthaus , Carlo Lay , Wolfgang Biesel
IPC分类号： B04B5/00 , B04B5/04 , B04B7/00 , B32B7/02 , F16L11/04 , F16L11/12
CPC分类号： B32B7/02 , B04B5/0442 , B04B7/00 , F16L11/04 , B04B2005/0492
摘要： Hose arrangement for a seal-less centrifuge having a soft inner layer and a hard outer layer and is formed by means of coextrusion.
摘要翻译：用于具有软内层和硬外层的无密封离心机的软管装置，并通过共挤出形成。

8. 发明申请

US20100049115A1 METHOD FOR PRIMING A BLOOD LINE SET 有权
标题翻译：用于引导血液线组的方法
公开(公告)号：US20100049115A1
公开(公告)日：2010-02-25
申请号：US12448301
申请日：2007-12-19
申请人： Wolfgang Biesel , Maria Millan Galante
发明人： Wolfgang Biesel , Maria Millan Galante
IPC分类号： A61M1/16 , A61J1/10 , A61L2/20
CPC分类号： A61M1/16 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M1/365
摘要： The invention relates to a method for priming a blood tubing set comprising a venous and an arterial line whose connections at the patient side are in communication with two separate inlets of a chamber of in particular a bag and whose connections at the machine side are in communication with a dialyzer comprising the steps: parallel filling of both the venous and the arterial line via a feed line so that priming liquid flows through both inlets into the chamber; and circulation of the priming liquid in the circuit of the lines, the dialyzer and the chamber via a pump so that one of the inlets of the chamber acts as an inlet and the other as an outlet. The invention likewise comprises a corresponding blood tubing set and a bag as well as methods for providing them.
摘要翻译：本发明涉及一种用于引导血管组的方法，其包括静脉和动脉管线，其在患者侧的连接与特别是袋的腔室的两个独立的入口连通，并且其在机器侧的连接处于连通状态透析器包括以下步骤：通过进料管线平行地填充静脉和动脉管线，使得引发液体通过两个入口进入腔室; 以及通过泵将引发液体在管线，透析器和腔室的回路中循环，使得腔室的入口中的一个作为入口，另一个作为出口。本发明同样包括相应的血管组和袋以及用于提供它们的方法。

9. 发明授权

US06299784B1 Method and apparatus for processing intra- or postoperative blood loss for autotransfusion 有权
标题翻译：用于自体输血的术中或术后失血的方法和装置
公开(公告)号：US06299784B1
公开(公告)日：2001-10-09
申请号：US09235964
申请日：1999-01-22
申请人： Wolfgang Biesel
发明人： Wolfgang Biesel
IPC分类号： B01D2126
CPC分类号： B04B5/0442 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , B04B2005/045 , A61M2202/0071
摘要： A method and an apparatus for continuous processing of intra- or postoperative blood loss for autotransfusion are disclosed. According to the present invention, certain cells of the cell suspension to be processed, mainly the red blood cells, are concentrated by centrifuging in a separation unit and removed from the separation unit without being rinsed or washed in the separation unit. The concentrated cell fraction is diluted with a physiological solution, preferably a Ringer's solution, after being removed from the separation unit.
摘要翻译：公开了用于连续处理自体输血或术后失血的方法和装置。根据本发明，待处理的细胞悬浮液的某些细胞，主要是红细胞，通过离心分离单元浓缩，并从分离单元中除去而不用在分离单元中进行漂洗或洗涤。在从分离单元中取出之后，将浓缩的细胞级分用生理溶液，优选林格氏溶液稀释。

10. 发明授权

US5445593A Method and apparatus for the continuous conditioning of a cell suspension 失效
标题翻译：用于连续调节细胞悬浮液的方法和装置
公开(公告)号：US5445593A
公开(公告)日：1995-08-29
申请号：US93491
申请日：1993-07-16
申请人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
发明人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
IPC分类号： B04B5/00 , A61M1/02 , A61M1/36 , B04B5/04 , C12N5/08 , B04B7/08
CPC分类号： A61M1/3693 , A61M1/3692 , A61M1/3696 , B04B5/0442 , A61M2202/0429 , B04B2005/045 , Y10T436/25375
摘要： A method and apparatus for the continuous conditioning of a cell suspension, more particularly whole blood, in order to obtain an erythrocyte concentrate which is returned to the patient by autotransfusion. In accordance with the invention there are three treatment stages, that is to say sedimentation of the cell suspension, the addition of washing solution to the cell concentrate and renewed sedimentation and separation of the washing solution.
摘要翻译：用于连续调节细胞悬浮液，特别是全血的方法和装置，以获得通过自体输血返回给患者的红细胞浓缩物。根据本发明，有三个处理阶段，即细胞悬浮液的沉淀，向细胞浓缩物中加入洗涤溶液和更新洗涤溶液的沉降和分离。

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