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1. 发明授权

US4774415A Device for sterilization of a hose coupling device in the connected condition 失效
标题翻译：在连接状态下对软管接头装置进行灭菌的装置
公开(公告)号：US4774415A
公开(公告)日：1988-09-27
申请号：US4502
申请日：1987-01-20
申请人： Hubert Biegel , Wolfram Weber , Arthur Meisberger , Bernd Mathiew , Wolfram Weber , Arthur Meisberger , Bernd Mathieu
发明人： Hubert Biegel , Wolfram Weber , Arthur Meisberger , Bernd Mathiew , Wolfram Weber , Arthur Meisberger , Bernd Mathieu
IPC分类号： A61L2/08 , A61M39/18 , A61L2/10 , G21K5/04 , H01J37/20
CPC分类号： A61M39/18 , A61L2/08
摘要： The device in accordance with the invention for the sterilization of a hose coupling device (in its connected condition) of dialysis apparatus, comprises an opening housing into which the coupling device is placed. The coupling device is subjected to infrared radiation from heating elements in the housing whose heating effect is monitored and automatically controlled by a temperature probe arranged under the coupling device in the housing. Since the temperature probe is designed to have such an infrared absorption characteristic that the temperature increase rate of the probe is substantially the same as that of the coupling device, one may be certain that the coupling device will have reached the desired temperature (which is detected at the temperature probe) with only a slight delay if any. At the same time there is the advantage that the interior of the coupling device is heated to substantially above the minimum necessary sterilization temperature.
摘要翻译：根据本发明的用于灭菌透析设备的软管联接装置（在其连接状态）的装置包括开口壳体，联接装置放置在该开口壳体中。耦合装置受到壳体中加热元件的红外辐射的影响，其加热效应被监测，并由设置在壳体中的耦合装置下方的温度探针自动控制。由于温度探针被设计成具有这样的红外吸收特性，使得探头的温度升高速率基本上与耦合装置的温度升高速率相同，所以可以确定耦合装置将达到所需的温度（被检测到）在温度探头）只有轻微的延迟（如果有的话）。同时具有将耦合装置的内部加热到基本上高于最低必需灭菌温度的优点。

2. 发明申请

US20110136653A1 METHOD FOR THE PRODUCTION OF A POROUS, CERAMIC SURFACE LAYER 审中-公开
标题翻译：用于生产多孔陶瓷表面层的方法
公开(公告)号：US20110136653A1
公开(公告)日：2011-06-09
申请号：US12376655
申请日：2007-08-08
申请人： Stefan Koebel , Wolfram Weber , Wolfhart Rieger
发明人： Stefan Koebel , Wolfram Weber , Wolfhart Rieger
IPC分类号： A61L33/02 , C04B38/06
CPC分类号： A61F2/30767 , A61C8/0012 , A61F2/3094 , A61F2002/30968 , A61F2310/00185 , A61F2310/00203 , A61F2310/00239 , A61F2310/00269 , A61F2310/00281 , A61F2310/00299 , A61F2310/00317 , A61F2310/00329 , A61F2310/00592 , A61F2310/00604 , A61F2310/00634 , A61F2310/00796 , A61F2310/00928 , A61L27/30 , A61L27/56 , C04B41/009 , C04B41/5025 , C04B41/5042 , C04B41/87 , C04B2111/00836 , C23C24/08 , C23C26/00 , C23C30/00 , C04B35/48 , C04B35/00 , C04B41/4539 , C04B41/455 , C04B41/4582
摘要： A method for producing a porous ceramic surface layer on a substrate includes providing a mixture including at least one polymer and at least one ceramic material and applying the mixture to the substrate.
摘要翻译：在基材上制造多孔陶瓷表面层的方法包括提供包括至少一种聚合物和至少一种陶瓷材料的混合物并将该混合物施加到基材上。

3. 发明申请

US20090273108A1 METHOD FOR DETERMINING SINTERING SHRINKAGE OF A PRE-SINTERED BODY 失效
标题翻译：用于确定预烧结体的烧结收缩的方法
公开(公告)号：US20090273108A1
公开(公告)日：2009-11-05
申请号：US12513129
申请日：2007-11-05
申请人： Stefan Koebel , Wolfram Weber
发明人： Stefan Koebel , Wolfram Weber
IPC分类号： C04B35/64 , A61C13/00
CPC分类号： C04B35/64 , A61C13/0004 , A61C13/0022 , B28B17/0072 , B28B23/0031 , C04B35/111 , C04B35/486 , C04B2235/765 , C04B2235/945 , C04B2235/9615
摘要： A method for determining a sintering shrinkage of a pre-sintered body. The method includes providing a green preform with at least one design feature. The green-preform is pre-sintered to form a white body. At least one change in the at least one design feature with the pre-sintering is recorded. An expected sintering shrinkage to a dense-sintered component is determined using the recorded change.
摘要翻译：一种用于确定预烧结体的烧结收缩率的方法。该方法包括提供具有至少一个设计特征的绿色预成型件。绿色预制件被预烧结以形成白色体。记录至少一个具有预烧结的设计特征的变化。使用记录的变化确定对致密烧结组分的预期烧结收缩。

4. 发明授权

US5445593A Method and apparatus for the continuous conditioning of a cell suspension 失效
标题翻译：用于连续调节细胞悬浮液的方法和装置
公开(公告)号：US5445593A
公开(公告)日：1995-08-29
申请号：US93491
申请日：1993-07-16
申请人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
发明人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
IPC分类号： B04B5/00 , A61M1/02 , A61M1/36 , B04B5/04 , C12N5/08 , B04B7/08
CPC分类号： A61M1/3693 , A61M1/3692 , A61M1/3696 , B04B5/0442 , A61M2202/0429 , B04B2005/045 , Y10T436/25375
摘要： A method and apparatus for the continuous conditioning of a cell suspension, more particularly whole blood, in order to obtain an erythrocyte concentrate which is returned to the patient by autotransfusion. In accordance with the invention there are three treatment stages, that is to say sedimentation of the cell suspension, the addition of washing solution to the cell concentrate and renewed sedimentation and separation of the washing solution.
摘要翻译：用于连续调节细胞悬浮液，特别是全血的方法和装置，以获得通过自体输血返回给患者的红细胞浓缩物。根据本发明，有三个处理阶段，即细胞悬浮液的沉淀，向细胞浓缩物中加入洗涤溶液和更新洗涤溶液的沉降和分离。

5. 发明授权

US5015374A Closure cap for dialyzers 失效
标题翻译：透析器盖帽
公开(公告)号：US5015374A
公开(公告)日：1991-05-14
申请号：US386284
申请日：1989-07-27
申请人： Bernd Mathieu , Michael Rinck , Jurgen Schnur , Dieter Selzer , Wolfram Weber
发明人： Bernd Mathieu , Michael Rinck , Jurgen Schnur , Dieter Selzer , Wolfram Weber
IPC分类号： A61M1/16 , A61M1/18 , A61M39/20 , B01D61/30 , B01D63/00 , B01D65/02
CPC分类号： B01D61/30 , B01D65/022 , A61M1/168 , A61M39/20 , B01D2321/16 , Y10S285/921
摘要： The invention relates to a closure cap (1) for dialyzers which is suitable for a so-called in-line sterilization. For this purpose the closure cap (1) comprises two cap parts (2, 3) of which the first cap part (2) is adapted to be mounted on a dialyzer flange (4) while the second cap part (3) is arranged movably in a receiving compartment (5) of the first cap part (2) between an open position and a closure position. In an open position passage of a sterilization medium is possible so that all the parts, sealing and guide surfaces can be reliably sterilized. In the closure position the second cap part (3) is pushed into a sealing position within the first cap part (2) so that contamination of the dialyzer after removal from the sterilization apparatus can be prevented with certainty.
摘要翻译：本发明涉及一种用于透析器的封闭盖（1），其适用于所谓的在线灭菌。为此，封闭盖（1）包括两个帽部分（2,3），第一帽部分（2）适于安装在透析器凸缘（4）上，而第二帽部分（3）可移动地布置在第一盖部分（2）的接收隔间（5）中处于打开位置和关闭位置之间。在灭菌介质的打开位置通道中，可以使所有的部件，密封和引导表面都可靠地消毒。在封闭位置，第二帽部分（3）被推入第一帽部分（2）内的密封位置，从而可以确定地防止从灭菌装置移除之后透析器的污染。

6. 发明授权

US4789473A Filter for obtaining plasma or plasma water 失效
标题翻译：用于获得等离子体或等离子体水的过滤器
公开(公告)号：US4789473A
公开(公告)日：1988-12-06
申请号：US1815
申请日：1987-01-08
申请人： Bernd Mathieu , Wolfram Weber , Wolfgang Schulz
发明人： Bernd Mathieu , Wolfram Weber , Wolfgang Schulz
IPC分类号： A61M1/02 , A61M1/18 , B01D63/02 , B29C41/04 , B29C70/84 , B01D13/01
CPC分类号： B01D63/022 , B01D63/02 , B29C41/045 , B29C70/845
摘要： A filter comprising a filter housing with an interior within which between two closure members filter membranes in the form of hollow fibers are disposed. Between the hollow fibers a free flow space remains to which are connected two connecting pieces disposed inclined on the housing. Through said connecting pieces blood is supplied to the interior so that a filtration from the outside to the inside into the hollow fibers is possible. This and the arrangement of the connecting pieces gives an extremely favourable flow approach to the hollow fibers so that the blood flow is hardly influenced in its velocity and flow behaviour because in addition to the cross-section of the free flow space is adapted to the cross section of the blood supply line. For making such a filter at least two filters are arranged parallel and spaced apart in a plane, the support surface for the filters being rotatably mounted and the axis of rotation not intersecting any of the two longitudinal axes of the filters. During the rotation and supplying of the casting or sealing compound for the closure members through end-face supply means into the interior inclined faces are formed which in their angle correspond to the angle (.alpha., .beta.) of the connecting pieces.
摘要翻译：一种过滤器，其包括具有内部的过滤器壳体，其中在两个封闭构件之间过滤中空纤维形式的膜。在中空纤维之间，剩余的自由流动空间连接到倾斜于壳体上的两个连接件。通过所述连接件将血液供应到内部，使得可以从外部到内部过滤到中空纤维中。这和连接件的布置给出了对中空纤维非常有利的流动方式，使得血流在其速度和流动行为几乎不受影响，因为除了自由流动空间的横截面适应于十字供血线段。为了制造这样的过滤器，至少两个过滤器在平面上平行并间隔布置，用于过滤器的支撑表面可旋转地安装，并且旋转轴线不与过滤器的两个纵向轴线中的任一个相交。在通过端面供给装置旋转和供给用于封闭构件的铸造或密封化合物的过程中，形成倾斜面，其倾斜角度对应于连接件的角度（α，β）。

7. 发明授权

US08366978B2 Method for determining sintering shrinkage of a pre-sintered body 失效
标题翻译：确定烧结体烧结收缩率的方法
公开(公告)号：US08366978B2
公开(公告)日：2013-02-05
申请号：US12513129
申请日：2007-11-05
申请人： Stefan Koebel , Wolfram Weber
发明人： Stefan Koebel , Wolfram Weber
IPC分类号： C04B35/64 , A61C13/00
CPC分类号： C04B35/64 , A61C13/0004 , A61C13/0022 , B28B17/0072 , B28B23/0031 , C04B35/111 , C04B35/486 , C04B2235/765 , C04B2235/945 , C04B2235/9615
摘要： A method for determining a sintering shrinkage of a pre-sintered body. The method includes providing a green preform with at least one design feature. The green-preform is pre-sintered to form a white body. At least one change in the at least one design feature with the pre-sintering is recorded. An expected sintering shrinkage to a dense-sintered component is determined using the recorded change.
摘要翻译：一种用于确定预烧结体的烧结收缩率的方法。该方法包括提供具有至少一个设计特征的绿色预成型件。绿色预制件被预烧结以形成白色体。记录至少一个具有预烧结的设计特征的变化。使用记录的变化确定对致密烧结组分的预期烧结收缩。

8. 发明授权

US5281202A Device for draining a flexible fluid container 失效
标题翻译：用于排出柔性流体容器的装置
公开(公告)号：US5281202A
公开(公告)日：1994-01-25
申请号：US939523
申请日：1992-09-03
申请人： Wolfram Weber , Hans J. Neumann , Thomas Scherer , Bernhard Glaser
发明人： Wolfram Weber , Hans J. Neumann , Thomas Scherer , Bernhard Glaser
IPC分类号： A61J1/14 , A61M1/02 , A61M1/30 , A61M5/148 , B01J4/00 , A61M37/00
CPC分类号： A61M5/148 , A61M1/029 , A61M1/30
摘要： A device is disclosed for draining flexible fluid containers, in particular blood bags which form part of an extracorporeal system in a single needle-type arrangement, having a movable plate (4b) and a fixed plate (4a) in which both plates are configured to confront a flexible fluid container. A force member (14), and a force transfer means (8, 18), are arranged in such a way that the force acting upon the movable plate (4b) increases as the container is drained.
摘要翻译：公开了用于排出柔性流体容器的装置，特别是形成具有单个针型布置的体外系统的一部分的血袋，具有可移动板（4b）和固定板（4a），其中两个板构造成面对柔性流体容器。强制构件（14）和力传递装置（8,18）被布置成使得作用在可动板（4b）上的力随着容器排出而增加。

9. 发明授权

US5268144A Method for sterilizing a medical unit 失效
标题翻译：对医疗单元进行消毒的方法
公开(公告)号：US5268144A
公开(公告)日：1993-12-07
申请号：US921907
申请日：1992-07-29
申请人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
发明人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
IPC分类号： A61L2/04 , A61L2/18 , A61M1/16 , B01D65/02 , A61L2/06 , A61L2/16
CPC分类号： A61L2/18 , A61L2/04 , B01D65/022 , A61M1/169 , B01D2321/08 , B01D2321/162
摘要： This invention relates to a method for sterilizing a medical unit having at least two connections for a fluid flow pathway where a sterilizing medium flows through the medical unit.Medical units of this type are e.g. medical filters, in particular dialyzers. A high degree of sterility is here required. This is accomplished through the steps of:(a) inserting the medical unit into a system under pressure-tight coupling of the at least two connections to a feed conduit and discharge conduit of the system under atmospheric conditions;(b) passing the sterilizing medium from the system through the medical unit for a given period of time;(c) closing the at least two connections in the coupled state and in a germproof manner, without the same being opened, on completion of the sterilization operation; and(d) removing said medical unit from said system as a sterile medical unit with closed connections.All steps, including the removal of the medical unit, are therefore carried out in a system where the sterility obtained is constantly maintained. This "inline sterilization" guarantees a high degree of sterility of the medical units treated.
摘要翻译：本发明涉及一种消毒医疗单元的方法，该医疗单元具有至少两个用于流体通路的连接，其中消毒介质流过医疗单元。这种类型的医疗单位是例如。医疗过滤器，特别是透析器。这里需要高度的无菌性。这通过以下步骤来实现：（a）在大气条件下，将至少两个连接压力联接到系统的进料管道和排出管道，将医疗单元插入系统中; （b）将灭菌介质从系统通过医疗单位一段给定的时间; （c）在所述灭菌操作完成时，在所述连接状态下并以无菌方式封闭所述至少两个连接件而不相同地打开; 和（d）将所述医疗单元从所述系统中移除为具有封闭连接的无菌医疗单元。因此，所有步骤，包括移除医疗单元，都是在不断得到不育的系统中进行的。这种“在线灭菌”保证所治疗的医疗单位的高度的无菌性。

10. 发明授权

US4790807A Centrifuge arrangement 失效
标题翻译：离心机安排
公开(公告)号：US4790807A
公开(公告)日：1988-12-13
申请号：US100236
申请日：1987-09-23
申请人： Hans-Jurgen Neumann , Wolfram Weber
发明人： Hans-Jurgen Neumann , Wolfram Weber
IPC分类号： B04B5/04 , B04B7/08
CPC分类号： B04B5/0442 , B04B5/0428
摘要： The invention relates to a centrifuge arrangement having a centrifuge rotor comprising a drive disc (18) connected to a drive source. Furthermore, the centrifuge rotor comprises at least one separation container (1, 32) which comprises a separation passage (6) and a separation chamber (9) whose outlet and inlet passages lead to the center of the drive disc (18). Advantageously, the separation container (1, 32) is made as self-supporting part of rigid or semi-rigid but flexible material and this makes it possible to insert said container easily into the drive disc (18) and in addition provides advantages in the production of the centrifuge arrangement according to the invention.
摘要翻译：本发明涉及具有离心机转子的离心机装置，该离心机转子包括连接到驱动源的驱动盘（18）。此外，离心机转子包括至少一个分离容器（1,32），其包括分离通道（6）和分离室（9），其出口和入口通道通向驱动盘（18）的中心。有利地，分离容器（1,32）被制成刚性或半刚性但柔性材料的自支撑部分，并且这使得可以将所述容器容易地插入到驱动盘（18）中，并且另外在生产根据本发明的离心机装置。

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