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1. 发明授权

US08574564B2 Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity 失效
标题翻译：免疫刺激核酸包装颗粒治疗超敏反应
公开(公告)号：US08574564B2
公开(公告)日：2013-11-05
申请号：US12576086
申请日：2009-10-08
申请人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
发明人： Wolfgang A. Renner , Martin F. Bachmann , Indulis Cielens , Conrad Johannes Coester , Klaus Dietmeier , Sebastian Fuchs , Vania Manolova , Patrik Maurer , Paul Pumpens , Regina Renhofa , Alain Tissot , Yu Zou
IPC分类号： A01N63/00 , A61K48/00
CPC分类号： A61K39/12 , A61K39/39 , A61K47/6901 , A61K47/6931 , A61K49/0004 , A61K49/0093 , A61K49/0097 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , B82Y5/00 , C12N2795/18123
摘要： The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.
摘要翻译：本申请涉及治疗超敏反应的组合物和方法，其中组合物包含用免疫刺激核酸包装的颗粒。本发明的组合物特别可用于治疗特应性湿疹，哮喘和IgE介导的过敏（I型过敏），特别是花粉过敏和房屋尘埃过敏。

2. 发明授权

US08691209B2 Packaging of immunostimulatory substances into virus-like particles: method of preparation and use 有权
标题翻译：将免疫刺激物质包装成病毒样颗粒：制备和使用方法
公开(公告)号：US08691209B2
公开(公告)日：2014-04-08
申请号：US13294006
申请日：2011-11-10
申请人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin F. Bachmann , Tazio Storni , Patrik Maurer , Alain Tissot , Katrin Schwarz , Edwin Meijerink , Gerd Lipowsky , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： A01N63/00 , C12N1/20 , C12N7/00
CPC分类号： A61K39/12 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/39 , A61K2039/52 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2730/10122 , C12N2730/10123 , C12N2795/00034 , C12N2795/18122 , Y02A50/412 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。此外，针对VLP和抗原的T细胞应答特别针对Th1型。因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

3. 发明授权

US07138252B2 Molecular antigen arrays 有权
公开(公告)号：US07138252B2
公开(公告)日：2006-11-21
申请号：US10617876
申请日：2003-07-14
申请人： Martin F. Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin F. Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： C12N15/09 , C12N15/40 , C12N1/21 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.

4. 发明申请

US20090123414A1 Il-15 Antigen Arrays And Uses Thereof 审中-公开
标题翻译： Il-15抗原阵列及其用途
公开(公告)号：US20090123414A1
公开(公告)日：2009-05-14
申请号：US11792749
申请日：2005-12-12
申请人： Martin F. Bachmann , Patrik Maurer , Yu Zou , Alain Tissot
发明人： Martin F. Bachmann , Patrik Maurer , Yu Zou , Alain Tissot
IPC分类号： A61K48/00 , A61K39/20
CPC分类号： A61K39/0008 , A61K39/0005 , A61K2039/5258
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序重复抗原阵列的组合物，其中所述抗原是IL-15蛋白，IL-15突变蛋白或IL-15片段。更具体地，本发明提供包含病毒样颗粒和至少一种IL-15蛋白，IL-15突变蛋白或与其连接的至少一个IL-15片段的组合物。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产用于治疗炎性和慢性自身免疫性疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明授权

US07517520B2 Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use 失效
标题翻译：将免疫刺激性寡核苷酸包装成病毒样颗粒：制备和使用方法
公开(公告)号：US07517520B2
公开(公告)日：2009-04-14
申请号：US10550518
申请日：2004-03-25
申请人： Vania Manolova , Martin F. Bachmann , Andreas Cornelius , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
发明人： Vania Manolova , Martin F. Bachmann , Andreas Cornelius , Patrik Maurer , Edwin Meijerink , Karl G. Proba , Katrin Schwarz
IPC分类号： A01N63/00 , C12N7/00 , C12N1/20
CPC分类号： C12N15/117 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K14/4748 , C07K2319/00 , C12N2310/18 , C12N2710/20022 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , C12N2760/10022 , C12N2760/10034 , C12N2795/18122 , C12N2795/18123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及病毒样颗粒（VLP）可以加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸的发现。这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。与抗VLP本身的免疫应答相似地，抗体任选偶联，融合或附着于VLP的抗原的免疫应答也被增强。此外，针对VLP和抗原的T细胞应答特别针对Th1型。因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

6. 发明申请

US20090123471A1 T-Cadherin antigen arrays and uses thereof 审中-公开
标题翻译： T-Cadherin抗原阵列及其用途
公开(公告)号：US20090123471A1
公开(公告)日：2009-05-14
申请号：US11666497
申请日：2005-10-31
申请人： Martin F. Bachmann , Philippe Saudan , Klaus Dietmeier , Alain Tissot
发明人： Martin F. Bachmann , Philippe Saudan , Klaus Dietmeier , Alain Tissot
IPC分类号： A61K39/395 , C07K14/00 , A61K39/00 , A61K38/16
CPC分类号： A61K39/385 , A61K47/6901 , A61K2039/6075 , A61K2039/627
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a T-cadherin domain protein, a combination of any T-cadherin domain proteins, a T-cadherin domain fragment or a combination of any T-cadherin domain fragments, linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of T-cadherin related disease, and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供了包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是T-cadherin结构域蛋白，任何T-cadherin结构域蛋白，T-钙粘蛋白结构域片段或与VLP分别连接的任何T-cadherin结构域片段的组合。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗T-钙粘蛋白相关疾病，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

7. 发明申请

US20120258130A1 VACCINATION REGIMEN FOR B-CELL VACCINES 审中-公开
标题翻译： B细胞疫苗的疫苗接种
公开(公告)号：US20120258130A1
公开(公告)日：2012-10-11
申请号：US13292579
申请日：2011-11-09
申请人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
发明人： Patrik Maurer , Thomas Pfister , Martin F. Bachmann , Philipp Müller , Wolfgang A. Renner
IPC分类号： A61K39/385 , A61P25/34 , A61P25/30
CPC分类号： A61K39/0013 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/55505
摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.
摘要翻译：本发明涉及疫苗接种和治疗或预防疾病领域。特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。本发明还提供了通过在受试者中诱导半抗原特异性抗体来预防或治疗疾病的方法，所述方法包括向所述受试者施用包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原的组合物。

8. 发明授权

US07537767B2 Melan-A- carrier conjugates 失效
标题翻译：黑色素A-载体缀合物
公开(公告)号：US07537767B2
公开(公告)日：2009-05-26
申请号：US10551054
申请日：2004-03-25
申请人： Martin F. Bachmann , Vania Manolova , Edwin Meijerink , Karl G. Proba , Katrin Schwartz
发明人： Martin F. Bachmann , Vania Manolova , Edwin Meijerink , Karl G. Proba , Katrin Schwartz
IPC分类号： A61K39/00 , A61K39/12 , A61K39/385
CPC分类号： A61K39/39 , A61K2039/5258 , A61K2039/55561 , A61K2039/6075 , A61K2039/62 , A61K2039/64 , C07K14/005 , C07K14/4748 , C12N2710/22022 , C12N2730/10122 , C12N2730/10123 , C12N2760/10022 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpGVLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含VLP的修饰病毒样颗粒（VLP），其可加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸，以及衍生自与其连接的MelanA的特定肽。这样的CpGVLP比其不含CpG的对应物显着地更具免疫原性，并且诱导增强的B和T细胞应答。与VLP本身的免疫应答相似，对于任何偶联，融合或附着于VLP的MelanA肽类似物的免疫应答也相似地增强。此外，针对MelanA肽类似物的T细胞应答特别针对Th1型。因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

9. 发明授权

US07128911B2 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US07128911B2
公开(公告)日：2006-10-31
申请号：US10289456
申请日：2002-11-07
申请人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin F. Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： A61K39/385 , A61K38/22 , A61K9/00 , C07K17/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

10. 发明申请

US20110070267A1 PACKAGED VIRUS-LIKE PARTICLES FOR USE AS ADJUVANTS: METHOD OF PREPARATION AND USE 审中-公开
标题翻译：用作ADJUVANTS的包装的病毒颗粒：制备和使用方法
公开(公告)号：US20110070267A1
公开(公告)日：2011-03-24
申请号：US12790708
申请日：2010-05-28
申请人： Martin F. Bachmann , Wolfgang A. Renner
发明人： Martin F. Bachmann , Wolfgang A. Renner
IPC分类号： A61K39/35 , A61K39/36 , A61P37/04 , A61P37/08
CPC分类号： C12N7/00 , A61K39/0011 , A61K39/35 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/55561 , A61K2039/55588 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C12N2730/10122 , C12N2730/10123 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded and packaged, respectively, with DNA oligonucleotides rich in non-methylated C and G (CpGs). If such CpG-VLPs are mixed with antigens, the immunogenicity of these antigens are dramatically enhanced. In addition, the T cell responses against the antigens are especially directed to the Th1 type. Surprisingly, no covalent linkage of the antigen to the VLP is required; it is sufficient to simply mix the VLPs with the adjuvants for co-administration. In addition, it was found that VLPs did not enhance immune responses unless they were loaded and packaged, respectively, with CpGs. Antigens mixed with CpG-packaged VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
摘要翻译：本发明涉及可以分别用富含非甲基化C和G（CpG）的DNA寡核苷酸装载和包装病毒样颗粒（VLPs）的发现。如果这种CpG-VLP与抗原混合，则这些抗原的免疫原性显着增强。此外，针对抗原的T细胞应答特别针对Th1型。令人惊讶的是，不需要抗原与VLP的共价连接; 简单地将VLP与用于共同给药的佐剂混合就足够了。此外，发现VLP除了分别用CpG装载和包装外，还没有增强免疫应答。因此，与CpG包装的VLP混合的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

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