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1. 发明授权

US07824557B2 Method for controlling microbial biofilm in aqueous systems 有权
标题翻译：在水系统中控制微生物生物膜的方法
公开(公告)号：US07824557B2
公开(公告)日：2010-11-02
申请号：US11835722
申请日：2007-08-08
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/20 , C02F2305/14 , Y10S210/916 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐。根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。此后，释放杀生物活性的水性核心直接与生物膜包裹的微生物反应。当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上膜，从而降低膜清洗的频率和持续时间并最终更换。

2. 发明授权

US07785478B2 Method for controlling protozoa that harbor bacteria 有权
标题翻译：防治细菌原生动物的方法
公开(公告)号：US07785478B2
公开(公告)日：2010-08-31
申请号：US11835717
申请日：2007-08-08
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel
IPC分类号： C02F1/50
CPC分类号： A01N25/28 , Y10S514/963 , A01N33/12 , A01N47/44 , A01N57/20
摘要： A method for controlling protozoa trophozites and cysts wherein biocides or control agents are encapsulated within microcapsules or manufactured into the core of liposomes, thereafter the biocide containing microcapsules or liposomes are then introduced into an aqueous system.
摘要翻译：一种用于控制原生动物滋养细胞和囊肿的方法，其中将杀生物剂或控制剂包封在微胶囊内或制成脂质体核心，然后将含有微胶囊或脂质体的杀生物剂引入含水体系中。

3. 发明申请

US20120114728A1 BIODELIVERY SYSTEMS 审中-公开
标题翻译：生物系统
公开(公告)号：US20120114728A1
公开(公告)日：2012-05-10
申请号：US13257211
申请日：2010-02-12
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Kimberly Murphy , Qing Zhao
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Kimberly Murphy , Qing Zhao
IPC分类号： A01N25/26 , A01N37/34 , A01N33/20 , A01N57/20 , A01P1/00 , A01N43/80 , A01N33/12 , B82Y99/00
CPC分类号： A61K31/425 , A01N25/28 , A01N43/80
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存坦克根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少降低膜清洗的频率和持续时间并最终更换。

4. 发明申请

US20100239627A1 QUARTERNARY AMMONIUM SALTS DELIVERY SYSTEMS 审中-公开
标题翻译：季铵盐销售系统
公开(公告)号：US20100239627A1
公开(公告)日：2010-09-23
申请号：US12408059
申请日：2009-03-20
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel
IPC分类号： A01N25/34 , A01N33/12 , A01P1/00
CPC分类号： A01N25/28 , A01N25/34 , A01N33/12
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存坦克根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少降低膜清洗的频率和持续时间并最终更换。

5. 发明授权

US08784659B2 Method for controlling microbial biofilm in aqueous systems 有权
标题翻译：在水系统中控制微生物生物膜的方法
公开(公告)号：US08784659B2
公开(公告)日：2014-07-22
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： C02F1/50
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐。根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上膜，从而降低膜清洗的频率和持续时间并最终更换。

6. 发明申请

US20110052656A1 METHOD FOR CONTROLLING MICROBIAL BIOFILM IN AQUEOUS SYSTEMS 有权
标题翻译：用于控制水质体系中微生物生物学的方法
公开(公告)号：US20110052656A1
公开(公告)日：2011-03-03
申请号：US12892490
申请日：2010-09-28
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel , Qing Zhao , Linna Wang , Dorothy Reynolds , Paul Frail , Juan Jiang , David M. Polizzotti
IPC分类号： A01N25/26 , A61K31/04 , A01N43/78 , A01N33/02 , A01N47/00 , A01N37/52 , A01N43/66 , A01N57/34 , A01N35/00 , A01N37/44 , A01N43/88 , A01N43/80 , A01N59/20 , A01N59/16 , A01N59/08 , A01N59/24 , A01N39/00 , A01N59/26 , A01P1/00
CPC分类号： C02F1/50 , A01N47/44 , A01N47/48 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2305/14 , A01N25/04 , A01N2300/00
摘要： A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种通过使用脂质体载体将抗微生物化合物引入复合生物膜基质的效率和有效性的方法，从而消除工业含水系统中的生物污垢，包括管道，热交换器，冷凝器，过滤系统和流体储存罐。根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦包含脂质体的抗微生物化合物变得与生物膜基质夹带，就可以进行脂质体的分解或程序分解。此后，释放杀生物的水性核心直接与生物膜包裹的微生物反应。当生物体死亡时，多糖/蛋白质基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物在微量过滤表面上膜，从而降低膜清洗的频率和持续时间并最终更换。

7. 发明申请

US20100239651A1 NITRILOPROPIONAMIDE DELIVERY SYSTEMS 审中-公开
标题翻译： NITRILOPROPIONAMIDE交付系统
公开(公告)号：US20100239651A1
公开(公告)日：2010-09-23
申请号：US12408027
申请日：2009-03-20
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel
IPC分类号： A01N25/34 , A01P1/00 , A01N37/34
CPC分类号： A01N25/34 , A01N25/28 , C02F2303/20 , A01N37/34
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存坦克根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少降低膜清洗的频率和持续时间并最终更换。

8. 发明申请

US20100239630A1 PHOSPHONIUM SALTS DELIVERY SYSTEMS 审中-公开
标题翻译：磷酸盐输送系统
公开(公告)号：US20100239630A1
公开(公告)日：2010-09-23
申请号：US12408061
申请日：2009-03-20
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel
IPC分类号： A01N25/26 , A01N57/34 , A01N57/20 , A01P1/00
CPC分类号： A01N57/34 , C02F1/001 , C02F1/50 , C02F2303/20 , A01N25/28 , A01N25/34
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained within the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存坦克根据本发明的一个实施方案，将含抗微生物剂的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦含有抗微生物化合物的脂质体被夹带在生物膜基质内，就可以进行脂质体的分解或分解。此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少降低膜清洗的频率和持续时间并最终更换。

9. 发明申请

US20110052655A1 METHODS AND VESICLES FOR CONTROLLING PROTOZOA 审中-公开
标题翻译：控制PROTOZOA的方法和方法
公开(公告)号：US20110052655A1
公开(公告)日：2011-03-03
申请号：US12843850
申请日：2010-07-26
申请人： Wilson Kurt WHITEKETTLE , Gloria Jean Tafel , Dorothy G. Reynolds , Paul Robert Frail , Linna Wang , Juan Jiang , Qing Zhao
发明人： Wilson Kurt WHITEKETTLE , Gloria Jean Tafel , Dorothy G. Reynolds , Paul Robert Frail , Linna Wang , Juan Jiang , Qing Zhao
IPC分类号： A01N25/34 , A01N59/00 , A01N59/08 , A01N59/16 , A01N59/20 , A01N63/02 , A01N63/00 , A01N65/00
CPC分类号： A01N25/28
摘要： A method for controlling protozoa trophozoites and cysts wherein one or more biocides or non-biocidal agents are encapsulated within a micro-capsule or nano-capsule and then introduced into an aqueous system. The micro-capsule or nano-capsule has an exterior composition adapted for digestion by the protozoa. A vesicle for controlling protozoa trophozoites and cysts is also provided.
摘要翻译：用于控制原生动物滋养体和囊肿的方法，其中将一种或多种杀生物剂或非杀生物剂包封在微胶囊或纳米胶囊内，然后引入含水体系中。微胶囊或纳米胶囊具有适于由原生动物消化的外部组合物。还提供了用于控制原生动物滋养体和囊肿的囊泡。

10. 发明申请

US20100239650A1 ISOTHIAZOLIN BIODELIVERY SYSTEMS 审中-公开
标题翻译： ISOTHIAZOLIN BIODELIVERY系统
公开(公告)号：US20100239650A1
公开(公告)日：2010-09-23
申请号：US12407953
申请日：2009-03-20
申请人： Wilson Kurt Whitekettle , Gloria Jean Tafel
发明人： Wilson Kurt Whitekettle , Gloria Jean Tafel
IPC分类号： A61K9/127 , A61K31/425
CPC分类号： A61K31/425 , A01N25/28 , A01N43/80
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks.According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
摘要翻译：已经发现了一种生物输送系统，其通过使用脂质体载体提高了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水系统中的生物污垢，包括管道，热交换，冷凝器，过滤系统和流体储存坦克根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入容易生物结垢和生物膜形成的水体系中。与微生物膜或细胞组成相似的脂质体容易并入现有的生物膜中。一旦含有脂质体的抗微生物化合物变得与生物膜基质夹带，则脂质体的分解或分解进行。此后，释放出杀生物核心，直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，在微滤膜的表面上胶体和颗粒固体以及溶解的有机物的沉积少降低膜清洗的频率和持续时间并最终更换。

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