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1. 发明授权

US07960544B2 Useful indole compounds 失效
标题翻译：有用的吲哚化合物
公开(公告)号：US07960544B2
公开(公告)日：2011-06-14
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译：具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。

2. 发明申请

US20090264653A1 USEFUL INDOLE COMPOUNDS 失效
标题翻译：有用的化合物
公开(公告)号：US20090264653A1
公开(公告)日：2009-10-22
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D413/14 , C07D209/04 , C07D235/00 , C07D403/04 , C07D215/02 , C07D471/02
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译：具有作为FAAH抑制剂活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。

3. 发明授权

US08884020B2 Indole compounds 有权
标题翻译：吲哚化合物
公开(公告)号：US08884020B2
公开(公告)日：2014-11-11
申请号：US12309993
申请日：2007-08-07
申请人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号： C07D209/18 , C07D209/22 , C07D401/06
CPC分类号： C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译：描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。该化合物至少在吲哚的3位被取代。

4. 发明申请

US20100197708A1 INDOLE COMPOUNDS 有权
标题翻译： INDOLE化合物
公开(公告)号：US20100197708A1
公开(公告)日：2010-08-05
申请号：US12309993
申请日：2007-08-07
申请人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
发明人： John Jeffrey Talley , Kevin Sprott , James Philip Pearson , G. Todd Milne , Wayne Schairer , Jane Yang , Charles Kim , Timothy Barden , Regina Lundrigan , Ara Mermerian , Mark G. Currie
IPC分类号： A61K31/506 , C07D401/12 , A61K31/4439 , C07D209/22 , A61K31/4045 , C07D403/12 , A61P3/04 , A61P25/06 , A61P29/00 , A61P25/22 , A61P27/06 , A61P37/08 , A61P11/06
CPC分类号： C07D209/18 , C07D209/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/04
摘要： Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.
摘要翻译：描述了可用于治疗疼痛，炎症和其它病症的吲哚衍生物。某些化合物是苄基衍生物，而其它化合物是苯甲酰基衍生物。该化合物至少在吲哚的3位被取代。

5. 发明授权

US07205329B2 Modulators of CRTH2 activity 失效
标题翻译： CRTH2活性调节剂
公开(公告)号：US07205329B2
公开(公告)日：2007-04-17
申请号：US11183626
申请日：2005-07-18
申请人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
发明人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D409/06 , C07D209/42
摘要： Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
摘要翻译：描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。

6. 发明申请

US20090062207A1 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US20090062207A1
公开(公告)日：2009-03-05
申请号：US11054071
申请日：2005-02-08
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Caroline Kurtz , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10 , C07K7/08 , C07K1/14 , C07H21/00 , A61P1/00 , C12N15/63 , C12N5/00
CPC分类号： C07K5/1016 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/245 , C07K14/705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

7. 发明授权

US07371727B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07371727B2
公开(公告)日：2008-05-13
申请号：US10899806
申请日：2004-07-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

8. 发明授权

US09617305B2 Treatments for gastrointestinal disorders 有权
公开(公告)号：US09617305B2
公开(公告)日：2017-04-11
申请号：US14124286
申请日：2012-06-08
申请人： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
发明人： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
IPC分类号： A61K38/10 , C07K7/08 , A61K38/51 , A61K45/06
CPC分类号： C07K7/08 , A61K38/10 , A61K38/51 , A61K45/06
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (IBD), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (BPH), pain, salt retention or fluid retention.

9. 发明授权

US07704947B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US07704947B2
公开(公告)日：2010-04-27
申请号：US11930696
申请日：2007-10-31
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。

10. 发明申请

US20090005534A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20090005534A1
公开(公告)日：2009-01-01
申请号：US11930696
申请日：2007-10-31
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。

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