专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5614170A Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI) 失效
标题翻译：有机酸N-烷基-N-羟基酰胺与含有磁共振成像（MRI）的乳状液的顺磁络合物
公开(公告)号：US5614170A
公开(公告)日：1997-03-25
申请号：US346885
申请日：1994-11-30
申请人： William P. Cacheris , Thomas J. Richard , Raymond C. Grabiak , Albert C. Lee
发明人： William P. Cacheris , Thomas J. Richard , Raymond C. Grabiak , Albert C. Lee
IPC分类号： A61K49/00 , A61K49/18 , C07C259/06 , A61B5/055
CPC分类号： A61K49/1806 , Y10S514/836 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA (diethylenetriaminepentaacetic acid), having a C.sub.10 -C.sub.30 saturated aliphatic group and an hydroxyl group bonded to the nitrogen atom. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI imaging.
摘要翻译：公开了顺磁性造影剂的乳液，以及制造和使用它们的方法。乳液含有水，分散的油相和顺磁性金属离子与有机酸螯合剂的复合物，例如具有C10-C30饱和脂族基团和与氮原子键合的羟基的DTPA（二亚乙基三胺五乙酸）。乳剂对于静脉内给药是非常稳定和治疗上可接受的，以增强MRI成像。

2. 发明授权

US5571498A Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). 失效
标题翻译：用于磁共振成像（MRI）的顺磁性造影剂的乳液。
公开(公告)号：US5571498A
公开(公告)日：1996-11-05
申请号：US252830
申请日：1994-06-02
申请人： William P. Cacheris , Robert J. Kaufman , Thomas J. Richard , Raymond C. Grabiak
发明人： William P. Cacheris , Robert J. Kaufman , Thomas J. Richard , Raymond C. Grabiak
IPC分类号： A61K49/18 , A61B5/055
CPC分类号： A61K49/1806 , Y10S424/90 , Y10S514/836 , Y10S514/938 , Y10T436/24
摘要： Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic chelator having a C.sub.10 -C.sub.30 unsaturated aliphatic group. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI.
摘要翻译：公开了顺磁性造影剂的乳液，以及制造和使用它们的方法。乳液含有水，分散油相和顺磁性金属离子与具有C10-C30不饱和脂肪族基团的有机螯合剂的络合物。对于静脉内施用，乳剂非常稳定和治疗上可接受以增强MRI。

3. 发明授权

US5403576A Iodo-phenylated chelates for magnetic resonance imaging 失效
标题翻译：用于磁共振成像的碘代 - 苯基螯合物
公开(公告)号：US5403576A
公开(公告)日：1995-04-04
申请号：US191832
申请日：1994-02-04
申请人： Youlin Lin , Muthanadar P. Periasamy , Donald R. VanDeripe , William P. Cacheris
发明人： Youlin Lin , Muthanadar P. Periasamy , Donald R. VanDeripe , William P. Cacheris
IPC分类号： G01R33/28 , A61K49/00 , A61K49/04 , A61K49/08 , C07F5/00 , C07F9/94 , C07F11/00 , C07F15/00 , C07F15/02 , C07F15/04 , C07F15/06 , C07K5/02 , G03C1/00 , G03C5/16 , A61B5/055 , A61K31/66
CPC分类号： A61K49/10 , A61K49/04 , A61K49/0438 , A61K49/085 , C07K5/022 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.
摘要翻译：用于增强身体器官和组织的体内诊断成像的混合物，以及其制备和使用方法。

4. 发明授权

US5155224A Manganese (II) chelates 失效
标题翻译：锰（II）螯合物
公开(公告)号：US5155224A
公开(公告)日：1992-10-13
申请号：US370478
申请日：1989-06-23
申请人： Scott M. Rocklage , William P. Cacheris , Gene Jamieson
发明人： Scott M. Rocklage , William P. Cacheris , Gene Jamieson
IPC分类号： A61K49/06 , C07C229/16 , C07D213/66 , C07D257/02 , C07D273/00 , C07F9/6558
CPC分类号： C07D213/66 , A61K49/06 , C07C229/16 , C07D257/02 , C07D273/00 , C07F9/65583
摘要： The process of this invention for preparing Mn(II) chelate comprises forming the Mn(II) chelate by mixing manganese (II) oxide (insoluble) with an aqueous suspension comprising a molar equivalent or molar excess of the insoluble protonated chelating compound at a temperature of from 20.degree.to 50.degree. C. When the reaction is carried out with a protonated chelating agent in the absence of base, a precipitate of the protonated Mn(II) chelate is formed. A low osmolarity MN(II) chelate solution can be formed from the precipitates by dissolving them in an aqueous solution of base. When the initial chelate forming reaction is carried out in a solution containing a molar equivalent or excess of sodium hydroxide, a low osmolarity solution of the Mn(II) chelate is directly formed with most chelating agents. Preferred chelating compounds for this process include DPDP, DTPA, DCTA, EDTP, DOTA, DOXA, DO3A and EDTA. The Nm(II) chelate precipitates and low osmolarity solutions formed by the above processes are also aspects of this invention.
摘要翻译：本发明制备Mn（II）螯合物的方法包括通过将锰（II）氧化物（不溶性）与包含摩尔当量或摩尔过量的不溶性质子化螯合化合物的水悬浮液在温度下混合形成Mn（II）螯合物为20〜50℃。当不存在碱时，用质子化螯合剂进行反应时，形成质子化的Mn（II）螯合物的沉淀物。通过将沉淀物溶解在碱的水溶液中，可以从沉淀物形成低摩尔渗透浓度的MN（II）螯合溶液。当初始螯合物形成反应在含有摩尔当量或过量氢氧化钠的溶液中进行时，Mn（II）螯合物的低渗透压溶液与大多数螯合剂直接形成。用于该方法的优选螯合化合物包括DPDP，DTPA，DCTA，EDTP，DOTA，DOXA，DO3A和EDTA。通过上述方法形成的Nm（II）螯合物沉淀物和低摩尔渗压浓度溶液也是本发明的一个方面。

5. 发明授权

US5087440A Heterocyclic derivatives of DTPA used for magnetic resonance imaging 失效
标题翻译： DTPA的杂环衍生物用于磁共振成像
公开(公告)号：US5087440A
公开(公告)日：1992-02-11
申请号：US468948
申请日：1990-01-23
申请人： William P. Cacheris , Stephen C. Quay
发明人： William P. Cacheris , Stephen C. Quay
IPC分类号： A61K49/04 , A61K49/06
CPC分类号： A61K49/04 , A61K49/06 , Y10S424/90 , Y10S514/836 , Y10T436/24
摘要： Gadolinium and calcium chelates of DTPA (diethylenetriaminepentaacetic acid) bisamides, such as a composition comprising a gadolinium chelate of a 6-carboxymethyl-3,9-bis (hydroxyalkyl-carbamoylmethyl)-3,6,9-triazaundecanedioic acid and a calcium chelate of a 6-carboxymethyl-3,9-bis(hydroxyalkyl-carbamoylmethyl)-3,6,9- triazaundecanedioic acid, are disclosed for use as magnetic resonance imaging contrast media.
摘要翻译： DTPA（二亚乙基三胺五乙酸）双酰胺的钆和钙螯合物，例如包含6-羧甲基-3,9-双（羟烷基 - 氨基甲酰甲基）-3,6,9-三氮杂十一烷二酸的钆螯合物和钙螯合物的钙螯合物公开了用作磁共振成像造影剂的6-羧甲基-3,9-双（羟烷基 - 氨基甲酰基甲基）-3,6,9-三氮杂十一烷二酸。

6. 发明授权

US5560902A Microfluidization of radioactive calcium/oxyanion-containing particles 失效
标题翻译：放射性钙/含氧阴离子颗粒的微流化
公开(公告)号：US5560902A
公开(公告)日：1996-10-01
申请号：US419800
申请日：1995-04-11
申请人： William P. Cacheris , Linda Meeh
发明人： William P. Cacheris , Linda Meeh
IPC分类号： A61B19/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61K51/00
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/773 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (
摘要翻译：使用微流化器制备固体磷灰石颗粒的方法，用于诸如磁共振成像，X射线和超声的医学诊断成像。合成所需的磷灰石颗粒，通过微流化器，并纯化以除去用于合成颗粒的过量碱，盐和其它材料。微流化器引起两个高压流在精确限定的微通道中以超高速度相互作用。制剂的微流化导致小（<5μm）和均匀的颗粒形成。涂层和净化（特别是通过切向流过滤），颗粒改善了颗粒的稳定性。

7. 发明授权

US5419892A Microfluidization of calcium/oxyanion-containing particles 失效
标题翻译：钙/含氧阴离子颗粒的微流化
公开(公告)号：US5419892A
公开(公告)日：1995-05-30
申请号：US249776
申请日：1994-07-26
申请人： William P. Cacheris , Linda Meeh
发明人： William P. Cacheris , Linda Meeh
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , A61K33/32 , A61K33/42
CPC分类号： A61K47/48861 , A61K47/48884 , A61K49/1818 , A61K49/1827 , A61K49/183 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/847 , Y10S977/896 , Y10S977/90 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Methods of preparing solid apatite particles using a microfluidizer, for use in medical diagnostic imaging such as magnetic resonance imaging, X-ray, and ultrasound. The desired apatite particles are synthesized, passed through a microfluidizer, and purified to remove excess base, salts, and other materials used to synthesize the particles. The microfluidizer causes two high pressure streams to interact at ultra high velocities in a precisely defined microchannel. Microfluidization of preparations causes small (
摘要翻译：使用微流化器制备固体磷灰石颗粒的方法，用于诸如磁共振成像，X射线和超声的医学诊断成像。合成所需的磷灰石颗粒，通过微流化器，并纯化以除去用于合成颗粒的过量碱，盐和其它材料。微流化器引起两个高压流在精确限定的微通道中以超高速度相互作用。制剂的微流化导致小（<5μm）和均匀的颗粒形成。涂层和净化（特别是通过切向流过滤），颗粒改善了颗粒的稳定性。

8. 发明授权

US4978763A Novel manganese(II) DTPA chelate 失效
标题翻译：新型锰（II）DTPA螯合物
公开(公告)号：US4978763A
公开(公告)日：1990-12-18
申请号：US370483
申请日：1989-06-23
申请人： Scott M. Rocklage , William P. Cacheris , Gene Jamieson
发明人： Scott M. Rocklage , William P. Cacheris , Gene Jamieson
IPC分类号： A61K49/06 , C07C229/16 , C07D213/66 , C07D257/02 , C07D273/00 , C07F9/6558
CPC分类号： C07D213/66 , A61K49/06 , C07C229/16 , C07D257/02 , C07D273/00 , C07F9/65583
摘要： The process of this invention for preparing Mn(II) chelate comprises forming the Mn(II) chelate by mixing manganese(II) oxide (insoluble) with an aqueous suspension comprising a molar equivalent or molar excess of the insoluble protonated chelating compound at a temperature of from 20.degree. to 50.degree. C. When the reaction is carried out with a protonated chelating agent in the absence of base, a precipitate of the protonated Mn(II) chelate is formed. A low osmolarity Mn(II) chelate solution can be formed from the precipitates by dissolving them in an aqueous solution of base. When the initial chelate forming reaction is carried out in a solution containing a molar equivalent or excess of sodium hydroxide, a low osmolarity solution of the Mn(II) chelate is directly formed with most chelating agents. Preferred chelating compounds for this process include DPDP, DTPA, DCTA, EDTP, DOTA, DOXA, DO3A and EDTA. The Mn(II) chelate precipitates and low osmolarity solutions formed by the above processes are also aspects of this invention.
摘要翻译：本发明制备Mn（II）螯合物的方法包括通过将锰（II）氧化物（不溶性）与包含摩尔当量或摩尔过量的不溶性质子化螯合化合物的水悬浮液在温度下混合形成Mn（II）螯合物为20〜50℃。当不存在碱时，用质子化螯合剂进行反应时，形成质子化的Mn（II）螯合物的沉淀物。通过将它们溶解在碱的水溶液中，可以通过沉淀物形成低摩尔渗透浓度的Mn（II）螯合溶液。当初始螯合物形成反应在含有摩尔当量或过量氢氧化钠的溶液中进行时，Mn（II）螯合物的低渗透压溶液与大多数螯合剂直接形成。用于该方法的优选螯合化合物包括DPDP，DTPA，DCTA，EDTP，DOTA，DOXA，DO3A和EDTA。通过上述方法形成的Mn（II）螯合物沉淀物和低摩尔渗压浓度溶液也是本发明的一个方面。

9. 发明授权

US5468465A Treated apatite particles for x-ray diagnostic imaging 失效
标题翻译：用于x射线诊断成像的经处理的磷灰石颗粒
公开(公告)号：US5468465A
公开(公告)日：1995-11-21
申请号：US271921
申请日：1994-07-06
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.
摘要翻译：公开了治疗磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱学（“MRS”），磁共振光谱成像（37MRSI“），X射线诊断成像和超声成像的医学诊断成像。公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。根据诊断成像技术，将磷灰石颗粒处理为磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后执行药物诊断程序。

10. 发明授权

US5362477A 19F magnetic resonance imaging agents which include a nitroxide moiety 失效
标题翻译： 19F磁共振成像剂，其包括氮氧化物部分
公开(公告)号：US5362477A
公开(公告)日：1994-11-08
申请号：US950343
申请日：1992-12-01
申请人： Dennis A. Moore , Max D. Adams , William P. Cacheris , David H. White , Muthunadar P. Periasamy , Raghavan Rajagopalan , Lynn A. deLearie , Steven R. Woulfe
发明人： Dennis A. Moore , Max D. Adams , William P. Cacheris , David H. White , Muthunadar P. Periasamy , Raghavan Rajagopalan , Lynn A. deLearie , Steven R. Woulfe
IPC分类号： A61K49/06 , A61B5/055
CPC分类号： A61K49/06 , Y10S514/832 , Y10T436/24
摘要： Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.
摘要翻译：公开了用于增强19F磁共振成像的方法和组合物，其利用具有增强的19F弛豫度的19F磁共振造影剂。公开了具有与未配对纺丝直接相关的增强的19F弛豫性能的含氟化合物。含氟化合物通过共价连接稳定的自由基，通过氟化络合剂与顺磁性金属离子的络合，或通过成盐或顺磁离子的电荷中和与非配对纺丝相关联。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式