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1. 发明授权

US06319268B1 Adjustable blood filtration system 有权
标题翻译：可调式血液过滤系统
公开(公告)号：US06319268B1
公开(公告)日：2001-11-20
申请号：US09630805
申请日：2000-08-02
申请人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
发明人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
IPC分类号： A61B1700
CPC分类号： A61F2/013 , A61B90/06 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076 , A61F2230/008
摘要： A modular blood filter device and delivery system, comprising a hollow vessel insertion device with a modular filter apparatus. The insertion device, which can be an introducer, includes a distal end adapted to enter an artery, and a proximal end adapted to receive a modular filter apparatus. When the insertion device is a cannula, the modular filter apparatus is received through a side port. The modular filter apparatus includes a shaft and an adjustable filter device or a removable filter associated with the shaft. The adjustable filter includes filter mesh, an adjustable frame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the mesh. The frame may be collapsed to the contracted condition, and may be removed from the vessel or embolic debris may be removed by an aspiration tube. The modular filter cartridge may be removed from the cannula, and a new modular filter cartridge may then be received therein.
摘要翻译：一种模块化血液过滤装置和输送系统，包括具有模块化过滤装置的中空容器插入装置。可以是导引器的插入装置包括适于进入动脉的远端，以及适于接收模块化过滤装置的近端。当插入装置是插管时，通过侧端口容纳模块式过滤装置。模块化过滤装置包括轴和可调节过滤器装置或与轴相关联的可移除过滤器。可调节过滤器包括过滤网，能够承担放大和收缩条件的可调节框架以及与框架相关联的框架上浆机构。可调节框架可以是自调节的或外部调整的以适应容器并捕获网状物中的栓塞物质。框架可以折叠到收缩状态，并且可以从血管中移除，或者可以通过抽吸管去除栓塞性碎屑。可以将模块化过滤器滤芯从插管中取出，然后可以在其中接收新的模块化过滤器滤芯。

2. 发明授权

US6007557A Adjustable blood filtration system 失效
标题翻译：可调式血液过滤系统
公开(公告)号：US6007557A
公开(公告)日：1999-12-28
申请号：US70660
申请日：1998-04-29
申请人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
发明人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
IPC分类号： A61B17/00 , A61B19/00 , A61F2/01
CPC分类号： A61F2/013 , A61B90/06 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076 , A61F2230/008
摘要： A modular blood filter device and delivery system, comprising a hollow vessel insertion device with a modular filter apparatus. The insertion device, which can be an introducer, includes a distal end adapted to enter an artery, and a proximal end adapted to receive a modular filter apparatus. When the insertion device is a cannula, the modular filter apparatus is received through a side port. The modular filter apparatus includes a shaft and an adjustable filter device or a removable filter associated with the shaft. The adjustable filter includes filter mesh, an adjustable flame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. Certain embodiments include a filter cartridge, and the shaft is inserted into the cartridge, thereby protecting the adjustable filter device therein. The cartridge may then be removably received by the insertion device. An expandable obturator may be used to ease the entry of the insertion device into the vessel. Indexing and locking mechanisms are described for aligning the cartridge or the obturator to the insertion device. Vessel sizing tools are also described for determining the size of the vessel into which the filter will be introduced. The insertion device may then be introduced into a blood vessel, and the adjustable filter device may be deployed through the device into the vessel The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the mesh. The frame may be collapsed to the contracted condition, and may be removed from the vessel or embolic debris may be removed by an aspiration tube. The modular filter cartridge may be removed from the cannula, and a new modular filter cartridge may then be received therein.
摘要翻译：一种模块化血液过滤装置和输送系统，包括具有模块化过滤装置的中空容器插入装置。可以是导引器的插入装置包括适于进入动脉的远端，以及适于接收模块化过滤装置的近端。当插入装置是插管时，通过侧端口容纳模块式过滤装置。模块化过滤装置包括轴和可调节过滤器装置或与轴相关联的可移除过滤器。可调节过滤器包括过滤网，可调节的火焰，能够承担放大和收缩的条件以及与框架相关联的框架上浆机构。某些实施例包括一个过滤器滤芯，并且该轴被插入到该盒中，从而保护其中的可调节过滤装置。然后，盒可以被插入装置可拆卸地接收。可以使用可膨胀闭孔器来容易地将插入装置进入容器。描述了分度和锁定机构，用于将盒或封闭器对准插入装置。还描述了用于确定将引入过滤器的容器尺寸的容器尺寸调整工具。然后可以将插入装置引入血管，并且可调节过滤器装置可以通过装置部署到容器中。可调框架可以是自调节的或外部调节的以适应容器并捕获网中的栓塞材料。框架可以折叠到收缩状态，并且可以从血管中移除，或者可以通过抽吸管去除栓塞性碎屑。可以将模块化过滤器滤芯从插管中取出，然后可以在其中接收新的模块化过滤器滤芯。

3. 发明授权

US07014648B2 Adjustable blood filtration device 有权
公开(公告)号：US07014648B2
公开(公告)日：2006-03-21
申请号：US10456726
申请日：2003-06-05
申请人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
发明人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B90/06 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076 , A61F2230/008
摘要： A medical device comprising a tubular member having a proximal end, a distal end, and a lumen extending therebetween. An adjustable filter is provided having a frame and a mesh disposed about the frame. The frame is generally circular when deployed and has a first point, a first arc extending 180° from the first point to a second point on the circular frame that is opposite the first point, and a second arc extending 180° from the first point to the second point. The filter is deployed by advancing the frame distally through the tubular member with the second point leading and the first point trailing.

4. 发明授权

US06656204B2 Adjustable blood filtration system 有权
公开(公告)号：US06656204B2
公开(公告)日：2003-12-02
申请号：US10001465
申请日：2001-10-31
申请人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
发明人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
IPC分类号： A61B1700
CPC分类号： A61F2/013 , A61B90/06 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076 , A61F2230/008
摘要： A modular blood filter apparatus and methods of use. The modular filter apparatus includes an adjustable frame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. Certain embodiments include a filter cartridge to protect the adjustable filter device therein. The cartridge may be removably introduced into a blood vessel, and the adjustable filter device may be deployed through the device into the vessel. The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the filter. The frame may be collapsed to the contracted condition, and may be removed from the vessel.

5. 发明授权

US6152947A Adjustable blood filtration system 有权
标题翻译：可调式血液过滤系统
公开(公告)号：US6152947A
公开(公告)日：2000-11-28
申请号：US392059
申请日：1999-09-08
申请人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
发明人： William M. Ambrisco , Richard O. Murphy , Timothy J. Wood , Roman Turovskiy , Tracy D. Maahs , Bruce S. Addis
IPC分类号： A61B17/00 , A61B19/00 , A61F2/01
CPC分类号： A61F2/013 , A61B90/06 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076 , A61F2230/008
摘要： A modular blood filter device and delivery system, comprising a hollow vessel insertion device with a modular filter apparatus. The insertion device, which can be an introducer, includes a distal end adapted to enter an artery, and a proximal end adapted to receive a modular filter apparatus. When the insertion device is a cannula, the modular filter apparatus is received through a side port. The modular filter apparatus includes a shaft and an adjustable filter device or a removable filter associated with the shaft. The adjustable filter includes filter mesh, an adjustable frame capable of assuming enlarged and contracted conditions and a frame sizing mechanism associated with the frame. Certain embodiments include a filter cartridge, and the shaft is inserted into the cartridge, thereby protecting the adjustable filter device therein. The cartridge may then be removably received by the insertion device. An expandable obturator may be used to ease the entry of the insertion device into the vessel. Indexing and locking mechanisms are described for aligning the cartridge or the obturator to the insertion device. Vessel sizing tools are also described for determining the size of the vessel into which the filter will be introduced. The insertion device may then be introduced into a blood vessel, and the adjustable filter device may be deployed through the device into the vessel. The adjustable frame may be self-adjusting or externally adjusted to fit the vessel and to capture embolic material in the mesh. The frame may be collapsed to the contracted condition, and may be removed from the vessel or embolic debris may be removed by an aspiration tube. The modular filter cartridge may be removed from the cannula, and a new modular filter cartridge may then be received therein.
摘要翻译：一种模块化血液过滤装置和输送系统，包括具有模块化过滤装置的中空容器插入装置。可以是导引器的插入装置包括适于进入动脉的远端，以及适于接收模块化过滤装置的近端。当插入装置是插管时，通过侧端口容纳模块式过滤装置。模块化过滤装置包括轴和可调节过滤器装置或与轴相关联的可移除过滤器。可调节过滤器包括过滤网，能够承担放大和收缩条件的可调节框架以及与框架相关联的框架上浆机构。某些实施例包括一个过滤器滤芯，并且该轴被插入到该盒中，从而保护其中的可调节过滤装置。然后，盒可以被插入装置可拆卸地接收。可以使用可膨胀闭孔器来容易地将插入装置进入容器。描述了分度和锁定机构，用于将盒或封闭器对准插入装置。还描述了用于确定将引入过滤器的容器尺寸的容器尺寸调整工具。然后可以将插入装置引入血管，并且可调节的过滤装置可以通过装置部署到容器中。可调节框架可以是自调节的或外部调整的以适应容器并捕获网状物中的栓塞物质。框架可以折叠到收缩状态，并且可以从血管中移除，或者可以通过抽吸管去除栓塞性碎屑。可以将模块化过滤器滤芯从插管中取出，然后可以在其中接收新的模块化过滤器滤芯。

6. 发明授权

US06706033B1 Modular access port for device delivery 有权
标题翻译：用于设备传送的模块化访问端口
公开(公告)号：US06706033B1
公开(公告)日：2004-03-16
申请号：US09365650
申请日：1999-08-02
申请人： Lorraine Mangosong Martinez , Jobert Balceta , Kevin Hahnen , Bruce Addis , Timothy J. Wood , Roman Turovskiy , Richard O. Murphy , Tracy D. Maahs
发明人： Lorraine Mangosong Martinez , Jobert Balceta , Kevin Hahnen , Bruce Addis , Timothy J. Wood , Roman Turovskiy , Richard O. Murphy , Tracy D. Maahs
IPC分类号： A61M2900
CPC分类号： A61B17/3415 , A61B17/3421 , A61B2017/00243 , A61B2017/22067 , A61B2017/3445 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/008
摘要： Modular systems comprising a cannula and at least one access port adjacent to a distal end of the cannula provide insertion of one or more therapeutic or diagnostic devices into a vessel or cardiac tissue through a single incision site. Other embodiments include a vessel introducer or multi-port introducer. The devices can be operated in combination or independently. The systems can be employed to provide multiple therapies, including blood perfusion, filtration, aspiration, vessel occlusion, atherectomy, and endoscopic devices. Methods of using the system for vessel cannulation are also disclosed herein.
摘要翻译：包括套管和邻近套管远端的至少一个进入口的模块化系统通过单个切口部位将一个或多个治疗或诊断装置插入血管或心脏组织。其他实施例包括血管引入器或多端口引导器。设备可以组合或独立运行。该系统可用于提供多种疗法，包括血液灌注，过滤，抽吸，血管闭塞，粥样斑块切除术和内窥镜装置。本文还公开了使用该系统用于血管插管的方法。

7. 发明授权

US06666846B1 Medical device introducer and obturator and methods of use 有权
公开(公告)号：US06666846B1
公开(公告)日：2003-12-23
申请号：US09439646
申请日：1999-11-12
申请人： Roman Turovskiy , Richard O. Murphy
发明人： Roman Turovskiy , Richard O. Murphy
IPC分类号： A61M5178
CPC分类号： A61B17/3421 , A61B17/3417 , A61B2017/00243 , A61B2017/3445 , A61B2017/3447 , A61F2002/011
摘要： An introducer having an elongate tubular member and a device connector releasably attached to a proximal end of the tubular member. The introducer allows exchange of medical instruments, such as a blood filter and cardioplegia catheter, through a single lumen. An obturator having a retractable blade for making incision on a tissue is insertable through the lumen of the introducer. Methods of using the obturator and the introducer for introducing medical device(s) into body cavity, such as a vessel or cardiac tissue, are also disclosed.

8. 发明授权

US06406471B1 Arterial filter with aspiration and methods of use 失效
标题翻译：带抽吸的动脉过滤器和使用方法
公开(公告)号：US06406471B1
公开(公告)日：2002-06-18
申请号：US09473584
申请日：1999-12-28
申请人： Yue-Teh Jang , Richard O. Murphy , Roman Turovskiy
发明人： Yue-Teh Jang , Richard O. Murphy , Roman Turovskiy
IPC分类号： A61M100
CPC分类号： A61M1/0058 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M1/0084
摘要： A filter comprising a porous material is arranged in a generally conical shape having an expandable base and a vertex. A reservoir tip is located at the vertex for collecting filtered embolic material. The tip communicates with a distal port and lumen of an aspiration tube for removing embolic material under vacuum. A vessel occluding device comprising a non-permeable material having an expandable conical shape and communicating with an aspiration tube is also disclosed. Methods of using the filter and occluding devices for protecting a patient from embolization during cardiovascular procedures are described.
摘要翻译：包括多孔材料的过滤器布置成具有可膨胀基部和顶点的大致圆锥形状。储液器尖端位于顶点处，用于收集过滤的栓塞物质。尖端与抽吸管的远端口和内腔连通，用于在真空下去除栓塞物质。还公开了一种包括具有可扩张圆锥形状并与抽吸管连通的不可渗透材料的容器封闭装置。描述了在心血管程序期间使用过滤器和闭塞装置来保护患者免于栓塞的方法。

9. 发明授权

US06723085B2 Arterial filter with aspiration and methods of use 失效
标题翻译：带抽吸的动脉过滤器和使用方法
公开(公告)号：US06723085B2
公开(公告)日：2004-04-20
申请号：US10174074
申请日：2002-06-17
申请人： Yue-Teh Jang , Richard O. Murphy , Roman Turovskiy
发明人： Yue-Teh Jang , Richard O. Murphy , Roman Turovskiy
IPC分类号： A61M100
CPC分类号： A61M1/0058 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M1/0084
摘要： A filter comprising a porous material is arranged in a generally conical shape having an expandable base and a vertex. An elongate member having a proximal end and a distal end is attached to the expandable base of the porous material at a first circumferential location of the expandable base and extends perpendicularly from a central axis of the filter. An aspiration tube, for removing embolic material under vacuum, communicates with an area at the first circumferential location of the expandable base. Methods of using the filter and occluding devices for protecting a patient from embolization during cardiovascular procedures are described.
摘要翻译：包括多孔材料的过滤器布置成具有可扩展基部和顶点的大致圆锥形状。具有近端和远端的细长构件在可膨胀基部的第一圆周位置处附接到多孔材料的可膨胀基部并且从过滤器的中心轴线垂直延伸。用于在真空下去除栓塞材料的抽吸管与可扩张基座的第一周向位置处的区域连通。描述了在心血管程序期间使用过滤器和闭塞装置来保护患者免于栓塞的方法。

10. 发明授权

US07427287B2 Medical device introducer and obturator and methods of use 有权
标题翻译：医疗器械引导器和闭孔器及使用方法
公开(公告)号：US07427287B2
公开(公告)日：2008-09-23
申请号：US11071624
申请日：2005-03-03
申请人： Roman Turovskiy , Richard O. Murphy
发明人： Roman Turovskiy , Richard O. Murphy
IPC分类号： A61B17/34 , A61M5/178
CPC分类号： A61B17/3421 , A61B17/3417 , A61B2017/00243 , A61B2017/3445 , A61B2017/3447 , A61F2002/011
摘要： An introducer having an elongate tubular member and a device connector releasably attached to a proximal end of the tubular member. The introducer allows exchange of medical instruments, such as a blood filter and cardioplegia catheter, through a single lumen. An obturator having a retractable blade for making incision on a tissue is insertable through the lumen of the introducer. Methods of using the obturator and the introducer for introducing medical device(s) into body cavity, such as a vessel or cardiac tissue, are also disclosed.
摘要翻译：引导器具有细长的管状构件和可释放地附接到管状构件的近端的装置连接器。引导器允许通过单个管腔交换诸如血液过滤器和心麻痹导管的医疗器械。具有用于在组织上进行切口的可伸缩刀片的闭塞器可插入导引器的内腔中。还公开了使用闭孔器和引导器将医疗装置引入体腔如血管或心脏组织的方法。

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