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1. 发明申请

US20090214489A1 PEPTIDES AND COMPOUNDS THAT BIND TO A RECEPTOR 审中-公开
标题翻译：与受体结合的肽和化合物
公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K35/12 , C07K7/06 , C07K1/107 , A61K38/08 , C12N5/00 , C12N5/08 , C07K7/64 , A61P7/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

2. 发明授权

US5643873A Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 失效
标题翻译：结合选丝素的肽和化合物，包括内皮细胞粘附分子1
公开(公告)号：US5643873A
公开(公告)日：1997-07-01
申请号：US241054
申请日：1994-05-11
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , A61K51/08 , C07K1/04 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： A61K49/0056 , A61K47/48238 , A61K51/08 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译：公开了结合选择素的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点炎症由一种或多种选择素的存在介导。

3. 发明授权

US07741062B2 Epitope-captured antibody display 失效
标题翻译：表位捕获抗体显示
公开(公告)号：US07741062B2
公开(公告)日：2010-06-22
申请号：US12420001
申请日：2009-04-07
申请人： William J. Dower , Steven E. Cwirla
发明人： William J. Dower , Steven E. Cwirla
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , C07K16/28 , C07K16/2878 , C40B30/04 , G01N33/531 , G01N33/6845 , G01N33/6857 , G01N2035/00158 , G01N2600/00
摘要： Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.
摘要翻译：提供了用于检测样品中靶蛋白的试剂和方法。试剂包括可复制的遗传包装，显示在由包装所携带的异源核酸表达的包装外表面上的蛋白质，以及与表达的蛋白质复合的一种或多种抗体，并且具有用于靶蛋白。因此，一段核酸编码由表达的多肽和靶蛋白共享的表位。试剂可以单独使用或作为文库或阵列的一部分来结合蛋白质样品中的靶蛋白以形成一种或多种复合物。通过确定复合物内的包装的异源核酸的片段的序列，可以鉴定靶蛋白，因为片段编码由表达的和靶蛋白共享的表位。

4. 发明授权

US06506362B1 Labeled compounds that bind to a thrombopoietin receptor 有权
标题翻译：与血小板生成素受体结合的标记化合物
公开(公告)号：US06506362B1
公开(公告)日：2003-01-14
申请号：US09832230
申请日：2001-04-10
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3819
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

5. 发明授权

US5723286A Peptide library and screening systems 失效
公开(公告)号：US5723286A
公开(公告)日：1998-03-03
申请号：US541108
申请日：1990-06-20
申请人： William J. Dower , Steven E. Cwirla , Ronald W. Barrett
发明人： William J. Dower , Steven E. Cwirla , Ronald W. Barrett
IPC分类号： C12N1/21 , C07K1/04 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , C07K14/435 , C07K14/675 , C12N7/00 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/70 , C12Q1/70 , C12R1/19 , C40B30/04 , C40B40/02 , G01N33/68 , C12N15/64 , C12Q1/60
CPC分类号： C40B30/04 , C07K1/047 , C07K14/435 , C07K14/675 , C07K5/0806 , C07K5/0812 , C07K5/1008 , C07K5/1016 , C12N15/1037 , C12N15/62 , C12N15/70 , C12Q1/70 , C40B40/02 , G01N33/6845 , G01N33/6878 , C07K2319/00
摘要： Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage particles are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor molecule.

6. 发明授权

US08227422B2 Peptides and compounds that bind to a receptor 有权
标题翻译：结合受体的肽和化合物
公开(公告)号：US08227422B2
公开(公告)日：2012-07-24
申请号：US11610226
申请日：2006-12-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

7. 发明授权

US07229757B2 Compounds displayed on icosahedral phage and methods of using same 失效
标题翻译：二十面体噬菌体上显示的化合物及其使用方法
公开(公告)号：US07229757B2
公开(公告)日：2007-06-12
申请号：US10105029
申请日：2002-03-21
申请人： Ronald W. Barrett , William J. Dower , Mark Gallop , Thomas F. Woiwode , Steven E. Cwirla
发明人： Ronald W. Barrett , William J. Dower , Mark Gallop , Thomas F. Woiwode , Steven E. Cwirla
IPC分类号： C12Q1/68
CPC分类号： C40B40/02 , C12N15/1037 , G01N33/6845
摘要： Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
摘要翻译：提供显示各种化合物的二十面体噬菌体及其收集物。在一些情况下，二十面体噬菌体包括用于记录附着于噬菌体的化合物或化合物的特征的核酸标签。还提供了许多用于使用二十面体噬菌体筛选化合物文库以获得所需生物学活性的不同方法，特别是用于受体介导的转运过程例如内吞作用和转胞吞作用的底物的化合物的测定。

8. 发明授权

US06251864B1 Peptides and compounds that bind to a receptor 有权
标题翻译：结合受体的肽和化合物
公开(公告)号：US06251864B1
公开(公告)日：2001-06-26
申请号：US09516704
申请日：2000-03-01
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3800
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

9. 发明授权

US5932546A Peptides and compounds that bind to the thrombopoietin receptor 失效
标题翻译：结合血小板生成素受体的肽和化合物
公开(公告)号：US5932546A
公开(公告)日：1999-08-03
申请号：US726464
申请日：1996-10-04
申请人： Ronald W. Barrett , William J. Dower , Steven E. Cwirla , Sherril S. Johnson , Nicholas C. Wrighton , David J. Duffin , Christopher R. Wagstrom
发明人： Ronald W. Barrett , William J. Dower , Steven E. Cwirla , Sherril S. Johnson , Nicholas C. Wrighton , David J. Duffin , Christopher R. Wagstrom
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06 , C07K7/08 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译：描述了结合并激活血小板生成素受体的肽和肽模拟物。这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

10. 发明授权

US5869451A Peptides and compounds that bind to a receptor 失效
公开(公告)号：US5869451A
公开(公告)日：1999-02-09
申请号：US764640
申请日：1996-12-11
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randoph B. DePrince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randoph B. DePrince , Surekha Podduturi , Qun Yin
IPC分类号： A61K38/00 , A61K38/02 , A61P7/00 , A61P43/00 , C07K5/00 , C07K7/00 , C07K14/52 , C07K17/08
CPC分类号： C07K14/524 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

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